메뉴 건너뛰기




Volumn 18, Issue 1, 1997, Pages 107-114

Induction of a rat liver benzo[a]pyrene-trans-7,8-dihydrodiol glucuronidating activity by oltipraz and β-naphthoflavone

Author keywords

[No Author keywords available]

Indexed keywords

BETA NAPHTHOFLAVONE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; OLTIPRAZ; POLYCYCLIC AROMATIC HYDROCARBON; XENOBIOTIC AGENT;

EID: 0031410745     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.1.107     Document Type: Article
Times cited : (39)

References (48)
  • 2
    • 0021007163 scopus 로고
    • IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, IARC Scientific Publications, Lyon, France
    • 2.IARC (1983) Polynuclear Aromatic Compounds, Part 1: Chemical, Environmental, and Experimental Data. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 32. IARC Scientific Publications, Lyon, France, pp. 1-476.
    • (1983) Polynuclear Aromatic Compounds, Part 1: Chemical, Environmental, and Experimental Data , vol.32 , pp. 1-476
  • 3
    • 0019074870 scopus 로고
    • Benzo[a]pyrene metabolism, activation, and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes
    • Gelboin,H.V. (1980) Benzo[a]pyrene metabolism, activation, and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiol. Rev., 60, 1107-1166.
    • (1980) Physiol. Rev. , vol.60 , pp. 1107-1166
    • Gelboin, H.V.1
  • 4
    • 0028960724 scopus 로고
    • Differential mutagenicity and cytotoxicity of (±)-benzo[a]pyrene-trans- 7,8-dihydrodiol and (±)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts
    • Quan,T., ReinersJ.J.Jr. Culp,S.J., Richter,P. and States,J.C. (1995) Differential mutagenicity and cytotoxicity of (±)-benzo[a]pyrene-trans- 7,8-dihydrodiol and (±)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts. Mol. Carcinogenesis, 12, 91-102.
    • (1995) Mol. Carcinogenesis , vol.12 , pp. 91-102
    • Quan, T.1    Reiners Jr., J.J.2    Culp, S.J.3    Richter, P.4    States, J.C.5
  • 5
    • 0025871840 scopus 로고
    • Roles of UDP-glucuronosyltransferases in chemical carcinogenesis
    • Bock,K.W. (1991) Roles of UDP-glucuronosyltransferases in chemical carcinogenesis. Crit. Rev. Biochem. Molec. Biol., 26, 129-150.
    • (1991) Crit. Rev. Biochem. Molec. Biol. , vol.26 , pp. 129-150
    • Bock, K.W.1
  • 8
    • 0025963906 scopus 로고
    • Metabolism of benzo[a]pyrene and (-) trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes from mirror carp
    • Zaleski,J., Steward,A.R. and Sikka,H.C. (1991) Metabolism of benzo[a]pyrene and (-) trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes from mirror carp. Carcinogenesis, 12, 167-174.
    • (1991) Carcinogenesis , vol.12 , pp. 167-174
    • Zaleski, J.1    Steward, A.R.2    Sikka, H.C.3
  • 9
    • 0017236842 scopus 로고
    • Enzymatic conjugation of benzo[a]pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid
    • Nemoto,N. and Gelboin,H.V. (1976) Enzymatic conjugation of benzo[a]pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid. Biochem. Pharmacol., 25, 1221-1226.
    • (1976) Biochem. Pharmacol. , vol.25 , pp. 1221-1226
    • Nemoto, N.1    Gelboin, H.V.2
  • 10
    • 0017752734 scopus 로고
    • Metabolism of benzo[a]pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives
    • Burke,M.D., Vadi,H., Jernström,B. and Orrenius,S. (1977) Metabolism of benzo[a]pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives. J. Biol. Chem., 252, 6424-6431.
    • (1977) J. Biol. Chem. , vol.252 , pp. 6424-6431
    • Burke, M.D.1    Vadi, H.2    Jernström, B.3    Orrenius, S.4
  • 11
    • 0023176662 scopus 로고
    • Metabolism of benzo[a]pyrene in primary cultures of human hepatocytes: Dose-response over a four-log range
    • Monteith,D.K., Novotny,A., Michalopoulos,G. and Strom,S.C. (1987) Metabolism of benzo[a]pyrene in primary cultures of human hepatocytes: dose-response over a four-log range. Carcinogenesis, 8, 983-988.
    • (1987) Carcinogenesis , vol.8 , pp. 983-988
    • Monteith, D.K.1    Novotny, A.2    Michalopoulos, G.3    Strom, S.C.4
  • 12
    • 0024994625 scopus 로고
    • Conjugation of chemical carcinogens by primary cultures of human hepatocytes
    • Monteith,D.K., Michaelopoulos,G. and Strom,S.C. (1990) Conjugation of chemical carcinogens by primary cultures of human hepatocytes. Xenobiotica, 20, 753-763.
    • (1990) Xenobiotica , vol.20 , pp. 753-763
    • Monteith, D.K.1    Michaelopoulos, G.2    Strom, S.C.3
