Effect of Cyanidin 3-O-β-Glucopyranoside on Micronucleus Induction in Cultured Human Lymphocytes by Four Different Mutagens

Environmental and Molecular Mutagenesis

Volumn 43, Issue 1, 2004, Pages 45-52

  Fimognari, Carmela ^a   Berti, Fausto ^a   Cantelli Forti, Giorgio ^a   Hrelia, Patrizia ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Anthocyanins; Anti mutagenesis; Apoptosis; Micronuclei

Indexed keywords

ANTHOCYANIN; ANTIOXIDANT; COLCHICINE; CY G; CYANIDIN 3 GLUCOSIDE; CYANIDIN 3 O BETA GLUCOPYRANOSIDE; GLUCOPYRANOSIDE; HYDROGEN PEROXIDE; MESYLIC ACID ETHYL ESTER; MITOMYCIN C; MUTAGENIC AGENT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL DIVISION; CHEMOPROPHYLAXIS; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG MECHANISM; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE CULTURE; MICRONUCLEUS; MUTAGENESIS;

ADULT; ANTHOCYANINS; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYL METHANESULFONATE; HUMANS; HYDROGEN PEROXIDE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MITOMYCIN; MUTAGENS; T-LYMPHOCYTES;

EID: 0842309803     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10212     Document Type: Article

References (33)

1. Amorini AM, Fazzina G, Lazzarino G, Tavazzi B, Di Pierro D, Santucci R, Sinibaldi F, Galvano F, Galvano G. 2001. Activity and mechanism of the antioxidant properties of cyanidin-3-O-beta-glucopyranoside. Free Radic Res 35:953-966.
2. Block G, Patterson B, Subar A. 1992. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18:1-29.
3. Bolognesi C, Lando C, Forni A, Landini E, Scarpato R, Migliore L, Bonassi S. 1999. Chromosomal damage and ageing: effect on micronuclei frequency in peripheral blood lymphocytes. Age Ageing 28:393-397.
4. Bomser J, Madhavi DL, Singletary K, Smith MA. 1996. In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med 62: 212-216.
5. Bonassi S, Fenech M, Lando C, Lin YP, Ceppi M, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti MP, Bolognesi C, Jia C, Di Giorgio M, Ferguson LR, Fucic A, Lima OG, Hrelia P, Krishnaja AP, Lee TK, Migliore L, Mikhalevich L, Mirkova E, Mosesso P, Muller WU, Odagiri Y, Scarffi MR, Szabova E, Vorobtsova I, Vral A, Zijno A. 2001. HUman Micro-Nucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes. I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ Mol Mutagen 37:31-45.
6. Cao G, Muccitelli HU, Sanchez-Moreno C, Prior RL. 2001. Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 73:920-926.
7. Caria H, Quintas A, Chaveca T, Rueff J. 1997. The role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells. Mutat Res 377:269-277.
8. De Flora S, Ramel C. 1988. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview. Mutat Res 202:285-306.
9. Fenech M. 1993. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285:35-44.
10. Fenech M, Morley AA. 1985. Measurement of micronuclei in lymphocytes. Mutat Res 147:29-36.
11. Fenech M, Crott J, Turner J, Brown S. 1999. Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. Mutagenesis 14:605-612.
12. M. 2002. Studies on the antimutagenesis of Phyllanthus orbicularis: mechanisms involved against aromatic amines in Salmonella assay. Mutat Res 517:251-254.
13. Fimognari C, Nusse M, Cesari R, Cantelli-Forti G, Hrelia P. 2001. Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. Mutat Res 495:1-9.
14. Ghiselli G, Nardini M, Baldi A, Scaccini C. 1998. Antioxidant activity of different phenolic fractions separated from an Italian red wine. J Agric Food Chem 46:361-367.
15. Hodnick WF, Sartorelli AC. 1993. Reductive activation of mitomycin C by NADH:cytochrome b5 reductase. Cancer Res 53:4907-4912.
16. Holland NT, Duramad P, Rothman N, Figgs LW, Blair A, Hubbard A, Smith MT. 2002. Micronucleus frequency and proliferation in human lymphocytes after exposure to herbicide 2,4-dichlorophenoxyacetic acid in vitro and in vivo. Mutat Res 521:165-178.
17. Kirsch-Volders M, Elhajouji A, Cundari E, Van Hummelen P. 1997. The in vitro micronucleus test: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction. Mutat Res 392:19-30.
18. Lazzé MC, Pizzala R, Savio M, Stivala LA, Prosperi E, Bianchi L. 2003. Anthocyanins protect against DNA damage induced by tert-butylhydroperoxide in rat smooth muscle and hepatoma cells. Mutat Res 535:103-115.
19. Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP. 2003. Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J 22:5501-5510.
20. Lietti A, Cristoni A, Picci M. 1976. Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. Arzneimittelforschung 26:829-832.
21. Mailhes JB, Marchetti F. 1994. Chemically-induced aneuploidy in mammalian oocytes. Mutat Res 320:87-111.
22. Manning FC, Patierno SR. 1996. Apoptosis: inhibitor of instigator of carcinogenesis? Cancer Invest 14:455-465.
23. Miller BM, Madle S, Albertini S. 1994. Can a "relatively simple" screening procedure for the detection of chemicals with aneugenic potential be recommended at the moment? Mutat Res 304:303-307.
24. Miyazawa T, Nakagawa K, Kudo M, Muraishi K, Someya K. 1999. Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans. J Agric Food Chem 47:1083-1091.
25. Pool-Zobel BL, Bub A, Schröder N, Rechkemmer G. 1999. Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cells. Eur J Nutr 38:227-234.
26. Roy M, Chakrabarty S, Sinha D, Bhattacharya RK, Siddiqi M. 2003. Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate: a green tea polyphenol. Mutat Res 523/524:33-41.
27. Tomasz M, Palom Y. 1997. The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity. Pharmacol Ther 76:73-87.
28. Tsuda T, Shiga K, Ohshima K, Kawakishi S, Osawa T. 1996. Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L. Biochem Pharmacol 52:1033-1039.
29. Tsuda T, Horio F, Osawa T. 1998. Dietary cyanidin 3-O-beta-D-glucoside increases ex vivo oxidation resistance of serum in rats. Lipids 33:583-588.
30. Tsuda T, Horio F, Kitoh J, Osawa T. 1999. Protective effects of dietary cyanidin 3-O-beta-D-glucoside on liver ischemia-reperfusion injury in rats. Arch Biochem Biophys 368:361-366.
31. Wang H, Cao G, Prior RL. 1997. Oxygen radical absorbing capacity of anthocyanins. J Agric. Food Chem 45:304-309.
32. Waters MD, Stack HF, Jackson MA. 1998. Inhibition of genotoxic effects of mammalian germ cell mutagens. Mutat Res 402:129-138.
33. Youdim KA, Martin A, Joseph JA. 2000. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic Biol Med 29:51-60.