Diethyldithiocarbamate enhances production of nitric oxide and TNF-α by lipopolysaccharide-stimulated rat Kupffer cells

Toxicological Sciences

Volumn 55, Issue 1, 2000, Pages 206-214

  Ishiyama, Hironobu ^a,c   Hoglen, Niel C ^b,c   Sipes, I Glenn ^c  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b PFIZER INC   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Diethyldithiocarbamate (DDC); NF B; Nitric oxide; Oxidative stress; Protein kinase C; Rat Kupffer cells; Tumor necrosis factor (TNF )

Indexed keywords

DIETHYLDITHIOCARBAMIC ACID; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ENZYME INHIBITION; IMMUNOCYTOCHEMISTRY; KUPFFER CELL; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CHELATING AGENTS; DITIOCARB; ENDOTOXINS; IMMUNOHISTOCHEMISTRY; KUPFFER CELLS; LIPOPOLYSACCHARIDES; MALE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STIMULATION, CHEMICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034071926     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Baeuerle, P. A., and Henkel, T. (1994). Function and activation of NF-κB in the immune system. Anna. Rev. Immunol. 12, 141-179.
2. Bankey, P., Carlson, A., Ortiz, M., Singh, R., and Cerra, F. (1990). Tumor necrosis factor production by Kupffer cells requires protein kinase-C activation. J. Surg. Res. 49, 256-261.
3. Bartle, W. R., Fisher, M. M., and Kerenyi, N. (1985). Disulfiram-induced hepatitis: report of two cases and review of the literature. Dig. Dis. Sci. 30, 834-837.
4. Berlin, R. G. (1989). Disulfiram hepatotoxicity: A consideration of its mechanism and clinical spectrum. Alcohol Alcoholism 24, 241-246.
5. Bulger, E. M., Garcia, I., and Maier, R. V. (1998). Dithiocarbamates enhance tumor necrosis factor-alpha production by rabbit alveolar macrophages, despite inhibition of NF-κB. Shock 9, 397-405.
6. Cathcart, R., Schwiers, E., and Ames, B. N. (1983). Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal. Biochem. 134, 111-116.
7. Decker, K. (1990). Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192, 245-261.
8. Dröge, W., Schulze-Osthoff, K., Mihm, S., Galter, D., Schenk, H., Eck, H. P., Roth, S. and Gmünder, H. (1994). Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J. 8, 1131-1138.
9. Edwards, M. J., Keller, B. J., Kauffman, F. C., and Thurman, R. G. (1993). The involvement of Kupffer cells in carbon tetrachloride toxicity. Toxicol. Appl. Pharmacol. 119, 275-279.
10. El Sisi, A. E., Earnest, D. L., and Sipes, I. G. (1993). Vitamine A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species. Toxicol. Appl. Pharmacol. 119, 295-301.
11. Fox, E. S., and Leingang, K. A. (1998). Inhibition of LPS-mediated activation in rat Kupffer cells by N-acetylcysteine occurs subsequent to NF-κB translocation and requires protein synthesis. J. Leukoc. Biol. 63, 509-514.
12. Goldstein, B. D., Rozen, M. G., Quintavalla, J. C., and Amoruso, M. A. (1979). Decrease in mouse lung and liver glutathione-peroxidase activity and potentiation of the lethal effects of ozone and paraquat by the superoxide dismutase inhibitor diethyldithiocarbamate. Biochem. Pharmacol. 28, 27-30.
13. Green, L. C., Ruiz de Luzuriaga, K., Wagner, D. A., Rand, W., Istfan, N., Young V. R., and Tannenbaum, S. R. (1981). Nitrate biosynthesis in man. Proc. Natl. Acad. Sci. U S A 78, 7764-7768.
14. Gunasekar, P. G., Kanthasamy, A. G., Borowitz, J. L., and Isom, G. E. (1995). Monitoring intracellular nitric oxide formation by dichlorofluorescin in neuronal cells. J. Neurosci. Methods 61, 15-21.
15. Gunawardhana, L., Lantz, R. C., Earnest, D. L., Abril, E. R., and Sipes, I. G. (1995). Differential production of superoxide by single Kupffer cells isolated from Fisher-344 and Sprague-Dawley rats following administration of the potent hepatotoxicant 1,2-dichlorobenzene. Cells Hep. Sinusoid 5, 45-47.
