Modulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Rats

Journal of Agricultural and Food Chemistry

Volumn 51, Issue 27, 2003, Pages 8113-8119

  Marnewick, Jeanine L ^a   Joubert, Elizabeth ^b   Swart, Pieter ^c   Van Der Westhuizen, Francois ^d   Gelderblom, Wentzel C ^a  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b ARC INFRUITEC NIETVOORBIJ   (South Africa)

^c STELLENBOSCH UNIVERSITY   (South Africa)

^d NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Glutathione; Glutathione S transferases; Honeybush (Cyclopia intermedia) tea; ORAC; Rat liver; Rooibos (Aspalathus lineariz) tea; UPD glucuronosyl transferases

Indexed keywords

DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; LIVER ENZYME; OXYGEN RADICAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; HERBAL MEDICINE; HONEYBUSH; LIVER; LIVER CYTOSOL; LIVER HOMOGENATE; LIVER METABOLISM; LIVER MICROSOME; MALE; MODULATION; MUTAGENESIS; NONHUMAN; OXIDATION; PROCESSING; RAT; ROOIBOS; STATISTICAL SIGNIFICANCE; TEA;

ANIMALS; ASPALATHUS; BEVERAGES; CAMELLIA SINENSIS; FABACEAE; FLAVONOIDS; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LIVER; MALE; OXIDATION-REDUCTION; PHENOLS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; TEA;

ANIMALIA; ASPALATHUS; ASPALATHUS LINEARIS; CAMELLIA; CAMELLIA SINENSIS; CYCLOPIA;

EID: 0346336046     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0344643     Document Type: Article

References (63)

