p53 antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20

Cancer Biology and Therapy

Volumn 1, Issue 3, 2002, Pages 277-283

  Jabbur, James R ^a   Zhang, Wei ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Cancer Genomics Laboratory   (United States)

Author keywords

Fas APO 1; Growth regulation; Mdm 2; Mutagenesis; Protein conformation; Transactivation

Indexed keywords

ASPARTIC ACID; CALPAIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; FAS ANTIGEN; GLUTATHIONE TRANSFERASE; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MDM2; PROTEIN P53; SERINE; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL CULTURE; CELL CYCLE; CHEMISTRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; HYDROGEN BOND; LEUKEMIA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROMOTER REGION; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; TRANSACTIVATION;

AMINO ACID SUBSTITUTION; ANTIGENS, CD95; ASPARTIC ACID; CALPAIN; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE TRANSFERASE; HUMANS; HYDROGEN BONDING; LEUKEMIA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SERINE; THREONINE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0346455680     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.81     Document Type: Article

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