Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 5, 2000, Pages 1005-1016

  Kuang, Rongze ^a   Epp, Jeffrey B ^a   Ruan, Sumei ^a   Chong, Lee S ^a   Venkataraman, Radhika ^a   Tu, Juan ^a   He, Shu ^a   Truong, Tien M ^a   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; SERINE PROTEINASE INHIBITOR; THIAZOLIDINE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; PKA; REACTION ANALYSIS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

CYCLIC S-OXIDES; DRUG DESIGN; ELASTIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

FELIS CATUS;

EID: 0034088325     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00038-9     Document Type: Article

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