1. Steele, V. E.; Kelloff, G. J.; Balentine, D.; Boone, C. W.; Metha, R.; Bagheri, D.; Sigman, C. C.; Zhu, S.; Sharma, S. Comparative chemopreventive mechanisms of green, black tea, and selected polyphenol extracts measured by in vitro bioassays. Carcinogenesis 2000, 21, 63-67.
2. Suganuma, M.; Okabe, S.; Sueoka, N.; Sueoka, E.; Matsuyama, S.; Imai, K. ; Nakachi, K.; Fujiki, H. Green tea and cancer prevention. Mutat. Res. 1999, 428, 339-344.
3. Mukhtar, H.; Katiyar, S. K.; Agarwal, R. Green tea and skin-Anticarcinogenic effects. J. Invest. Dermatol. 1994, 102, 3-7.
4. Cademi, G.; De Filippo, D.; Luceri, C.; Salvadori, M.; Giannini, A.; Biggeri, A.; Remy, S.; Cheynier, V.; Dolara, P. Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats. Carcinogenesis 2000, 21, 1965-1969.
5. Sun, C.-L.; Yuan, J.-M.; Lee, M.-J.; Yang, C. S.; Gao, Y.-T.; Ross, R. K.; Yu, MC. Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. Carcinogenesis 2002, 23, 1497-1503.
6. Marnewick, J. L.; Gelderblom, W. C. A.; Joubert,E. An investigation on the antimutagenic properties of South African herbal teas. Mutat. Res. 2000, 471, 157-166.
7. Joubert, E. Effect of controlled conditions during deep bed processing and drying on rooibos tea (Aspalathus linearis). J. Food Process. Preserv. 1998, 22, 405-417.
8. Du Toit, J.; Joubert, E. Optimisation of the fermentation parameters of honeybush tea (Cyclopia). J. Food Quality 1999, 22, 241-256.
9. Standley, L.; Winterton, P.; Marnewick, J. L.; Gelderblom, W. C. A.; Joubert, E.; Britz, T. J. Influence of processing stages on antimutagenic and antioxidant potentials of rooibos tea. J. Agric. Food Chem. 2001, 49, 114-117.
10. Richards, E. S. Antioxidant and antimutagenic activities of Cyclopia species and activity-guided fractionation of C. intermedia. M.S. Thesis, University of Stellenbosch, Stellenbosch, South Africa, 2003.
11. Morton, J. Rooibos tea, Aspalathus linearis, a caffeineless, low-tannin beverage. Econ. Bot. 1983, 37, 164-173.
12. Sasaki, Y.-K.; Yamada, H.; Shimoi, K.; Kator, K.; Kinea, N. The clastogen-suppressing effects of green tea, Po-lei tea, and rooibos tea in CHO cells and mice. Mutat. Res. 1993, 286, 221-232.
13. Yoshikawa, T., Natio, Y., Oyamada, H., Ueda, S., Tanigawa, T., Takemura, T., Sugino, S., Kondo, M. Scavenging affects of Aspalathus linearis (rooibos tea) on active oxygen species. Adv. Exp. Med. Biol. 1990, 264, 171-174.
14. Hubbe, M. E., Joubert, E. Hydrogen donating ability of honey-bush tea (Cyclopia intermedia) as a measure of antioxidant activity. In Polyphenol Communications; Martens, S., Treutter, D., Forkmann, G., Eds.; TUM: 2000; pp 361-362.
15. Greenish, H. G. Cape tea. Pharm. J. Trans., 3rd Ser.; 1881, 550, 549-551.
16. Terblanche, S. E. Report on Honeybush tea. Department of Biochemistry, University of Port Elizabeth, Port Elizabeth, South Africa, 1982.
17. Rabe, C.; Steenkamp, J. A.; Joubert, E.; Burger, J. F. W.; Ferreira, D. Phenolic metabolites from rooibos tea (Aspalathus linearis). Phytochemistry 1994, 35, 1559-1565.
18. Joubert, E. HPLC quantification of the dihydrochalcones, aspalathin, and nothofagin in rooibos tea (Aspalathus linearis) as affected by processing Food Chem. 1996, 55, 403-411.
19. De Nysschen, A. M.; Van Wyk, B.-E.; Van Heerden, F. R.; Schutte, A. L. The major phenolic compounds in the leaves of Cyclopia species (Honeybush tea). Biochem. Syst. Ecol. 1996, 24, 243-246.
20. Ferreira, D.; Kamara, B. L.; Brandt, E. V.; Joubert, E. Phenolic compounds from Cyclopia intermedia (honeybush tea). J. Agric. Food Chem. 1998, 46, 3406-3410.
21. Kamara, B. I., Brandt, E. V., Ferreira, D., Joubert, E. Polyphenols from honeybush tea (Cyclopia intermedia). J. Agric. Food Chem. 2003, 53, 3874-3879.