16. Gunawardhana, L., Mobley, S. A., and Sipes, I. G. (1993). Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fisher-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells. Toxicol. Appl. Pharmacol. 119, 205-213.
17. Hofsli, E., Bakke, O., Nonstad, U., and Espevik, T. (1989). A flow cytometric and immunofluorescence microscopic study of tumor necrosis factor production and localization in human monocytes. Cellular Immunol. 122, 405-415.
18. Hoglen, N. C., Younis, H. S., Hartley, D. P., Gunawardhana, L., Lantz, R. C., and Sipes, I. G. (1998). 1,2-Dichlorobenzene-induced lipid peroxidation in male Fisher 344 rats is Kupffer cell dependent. Toxicol. Sci. 46, 376-385.
19. Ishiyama, H., Hoglen, N. C., and Sipes, I. G. (1998). Role of Kupffer cells in rat liver injury induced by diethyldithiocarbamate: effect on Kupffer cell function. Toxicologist 42, 367.
20. Ishiyama, H., Ogino, K., and Hobara, T. (1995). Role of Kupffer cells in rat liver injury induced by diethyldithiocarbamate. Eur. J. Pharmacol. 292, 135-141.
21. Ishiyama, H., Ogino, K., Shimomura, Y., Kanbe, T., and Hobara, T. (1990). Hepatotoxicity of diethyldithiocarbamate in rats. Pharmacol. Toxicol. 67, 426-430.
22. Ishiyama, H., Yamasaki, K., Imaizumi, T., Kanbe, T., Ogino, K., Oka, S., Okazaki, Y., and Takemoto, T. (1988). Gastric antral ulcer produced by diethyldithiocarbamate in rats. J. Clin. Biochem. Nutr. 5, 155-163.
23. Izumi, Y., Ogino, K., Murata, T., Kobayashi, H., and Hobara, T. (1994). Effects of diethyldithiocarbamate on activating mechanisms of neutrophils. Pharmcol. Toxicol. 74, 280-286.
24. Kelner, M. J., and Alexander, N. M. (1986). Inhibition of erythrocyte superoxide dismutase by diethyldithiocurbamate also results in oxyhemoglobin-catalyzed glutathione depletion and methemoglobin production. J. Biol. Chem. 261, 1636-1641.
25. Knook, D. L., and Sleyster, E. C. (1976). Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation. Exp. Cell Res. 99, 444-449.
26. Laskin, D. L. (1990). Nonparenchymal cells and hepatotoxicity. Semin. Liver Dis. 10, 293-304.
27. Le Bel, C. P., Ischiropoulos, H., and Bondy, S. C. (1992). Evaluation of the probe 2′,7′-dichlororluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5, 227-231.
28. Lichtman, S. N., Wang, J., and Lemasters, J. J. (1998). Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: Sequence of intracellular signaling pathways. J. Leukoc. Biol. 64, 368-372.
29. 2+ are required for endotoxin-stimulated TNF-alpha release by rat Kupffer cells. Am. J. Physiol. 271, G920-G928.
30. 6-(l-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J. Med. Chem. 37, 3886-3888.
31. Mülsch, A., Schray-Utz, B., Mordvintcev, P. I., Hauschildt, S., and Busse, R. (1993). Diethyldithiocarbamate inhibits induction of macrophage NO synthase. FEBS Lett. 321, 215-218.
32. Nathan, C. (1992). Nitric oxide as a secretory product of mammalian cells. FASEB J. 6, 3051-3064.
33. Nobel, C. S. I., Kimland, M., Lind, B., Orrenius, S., and Slater, A. F. G. (1995). Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J. Biol. Chem. 270, 26202-26208.
34. Nussler, A. K., and Billiar, T. R. (1993). Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukoc. Biol. 54, 171-178.
35. Ogino, K. Hobara, T., Ishiyama, H., Yamasaki, K., Kobayashi, H., Izumi, Y., and Oka, S. (1992). Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats. Eur. J. Pharmacol. 212, 9-13.
36. Ogino, K. Hobara, T., Oka, S., Ishiyama, H., Yamasaki, K., and Kanbe, T. (1991). Reduction of the extent of diethyldithiocarhamate-induced antral gastric ulcer by neutrophil depletion in the rat. Pharmacol. Toxicol. 68, 144-145.
