An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification

Journal of Biological Chemistry

Volumn 277, Issue 48, 2002, Pages 46233-46242

  Xue, Tian ^a   Li, Ronald A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS;

ION CHANNELS;

PACEMAKERS;

CYSTEINE; ION CHANNEL; THIOL DERIVATIVE; THIOMESYLIC ACID METHYL ESTER;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHEMICAL MODIFICATION; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; HEART CONTRACTION; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; MOUSE; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYSTEINE; ION CHANNELS; MEMBRANE POTENTIALS; MICE; MUTAGENESIS; NERVE TISSUE PROTEINS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

ANIMALIA;

EID: 0037195838     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204915200     Document Type: Article

References (37)

1. Gauss, R., Seifert, R., and Kaupp, U. B. (1998) Nature 393, 583-587
2. Ludwig, A., Zong, X., Jeglitsch, M., Hofmann, F., and Biel, M. (1998) Nature 393, 587-591
3. Santoro, B., Liu, D. T., Yao, H., Bartsch, D., Kandel, E. R., Siegelbaum, S. A., and Tibbs, G. R. (1998) Cell 93, 717-729
4. Xue, T., Marbán, E., and Li, R. A. (2002) Circ. Res. 90, 1267-1273
5. Chen, S., Wang, J., and Siegelbaum, S. A. (2001) J. Gen. Physiol. 117, 491-504
6. Ulens, C., and Tytgat, J. (2001) J. Biol. Chem. 276, 6069-6072.
7. Benitah, J. P., Tomaselli, G. F., and Marbán, E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7392-7396
8. Tsushima, R. G., Li, R. A., and Backx, P. H. (1997) J. Gen. Physiol. 110, 59-72
9. Creighton, T. (1997) Proteins: Structures and Molecular Properties, 5th Ed., W. H. Freeman & Co., New York
10. Karlin, A., and Akabas, M. H. (1998) Methods Enzymol. 293, 123-145
11. Li, R. A., Velez, P., Chiamvimonvat, N., Tomaselli, G. F., and Marbán, E. (2000) J. Gen. Physiol. 115, 81-92
12. Perez-Garcia, M. T., Chiamvimonvat, N., Marbán, E., and Tomaselli, G. F. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 300-304
13. Lu, Q., and Miller, C. (1995) Science 268, 304-307
14. Akabas, M. H., Stauffer, D. A., Xu, M., and Karlin, A. (1992) Science 258, 307-310
15. Akabas, M. H., and Karlin, A. (1995) Biochemistry 34, 12496-12500
16. Akabas, M. H., Kaufmann, C., Archdeacon, P., and Karlin, A. (1994) Neuron 13, 919-927
17. Sun, Z. P., Akabas, M. H., Goulding, E. H., Karlin, A., and Siegelbaum, S. A. (1996) Neuron 16, 141-149
18. Hille, B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associates, Inc., Sunderland, MA
19. Santoro, B., and Tibbs, G. R. (1999) Ann. N. Y. Acad. Sci. 868, 741-764
20. Zagotta, W. N., and Siegelbaum, S. A. (1996) Annu. Rev. Neurosci. 19, 235-263
21. Ludwig, A., Zong, X., Hofmann, F., and Biel, M. (1999) Cell. Physiol. Biochem. 9, 179-186
22. Horn, R. (1998) Methods Enzymol. 293, 145-155
23. Balser, J. R., Nuss, H. B., Chiamvimonvat, N., Perez-Garcia, M. T., Marbán, E., and Tomaselli, G. F. (1996) J. Physiol. (Lond.) 494, 431-442
24. Yellen, G. (1998) Q. Rev. Biophys. 31, 239-295
25. Marten, I., and Hoshi, T. (1998) Biophys. J. 74, 2953-2962
26. Townsend, C., and Horn, R. (1997) J. Gen. Physiol. 110, 23-33
27. Azene, E., Xue, T., Marbán, E., and Li, R. A. (2002) Circulation, in press
28. Chiamvimonvat, N., Perez-Garcia, M. T., Ranjan, R., Marbán, E., and Tomaselli, G. F. (1996) Neuron 16, 1037-1047
29. Tsushima, R. G., Li, R. A., and Backx, P. H. (1997) J. Gen. Physiol. 109, 463-475
30. Chiamvimonvat, N., Perez-Garcia, M. T., Tomaselli, G. F., and Marbán, E. (1996) J. Physiol. (Lond.) 491, 51-59
31. Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., and MacKinnon, R. (1998) Science 280, 69-77
32. Li, R. A., Ennis, E., Tomaselli, G., and Marbán, E. (2001) Circulation 104, 11-309
33. Dun, W., Jiang, M., and Tseng, G. N. (1999) Pflügers Arch. 439, 141-149
34. Pardo-Lopez, L., Zhang, M., Liu, J., Jiang, M., Possani, L. D., and Tseng, G. N. (2002) J. Biol. Chem. 277, 16403-16411
35. Kaupp, U. B., and Seifert, R. (2001) Annu. Rev. Physiol. 63, 235-257
36. Clapham, D. E. (1998) Neuron 21, 5-7
37. Henrikson, C. A., Azene, E., Dong, P., Marbán, E., and Li, R. A. (2002) Circulation, in press