Probiotics to enhance anti-infective defences in the gastrointestinal tract

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 17, Issue 5, 2003, Pages 755-773

  Gill, Harsharnjit S ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

Antibodies; Bifidobacterium; Cytokines; Diarrhoea; Immune response; Lactobacillus; Mucin; Natural killer cells; Phagocytic cells; Probiotics; Rotavirus

Indexed keywords

ACETIC ACID; ANTIBIOTIC AGENT; BACTERIOCIN; CARBON DIOXIDE; CYTOKINE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTEGRIN; INTERLEUKIN 1; LACTIC ACID; MUCIN; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; NEUTRALIZING ANTIBODY; PLACEBO; PROBIOTIC AGENT; TYPHOID VACCINE; YOGHURT; HN 019; UNCLASSIFIED DRUG;

ACUTE GASTROENTERITIS; BACTERIAL INFECTION; BACTERIUM ADHERENCE; CLINICAL TRIAL; CLOSTRIDIUM DIFFICILE; CYTOKINE PRODUCTION; DIARRHEA; DRUG EFFICACY; DRUG MECHANISM; DRUG SPECIFICITY; GASTROINTESTINAL INFECTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOST RESISTANCE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; INTESTINE MOTILITY; INTESTINE MUCOSA PERMEABILITY; LACTIC ACID BACTERIUM; NONHUMAN; PERMEABILITY BARRIER; REVIEW; TRAVELLER DIARRHEA; VIRUS INFECTION; ANTIMICROBIAL ACTIVITY; DEFENSE MECHANISM; GASTROINTESTINAL TRACT; HOSPITAL INFECTION; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; META ANALYSIS; NATURAL KILLER CELL; SYSTEMATIC REVIEW;

ANIMALS; BACTERIAL INFECTIONS; BIFIDOBACTERIUM; CYTOKINES; DIARRHEA; DIGESTIVE SYSTEM; GASTROINTESTINAL DISEASES; HUMANS; IMMUNITY; LACTOBACILLUS; PROBIOTICS; VIRUS DISEASES;

EID: 0347353507     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6918(03)00074-X     Document Type: Review

References (110)

