Protease-activated receptors

Current Topics in Developmental Biology

Volumn 54, Issue , 2003, Pages 343-369

  Bahou, Wadie F ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 1;

ANGIOGENESIS; ANIMAL; CARDIOVASCULAR DISEASE; CELL MEMBRANE; ENZYMOLOGY; EUKARYOTIC CELL; HUMAN; METABOLISM; NEOPLASM; PHYSIOLOGY; REVIEW;

ANIMALS; CARDIOVASCULAR DISEASES; CELL MEMBRANE; ENDOPEPTIDASES; EUKARYOTIC CELLS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTOR, PAR-1; RECEPTORS, CELL SURFACE;

EID: 0642339103     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0070-2153(03)54014-5     Document Type: Review

References (118)

1. P Andrade-Gordon C.K Derian B.E Maryanoff H.-C Zhang M.F Addo W.M Cheung B.P Damiano M.R D'Andrea A.L Darrow L de Gavavilla A.J Eckardt E Giardino B Haertlein D.F McComsey Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats J. Pharmacol. Exp. Ther. 298 2001 34 42
2. P Andrade-Gordon B.E Maryanoff C.K Derian H.-C Zhang M.F Addo A.L Darrow A.J Eckardt W.J Hoekstra D.F McComsey D Oksenberg E.E Reynolds R.J Santulli R Scarborough E.M Smit K.B White Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor Proc. Natl. Acad. Sci. USA 96 1999 12257 12262
3. W Bahou B Coller C Potter K Norton J Kutok M Goligorsky The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation J. Clin. Invest. 91 1993 1405 1413
4. W.F Bahou W.C Nierman A.S Durkin C.L Potter D.J Demetrick Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5 Blood 82 1993 1532 1537
5. R Bar-Shavit A Kahn G.D Wilner J.W Fenton Monocyte chemotaxis: stimulation by specific exosite region in thrombin Science 220 1983 728 731
6. D Baykal J Schmedtje Jr. M Runge Role of the thrombin receptor in restenosis and atherosclerosis Am. J. Cardiol. 75 1995 82B 87B
7. M Bernatowicz C Klimas K Hartl M Peluso N Alegretto S.M Seiler Development of potent thrombin receptor antagonist peptides J. Med. Chem. 39 1996 4879 4887
8. B Blomback M Blomback B Hessel S Iwanaga Structure of N-terminal fragments of fibrinogen and specificity of thrombin Nature 215 1967 1445 1448
9. L.F Brass D.R Manning A.G Williams M.J Woolkalis M Poncz Receptor and G protein-mediated responses to thrombin in HEL cells J. Biol. Chem. 266 1991 958 965
10. L Brass R Vassallo E Belmonte M Ahuja K Cichowski J Hoxie Structure and function of the human platelet thrombin receptor Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus J. Biol. Chem. 267 1992 13795 13798
11. K Brummel S Butenas K.G Mann An integrated study of fibrinogen during blood coagulation J. Biol. Chem. 274 1999 22862 22870
12. T.H Bugge Q Xiao K Kombrinck M Flock K Holmbäck M Danton M.C Colbert D Witte K Fujikawa E Davie J Degan Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation Proc. Natl. Acad. Sci. USA 93 1996 6258 6263
13. E Camerer W Huang S.R Coughlin Tissue factor- and Factor X-dependent activation of PAR2 by Factor VIIa Proc. Natl. Acad. Sci. USA 97 2000 5255 5260
14. P Carmeliet N Mackman Moons T Luther P Gressens I Vanvlaenderen Demunck M Kasper G Breier P Evrard M Muller W Risau T Edgington D Coleen Role of tissue factor in embryonic blood vessel development Nature 383 1996 73 75
15. H Carveth R Shaddy R Whatley T McIntyre S Prescott G Zimmerman Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin Sem. Thromb. Hemost. 18 1992 126 134
16. J Chen M Ishii L Wang K Ishii S.R Coughlin Thrombin receptor activation Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode J. Biol. Chem. 269 1994 16041 16045
17. J Chesebro P Zoldhhelyi V Fuster Pathogenesis of thrombosis in unstable angina Am. J. Cardiol. 68 1991 2B 10B
