Genetics of neuroendocrine and carcinoid tumours

Endocrine-Related Cancer

Volumn 10, Issue 4, 2003, Pages 437-450

  Leotlela, P D ^a   Jauch, A ^b   Holtgreve Grez, H ^b   Thakker, R V ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RETINOIC ACID RECEPTOR BETA; TRANSFORMING GROWTH FACTOR ALPHA; UVOMORULIN;

AMINO ACID SEQUENCE; CANCER GENETICS; CANCER SURVIVAL; CARCINOID; CHROMOSOME 11Q; CHROMOSOME 16Q; CHROMOSOME 18; CHROMOSOME 5Q; CHROMOSOME LOSS; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; DNA METHYLATION; ENDODERM; FEMALE; GENE DELETION; HUMAN; MALE; MEN1 GENE; MOLECULAR GENETICS; MULTIPLE ENDOCRINE NEOPLASIA; NEURAL CREST; NEUROECTODERM; NEUROENDOCRINE TUMOR; ONCOGENE RAS; POINT MUTATION; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SURVIVAL RATE; TUMOR CLASSIFICATION; TUMOR LOCALIZATION; TUMOR SUPPRESSOR GENE;

CARCINOID TUMOR; CHROMOSOME ABERRATIONS; DNA METHYLATION; FEMALE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; NEUROENDOCRINE TUMORS; ONCOGENES; PEDIGREE; PROTO-ONCOGENE PROTEINS;

EID: 0346458492     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0100437     Document Type: Conference Paper

References (113)

1. Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, Park SY, Saggar S, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ & Burns AL 1999 Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96 143-152.
2. Anderson RE 1966 A familial instance of appendiceal carcinoid. American Journal of Surgery 111 738-740.
3. Arany I, Rady P, Evers BM, Tyring SK & Townsend CM Jr 1994 Analysis of multiple molecular changes in human endocrine tumours. Surgical Oncology 3 153-159.
4. Astuti D, Douglas F, Lennard TW, Aligianis IA, Woodward ER, Evans DG, Eng C, Latif F & Maher ER 2001a Germline SDHD mutation in familial phaeochromocytoma. Lancet 357 1181-1182.
5. Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E, Skoldberg F, Husebye ES, Eng C & Maher ER 2001b Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. American Journal of Human Genetics 69 49-54.
6. Badenhop RF, Cherian S, Lord RS, Baysal BE, Taschner PE & Schofield PR 2001 Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss. Genes Chromosomes and Cancer 31 255-263.
7. Barghorn A, Komminoth P, Bachmann D, Rutimann K, Saremaslani P, Muletta-Feurer S, Perren A, Roth J, Heitz PU & Speel EJ 2001 Deletion at 3p25.3-p23 is frequently encountered in endocrine pancreatic tumours and is associated with metastatic progression. Journal of Pathology 194 451-458.
8. Baudin E, Bidart JM, Rougier P, Lazar V, Ruffie P, Ropers J, Ducreux M, Troalen F, Sabourin JC, Comoy E, Lasser P, DeBaere T & Schlumberger M 1999 Screening for multiple endocrine neoplasia type 1 and hormonal production in apparently sporadic neuroendocrine tumors. Journal of Clinical Endocrinology and Metabolism 84 69-75.
9. Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, van der Mey A, Taschner PE, Rubinstein WS, Myers EN, Richard CW III, Cornelisse CJ, Devilee P & Devlin B 2000 Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287 848-851.
10. Bergman L, Boothroyd C, Palmer J, Grimmond S, Walters M, Teh B, Shepherd J, Hartley L & Hayward N 2000 Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours. British Journal of Cancer 83 1003-1008.
11. Bird AP 1986 CpG-rich islands and the function of DNA methylation. Nature 321 209-213.
12. Bordi C 1995 Endocrine tumours of the stomach. Pathology, Research and Practice 191 373-380.
13. Brambilla E, Travis WD, Colby TV, Corrin B & Shimosato Y 2001 The new World Health Organisation classification of lung tumours. European Respiratory Journal 18 1059-1068.
14. Brown MA & Solomon E 1997 Studies on inherited cancers: outcomes and challenges of 25 years. Trends in Genetics 13 202-206.