1. Isolauri E. Juntunen M. Rautanen T. et al. A human Lactobacillus strain (Lactobacillus casei sp GG) promotes recovery from acute diarrhoea in children Pediatrics 88 1991 90-97
2. Isolauri E. Kaila M. Mykkanen H. et al. Oral bacteriotherapy for viral gastroenteritis Digestive Diseases and Science 39 1994 2595-2600
3. Majamaa H. Isolauri E. Saxelin M. Vesikari T. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis Journal of Pediatric Gastroenterology and Nutrition 20 1995 333-338
4. Shornikova A.V. Casas I.A. Isolauri E. et al. Lactobacillus reuteri as a therapeutic agent in acute diarrhoea in young children Journal of Pediatric Gastroenterology and Nutrition 24 1997 399-404
5. Van Niel C.W. Feudtner C. Garrison M.N. Christakis D.A. Lactobacillus therapy for acute infectious diarrhoea in children: a meta analysis Pediatrics 109 2002 678-684
6. Guandalini S. Pensabene L. Zikri M.A. et al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhoea: a multicenter European trial Journal of Pediatric Gastroenterology and Nutrition 30 2000 54-60
7. Saavadra J.M. Bauman N.A. Oung I. et al. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus Lancet 344 1994 1046-1069
8. Oberhelman R. Gilman R.H. Sheen P. et al. A placebo controlled trial of Lactobacillus GG to prevent diarrhoea in undernourished Peruvian children Journal of Paediatrics 134 1999 15-20
9. Pedone C. Bernabeu A. Postaire E. et al. The effect of supplementation with milk fermented by Lactobacilus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres International Journal of Clinical Practice 53 1999 179-184
10. Szajewska H. Kotowska M. Mrukowickz J.Z. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhoea in infants Journal of Pediatrics 138 2001 361-365
11. Araki T. Shinozaki T. Irie Y. Miyazawa Y. Trial of oral administration of Bifidobacterium breve for the prevention of rotavirus infection Journal of the Japanese Association of Infectious Diseases 73 1999 305-310
12. Teitelbaum J.E. Walker A.W. Nutritional impact of pre and probiotics as protective gastrointestinal organisms Annual Review of Nutrition 22 2002 107-138
13. Pathmakanthan S. Meance S. Edwards C.A. Probiotics: a review of human studies to date and methodological approaches Medical Ecology in Health and Disease 2 supplement 2000 10-13
14. Marteau P. Seksik P. Jain R. Probiotics and intestinal health effects: a clinical perspective British Journal of Nutrition 88 2002 S51-S57
15. Orrhage K. Brismar B. Nord C.E. Effects of supplements of Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microbiota during administration of clindamycin Microbiology, Ecology, Health and Disease 7 1994 17-25
16. McFarland L.V. Surawicz C.M. Greenberg R.N. et al. Prevention of beta lactam associated diarrhoea by Saccharomyces boulardii compared to placebo American Journal of Gastroenterology 90 1995 439-448
17. Vanderhoof J.A. Whitney D.B. Antonson D.L. et al. Lactobacillus GG in the prevention of antibiotic-associated diarrhoea in children Journal of Pediatrics 135 1999 564-568
18. D'Souza A.L. Rajkumar C. Cooke J. Bulpitt J. Probiotics in prevention of antibiotic-associated diarrhoea: meta analysis British Medical Journal 324 2002 1361-1364
19. Pozo-Olano J.D. Warram J.H. Gomez R.G. Cavazos M.G. Effect of a lactobacilli preparation on traveler's diarrhea. A randomized, double blind clinical trial Gastroenterology 74 1978 829-830
20. Kollaritsch H Stemberger H Ambrosch P et al. Prophylaxe des reisendiarrhoe mit einem Lyophilisat von Lactobacillus acidophilus. In Proceedings of the Gemeinsame Tagung des Deutschen Tropenmedizinischen Gesellschaft, Oesterreichen Gesellschaft fur Tropenmedizin und Parasitologie, Abstract 92. Garmisch-Partenkirchen, 1983.
21. Black F.T. Andersen P.L. Orskov J. et al. Prophylactic efficacy of lactobacilli on traveller's diarrhoea Travel Medicine 7 1989 333-335
22. Oksanen P.J. Salminen S. Saxelin M. et al. Prevention of travellers diarrhoea by Lactobacillus GG Annals of Medicine 22 1990 53-56
23. Kollaritsch H. Holst H. Grobara P. Wiedermann G. Prophylaxe der reisediarrhöe mit Saccharomyces boulardii. [Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study] Forstchrite der Medizine 111 1993 153-156
24. Katelaris P.H. Salam I. Lactobacilli to prevent traveller's diarrhoea? New England Journal of Medicine 333 1995 1360-1361
25. Hilton E. Kolakowski P. Singer C. Smith M. Efficacy of Lactobacillus GG as a diarrheal preventive in travellers Journal of Travel Medicine 4 1997 41-43
26. Felley C.P. Corthesy-Thelaz I. Rivero J.L. et al. Favourable effects of an acidified milk (LC-1) on Helicobacter pylori gastritis in man European Journal of Gastroenterology and Hepatology 13 2001 25-29