22. Hollman, P. C. H.; Tijburg, L. B. M.; Yang, C. S. Bioavailability of flavonoids from tea. Crit. Rev. Food Sci. Nutr. 1997, 37, 719-738.
23. Hara, Y.; Luo, S.-J.; Wickremasinghe, R. L.; Yamanishi, T. Chemical composition of tea. Food Rev. Int, 1995, 11, 435-456.
24. Wilkinson, J.; Clapper, M. I. Detoxication enzymes and chemoprevention. Proc. Soc. Exp. Biol. Med. 1997, 216, 192-200.
25. Kessler, F. K.; Ritter, J. K. Induction of a rat liver benzo[a]-pyrene-trans-7,8-dihydrodiol glucuronidating activity by oltipraz and B-naphthoflavone. Carcinogenesis 1997, 18, 107-114.
26. Egner, P. A.; Kensler, T. W.; Prestera, T. T.; Talalay, P.; Libby, A. H. ; Joyner, H. H.; Curphey, T. J. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. Carcinogenesis 1994, 15, 177-181.
27. 1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H/Quinone oxidoreductase in rat liver. Cancer Res. 2000, 60, 957-969.
28. Siess, M.-H.; Le Bon, A.-M.; Canivenc-Lavier, M.-C.; Suschetet, M. Mechanisms involved in the chemoprevention of flavonoids. BioFactors 2000, 12, 193-199.
29. Kensler, T. W.; Egner, P. A.; Trush, M. A.; Bueding, E.; Groopman, J. D. Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin, and a dithiothione. Carcinogenesis 1985, 6, 759-763.
30. Kensler, T. W.; Egner, P. A.; Dolan, P. M.; Groopman, J. D.; Roebuck, B. D. Mechanisms of protection against aflatoxin tumorigenicity in rats fed oltipraz and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones. Cancer Res. 1987, 47, 4271-4277.
31. , Kensler, T. W.; He, X.; Otieno, M. Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adducts biomarkers. Cancer Epidemiol. Biomarkers Prev. 1998, 7, 127-34.
32. Singleton, V. L.; Rossi, J. A. Colorimetry of total phenolics with phosphotungstic acid reagents. Am. J. Enol. Vitic. 1965, 16, 144-158.
33. Kramling, T. E.; Singleton, V. L. An estimate of the nonflavonoid phenols in wines. Am. J. Enol. Vitic. 1969, 20, 86-92.
34. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
35. Habig, W. H.; Pabst, M. J.; Jakoby, W. B. Glutathione S-Transferases, the first enzymatic step on mercapturic acid formation. J. Biol. Chem. 1974, 249, 7130-7139.
36. Bock, K. W.; Burchell, B.; Dutton, G. J.; Hanninen, O.; Mulder, G. J.; Owens, I. S.; Siest, G.; Tephly, T. R. UDP-glucuronosyl-transferase activities - Guidelines for consistent interim terminology and assay condition. Biochem. Pharmacol. 1983, 32, 953-955.
37. Tietze, F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidised glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 1969, 27, 502-522.
38. Cao, G.; Prior, R. L. Measurement of oxygen radical absorbance capacity in biological samples. Methods Enzymol. 1998, 299, 50-62.
39. Parke, D. V.; Ioannides, C. The role of nutrition in toxicology. Annu. Rev. Nutr. 1981, 1, 207-234.
40. Manteiga, R.; Park, D. L.; Ali, S. S. Risks associated with consumption of herbal teas. Rev. Environ. Contam. Toxico. 1997, 150, 1-30.
41. Xu, Y.; Han, C. The effect of Chinese tea on the occurrence of esophageal tumours induced by N-nitrosomethylbenzylamine in vivo. Biomed. Environ. Sci. 1990, 3, 406-412.
42. Hirose, M.; Hoshiya, T.; Akagi, K.; Takasi, S.; Hara, Y.; Ito, N. Effects of green tea catechins in rat multi-organ carcinogenesis model. Carcinogenesis 1993, 14, 1549-1553.
43. Hesseling, P. B.; Klopper, J. F.; Van Heerden, P. D. R. Die effek van rooibostee op ysterabsorpsie. SA Med. J. 1979, 55, 631-632.
44. Prystai, E. A.; Kies, C. V.; Driskell, J. A. Calcium, copper, iron, magnesium, and zinc utilization of humans affected by consumption of black, decaffeinated black, and green teas. Nutr. Res. 1999, 19, 167-177.