18. W.M Cheung M.R D'Andrea P Andrade-Gordon B.P Damiano Altered vascular injury responses in mice deficient in protease-activated receptor-1 Thromb. & Vasc. Biol. 1999 1999 3014 3024
19. G Cirino M Cicala M Bucci L Sorrentino J Maraganore S Stove Thrombin functions as an inflammatory mediator through activation of its receptor J. Exp. Med. 183 1996 821 827
20. T Cocks B Fong J Chow G Anderson A Frauman R Goldie P Henry M Carr R Hamilton J Moffatt A protective role for protease-activated receptors in the airways Nature 398 1999 156 160
21. A Connolly H Ishihara M.L Kahn R.V Farese S.R Coughlin Role of the thrombin receptor in development and evidence for a second receptor Nature 38 1996 516 519
22. J Cook G Sitko B Bednar C Condra M Mellott D Feng R Nutt J Shafer R Gould T Connolly An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey Circulation 91 1995 2961 2971
23. J Cui K.S O'Shea A Purkayastha T.L Saunders D Ginsburg Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V Nature (Lond.) 384 1996 66 68
24. M Cunningham E Rondeau X Chen S.R Coughlin S Holdsworth P Tipping Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomemlonephritis J. Exp. Med. 191 2000 455 462
25. L.D Cupit V.A Schmidt W.F Bahou Proteolytically activated receptor-3 A member of an emerging gene family of protease receptors expressed on vascular endothelial cells and platelets Trends Cardiovasc. Med. 9 1999 42 48
26. M D'Andrea C Derian R.J Santulli P Andrade-Gordon Differential expression of protease-activated receptors-1 and -2 stromal fibroblasts of normal, benigh, and malignant human tissues Am. J. Pathol. 158 2001 2031 2041
27. A.L Darrow W Fung-Leung R.D Ye R.J Santulli W.M Cheung C.K Derian C.L Burns B.P Damiano L Zhou C.M Keena P Peterson P Andrade-Gordon Biological consequences of thrombin receptor deficiency in mice Thromb. Haemost. 76 1996 860 866
28. M Dewerchin Z Liang L Moons P Carmeliet F Castellino D Collen E Rosen Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice Thromb. Haemost. 83 2000 185 190
29. H Dohlman J Thorner M Caron R Letkowitz Model systems for the study of seven-transmembrane-segment receptors Annu. Rev. Biochem. 60 1991 653 688
30. M.R Downing J.W Bloom K.G Maan Comparison of the inhibition of thrombin by three plasma protease inhibitors Biochemistry 17 1978 2649
31. J Ehrlich E Boyle J Labriola J Kovacich R Santucci C Fearns E Morgan W Yun T Luther O Kojikawa T Martin T Pohlman E Vernier N Mackman Inhibition of the tissue factor-thrombin pathway limits infarct size after myocardial ischemia-reperfusion injury by reducing inflammation Am. J. Pathol. 157 2000 1849 1862
32. C.T Esmon The regulation of natural anticoagulant pathways Science 235 1987 1348 1352
33. C.T Esmon Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin? Blood 95 2000 1113 1116
34. S Even-Ram B Uziely P Cohen S Grisaru-Granovsky M Maoz Y Ginzburg R Reich I Vlodavsky R Bar-Shavit Thrombin receptor overexpression in malignant and physiological invasion processes Nat. Med. 4 1998 909 914
35. T Faruqi E Weiss M.J Shapiro W Huang S.R Coughlin Structure-function analysis of protease-activated receptor 4 tethered ligand peptides Determinants of specificity and utility in assays of receptor function J. Biol. Chem. 2000 2000 19728 19734
36. M.I Furman L Longbin S.E Benoit R.C Becker M.R Barnard A.D Michelson The cleaved peptide of the thrombin receptor is a strong platelet agonist Proc. Natl. Acad. Sci. USA 95 1998 3082 3087