15. Chan AO, Kim SG, Bedeir A, Issa JP, Hamilton SR & Rashid A 2003 CpG island methylation in carcinoid and pancreatic endocrine tumors. Oncogene 22 924-934.
16. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL & Marx SJ 1997 Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276 404-407.
17. Couce ME, Bautista D, Costa J & Carter D 1999 Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms. Diagnostic Molecular Pathology 8 71-79.
18. D'Adda T, Candidus S, Denk H, Bordi C & Hofler H 1999a Gastric neuroendocrine neoplasms: tumour clonality and malignancy-associated large X-chromosomal deletions. Journal of Pathology 189 394-401.
19. D'Adda T, Keller G, Bordi C & Hofler H 1999b Loss of heterozygosity in 11q13-14 regions in gastric neuroendocrine tumors not associated with multiple endocrine neoplasia type 1 syndrome. Laboratory Investigation 79 671-677.
20. Dammann R, Takahashi T & Pfeifer GP 2001 The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. Oncogene 20 3563-3567.
21. Debelenko LV, Brambilla E, Agarwal SK, Swalwell JI, Kester MB, Lubensky IA, Zhuang Z, Guru SC, Manickam P, Olufemi SE, Chandrasekharappa SC, Crabtree JS, Kim YS, Heppner C, Burns AL, Spiegel AM, Marx SJ, Liotta LA, Collins FS, Travis WD & Emmert-Buck MR 1997a Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Human Molecular Genetics 6 2285-2290.
22. Debelenko LV, Emmert-Buck MR, Zhuang Z, Epshteyn E, Moskaluk CA, Jensen RT, Liotta LA & Lubensky IA 1997b The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology 113 773-781.
23. Debelenko LV, Swalwell JI, Kelley MJ, Brambilla E, Manickam P, Baibakov G, Agarwal SK, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Travis WD & Emmert-Buck MR 2000 MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma. Genes Chromosomes and Cancer 28 58-65.
24. Dong Q, Debelenko LV, Chandrasekharappa SC, Emmert-Buck MR, Zhuang Z, Guru SC, Manickam P, Skarulis M, Lubensky IA, Liotta LA, Collins FS, Marx SJ & Spiegel AM 1997 Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1. Journal of Clinical Endocrinology and Metabolism 82 1416-1420.
25. Emmert-Buck MR, Lubensky IA, Dong Q, Manickam P, Guru SC, Kester MB, Olufemi SE, Agarwal S, Burns AL, Spiegel AM, Collins FS, Marx SJ, Zhuang Z, Liotta LA, Chandrasekharappa SC & Debelenko LV 1997 Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. Cancer Research 57 1855-1858.
26. Eschbach JW & Rivaldo JA 1962 Metastatic carcinoid; a familial occurrence. Annals of Internal Medicine 57 647-650.
27. Fujii T, Kawai T, Saito K, Hishima T, Hayashi Y, Imura J, Hironaka M, Hosoya Y, Koike M & Fukayama M 1999 MEN1 gene mutations in sporadic neuroendocrine tumors of foregut derivation. Pathology International 49 968-973.
28. Gimm O, Armanios M, Dziema H, Neumann HP & Eng C 2000 Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma. Cancer Research 60 6822-6825.
29. Goebel SU, Heppner C, Burns AL, Marx SJ, Spiegel AM, Zhuang Z, Lubensky IA, Gibril F, Jensen RT & Serrano J 2000 Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas. Journal of Clinical Endocrinology and Metabolism 85 116-123.
30. Gortz B, Roth J, Krahenmann A, de Krijger RR, Muletta-Feurer S, Rutimann K, Saremaslani P, Speel EJ, Heitz PU & Komminoth P 1999 Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. American Journal of Pathology 154 429-436.
31. Griffiths DF, Williams GT & Williams ED 1987 Duodenal carcinoid tumours, phaeochromocytoma and neurofibromatosis: islet cell tumour, phaeochromocytoma and the von Hippel-Lindau complex: two distinctive neuroendocrine syndromes. Quarterly Journal of Medicine 64 769-782.
32. Guo SS, Arora C, Shimoide AT & Sawicki MP 2002 Frequent deletion of chromosome 3 in malignant sporadic pancreatic endocrine tumors. Molecular and Cellular Endocrinology 190 109-114.
