Induction and regulation of Th1-inducing cytokines by bacterial DNA, lipopolysaccharide, and heat-inactivated bacteria

Infection and Immunity

Volumn 67, Issue 12, 1999, Pages 6257-6263

  Huang, L Y ^a   Krieg, A M ^b   Eller, N ^a   Scott, D E ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRUCELLA ABORTUS; CONTROLLED STUDY; CYTOKINE RELEASE; HELPER CELL; IMMUNE RESPONSE; IMMUNITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; BRUCELLA ABORTUS; CYTOKINES; DNA, BACTERIAL; HEAT; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; SPLEEN; TH1 CELLS;

EID: 0032743542     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Anitescu, M., J. H. Chace, R. Tuetken, A. K. Yi, D. J. Berg, A. M. Krieg, and J. S. Cowdery. 1997. Interleukin-10 functions in vitro and in vivo to inhibit bacterial DNA-induced secretion of IL-12. J. Interferon Cytokine Res. 12: 781-788.
2. Ballas, Z. K., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of natural killer activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840-1845.
3. Berg, D. J., R. Kuhn, K. Rajewsky, W. Muller, S. Menon, N. Davidson, G. Grunig, and D. Rennick. 1995. Interleukin-10 is a central regulator of the responses to LPS in murine models of endotoxic shock and the Schwartzman reaction but not endotoxin tolerance. J. Clin. Investig. 96:2339-2347.
4. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular Responses to Interferon-gamma. Annu. Rev. Immunol. 15:749-795.
5. Bradley, L. M., D. K. Dalton, and M. Croft. 1996. A direct role for IFN-gamma in regulation of Th1 cell development. J. Immunol. 157:1350-1358.
6. Bradley, L. M., K. Yoshimoto, and S. L. Swain. 1995. The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J. Immunol. 155:1713-1724.
7. + T cells. J. Exp. Med. 178:1655-1663.
8. Chace, J. H., N. A. Hooker, K. L. Mildenstein, A. M. Krieg, and J. S. Cowdery. 1997. Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84:185-193.
9. Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper (Th1) Immunity. J. Exp. Med. 186:1623-1631.
10. Clerici, M., and G. M. Shearer. 1993. A Th1 to Th2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107-111.
11. Cowdery, J. S., J. H. Chace, A.-K. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156:4570-4575.
12. Da Costa, M., J.-P. Guillou, B. Garin-Bastuji, M. Thiebaud, and G. Dubray. 1996. Specificity of six gene sequences for the detection of the genus Brucella by DNA amplification. J. Appl. Bacteriol. 81:267-275.
13. Davis, H. L., R. Weeranta, T. J. Waldschmidt, L. Tygrett, J. Schorr, and A. M. Krieg. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160:870-876.
14. DeKruff, R. H., R. S. Gieni, and D. T. Umetsu. 1997. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J. Immunol. 158:359-366.
15. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, Jr., M. P. Beckman, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303-333.
16. Finkelman, F. D., I. M. Katona, T. R. Mosmann, and R. L. Coffman. 1988. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J. Immunol. 140:1022-1027.
17. Finkelman, F. D., I. M. Katona, J. F. Urban, Jr., J. Holmes, J. Ohara, A. S. Tung, J. v. Sample, and W. E. Paul. 1988. IL-4 is required to generate and sustain in vivo IgE responses. J. Immunol. 141:2335-2341.
18. Finkelman, F. D., T. Shea-Donohue, J. Goldhill, C. A. Sullivan, S. C. Morris, K. B. Madden, W. C. Gause, and J. F. J. Urban. 1997. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu. Rev. Immunol. 15:505-533.
19. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815-3822.
20. Flesch, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J. Exp. Med. 181:1615-1621.
21. Gajewski, T. F., J. Joyce, and F. W. Fitch. 1989. Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of Th1 and Th2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma. J. Immunol. 143:15-22.
22. Gately, M. K., D. M. Carvajal, S. E. Connaughton, S. Gilessen, R. R. Warrier, K. D. Kolinsky, V. L. Wilkinson, C. M. Dwyer, G. F. J. Higgins, F. J. Podlaski, D. A. Faherty, P. C. Familletti, A. S. Stern, and D. H. Presky. 1996. Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann. N. Y. Acad. Sci. 795:1-12.
23. Gillessen, S., D. Carvajal, P. Ling, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25:200-206.
24. Goldstein, J., T. Hoffman, C. Frasch, E. F. Lizzio, P. R. Beining, D. Hochstein, Y. L. Lee, R. D. Angus, and B. Golding. 1992. Lipopolysaccharide (LPS) from Brucella abortus is less toxic that that from Escherichia coli, suggesting the possible use of B. abortus or LPS from B. abortus as a carrier in vaccines Infect. Immun. 60:1385-1389.
25. Hayes, M. P., J. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646-650.
26. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
27. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