37. R.E Gertstzen J.I Chen M Ishii K Ishii L Wang T Nanevicz C.W Turck T.-K Vu S.R Coughlin Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface Nature 368 1994 648
38. C Griffin Y Srinivasan Y.-W Zheng W Huang S.R Coughlin A role for thrombin receptor signaling in endothelial cells during embryonic development Science 293 2001 1666 1669
39. J Hartwig G Bokoch C Carpenter P Janmey L Taylor A Toker T Stossel Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets Cell 82 1995 643 653
40. A Hasan S Amenta A Schmaier Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, and selective inhibitors of alpha-thrombin induced platelet activation Circulation 94 1996 517 528
41. R Hauck C Schulz A Schomig R Hoffman J.R Panettieri alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors Am. J. Physiol. 277 1999 L22 L29
42. M Heras J Chesebro M Webster J Mruk D Grill W Penny E.J.W Bowie L Badimon V Fuster Hirudin, heparin and placebo during deep arterial injury in the pig: the in vivo role of thrombin in platelet-mediated thrombosis Circulation 82 1990 1476 1484
43. J Herbert A Guy I Lamarche A Mares P Savi F Dol Intimal hyperplasia following vascular injury is not inhibited by an antisense thrombin receptor oligodeoxynucleotide J. Cell. Physiol. 170 1997 106 114
44. L Hou S Ravenall M Macey P Harriott S Kapas G.L Howells Protease-activated receptors and their role in IL-6 and NF-IL-6 expression in human gingival fibroblasts J. Periodontal. Res. 33 1998 205 211
45. D.T Hung T.-K Vu V.I Wheaton K Ishii S.R Coughlin Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation J. Clin. Invest. 89 1992 1350 1353
46. H Ishihara A Connolly D Zeng M.L Kahn W Zheng C Timmons T Tram S.R Coughlin Protease-activated receptor 3 is a second thrombin receptor in humans Nature 386 1997 502 506
47. A.L Jenkins C Chinni M Deniesse B.D Blackhart Expression of protease-activated receptor-2 during development Dev. Dynam. 218 2000 465 471
48. K Johnson Y Choi E Degroot I Samuels A Creasey L Aarden Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation J. Immunol. 160 1998 5130 5135
49. M.L Kahn M Nakanishi-Matsui M.J Shapiro H Ishihara S.R Coughlin Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin J. Clin. Invest. 103 1999 879 887
50. M.L Kahn Y.W Zheng W Huang V Bigornia D Zeng S Moff R.V Farese Jr. C Tam S.R Coughlin A dual thrombin receptor system for platelet activation Nature 394 1998 690 694
51. M Kimura T Anersen J Fenton W Bahou A Aviv Plasmin-platelet interaction involves cleavage of the functional thrombin receptor Am. J. Physiol. (Cell Physiol.) 40 1996 C54 C60
52. R.L Kinlough-Rathbone M Rand M.A Packham Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets Blood 82 1993 103 106
53. T Kozasa X Jiang M Hart P Sternweis W Singer A Gilman G Bollag P Sternweis RhoGEF, a GTPase-activating protein for Galpha2 and Galpha3 Science 280 1998 2109 2111
54. B Lebonniec C.T Esmon Glu-192—Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin Proc. Natl. Acad. Sci. USA 88 1991 7371 7375
55. L.-W Liu T.-K Vu C Esmon S Coughlin The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity J. Biol. Chem. 266 1991 16977 16980
56. A Lourbakos C Chinni P Thompson J Potempa J Travis E Mackie R Pike Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis FEBS Lett. 435 1998 45 48
57. J.M Maraganore P Bourdon J Jablonski K.L Ramachandran J.W Fenton Design and characterization of Hirulogs: A novel class of bivalent peptide inhibitors of thrombin Biochemistry 29 1990 7095 7101
58. I.I Mathews K.P Padmanabhan V Ganesh A Tulinsky M Ishii J Chen C.W Turck S.R Coughlin J.W Fenton Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes Biochemistry 33 1994 3266 3279
