Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 2, 2001, Pages 243-246

  Macdonald, Simon J F ^a   Dowle, Michael D ^a   Harrison, Lee A ^a   Spooner, Julie E ^a   Shah, Pritom ^a   Johnson, Martin R ^a   Inglis, Graham G A ^a   Clarke, Geoffrey D E ^a   Belton, David J ^a   Smith, Robin A ^a   Molloy, Christopher R ^a   Dixon, Mary ^a   Murkitt, Graham ^a   Godward, Rosalind E ^a   Skarzynski, Tadeusz ^a   Singh, Onkar M P ^a   Kumar, K Abhhilash ^a   Hodgson, Simon T ^a   McDonald, Edward ^a   Hardy, George W ^a   Finch, Harry ^a   more..

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LACTAM DERIVATIVE; LEUKOCYTE ELASTASE INHIBITOR; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HAMSTER; LIVER MICROSOME; NONHUMAN; SWINE;

ACYLATION; ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS; LEUKOCYTE ELASTASE; MODELS, MOLECULAR; NEUTROPHILS; PANCREAS; PROTEIN BINDING; PYRROLIDINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

CRICETINAE; SUIDAE;

EID: 0035931469     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00632-6     Document Type: Article

References (16)

1. Orally active, intracellular inhibitors of Human Leukocyte Elastase (HLE)