  • 14
    • 0029021815 scopus 로고
    • Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review
    • Raunio,H., Husgafvel-Pursiainen,K., Anttila,S., Hietanen,E., Hirvonen,A. and Pelkonen,O. (1995) Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review. Gene, 159, 113-121.
    • (1995) Gene , vol.159 , pp. 113-121
    • Raunio, H.1    Husgafvel-Pursiainen, K.2    Anttila, S.3    Hietanen, E.4    Hirvonen, A.5    Pelkonen, O.6
  • 15
    • 0027402335 scopus 로고
    • Glucuronidation of carcinogen metabolites by complementary DNA-expressed uridine 5′-diphosphate glucuronosyltransferases
    • Mackenzie,P.I., Rodbourn,L. and Iyanagi,T. (1993) Glucuronidation of carcinogen metabolites by complementary DNA-expressed uridine 5′-diphosphate glucuronosyltransferases. Cancer Res., 53, 1529-1533.
    • (1993) Cancer Res. , vol.53 , pp. 1529-1533
    • Mackenzie, P.I.1    Rodbourn, L.2    Iyanagi, T.3
  • 16
    • 0027134662 scopus 로고
    • The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyl-transferases
    • Jin,C.J., Miners,J.O., Burchell,B. and Mackenzie, P.I. (1993) The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyl-transferases. Carcinogenesis, 14, 2637-2639.
    • (1993) Carcinogenesis , vol.14 , pp. 2637-2639
    • Jin, C.J.1    Miners, J.O.2    Burchell, B.3    Mackenzie, P.I.4
  • 17
    • 0027394238 scopus 로고
    • Chemical and molecular regulation of enzymes that detoxify carcinogens
    • Prestera,T., Holtzclaw,W. D., Zhang,Y. and Talalay,P. (1993) Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc. Natl Acad. Sci USA, 90, 2965-2969.
    • (1993) Proc. Natl Acad. Sci USA , vol.90 , pp. 2965-2969
    • Prestera, T.1    Holtzclaw, W.D.2    Zhang, Y.3    Talalay, P.4
  • 19
    • 0002948349 scopus 로고
    • Chemoprotection by oltipraz and other dithiolethiones
    • Wattenberg,L., Lipkin,M., Boone,C. and Kelloff,G. (eds). CRC Press, Boca Raton, FL
    • Kensler,T.W., Groopman,J.D. and Roebuck,B.D. (1992) Chemoprotection by oltipraz and other dithiolethiones. In Wattenberg,L., Lipkin,M., Boone,C. and Kelloff,G. (eds), Cancer Chemoprevention. CRC Press, Boca Raton, FL, pp. 205-226.
    • (1992) Cancer Chemoprevention , pp. 205-226
    • Kensler, T.W.1    Groopman, J.D.2    Roebuck, B.D.3
  • 21
    • 0023204238 scopus 로고
    • Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones
    • Kensler,T.W., Egner,P.A., Dolan,P.M., Groopman,J.D. and Roebuck,B.D. (1987) Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones. Cancer Res., 47, 4271-4277.
    • (1987) Cancer Res. , vol.47 , pp. 4271-4277
    • Kensler, T.W.1    Egner, P.A.2    Dolan, P.M.3    Groopman, J.D.4    Roebuck, B.D.5
  • 22
    • 0021893276 scopus 로고
    • Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione
    • Kensler,T.W., Egner,P.A., Trush,M.A., Bueding,E. and Groopman,J.D. (1985) Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione. Carcinogenesis, 6, 759-763.
    • (1985) Carcinogenesis , vol.6 , pp. 759-763
    • Kensler, T.W.1    Egner, P.A.2    Trush, M.A.3    Bueding, E.4    Groopman, J.D.5
  • 24
    • 0022450211 scopus 로고
    • The influence of recombinant DNA derived human and murine interferons on mouse hepatic drug metabolism
    • Franklin,M.R. and Finkle,B.S. (1986) The influence of recombinant DNA derived human and murine interferons on mouse hepatic drug metabolism. Fund. Appl. Toxicol., 7, 165-169.
    • (1986) Fund. Appl. Toxicol. , vol.7 , pp. 165-169
    • Franklin, M.R.1    Finkle, B.S.2
  • 26
    • 0020060072 scopus 로고
    • On the functional heterogeneity of UDP-glucuronyltransferase of mouse liver microsomes
    • Bansal,S., Li,H.C., Holmes,G. and Gessner,T. (1982) On the functional heterogeneity of UDP-glucuronyltransferase of mouse liver microsomes. Res. Comm. Chem. Path. Pharmacol., 35, 291-302.
    • (1982) Res. Comm. Chem. Path. Pharmacol. , vol.35 , pp. 291-302
    • Bansal, S.1    Li, H.C.2    Holmes, G.3    Gessner, T.4
  • 27
    • 0020431254 scopus 로고
    • Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous and Wistar rat livers by pregnenolone 16α-carbonitrile
    • Watkins,J.B. and Klaassen,C.D. (1982) Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous and Wistar rat livers by pregnenolone 16α-carbonitrile. Drug Metab. Disp., 10, 590-594.
    • (1982) Drug Metab. Disp. , vol.10 , pp. 590-594
    • Watkins, J.B.1    Klaassen, C.D.2
  • 28