27. Armuzzi A. Cremonini F. Bartolozzi F. et al. The effect of oral administration of Lactobacillus GG on antibiotic-associated gastrointestinal side-effects during Helicobacter pylori eradication therapy Alimentary Pharmacology and Therapeutics 15 2001 163-169
28. Candicci F. Armuzzi A. Cremonini F. et al. A lyophilised and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rate Alimentary Pharmacology and Therapeutics 14 2002 1625-1629
29. Sarker S.A. Gyr K. Non-immunological defence mechanisms of the gut Gut 33 1992 987-993
30. Ouwehand A.C. Kirjavainen P.V. Shortt C. Salminene S. Probiotics: mechanisms and established effects International Dairy Journal 9 1999 43-52
31. Michetti P. Dorta G. Wiesel P.H. et al. Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii) La1 on Helicobacter pylori infection in humans Digestion 60 1999 203-209
32. O'Sullivan D.J. Kullen M.J. Tracking of probiotic bifidobacteria in the intestine International Dairy Journal 8 1998 513-525
33. Bernet M.F. Brassart D. Neeser J.A. Servin A.L. Adhesion of human bifidobacteria strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interactions Applied and Environmental Microbiology 59 1993 4121-4128
34. Bernet M.F. Brassart D. Neeser J.A. Servin A.L. Lactobacillus acidophilus LA1 binds to cultured epithelial cell lines and inhibit cell attachment and cell invasion by enterovirulant bacteria Gut 35 1994 483-489
35. Gopal P. Prasad J. Smart J. Gill H.S. In vitro adherence properties of Lactobacillus rhamnosus, HN001 and Bifidobacterium lactis HN019 strains and their antagonistic activity against an enterotoxigenic Escherichia coli International Journal of Food Microbiology 67 2001 207-216
36. Hudault S. Livin V. Bernet-Camard M.F. Servin A. Antagonistic activity exerted in vitro and in vivo by Lactobacillus strain GG against Salmonella typhimurium S5 infection Applied and Environmental Microbiology 63 1997 513-518
37. Sanderson I.R. Walker W.A. Mucosal barrier. In Ogra P.L. Mestecky J. & Lamm M.E. (Eds.), Handbook of Mucosal Immunology 1994 41-51 Academic Press London
38. Mack D.R. Michail S. Wei S. et al. Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing mucin gene expression American Journal of Physiology 276 1999 G941-G950
39. Jarry A. Vallette G. Branka J.E. Laboisse C. Direct secretory effect of interleukin-1 via type I receptors in human colonic mucous epithelial cells (HT-29-C1.16E) Gut 38 1996 240-242
40. Plaisancie P. Barcelo A. Moro F. et al. Effects of neurotransmitters, gut hormones, and anti-inflammtaory mediators on mucus discharge in rat colon American Journal of Physiology 275 1998 G1073-G1084
41. Isolauri E. Majamaa H. Arvola T. et al. Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling rates Gastroenterology 105 1993 1643-1650
42. Terpend K. Blaton M.A. Candalh C. et al. Intestinal barrier function and cows milk sensitisation in guinea pigs fed milk or fermented milk Journal of Pediatric Gastroenterology and Nutrition 28 1999 191-198
43. Madsen K. Cornish A. Soper P. et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function Gastroenterology 121 2001 580-591
44. Neish A.S. Gewirtz A.T. Zeng H. et al. Prokaeryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination Science 289 2000 1560-1563
45. Gorbach S.L. Banwell J.G. Joacobs B. et al. Intestinal microflora in in Asiatic cholera. I. 'Rice water stool' Journal of Infectious Diseases 121 1970 32-37
46. Ventrappen G. Janssens J. Peeters T.L. The migrating motor complex Medical Clinics of North America 65 1981 1311-1329
47. Grimaud J.C. Bouvier J.G. Bertolino J.G. et al. Effets du lait fermente contenant du Bifidobacterium sur le temps de transit colique Gastroenterology and Clinical Biology 17 1993 A127
48. Takiguchi R. Miyamoto M. Mochizuki A. et al. Effect of fermented milk administration on defecation and faecal microflora of healthy volunteers Japanese Journal of Nutrition 11 1998 117-122
49. Mance S. Turchet P. Raimondi A. et al. Effect of a milk fermented by Bifidobacterium Sp. DN-173010 (BIO) on the oro-faecal transit time in eldery Gut 45 supplement 1999 A327
50. Heyman M. How dietary antigens access the mucosal immune system Proceedings of the Nutrition Society 60 2001 419-426
51. Jack R.S. Schutt C. Broker B.M. The guardians at the gate Trends in Immunology 23 2002 423-424
52. Kagnoff M.F. Eckmann L. Epithelial cells as sensors for microbial infection Journal of Clinical Investigation 100 1997 6-10
53. Uehara A. Sugawara S. Takada H. Priming of human oral epithelial cells by interferon-γ to secrete cytokines in response to lipoloysaccharide, lipotechoic acid and peptidoglycans Journal of Medical Microbiology 51 2002 624-636
54. Blum S. Delneste S. Alvarej S. et al. Interactions between commensal bacteria and mucosal immunocompetent cells International Dairy Journal 9 1999 63-68
55. Rescigno M. Urbano M. Valzasina B. et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria Nature Immunology 2 2001 361-367
