Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung

Molecular Therapy

Volumn 8, Issue 6, 2003, Pages 948-956

  Ziady, Assem Galal ^a   Gedeon, Christopher R ^b   Muhammad, Osman ^b   Stillwell, Virginia ^a   Oette, Sharon M ^b   Fink, Tamara L ^b   Quan, Will ^a   Kowalczyk, Tomasz H ^b   Hyatt, Susannah L ^b   Payne, Jennifer ^b   Peischl, Angela ^b   Seng, J E ^c   Moen, Robert C ^b   Cooper, Mark J ^b   Davis, Pamela B ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b Copernicus Therapeutics Inc ^*  (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Compacted DNA nanoparticles; CpG motifs; In vivo gene delivery to the lung; Inflammatory cytokines; PEGylated poly l lysine

Indexed keywords

COMPLEMENT; CYTOKINE; DNA; GENOMIC DNA; INTERLEUKIN 6; LIPOFECTIN; MACROGOL; MACROPHAGE INFLAMMATORY PROTEIN 2; NAKED DNA; NANOPARTICLE; POLYLYSINE; SODIUM CHLORIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD ANALYSIS; CELL COUNT; CELL INFILTRATION; COMPLEX FORMATION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; GENETIC TRANSFECTION; GROOMING; GROWTH; HEMATOLOGICAL PARAMETERS; HISTOLOGY; LUNG LAVAGE; LUNG VEIN; MALE; MOLECULAR STABILITY; MONONUCLEAR CELL; MOUSE; NEUTROPHIL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHYSICAL ACTIVITY; PROVOCATION TEST; RESPIRATORY EPITHELIUM; SUSPENSION; TOXICITY TESTING;

ESCHERICHIA COLI; MURINAE;

EID: 0347917175     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2003.09.002     Document Type: Article

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