Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest

Cancer Research

Volumn 61, Issue 19, 2001, Pages 7030-7033

  Stavridi, E S ^a   Chehab, N H ^a   Malikzay, A ^a   Halazonetis, T D ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN P53; SERINE;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; DEPHOSPHORYLATION; DNA BINDING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION;

14-3-3 PROTEINS; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MUTATION; OSTEOSARCOMA; PRECIPITIN TESTS; PROTEIN ISOFORMS; SUBSTRATE SPECIFICITY; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TYROSINE 3-MONOOXYGENASE;

EID: 0035476793     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Surfing the p53 network
2. The DNA damage response: Putting checkpoints in perspective
3. WAF1, a potential mediator of p53 tumor suppression
4. 14-3-3 Sigma is a p53-regulated inhibitor of G2/M progression
5. 14-3-3 Sigma is required to prevent mitotic catastrophe after DNA damage
6. Cooperative effects of genes controlling the G(2)/M checkpoint
7. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
8. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
9. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
10. Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53
11. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
12. Mdm2 promotes the rapid degradation of p53
13. Regulation of p53 stability by Mdm2
14. p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
15. The complexity of p53 modulation: Emerging patterns from divergent signals
16. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
17. An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants
18. The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding
19. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
20. Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions
21. Evolution of the 14-3-3 protein family: Does the large number of isoforms in multicellular organisms reflect functional specificity?
22. Specific interactions with TBP and TFIIB in vitro suggest that 14-3-3 proteins may participate in the regulation of transcription when part of a DNA binding complex