59. F Meloni A Schmaier Low molecular weight kininogen binds to platelets to modulate thrombin-induced platelet activation J. Biol. Chem. 266 1991 6786 6794
60. H Mirza V Schmidt C Derian J Jesty W Bahou Mitogenic responses mediated through the proteinase activated receptor-2 are induced by mast cell α - and β - tryptases Blood 90 1997 3914 3922
61. H Mirza V Yatsula W.F Bahou The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells Molecular characterization and evidence for functional coupling to the thrombin receptor J. Clin. Invest. 97 1996 1705 1714
62. M Molino D.F Bainton J Hoxie S.R Coughlin L.F Brass Thrombin receptors on human platelets Initial localization and subsequent redistribution during platelet activation J. Biol. Chem. 272 1997 6011 6017
63. M Molino N Blanchard E Belmonte A.P Tarver C Abrams J.A Hoxie C Cerletti L.F Brass Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin J. Biol. Chem. 270 1995 11168 11175
64. M Molino P Raghunath M Ahuja J.A Hoxie L Bras E.S Barnathan Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells Arteriosclerosis Thrombosis Vasc. Biol. 18 1998 825 832
65. M Molino M.J Woolkalis J Reavey-Cantwell D Practico P Andrade-Gordon L Brass Endothelial cell thrombin receptors and PAR-2: two protease-activated receptors located in a single cellular environment J. Biol. Chem. 272 1997 11133 11141
66. D Mosher A Vaheri J Choate C Gahmberg Action of thrombin on surface glycoproteins of human platelets Blood 53 1979 437 445
67. B Mueller R Reisfeld T.S Edgington W Ruf Expression of tissue factor by melanoma cells promotes efficient hematogeneous metastasis Proc. Natl. Acad. Sci. USA 11 1992 832 836
68. M Nakanishi-Matsui Y.W Zheng D Sulciner E Weiss M Ludeman S Coughlin PAR3 is a cofactor for PAR4 activation by thrombin Nature 404 2000 609 613
69. T Nanevicz L Wang M Chen M Ishii S.R Coughlin Thrombin receptor activating mutations Alteration of an extracellular agonist recognition domain causes constitutive signaling J. Biol. Chem. 271 1996 702 706
70. N.A Nelken S.J Soifer J O'Keefe T.-K.H Vu I.F Charo S.R Coughlin Thrombin receptor expression in normal and atherosclerotic human arteries J. Clin. Invest. 90 1992 1614 1621
71. H Neurath Evolution of proteolytic enzymes Science 224 1984 350 357
72. ∗ J. Biol. Chem. 271 1996 28407 28413
73. M.K.F Nierodzik S Karpatkin Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo Cancer Res. 52 1992 3267 3272
74. M.L Nierodzik K Chen K Takeshita J.J Li Y.Q Huang X.S Feng M.R D'Andrea P Andrade-Gordon S Karpatkin Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin—enhances experimental pulmonary metastasis Blood 92 1998 3694 3700
75. M.L Nierodzik A Plotkin F Kajumo S Kartpatkin Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo J. Clin. Invest. 87 1991 299 336
76. K.J Norton R.M Scarborough J.L Kutok M.A Escobedo L Nannizzi B.S Coller Immunologic analysis of the cloned platelet thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and insertion of the tethered ligand into a protected environment Blood 82 1993 2125 2136
77. S Nystedt K Emilsson A.K Larsson B Strombeck J Sundelin Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2 Eur. J. Biochem. 232 1995 84 89
78. S Nystedt K Emilsson C Wahlestedt J Sundelin Molecular cloning of a potential proteinase activated receptor Proc. Natl. Acad. Sci. USA 91 1994 9208 9212
79. S Nystedt S Ramakrishnan J Sundelin The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells J. Biol. Chem. 271 1996 14910 14915