28. Klinman, D. M., G. Yamshchikov, and Y. Ishigatsubo. 1997. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol. 158:3635-3639.
29. Klinman, D. M., A. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA 93:2879-2883.
30. Krieg, A. M., A. K. Yi, J. Schorr, and H. L. Davis. 1998. The role of CpG dinucleotides in DNA vaccines. Trends Microbiol. 6:23-27.
31. Ladel, C. H., G. Szalay, D. Riedel, and S. H. E. Kaufmann. 1997. Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages. Infect. Immun. 65:1936-1938.
32. Lamont, A. G., and L. Adorini. 1996. IL-12: a key cytokine in immune regulation. Immunol. Today 17:214-217.
33. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin-12 p40 gene promoter is primed by interferon-gamma in monocytic cells. J. Exp. Med. 183:147-157.
34. Maggi, E., P. Parronchi, R. Manetti, C. Simonelli, M.-P. Picclnnl, F. S. Rugiu, M. De Carli, M. Ricci, and S. Romagnani. 1992. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J. Immunol. 148:2142-2147.
35. Manetti, R., F. Annunziato, L. Tomasevic, V. Gianno, P. Parronchi, S. Romagnani, and E. Maggi. 1995. Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12. Eur. J. Immunol. 25: 2656-2660.
36. Mannetti, R., P. Paronchi, M. G. Giudizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (IL 12 [IL-12]) induces T helper type I (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
37. Maruo, S., M. Oh-hora, H. Ahn, S. Ono, M. Wysocka, Y. Kaneko, H. Yagita, K. Okumura, H. Kikutani, T. Kishimoto, M. Kobayashi, T. Hamaoka, G. Trinchieri, and H. Fujiwara. 1997. B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC in-teractions. J. lmmunol 158:120-126.
38. Moore, K. W., A. O'Garra, R. de Waal-Maleryt, P. Vieira, and T. R. Mos-mann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165-190.
39. Mosmann, T. R., and R. L. Coffman. 1989. ThI and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
40. Noble, A., D. Z. Staynov, and D. M. Kemeny. 1993. Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-gamma. Immunology 79:562.
41. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K, Torigoe, T. Okura, Y. Nukada, K. Hattori, K. Akita, M. Namba, F. Tanabe, K. Konishi, S. Fukuda, and M. Kurimoto. 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378:88-91.
42. Oriss, T. B., S. A. McCarthy, B. F. Morel, M. A. K. Campana, and P. A. Morel. 1997. Crossregulation between T helper cell (Th)1 and Th2. J. Immunol. 158:3666-3672.
43. Ozman, L., M. Pericin, J. Hakimi, R. A. Chizzonite, M. Wysocka, G. Trinchieri, M. Gately, and G. Garotta. 1994. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med. 180:907-915.
44. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241-251.
45. Pisetsky, D. S. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity 5:303-310.
46. Raz, E., H. Tighe, Y. Sato, M. Corr, J. A. Dudler, M. Roman, S. L. Swain, H. L. Spiegelberg, and D. A. Carson. 1996. Preferential induction of Th1 immune response and inhibition of specific IgE antibody formation by plas-mid DNA immunization. Proc. Natl. Acad. Sci. USA 93:5141-5145.
47. Reis e Sousa, C., S. Hieny, T. Scharton-Kerston, D. Jankovic, H. Charest, R. N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819-1829.
48. Roman, M., E. Martin-Orozko, J. S. Goodman, M.-D. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:849-854.
49. Scott, D. E., I. Agranovich, J. Inman, M. Gober, and B. Golding. 1997. Inhibition of primary and recall allergen-specific T helper cell type 2-mediated responses by a T helper cell type 1 stimulus J. Immunol. 159:107-116.
50. Scott, D. E., and L.-Y. Huang. Unpublished data.
51. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production. J. Immunol. 156:1196-1206.
52. Street, N. E., J. H. Schumacher, T. Fong, H. Bass, D. F. Fiorentino, J. A. Leverah, and T. R. Mosmann. 1990. Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells. J. Immunol. 144:1629-1639.
53. Sutterwala, F. S., G. J. Noel, R. Clynes, and D. M. Mosser. 1997. Selective suppression of interleukin-12 induction after macrophage receptor ligation. J. Exp. Med. 185:1977-1985.
54. + T cells. Int. Immunol. 5:877-883.
55. Trinchieri, G. 1995. IL-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 3:251-276.
56. Trinchieri, G. 1997. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma). Curr. Opin. Immunol. 9:17-23.
57. Ulrich, J. T., and K. R. Myers. 1995. Monophosphoryl lipid A as an adjuvant. Past experiences and new directions. Pharmacol. Biotechnol. 6:495-524.
58. VanCott, T. C., R. W. Kaminski, J. R. Mascola, V. S. Kalyanaraman, N. M. Wassef, C. R. Alving, J. T. Ulrich, G. H. Lowell, and D. L., Birx. 1998. HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with the oligomeric gp160. J. Immunol. 160:2000-2012.
59. Wenner, C. A., M. L. Guler, S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1996. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper 1 development. J. Immunol. 156:1442-1447.