Loss of heterozygosity in 11q13-14 regions in gastric neuroendocrine tumors not associated with multiple endocrine neoplasia type 1 syndrome

Laboratory Investigation

Volumn 79, Issue 6, 1999, Pages 671-677

  D'Adda, Tiziana ^a   Keller, Gisela ^b   Bordi, Cesare ^a   Höfler, Heinz ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GASTRIN;

ARTICLE; CARCINOID; CHROMOSOME 11Q; CLINICAL ARTICLE; DISEASE ASSOCIATION; DNA POLYMORPHISM; ENTEROCHROMAFFIN CELL; GENE LOCUS; HETEROZYGOSITY LOSS; HUMAN; MULTIPLE ENDOCRINE NEOPLASIA; NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; STOMACH TUMOR; SUPPRESSOR GENE;

CARCINOID TUMOR; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; GENETIC MARKERS; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; NEUROENDOCRINE TUMORS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; STOMACH NEOPLASMS; TRINUCLEOTIDE REPEATS;

EID: 0033049538     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Azzoni C, Doglioni C, Viale G, Delle Fave G, Deboni M, Caruana P, Ferraro G, and Bordi C (1996). Involvement of BCL-2 oncoprotein in the development of enterochromaffin-like cell gastric carcinoids. Am J Surg Pathol 20:433-441.
2. Beckmann MW, Picard F, An HX, van Roeyen CRC, Dominik SI, Mosny DS, Schnürch HG, Bender HG, and Niederacher D (1996). Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer. Br J Cancer 73:1220-1226.
3. Bordi C, D'Adda T, Azzoni C, Canavese G, and Brandi ML (1998). Gastrointestinal endocrine tumors: Recent developments. Endocr Pathol 9:99-115.
4. Bordi C, D'Adda T, Azzoni C, Pilato FP, and Caruana P (1995). Hypergastrinemia and gastric enterochromaffin-like cells. Am J Surg Pathol 19(Suppl 1):S8-S19.
5. Bordi C, Falchetti A, Azzoni C, D'Adda T, Canavese G, Guariglia A, Santini D, Tomassetti P, and Brandi ML (1997). Aggressive forms of gastric neuroendocrine tumors in multiple endocrine neoplasia type 1. Am J Surg Pathol 21:1075-1082.
6. Bordi C, Falchetti A, Buffa R, Azzoni C, D'Adda T, Caruana P, Rindi G, and Brandi ML (1994). Production of basic fibroblast growth factor by gastric carcinoid tumors and their putative cells of origin. Hum Pathol 25:175-180.
7. Bordi C, Yu J-Y, Baggi MT, Davoli C, Pilato FP, Baruzzi G, Gardini G, Zamboni G, Franzin G, Papotti M, and Bussolati G (1991). Gastric carcinoids and their precursor lesions: A histologic and immunohistochemical study of 23 cases. Cancer 67:663-672.
8. Cadiot G, Laurent-Puig P, Thuille B, Lehy T, Mignon M, and Olschwang S (1993). Is the multiple endocrine neoplasia type-1 gene a suppressor for fundic argyrophil tumors in the Zollinger-Ellison syndrome? Gastroenterology 105:579-582.
9. Chakrabarti R, Srivatsan ES, Wood TF, Eubanks PJ, Ebrahimi SA, Gatti RA, Passaro EJ, and Sawicki MP (1998). Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13. Genes Chromosomes Cancer 22:130-137.
10. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang ZP, Lubensky IA, Liotta LA, Crabtree JS, Wang YP, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong QH, Spiegel AM, Burns AL, and Marx SJ (1997). Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276:404-407.
11. Debelenko LV, Emmert-Buck MR, Zhuang Z, Epshteyn E, Moskaluk CA, Jensen RT, Liotta LA, and Lubensky IA (1997a). The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology 113:773-781.
12. Debelenko LV, Zhuang ZP, Emmert-Buck MR, Chandrasekharappa SC, Manickam P, Guru SC, Marx SJ, Skarulis MC, Spiegel AM, Collins FS, Jensen RT, Liotta LA, and Lubensky IA (1997b). Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. Cancer Res 57:2238-2243.
13. Eubanks PJ, Sawicki MP, Samara GJ, Gatti R, Nakamura Y, Tsao D, Johnson C, Hurwitz M, Wan YJY, and Passaro E (1994). Putative tumor-suppressor gene on chromosome 11 is important in sporadic endocrine tumor formation. Am J Surg 167:180-185.
14. Falchetti A, Morelli A, Amorosi A, Tonelli F, Fabiani S, Martineti V, Castello R, Furlani L, and Brandi ML (1997). Allelic loss in parathyroid tumors from individuals homozygous for multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 82:2278-2282.
15. Friedman E, Sakaguchi K, Bale AE, Falchetti A, Streeten E, Zimering MB, Weinstein LS, McBride WO, Nakamura Y, Brandi ML, Norton JA, Aurbach GD, Spiegel AM, and Marx SJ (1989). Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. N Engl J Med 321:213-218.
16. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, and Weissenbach J (1994). The 1993-94 Genethon human genetic linkage map. Nat Genet 7:246-339.
17. Håkanson R, Tielemans Y, Chen D, Andersson K, Mattsson H, and Sundler F (1993). Time-dependent changes in enterochromaffinlike cell kinetics in stomach of hypergastrinemic rats. Gastroenterology 105:15-21.
18. Heppner C, Kester MB, Agarwal SK, Debelenko LV, Emmert-Buck MR, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Doppman JL, Alexander RH, Kim YS, Saggar SK, Lubensky IA, Zhuang ZP, Liotta LA, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, and Marx SJ (1997). Somatic mutation of the MEN1 gene in parathyroid tumours. Nat Genet 16:375-378.
19. Iwasaki H, Stewart PW, Dilley WG, Holt MS, Steinbrueck TD, Wells SAJ, and Donis-Keller H (1992). A minisatellite and a microsatellite polymorphism within 1.5 kb at the human muscle glycogen phosphorylase (PYGM) locus can be amplified by PCR and have combined informativeness of PIC 0.95. Genomics 13:7-15.
20. Knudson AG (1971). Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823.
21. Larsson C, Skogseid B, Öberg K, Nakamura Y, and Nordenskjöld M (1988). Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature 332:85-87.
22. Mahr S, Neumayer N, Kolb HJ, Schepp W, Classen M, and Prinz C (1998). Growth factor effects on apoptosis of rat gastric enterochromaffin-like cells. Endocrinology 139:4380-4390.
23. Manickam P, Guru SC, Debelenko LV, Agarwal SK, Olufemi S-E, Weisemann JM, Boguski MS, Crabtree JS, Wang Y, Roe BA, Lubensky IA, Zhuang Z, Kester MB, Burns AL, Spiegel AM, Marx SJ, Liotta LA, Emmert-Buck MR, Collins FS, and Chandrasekharappa SC (1997). Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. Hum Genet 101:102-108.
24. Morelli A, Falchetti A, Amorosi A, Tonelli F, Bearzi I, Ranaldi R, and Brandi ML (1996). Clonal analysis by chromosome 11 microsatellite-PCR of microdissected tumors from MEN1 patients. Biochem Biophys Res Commun 227:736-742.
25. Rindi G, Azzoni C, La Rosa S, Klersy C, Paolotti D, Rappel S, Stolte M, Capella C, Bordi C, and Solcia E (in press, 1999). ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: Prognostic evaluation by pathological analysis. Gastroenterology 116:532-542.
26. Rindi G, Bordi C, Rappel S, La Rosa S, Stolte M, and Solcia E (1996). Gastric carcinoids and neuroendocrine carcinomas: Pathogenesis, pathology and behavior: Clinicopathologic analysis of 205 cases. World J Surg 20:158-172.
27. Rindi G, Luinetti O, Cornaggia M, Capella C, and Solcia E (1993). Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: A clinicopathologic study. Gastroenterology 104:994-1006.
28. Sawicki M, Arnold E, Ebrahimi S, Duell T, Jin S, Wood T, Chakrabarti R, Peters J, Wan Y, Samara G, Weier HU, Udar N, Passaro EJ, and Srivatsan ES (1997). A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. Genomics 42:405-412.
29. Shows TB, Alders M, Bennet S, Burbee D, Cartwright P, Chandrasekharappa S, Cooper P, Courseaux A, Davies C, Devignes M-D, Devilee P, Elliott R, Evans G, Fantes J, Garner H, Gaudray P, Gerhard DS, Gessler M, Higgins M, Hummerich H, James M, Lagercrantz J, Litt M, Little P, Mannens M, Munroe D, Nowak N, O'Brien S, Parker N, Perlin M, Reid L, Richard C, Sawicki M, Swallow D, Thakker R, van Heyningen V, van Schothorst E, Vorechovsky I, Wadelius C, Weber B, and Zabel B (1996). Report of the Fifth International Workshop on Human Chromosome 11 Mapping (1996). Cytogenet Cell Genet 74:1-56.
30. Solcia E, Bordi C, Creutzfeldt W, Dayal Y, Dayan AD, Falkmer S, Grimelius L, and Havu N (1988). Histopathological classification of nonantral gastric endocrine growths in man. Digestion 41:185-200.
31. Thakker RV, Bouloux P, Wooding C, Chotai K, Broad PM, Spurr NK, Besser GM, and O'Riordan JL (1989). Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11. N Engl J Med 321:218-224.
32. Toliat M-R, Berger W, Hilger Ropers H, Neuhaus P, and Wiedenmann B (1997). Mutations in the MEN1 gene in sporadic tumours of the gastroenteropancreatic system. Lancet 350:1223.
33. Zhuang ZP, Vortmeyer AO, Pack S, Huang S, Pham TU, Wang C, Park W-S, Agarwal SK, Debelenko LV, Kester MB, Guru SC, Manickam P, Olufemi SE, Yu F, Heppner C, Crabtree JS, Skarulis MC, Venzon DJ, Emmert-Buck MR, Spiegel AM, Chandrasekharappa SC, Collins FS, Burns AL, Marx SJ, Jensen RT, Liotta LA, and Lubensky IA (1997). Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res 57: 4682-4686.