33. Guru SC, Goldsmith PK, Burns AL, Marx SJ, Spiegel AM, Collins FS & Chandrasekharappa SC 1998 Menin, the product of the MEN1 gene, is a nuclear protein. PNAS 95 1630-1634.
34. Han HS, Kim HS, Woo DK, Kim WH & Kim YI 2000 Loss of heterozygosity in gastric neuroendocrine tumor. Anticancer Research 20 2849-2854.
35. Harbour JW, Lai SL, Whang-Peng J, Gazdar AF, Minna JD & Kaye FJ 1988 Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241 353-357.
36. Heppner C, Bilimoria KY, Agarwal SK, Kester M, Whitty LJ, Guru SC, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ & Burns AL 2001 The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 20 4917-4925.
37. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM et al. 1994 Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. PNAS 91 9700-9704.
38. Hessman O, Lindberg D, Skogseid B, Carling T, Hellman P, Rastad J, Akerstrom G & Westin G 1998 Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. Cancer Research 58 377-379.
39. Hessman O, Skogseid B, Westin G & Akerstrom G 2001 Multiple allelic deletions and intratumoral genetic heterogeneity in menl pancreatic tumors. Journal of Clinical Endocrinology and Metabolism 86 1355-1361.
40. Hiyama K, Hasegawa K, Ishioka S, Takahashi N & Yamakido M 1993 An atypical carcinoid tumor of the lung with mutations in the p53 gene and the retinoblastoma gene. Chest 104 1606-1607.
41. Jakobovitz O, Nass D, DeMarco L, Barbosa AJ, Simoni FB, Rechavi G & Friedman E 1996 Carcinoid tumors frequently display genetic abnormalities involving chromosome 11. Journal of Clinical Endocrinology and Metabolism 81 3164-3167.
42. Jones PA & Baylin SB 2002 The fundamental role of epigenetic events in cancer. Nature Reviews. Genetics 3 415-428.
43. Kaji H, Canaff L, Lebrun JJ, Goltzman D & Hendy GN 2001 Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. PNAS 98 3837-3842.
44. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F & Pinkel D 1992 Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258 818-821.
45. Kallioniemi OP, Kallioniemi A, Sudar D, Rutovitz D, Gray JW, Waldman F & Pinkel D 1993 Comparative genomic hybridization: a rapid new method for detecting and mapping DNA amplification in tumors. Seminars in Cancer Biology 4 41-46.
46. Kanthan R, Saxena A & Kanthan SC 2001 Goblet cell carcinoids of the appendix: immunophenotype and ultrastructural study. Archives of Pathology and Laboratory Medicine 125 386-390.
47. Kinova S, Duris I, Kovacova E, Stvrtina S, Galbavy S & Makaiova I 2001 Malignant carcinoid in two brothers. Bratislavske Lekarske Listy 102 231-234.
48. Kinzler KW & Vogelstein B 1997 Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386 761-763.
49. Knudson AG Jr 1971 Mutation and cancer: statistical study of retinoblastoma. PNAS 68 820-823.
50. Knudson AG Jr 1974 Heredity and human cancer. American Journal of Pathology 77 77-84.
51. Kovatich A, Friedland DM, Druck T, Hadaczek P, Huebner K, Comis RL, Hauck W & McCue PA 1998 Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors. Cancer 83 1109-1117.
52. Kytola S, Nord B, Elder EE, Carling T, Kjellman M, Cedermark B, Juhlin C, Hoog A, Isola J & Larsson C 2002 Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas. Genes Chromosomes and Cancer 34 325-332.
53. Le Douarin NM 1988 On the origin of pancreatic endocrine cells. Cell 53 169-171.
54. Lemmens IH, Forsberg L, Pannett AA, Meyen E, Piehl F, Turner JJ, Van de Ven WJ, Thakker RV, Larsson C & Kas K 2001 Menin interacts directly with the homeobox-containing protein Pem. Biochemical and Biophysical Research Communications 286 426-431.
55. Lengauer C, Kinzler KW & Vogelstein B 1997 Genetic instability in colorectal cancers. Nature 386 623-627.
56. Levin NA, Brzoska PM, Warnock ML, Gray JW & Christman MF 1995 Identification of novel regions of altered DNA copy number in small cell lung tumors. Genes Chromosomes and Cancer 13 175-185.