80. P.J O'Brien N Prevost M Molino M Hollinger M Woolkalis D Woulfe L Bras Thrombin responses in human endothelial cells Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1 J. Biol. Chem. 275 2000 13502 13509
81. M Papadaki J Ruef K Nguyen F Li C Patterson S Eskin L McIntire M Runge Differential regulation of protease activated receptor-1 and tissue plasminogen activator expression by shear stress in vascular smooth muscle cells Circ. Res. 83 1998 1027 1034
82. D Practico N Murphy D Fitzgerald Interaction of a thrombin inhibitor and a platelet GP IIb/IIIa antagonist in vivo : evidence that thrombin mediates platelet aggregation and subsequent thromboxane A2 formation during coronary thrombolysis J. Pharmacol. Exp. Ther. 281 1997 1178 1185
83. R Puri F Zhou C Hu R Colman R Colman High molecular weight kininogen inhibits thrombin-induced platelet aggregation and cleavage of aggregin by inhibiting binding of thrombin to platelets Blood 77 1991 500 507
84. L Rao U Pendurthi Factor VIIIa-induced gene expression: potential implications in pathophysiology Trends Cardiovasc. Med. 11 2001 14 21
85. P Renesto M Si-Tahar M Moniatte V Balloy A Vandorsselaer D Pidard M Chignard Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor Blood 89 1997 1944 1953
86. M Riewald W Ruf Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor Proc. Natl. Acad. Sci. USA 98 2001 7742 7747
87. M Riewald V Kravchenko R Petrovan P O'Brien L Brass R Ulevitch W Ruf Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1 Blood 97 2001 3109 3116
88. E Rosen J Chan E Idusogie F Clotman G Vlasuk T Luther L Jalbert S Albrecht L Zhong A Lissens L Schoonjans L Moons D Collen F Castellino P Carmeliet Mice lacking factor VII develop normally but suffer fatal perinatal bleeding Nature 390 1997 290 294
89. R.D Rosenberg The absence of the blood clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system Thromb. Haemost. 74 1996 52 57
90. G.R Sambrano W Huang T Faruqi S Mahrus C Craik S Coughlin Cathepsin G activates protease-activated receptor-4 in human platelets J. Biol. Chem. 275 2000 6819 6823
91. R Scarborough M Naughton W Teng D Hung J Rose T Vu V Wheaton C Turck S Coughlin Tethered ligand agonist peptides: structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function J. Biol. Chem. 267 1992 13146 14149
92. T Schlaeger S Bartunkova J Lawitts G Teichmann W Risau U Deutsch T Saton Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice Proc. Natl. Acad. Sci. USA 94 1997 3058 3063
93. K.T Schmeidler-Sapiro O.D Ratnoff E.M Gordon Mitogenic effects of coagulation factor XII and factor XIIa on Hep G2 cells Proc. Natl. Acad. Sci. USA 88 1991 4382 4385
94. V Schmidt E Vitale W Bahou Genomic cloning and characterization of the human thrombin receptor gene: evidence for a novel gene family that includes PAR-2 J. Biol. Chem. 271 1996 9307 9312
95. V.A Schmidt W.C Nierman T.B Feldblyum D.R Maglott W.F Bahou The human thrombin receptor and proteinase activated receptor-2 genes are tightly linked on chromosome 5q13 Br. J. Haematol. 97 1997 523 529
96. V.A Schmidt W.C Nierman D.R Maglott L.D Cupit K.A Moskowitz J.A Wainer W.F Bahou The human proteinase-activated receptor-3 (PAR-3) gene Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets J. Biol. Chem. 273 1998 15061 15068
97. C Shima M Majima M Katori A stable metabolite Arg-Pro-Pro-Gly-Phe of bradykinin in the degradation pathway in human plasma Japan J. Pharmacol. 60 1992 111 119
98. C Sobey J Moffatt T Cocks Evidence for selective effects of chronic hypertension on cerebral artery vasodilation to protease-activated receptor-2 activation Stroke 30 1999 1933 1940
