Synthesis and evaluation of N1/C4-substituted β-lactams as PPE and HLE inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 1, 2004, Pages 129-138

  Gérard, Stéphane ^a   Galleni, Moreno ^b   Dive, Georges ^b   Marchand Brynaert, Jacqueline ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Elastase; N acylation; N thioacylation; Serine protease inhibition; lactam

Indexed keywords

1 (BENZYLAMINO)THIOCARBONYL 4 (BENZYLOXY)CARBONYL 2 AZETIDINONE; 1 (ETHYLOXY)THIOCARBONYL 4 (BENZYLOXY)CARBONYL 2 AZETIDINONE; 1 (PHENETHYLOXY)CARBONYL 4 (BENZYLAMINO)CARBONYL 2 AZETIDINONE; 1 (PHENETHYLOXY)CARBONYL 4 (DIBENZYLAMINO)CARBONYL 2 AZETIDINONE; BETA LACTAM DERIVATIVE; LEUKOCYTE ELASTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; SUBSTITUTION REACTION;

EID: 0347301852     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.009     Document Type: Article

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