57. Lohmann DR, Fesseler B, Putz B, Reich U, Bohm J, Prauer H, Wunsch PH & Hofler H 1993a Infrequent mutations of the p53 gene in pulmonary carcinoid tumors. Cancer Research 53 5797-5801.
58. Lohmann DR, Funk A, Niedermeyer HP, Haupel S & Hofler H 1993b Identification of p53 gene mutations in gastrointestinal and pancreatic carcinoids by nonradioisotopic SSCA. Virchows Archiv B, Cell Pathology including Molecular Pathology 64 293-296.
59. Lollgen RM, Hessman O, Szabo E, Westin G & Akerstrom G 2001 Chromosome 18 deletions are common events in classical midgut carcinoid tumors. International Journal of Cancer 92 812-815.
60. Lopez-Egido J, Cunningham J, Berg M, Oberg K, Bongcam-Rudloff E & Gobl A 2002 Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity. Experimental Cell Research 278 175-183.
61. Mailman MD, Muscarella P, Schirmer WJ, Ellison EC, O'Dorisio TM & Prior TW 1999 Identification of MEN1 mutations in sporadic enteropancreatic neuroendocrine tumors by analysis of paraffin-embedded tissue. Clinical Chemistry 45 29-34.
62. Maitra A, Krueger JE, Tascilar M, Offerhaus GJ, Angeles-Angeles A, Klimstra DS, Hruban RH & Albores-Saavedra J 2000 Carcinoid tumors of the extrahepatic bile ducts: a study of seven cases. American Journal of Surgical Pathology 24 1501-1510.
63. du Manoir S, Speicher MR, Joos S, Schrock E, Popp S, Dohner H, Kovacs G, Robert-Nicoud M, Lichter P & Cremer T 1993 Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Human Genetics 90 590-610.
64. Milunsky JM, Maher TA, Michels VV & Milunsky A 2001 Novel mutations and the emergence of a common mutation in the SDHD gene causing familial paraganglioma. American Journal of Medical Genetics 100 311-314.
65. Momparler RL & Bovenzi V 2000 DNA methylation and cancer. Journal of Cellular Physiology 183 145-154.
66. Momparler RL, Eliopoulos N & Ayoub J 2000 Evaluation of an inhibitor of DNA methylation, 5-aza-2ó-deoxycytidine, for the treatment of lung cancer and the future role of gene therapy. Advances in Experimental Medicine and Biology 465 433-446.
67. Nakano H, Yamamoto F, Neville C, Evans D, Mizuno T & Perucho M 1984 Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. PNAS 81 71-75.
68. Oberg K 1998 Carcinoid tumors: current concepts in diagnosis and treatment. Oncologist 3 339-345.
69. Oberg K 2002 Carcinoid tumors: molecular genetics, tumor biology, and update of diagnosis and treatment. Current Opinion in Oncology 14 38-45.
70. Ohkura N, Kishi M, Tsukada T & Yamaguchi K 2001 Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23. Biochemical and Biophysical Research Communications 282 1206-1210.
71. Oliveira AM, Tazelaar HD, Wentzlaff KA, Kosugi NS, Hai N, Benson A, Miller DL & Yang P 2001 Familial pulmonary carcinoid tumors. Cancer 91 2104-2109.
72. Onuki N, Wistuba II, Travis WD, Virmani AK, Yashima K, Brambilla E, Hasleton P & Gazdar AF 1999 Genetic changes in the spectrum of neuroendocrine lung tumors. Cancer 85 600-607.
73. Pal T, Liede A, Mitchell M, Calender A & Narod SA 2001 Intestinal carcinoid tumours in a father and daughter. Canadian Journal of Gastroenterology 15 405-409.
74. Pannett AA & Thakker RV 1999 Multiple endocrine neoplasia type 1. Endocrine-Related Cancer 6 449-473.
75. Pannett AA & Thakker RV 2001 Somatic mutations in MEN type 1 tumors, consistent with the Knudson 'two-hit' hypothesis. Journal of Clinical Endocrinology and Metabolism 86 4371-4374.
76. Perren A, Barghorn A, Schmid S, Saremaslani P, Roth J, Heitz PU & Komminoth P 2001 The role of succinate-dehydrogenase-d (SDHD) tumor suppressor gene on 11q23 in endocrine tumors. Virchows Archiv B, Cell Pathology including Molecular Pathology 439 389.