99. S Soifer K Peters J O'Keefe S.R Coughlin Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development Am. J. Pathol. 144 1994 60 69
100. S Steinberg R Robinson H Lieberman D Stern M Rosen Thrombin modulates phosphoinositide metabolism, cytosolic calcium, and impulse initiation in the heart Circ. Res. 68 1991 1216 1229
101. M Steinhoff N Vergnolle S Young M Tognetto S Amadesi H Ennes M Trevisani M hollenberg J.C.G Wallace S Mitchell L Williams P Geppetti E Mayer N Bunnett Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism Nat. Med. 6 2000 151 158
102. ∼protein-activated human phosphoinositide-3 kinase Science 269 1995 690 693
103. H.S Suidan J Bouvier E Schaerer S.R Stone D Monard J Tschopp Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes Proc. Natl. Acad. Sci. USA 91 1994 8112 8116
104. W.Y Sun D.P Witte J.L Degen M.C Colbert M.C Burkart K Holmbäck Q Xiao T.H Bugge S.J Degen Prothrombin deficiency results in embryonic and neonatal lethality in mice Proc. Natl. Acad. Sci. USA 95 1998 7597 7602
105. M Takada H Tanaka T Yamada O Ito M Kogushi M Yanagimachi T Kawamura T Musha F Yoshida M Ito H Kobayashi S Yoshitake I Saito Antibody to thrombin receptor inhibits neointimal smooth muscle cell accumulation without causing inhibition of platelet aggregation or altering hemostatic parameters after angioplasty in rat Circ. Res. 82 1998 980 987
106. J.F Taylor A Chang C.T Esmon A D'Angelo S Vigano-D'angelo K Blick Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon J. Clin. Invest. 97 1987 918 925
107. J.F Taylor A Chang W Ruf J Morrissey L Hinshaw R Catlett K Blick T Edginton Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody Circ. Shock 1991 1991 33 127134
108. C Tiruppathi H Lum T.T Andersen J.W Fenton 2. A.B Malik Thrombin receptor 14-amino acid peptide binds to endothelial cells and stimulates calcium transients Am. J. Physiol. 263 1992 L595 L601
109. J Toomey K Kratzer N Lasky J Stanton Jr.G Broze Targeted disruption of the murine tissue factor gene results in embryonic lethality Blood 88 1996 1583 1587
110. V.S.N Turgeon L Houenou Thrombin: a neuronal cell modulator Thromb. Res. 99 2001 417 427
111. J Venter M Adams G Sutton A Kerlavage H Smith M Hunkapiller Shotgun sequencing of the human genome Science 280 1998 1540 1542
112. T Vu D Hung V Wheaton S Coughlin Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Cell 64 1991 1057 1068
113. T.-K Vu V Wheaton D Hung I Charo S Coughlin Domains specifying thrombin-receptor interaction Nature 353 1991 674 677
114. J Wilcox J Rodriguez R Subramanian J Ollerenshaw C Zhong D Hayzer C Horaist S Hanson A Lumdsen T Salam Characterization of thrombin receptor expression during vascular lesion formation Circ. Res. 75 1994 1029 1038
115. W Xu H Andersen T.E Whitmore S.R Presnell D.P Yee A Shing T Gilbert E.W Davie D.C Foster Cloning and characterization of human protease-activated receptor 4 Proc. Natl. Acad. Sci. USA 95 1998 6642 6646
116. J Xue Q Wu L.A Westfield E.A Tuley D Lu Q Zhang K Shim X Zheng J.E Sadler Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice Proc. Natl. Acad. Sci. USA 95 1998 7603 7607
117. G Zimmerman T McIntyre S Prescott Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro J. Clin. Invest. 76 1985 2235 2246
118. S Zucker C Conner B Dimassimo H Ende W Bahou Thrombin induces cell surface activation of gelatinase A in vascular endothelial cells: physiological regulation of angiogenesis J. Biol. Chem. 270 1995 23730 23738