56. Claassen E. Van Winsen R. Posno M. Boersma W.J.A. New and safe oral line vaccines based on Lactobacillus. In Mestecky J. Russell M.W. Jackson S.M. et al. (Eds.), Advances in Mucosal Immunology 1995 1553-1558 Plenum Press New York
57. Johansson M.L. Molin G. Jeppsson B. et al. Administration of different Lactobacillus strains in fermented oatmeal soup: in vivo colonisation of human intestinal mucosa and effect on the indigenous flora Applied and Environmental Microbiology 59 1993 15-20
58. Schiffrin E.J. Brassart D. Servin A. et al Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection American Journal of Clinical Nutrition 66 1997 515S-520S
59. Hessle C. Andersson B. Wold A.E. Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while Gram-negative bacteria preferentially stimulate IL-10 production Infection and Immunity 68 2000 3581-3586
60. Pochard P. Gosset P. Grangette C. et al. Lactic acid bacteria inhibit Th2 cytokine production by mononuclear cells from allergic patients Journal of Allergy and Clinical Immunology 110 2002 617-623
61. Christensen H.R. Hanne F. Pestika J.J. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells Journal of Immunology 168 2002 171-178
62. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adoptive immunity Nature Reviews Immunology 3 2003 133-146
63. Shanahan F. Nutrient tasting and signalling mechanisms in the gut. V. Mechanisms of immunologic sensation of intestinal contents American Journal of Physiology Gastrointestinal and Liver Physiology 278 2000 G191-G196
64. Delneste Y. Donnet-Hughes A. Schiffrin E.J. Functional foods: mechanisms of action on immunocompetent cells Nutrition Reviews 56 1998 S93-S98
65. Haller D. Bode C. Hammes W.P. et al. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leukocyte co-culture Gut 47 2000 79-87
66. McCracken V.J. Chun T. Baldeon M.E. et al. TNF-α sensitises HT-29 colonic epithelial cells to intestinal lactobacilli Experimental Biology and Medicine 227 2002 665-670
67. Maassen C.B.M. van Holten-Neelen C. Balk F. et al. Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains Vaccine 18 2000 2613-2623
68. Perdigon G. Galdeano C.M. Valdez J.C. Medici M. Interaction of lactic acid bacteria with the gut immune system European Journal of Clinical Nutrition 56 2002 S21-S26
69. de Simone C. Bianchi Salvadori B. Jirillo E. et al. Modulation of immune activities in humans and animals by dietary lactic acid bacteria. In Chandan R.C. (Ed.), Yogurt Nutritional and Health Properties 1989 201-213 John Libbey Eutotext London
70. Solis Pereyra B. Lemonnier D. Induction of 2-5A synthetase activity and interferon in humans by bacteria used in dairy products European Cytokine Network 2 1991 137-140
71. Wheeler J.G. Shema S. Bogle M.L. et al. Immune and clinical impact of Lactobacillus acidophilus on asthma Annals of Allergy, Asthma and Immunology 79 1997 229-233
72. Halpern G.M. Vruwink K.G. Van De Water J. et al. Influence of long-term yoghurt consumption in young adults International Journal of Immunotherapy 7 1991 205-210
73. + lymphocytes Nutritional Biochemistry 8 1997 25-31
74. Kishi A. Uno K. Matsubara Y. et al. Effect of the oral administration of Lactobacillus brevis subsp. coagulans on interferon producing capacity in humans Journal of the American College of Nutrition 15 1996 408-412
75. Arunachalam K. Gill H.S. Chandra R.K. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019) European Journal of Clinical Nutrition 54 2000 1-5
76. Trapp C.L. Chang C.C. Halpern G.M. et al. The influence of chronic yogurt consumption on populations of young and elderly adults International Journal of Immunotherapy 9 1993 53-64
77. Solis Pereyra B. Lemonnier D. Induction of human cytokines by bacteria used in dairy foods Nutrition Research 13 1993 1127-1140
78. Solis Pereyra B. Aattouri N. Lemonnier D. Role of food in the stimulation of cytokine production American Journal of Clinical Nutrition 66 1997 521S-525S
79. Miettinen M. Vuopio-Varkila J. Varkila K. Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria Infection and Immunity 64 1996 5403-5405
80. Cross M.L. Mortensen R. Kudsk J. Gill H.S. Probiotic stimulation of a mixed Th1/Th2 cytokine profile in pro-Th2 antigen-primed mice Medical Microbiology and Immunology 191 2002 49-53
81. Miettinen M. Matikainen S. Vupio-Varrkila J. et al. Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18 and gamma interferon production in human peripheral blood mononuclear cells Infection and Immunity 66 1998 6058-6062
82. Nussler A.K. Thomson A.W. Immunomodulatory agents in the laboratory and clinic Parasitology 105 1992 S5-S23
83. Steidler L. Robison K. Chamberlin L. et al. Mucosal delivery of murine interleukin-2 (IL-2) and IL-6 by recombinant strain of Lactococcus lactis coexpressing antigen and cytokine Infection and Immunology 66 1998 3183-3189