77. Petersen I, Bujard M, Petersen S, Wolf G, Goeze A, Schwendel A, Langreck H, Gellert K, Reichel M, Just K, du Manoir S, Cremer T, Dietel M & Ried T 1997 Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. Cancer Research 57 2331-2335.
78. Ramnani DM, Wistuba II, Behrens C, Gazdar AF, Sobin LH & Albores-Saavedra J 1999 K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix. Cancer 86 14-21.
79. Rindi G, Luinetti O, Cornaggia M, Capella C & Solcia E 1993 Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology 104 994-1006.
80. Robertson KD & Jones PA 2000 DNA methylation: past, present and future directions. Carcinogenesis 21 461-467.
81. Sameshima Y, Matsuno Y, Hirohashi S, Shimosato Y, Mizoguchi H, Sugimura T, Terada M & Yokota J 1992 Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma. Oncogene 7 451-457.
82. Schwartsmann G, Schunemann H, Gorini CN, Filho AF, Garbino C, Sabini G, Muse I, DiLeone L & Mans DR 2000 A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer. Investigational New Drugs 18 83-91.
83. Shan L, Nakamura M, Nakamura Y, Utsunomiya H, Shou N, Jiang X, Jing X, Yokoi T & Kakudo K 1998 Somatic mutations in the RET protooncogene in Japanese and Chinese sporadic medullary thyroid carcinomas. Japanese Journal of Cancer Research 89 883-886.
84. Shimizu T, Tanaka S, Haruma K, Kitadai Y, Yoshihara M, Sumii K, Kajiyama G & Shimamoto F 2000 Growth characteristics of rectal carcinoid tumors. Oncology 59 229-237.
85. Shivapurkar N, Toyooka S, Eby MT, Huang CX, Sathyanarayana UG, Cunningham HT, Reddy JL, Brambilla E, Takahashi T, Minna JD, Chaudhary PM & Gazdar AF 2002 Differential inactivation of caspase-8 in lung cancers. Cancer Biology and Therapy 1 65-169.
86. Sowa H, Kaji H, Canaff L, Hendy GN, Tsukamoto T, Yamaguchi T, Miyazono K, Sugimoto T & Chihara K 2003 Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage. Journal of Biological Chemistry 278 21058-21069.
87. Sukhodolets KE, Hickman AB, Agarwal SK, Sukhodolets MV, Obungu VH, Novotny EA, Crabtree JS, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL & Marx SJ 2003 The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Molecular and Cellular Biology 23 493-509.
88. Tang X, Khuri FR, Lee JJ, Kemp BL, Liu D, Hong WK & Mao L 2000 Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. Journal of the National Cancer Institute 92 1511-1516.
89. Taschner PE, Jansen JC, Baysal BE, Bosch A, Rosenberg EH, Brocker-Vriends AH, van Der Mey AG, van Ommen GJ, Cornelisse CJ & Devilee P 2001 Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene. Genes Chromosomes and Cancer 31 274-281.
90. Teh BT 1998 Thymic carcinoids in multiple endocrine neoplasia type 1. Journal of Internal Medicine 243 501-504.
91. Teh BT, Zedenius J, Kytola S, Skogseid B, Trotter J, Choplin H, Twigg S, Famebo F, Giraud S, Cameron D, Robinson B, Calender A, Larsson C & Salmela P 1998 Thymic carcinoids in multiple endocrine neoplasia type 1. Annals of Surgery 228 99-105.
92. Thakker RV 1993 The molecular genetics of the multiple endocrine neoplasia syndromes. Clinical Endocrinology 38 1-14.
93. Thakker RV 1994 The role of molecular genetics in screening for multiple endocrine neoplasia type 1. Endocrinology and Metabolism Clinics of North America 23 117-135.
94. Thakker RV 2000 Multiple endocrine neoplasia type 1. Endocrinology and Metabolism Clinics of North America 29 541-567.
95. Thakker RV & Ponder BA 1988 Multiple endocrine neoplasia. Bailliere's Clinical Endocrinology and Metabolism 2 1031-1067.
96. The European Consortium on MEN1 1997 Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. Human Molecular Genetics 6 1177-1183.
97. Toliat MR, Berger W, Ropers HH, Neuhaus P & Wiedenmann B 1997 Mutations in the MEN I gene in sporadic neuroendocrine tumours of gastroenteropancreatic system. Lancet 350 1223.