37. Ogino, K. Oka, S., Matsuura, I., Sakaida, S., Yoshimura, S., Matsuda, K., Sasaki, Y., Yamamoto, K., Yoshikawa, T., Okazaki, Y., and Takemoto, T. (1987). Ulcer formation in rat stomach with diethyldithiocarbamate. J. Clin. Biochem. Nutr. 3, 189-193.
38. Oka, S., Ogino, K., Hobara, T., Yoshimura, S., Yanai, H., Okazaki, Y., Takemoto, T., Ishiyama, H., Imaizumi, T., Yamasaki, K., and Kanbe, T. (1990). Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat. Experientia 46, 281-283.
39. Puglia, C. D., and Loeb, G. A. (1984). Influence of rat brain superoxide dismutase inhibition by diethyldithiocarbamate upon the rate of development of central nervous system oxygen toxicity. Toxicol. Appl. Pharmacol. 75, 258-264.
40. Rabkin, J. M., Corless, C. L., Orloff, S. L., Benner, K. G., Flora, K. D., Rosen H. R., and Olyaei, A. J. (1998): Liver transplantation for disulfiram-induced hepatic failure. Am. J. Gastroenterol. 93, 830-831.
41. Ravi, R., Krall, A., Rybak, L. P., and Struble, R. G. (1997). Olfactory mucosal lesions following subcutaneous diethyldithiocarbamate (DDTC). Neuro. Toxicology 18, 123-128.
42. Ravi, R., Rybak, L. P., and Struble, R. G. (1992). Olfactory mucosa degeneration following treatment by the chelating agent diethyldithiocarbamate (DDC). Soc. Neurosci. Abstr. 18, 1196.
43. Schmalbach, T. K., Datta, R., Kufe, D. W., and Sherman, M. L. (1992). Transcriptional regulation of cytokine expression by diethyldithiocarbamate in human HL-60 promyelocytic leukemia cells. Biochem. Pharmacol. 44, 365-371.
44. Schreck, R., Meier, B., Männel, D. N., Dröge, W., and Baeuerle, P. A. (1992). Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med. 175, 1181-1194.
45. Sipes, I. G., Elsisi, A. E. D., Simm, W. W., Mobley, S. A., and Earnest, D. L. (1989). Role of reactive oxygen species secreted by activated Kupffer cells in the potentiation of carbon tetrachloride hepatotoxicity by hypervitaminosis A. In Cells of the Hepatic Sinusoid (E. Wisse, D. L. Knock, and K. Decker, Eds.), Vol. 2, pp. 376-379. The Kupffer Cell Foundation, Rijswijk, The Netherlands.
46. Spitzer, J. A. (1994). Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats. Hepatology 19, 217-228.
47. Stadler, J., Harbrecht, B. G., DiSilvio, M. D., Curran, R. D., Jordan, M. L., Simmons, R. L., and Billiar, T. R. (1993), Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J. Leukoc. Biol. 53, 165-172.
48. Stott, I., Murthy, A., Robinson, A., Thomas N. W., and Fry J. R. (1997). Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat. Hum. Exp. Toxicol. 16, 262-266.
49. Tátrai, E., Náray, M., Brózik, M., Adamis, Z., and Ungváry, G. (1998) Combined pulmonary toxicity of diethyldithiocarbamate and lead (II) oxide in rats. J. Appl. Toxicol. 18, 33-37.
50. Togashi, H., Sasaki, M., Frohman, E., Taira, E., Ratan, R. R., Dawson, T. M. and Dawson, V. L. (1997). Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression. Proc. Natl. Acad. Sci. U S A 94, 2676-2680.
51. Tran-Thi, T. A., Decker, K., and Baeuerle, P. A. (1995). Differential activation of transcription factors NF-κB and AP-1 in rat liver macrophages. Hepatology 22, 613-619.
52. Trombetta, L. D., Toulon, M., and Jamall, I. S. (1988). Protective effects of glutathione on diethyldithiocarbamate (DDC) cytotoxicity: A possible mechanism. Toxicol. Appl. Pharmacol. 93, 154-164.
53. Winwood, P. J., and Arthur, M. J. P. (1993). Kupffer cells: their activation and role in animal models of liver injury and human liver disease. Semin. Liver Dis. 13, 50-59.
54. Yamano, T., and Morita, S. (1992). Hepatotoxicity of trichlorofon and dichlorvos in isolated rat hepatocytes. Toxicology 76, 69-77.
55. Younes, M., and Siegers, C. P. (1980). Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein. Arch. Toxicol. 45, 61-65.