45. Temme, E. H.; Van Hoydonck, P. G. Tea consumption and iron status. Eur. J. Clin. Nutr. 2002, 56, 379-386.
46. Hubbe, M. E.; Joubert, E. In vitro superoxide anion radical scavenging activity of honeybush tea (Cyclopia). In Dietary Anticarcinogens and Antimutagens - Chemical and Biological Aspects; Johnson, I. T., Fenwick, G. R., Eds.; The Royal Society of Chemistry: Cambridge, U.K., 2000; pp 242-44.
47. Von Gadow, A.; Joubert, E.; Hansmann, C. F. Comparison of the antioxidant activity of rooibos tea (Aspalathus linearis) with green, oolong, and black tea. Food Chem. 1997, 60, 73-77.
48. Prior, R. L. and Cao, G. Antioxidant capacity and polyphenolic components of teas: implications for altering in vivo antioxidant status. Proc. Soc. Exp. Biol. Med. 1999, 220, 255-261.
49. Wang, S. Y.; Jiao, H. Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals and singlet oxygen. J. Agric. Food Chem. 2000, 48, 677-5684.
50. Kidd, P. M. Glutathione: Systemic protectant against oxidative and free radical damage. Alt. Med. Rev. 1997, 2, 155-176.
51. Van Acker, F.; Schouten, O.; Haenen, G. R. M. M.; Van der Vijg, W. J. F. ; Bast, A. Flavonoids can replace α-tocopherol as antioxidant. FEBS Lett. 2000, 473, 145-148.
52. Exner, R.; Wessner, B.; Manhart, N.; Roth, E. Therapeutic potential of glutathione. Wien. Klin. Wochenschr. 2000, 112, 610-616.
53. Nanjo, F.; Honda, M.; Okushio, K.; Matsumoto, N.; Ishigaki, F.; Ishigami, T.; Hara, Y. Effects of dietary tea catechins on alpha-tocopherol levels, lipid peroxidation and erythrocyte deformability in rats fed high palm oil and perilla oil diets. Biol. Pharm. Bull. 1993, 16, 1156-1164.
54. Sohn, O. S.; Surace, A.; Fiala, E. S.; Richie, J. P.; Colosimo, S.; Zang, E.; Weisburger, J. H. Effects of green and black tea on hepatic xenobiotic metabolising systems in male F344 rat. Xenobiotica 1994, 24, 119-127.
55. Mannervik, B. The isoenzymes of glutathione-S-transferases. Adv. Enzymol. 1985, 57, 357-417.
56. Miller, E. C.; Miller, J. A. Some historical perspectives on the metabolism of xenobiotic chemicals to reactive intermediates. In Bioactivation of Foreign Compounds; M. W. Anders., Ed.; Academic Press: New York, 1985; pp 1-28.
57. Knasmuller, S.; Parzefall, W.; Sanyal, R.; Ecker, S.; Schwab, C.; Uhl, M.; Mersch-Sundermann, V.; Williamson, G.; Hietsch, G.; Langer, T.; Darroudi, F.; Natarajan, A. T. Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mutat. Res. 1998, 402, 185-202.
58. Bu-Abbas, A., Clifford, M. N.; Ioannides, C.; Walker, R. Stimulation of rat hepatic UDP-glucuronosyl transferase activity following treatment with green tea. Food Chem. Toxicol. 1995, 33, 27-30.
59. Lin, Y.-L., Cheng, C.-Y., Lin, Y.-P., Lau, Y.-W., Juan, I.-M., Lin, J.-K. Hypolipidemic effect of green tea leaves through induction of antioxidant and phase II enzymes including superoxide dismutase, catalase, and glutathione S-transferase in rats. J. Agric. Food Chem. 1998, 46, 1893-1899.
60. Embola, C. W.; Sohn, O. S.; Fiala, E. S.; Weisburger, J. H. Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats. Food Chem. Toxicol. 2002, 40, 841-844.
61. Bu-Abbas, A.; Clifford, M. N.; Walker, R.; Ioannides, C. Contribution of caffeine and flavanols in the induction of hepatic phase II activities by green tea. Food Chem. Toxicol. 1998, 36, 617-621.
62. Marnewick, J. L.; Gelderblom, W. C. A.; Batenburg, W.; Joubert, E. Ex vivo protective effects of South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) against carcinogen-induced mutagenesis. Mutat. Res. 2001, 483 (S 1), S105.
63. Chen, H. Y.; Yen, G, C. Possible mechanisms of antimutagens by various teas as judged by their effects on mutagenesis by 2-amino-3-methylimidazo[4,5-f]quinoline and benzo[a]pyrene. Mutat. Res. 1997, 393, 115-122.