98. Tonnies H, Toliat MR, Ramel C, Pape UF, Neitzel H, Berger W & Wiedenmann B 2001 Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation. Gut 48 536-541.
99. Toyooka S, Toyooka KO, Maruyama R, Virmani AK, Girard L, Miyajima K, Harada K, Ariyoshi Y, Takahashi T, Sugio K, Brambilla E, Gilcrease M, Minna JD & Gazdar AF 2001 DNA methylation profiles of lung tumors. Molecular Cancer Therapeutics 1 61-67.
100. Trump D, Farren B, Wooding C, Pang JT, Besser GM, Buchanan KD, Edwards CR, Heath DA, Jackson CE, Jansen S, Lips K, Monson JP, O'Halloran D, Sampson J, Shalet SM, Wheeler MH, Zink A & Thakker RV 1996 Clinical studies of multiple endocrine neoplasia type 1 (MEN1). Quarterly Journal of Medicine 89 653-669.
101. Turner JJ, Leotlela PD, Pannett AA, Forbes SA, Bassett JH, Harding B, Christie PT, Bowen-Jones D, Ellard S, Hattersley A, Jackson CE, Pope R, Quarrell OW, Trembath R & Thakker RV 2002 Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1. Journal of Clinical Endocrinology and Metabolism 87 2688-2693.
102. Tycko B 2000 Epigenetic gene silencing in cancer. Journal of Clinical Investigation 105 401-407.
103. Ullmann R, Petzmann S, Klemen H, Fraire AE, Hasleton P & Popper HH 2002 The position of pulmonary carcinoids within the spectrum of neuroendocrine tumors of the lung and other tissues. Genes Chromosomes and Cancer 34 78-85.
104. Vinik AI 2001 Carinoid tumours. In Endocrinology, edn. 4, pp 2533-2546. Eds LJ DeGroot & JL Jameson. Philadelphia: W.B. Saunders Company.
105. Virmani AK, Rathi A, Sathyanarayana UG, Padar A, Huang CX, Cunnigham HT, Farinas AJ, Milchgrub S, Euhus DM, Gilcrease M, Herman J, Minna JD & Gazdar AF 2001 Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas. Clinical Cancer Research 7 1998-2004.
106. Vogelstein B & Kinzler KW 1993 The multistep nature of cancer. Trends in Genetics 9 138-141.
107. Wang EH, Ebrahimi SA, Wu AY, Kashefi C, Passaro E Jr & Sawicki MP 1998 Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Research 58 4417-4420.
108. Yaguchi H, Ohkura N, Tsukada T & Yamaguchi K 2002 Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23. Journal of Biological Chemistry 277 38197-38204.
109. Younossian AB, Bründler M & Tötsch M 2002 Feasibility of the new WHO classification of pulmonary neuroendocrine tumours. Swiss Medical Weekly 132 535-540.
110. Yumita W, Ikeo Y, Yamauchi K, Sakurai A & Hashizume K 2003 Suppression of insulin-induced AP-1 transactivation by menin accompanies inhibition of c-Fos induction. International Journal of Cancer 103 738-744.
111. Zhao J, de Krijger RR, Meier D, Speel EJ, Saremaslani P, Muletta-Feurer S, Matter C, Roth J, Heitz PU & Komminoth P 2000 Genomic alterations in well-differentiated gastrointestinal and bronchial neuroendocrine tumors (carcinoids): marked differences indicating diversity in molecular pathogenesis. American Journal of Pathology 157 1431-1438.
112. Zhuang Z, Ezzat SZ, Vortmeyer AO, Weil R, Oldfield EH, Park WS, Pack S, Huang S, Agarwal SK, Guru SC, Manickam P, Debelenko LV, Kester MB, Olufemi SE, Heppner C, Crabtree JS, Burns AL, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Emmert-Buck MR, Liotta LA, Asa SL & Lubensky IA 1997a Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Research 57 5446-5451.
113. Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Agarwal SK, Debelenko LV, Kester M, Giru SC, Manickam P, Olufemi SE, Yu F, Heppner C, Crabtree JS, Skarulis MC, Venzon DJ, Emmert-Buck MR, Speigel AM, Chandrasekharappa SC, Collins FS, Burns AL, Marx SJ, Lubensky IA et al. 1997b Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Research 57 4682-4686.