84. Gill H.S. Rutherfurd K.J. Gopal P. Cross M.L. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019 American Journal of Clinical Nutrition 74 2001 833-839
85. Gill H.S. Rutherfurd K.J. Cross M.L. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes Journal of Clinical Immunology 21 2001 264-271
86. Chiang B.L. Sheih Y.H. Wang L.H. Gill H.S. Enhancement of immunity by Bifidobacterium lactis: optimisation and definition of cellular responses European Journal of Clinical Nutrition 54 2000 849-855
87. Schiffrin E.J. Rochar F. Link-Amster H. et al. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria Journal of Dairy Science 78 1995 491-497
88. Donnet-Hughes A. Rochat F. Serrant P. et al. Modulation of nonspecific mechanisms of defense by lactic acid bacteria: effective dose Journal of Dairy Science 82 1999 863-869
89. Spanhaak S. Havenaar R. Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans European Journal of Clinical Nutrition 52 1998 899-907
90. Pelto L. Isolauri E. Lilius E.M. et al. Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects Clinical and Experimental Allergy and Immunology 28 1998 1474-1479
91. He F. Tuomola E. Arvilommi H. Salminen S. Modulation of humoral immune response through probiotic intake FEMS Immunology and Medical Microbiology 29 2000 47-52
92. Gill H.S. Cross M.L. Rutherfurd K.J. Gopal P.K. Dietary probiotic supplementation to enhance cellular immunity in the elderly British Journal of Biomedical Science 58 2001 94-96
93. Gill H.S. Rutherfurd K.J. Probiotic supplementation to enhance human natural immunity: effects of a newly characterised immunostimulatory strain (Lactobacillus rhamnosus HN001) on leucocyte phagocytosis Nutrition Research 21 2001 183-189
94. Sheih Y.H. Chiang B.L. Wang L.H. et al. Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001 Journal of the American College of Nutrition 20 2001 149-156
95. Mikes Z. Ferenicik M. Jahnova E. et al. Hypocholesterolemic and immunostimulatory effects of orally applied Enterococcus faecium M-74 in man Folia Microbiologica 40 1995 639-646
96. Gill H.S. Dairy products and the immune function in the elderly. In Mattila-Sandholm T. & Saarela M. (Eds.), Functional Dairy Products 2003 132-168 CRC Press Cambridge, FL
97. Gill H.S. Stimulation of the immune system by lactic cultures International Dairy Journal 8 1998 535-544
98. Marteau P. Vaerman J.P. Dehennin J.P. et al. Effect of intrajejunal perfusion and chronic ingestion of Lactobacillus johnsonii strain La1 on serum concentrations and jejunal secretions of immunoglobulins and serum proteins in healthy humans Gastroenterology and Clinical Biology 21 1997 293-298
99. Isolauri E. Joensus J. Suomalainen H. et al. Improved immunogenicity of oral D x RRV reabsorbant rotavirus vaccine by Lactobacillus casei GG Vaccine 13 1995 310-312
100. Majamaa H. Isolauri E. Saxelin M. Vesikari T. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis Journal of Pediatric Gastroenterology and Nutrition 20 1995 333-338
101. Kaila M. Isolauri E. Saxelin M. et al. Viable versus inactivated Lactobacillus strain GG in acute rotavirus diarrhoea Archives of Disease in Childhood 72 1995 51-53
102. Kaila M. Isolauri E. Soppi E. et al. Enhancement of the circulating antibody secreting cell response in human diarrhoea by a human Lactobacillus strain Pediatric Research 32 1992 141-144
103. Fukushima Y. Kawata Y. Hara H. et al. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children International Journal of Food Microbiology 42 1998 39-44
104. Link-Amster H. Rochat F. Saudan K.Y. et al. Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake FEMS Immunology and Medical Microbiology 10 1994 55-64
105. de Vrese M. Fenselau S. Feindt F. et al. Einfluss von probiotika auf die immunantwort auf eine polioschluckimpfung [Effects of probiotics on immune response to polio vaccination] Proceedings of the German Nutrition Society 3 2001 7
106. Yasui H. Mike A. Ohwaki M. Immunogenicity of Bifidobacterium breve and change in antibody production in Peyer's patches after oral administration Journal of Dairy Science 72 1989 30-35
107. Malin M. Verronen P. Mykkanen H. et al. Increased bacterial urease activity in faeces in juvenile chronic arthritis: evidence of altered intestinal microflora? British Journal of Rheumatology 35 1996 689-694
108. Isolauri E. Arvola T. Sutas Y. et al. Probiotics in the management of atopic eczema Clinical and Experimental Allergy 30 2000 1604-1610
109. Sutas Y. Hurme M. Isolauri E. Down-regulation of anti-CD3 antibody-induced IL-4 production by bovine caseins hydrolysed with Lactobacillus GG-derived enzymes Scandinavian Journal of Immunology 43 1996 687-689
110. De Simone C. Rosati E. Moretti S. et al. Probiotics and stimulation of the immune response European Journal of Clinical Nutrition 45 1991 32-34