Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas

Genes Chromosomes and Cancer

Volumn 34, Issue 3, 2002, Pages 325-332

  Kytölä, Soili ^a,b   Nord, Brita ^a   Elder, Elisabeth Edström ^a   Carling, Tobias ^c,d   Kjellman, Magnus ^a   Cedermark, Björn ^a   Juhlin, Claes ^c   Höög, Anders ^a   Isola, Jorma ^b   Larsson, Catharina ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOID; CATECHOLAMINE RELEASE; CHROMOSOME 11; GENE DELETION; GENE LOCUS; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MERKEL CELL TUMOR; MIDGUT; PARAGANGLIOMA; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; TUMOR LOCALIZATION; TUMOR SUPPRESSOR GENE;

ABDOMINAL NEOPLASMS; ADRENAL GLAND NEOPLASMS; CARCINOID TUMOR; CARCINOMA, MERKEL CELL; ELECTRON TRANSPORT COMPLEX II; GENETIC MARKERS; HUMANS; INTESTINAL NEOPLASMS; LOSS OF HETEROZYGOSITY; MULTIENZYME COMPLEXES; MUTATION; MUTATION, MISSENSE; NEOPLASMS; OXIDOREDUCTASES; PARAGANGLIOMA; PHEOCHROMOCYTOMA; POLYMORPHISM, GENETIC; SKIN NEOPLASMS; SUCCINATE DEHYDROGENASE;

EID: 18444375876     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10081     Document Type: Article

References (24)

1. Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas
2. Germline SDHD mutation in familial phaeochromocytoma
3. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
4. Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss
5. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
6. Comparative genomic hybridization reveals frequent losses of chromosomes 1p and 3q in pheochromocytomas and abdominal paragangliomas, suggesting a common genetic etiology
7. Loss of heterozygosity in the short arm of chromosome 1 in pheochromocytoma and abdominal paraganglioma
8. Over-representation of a germ-line RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation
9. Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma
10. MEN1 gene mutation analysis of sporadic adrenocortical lesions
11. A single-nucleotide polymorphic variant of the RET proto-oncogene is underrepresented in sporadic Hirschsprung disease
12. MEN1 gene analysis in sporadic adrenocortical neoplasms
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14. Characterization of the human SDHD gene encoding the small subunit of cytochrome b (cybS) in mitochondrial succinate- ubiquinone oxidoreductase
15. Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples
16. Genotyping of adrenocorticaI tumors: Very frequent deletions of the MEN1 locus in 11q13 and of a 1-cenrimorgan region in 2p16
17. Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorigenesis of midgut carcinoids
18. Novel mutations and the emergence of a common mutation in the SDHD gene causing familial paraganglioma
19. Mutations in SDHC cause autosomal dominant paraganglioma, type 3
20. Sporadic follicular thyroid tumors show loss of a 200-kb region in 11q13 without evidence for mutations in the MEN1 gene
21. Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus
22. Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene
23. Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genornic hybridization
24. Multiple endocrine neoplasia type 1