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski,P. and Sacchi,N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 29
    • 0023019287 scopus 로고
    • Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase
    • Iyanagi,T., Haniu,M., Sogawa,K., Fujii-Kuriyama,Y., Watanabe,S., Shively,J.E. and Anan,K.F. (1986) Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. J. Biol. Chem., 261, 15607-15614.
    • (1986) J. Biol. Chem. , vol.261 , pp. 15607-15614
    • Iyanagi, T.1    Haniu, M.2    Sogawa, K.3    Fujii-Kuriyama, Y.4    Watanabe, S.5    Shively, J.E.6    Anan, K.F.7
  • 30
    • 0023035858 scopus 로고
    • Rat liver UDP-glucuronosyltransferase: Sequence and expression of a cDNA encoding a phenobarbital-inducible form
    • Mackenzie,P.I. (1986) Rat liver UDP-glucuronosyltransferase: sequence and expression of a cDNA encoding a phenobarbital-inducible form. J. Biol. Chem., 261, 6119-6125.
    • (1986) J. Biol. Chem. , vol.261 , pp. 6119-6125
    • Mackenzie, P.I.1
  • 31
    • 0344950089 scopus 로고
    • Primary structure of a cytochrome P-450: Coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver
    • Fujii-Kuriyama,Y., Mizukami,Y., Kawajiri,K., Sogawa,K. and Muramatsu,M. (1982) Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver. Proc. Natl Acad. Sci. USA., 79, 2793-2797.
    • (1982) Proc. Natl Acad. Sci. USA. , vol.79 , pp. 2793-2797
    • Fujii-Kuriyama, Y.1    Mizukami, Y.2    Kawajiri, K.3    Sogawa, K.4    Muramatsu, M.5
  • 33
    • 0021991405 scopus 로고
    • Human dioxin-inducible cytochrome P1-450: Complementary DNA and amino acid sequence
    • Jaiswal,A.K., Gonzalez,F.J. and Nebert,D.W. (1985) Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science, 228, 80-82.
    • (1985) Science , vol.228 , pp. 80-82
    • Jaiswal, A.K.1    Gonzalez, F.J.2    Nebert, D.W.3
  • 34
    • 0020306578 scopus 로고
    • A comparison of the isoelectric points of mouse liver UDP-glucuronosyltransferase enzymes conjugating the twelve benzo[a]pyrene phenols
    • Owens,I.S. and Mackenzie,P.I. (1982) A comparison of the isoelectric points of mouse liver UDP-glucuronosyltransferase enzymes conjugating the twelve benzo[a]pyrene phenols. Biochem. Biophys. Res. Comm., 109, 1075-1082.
    • (1982) Biochem. Biophys. Res. Comm. , vol.109 , pp. 1075-1082
    • Owens, I.S.1    Mackenzie, P.I.2
  • 35
    • 0001488917 scopus 로고
    • Polycyclic aromatic hydrocarbons: Metabolic activation to ultimate carcinogens
    • Anders,M.W. (ed.). Academic Press, New York
    • Thakker,D.R., Yagi,H., Levin,W., Wood,A.W., Conney,A.H. and Jerina,D.M. (1985) Polycyclic aromatic hydrocarbons: metabolic activation to ultimate carcinogens. In Anders,M.W. (ed.), Bioactivation of Foreign Compounds. Academic Press, New York, pp. 178-242.
    • (1985) Bioactivation of Foreign Compounds , pp. 178-242
    • Thakker, D.R.1    Yagi, H.2    Levin, W.3    Wood, A.W.4    Conney, A.H.5    Jerina, D.M.6
  • 36
    • 0028044817 scopus 로고
    • A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UGT2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols and carboxylic acids
    • Pritchard,M., Fournel-Gigleux,S., Siest,G., Mackenzie,P. and Magdalou,J. (1994) A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UGT2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols and carboxylic acids. Molec. Pharmacol., 45, 42-50.
    • (1994) Molec. Pharmacol. , vol.45 , pp. 42-50
    • Pritchard, M.1    Fournel-Gigleux, S.2    Siest, G.3    Mackenzie, P.4    Magdalou, J.5
  • 37
    • 0028956177 scopus 로고
    • Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: Initiation of micronuclei by benzo[a]pyrene and benzo[e]pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts
    • Vienneau,D.S., DeBoni,U. and Wells,P.G. (1995) Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo[a]pyrene and benzo[e]pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts. Cancer Res., 55, 1045-1051.
    • (1995) Cancer Res. , vol.55 , pp. 1045-1051
    • Vienneau, D.S.1    DeBoni, U.2    Wells, P.G.3
  • 38
    • 0026706445 scopus 로고
    • In vitro and in vivo biotransformation and covalent binding of benzo[a]pyrene in Gunn and RHA rats with a genetic deficiency in bilirubin uridine diphosphate-glucuronosyltransferase
    • Hu,Z. and Wells,P.G. (1992) In vitro and in vivo biotransformation and covalent binding of benzo[a]pyrene in Gunn and RHA rats with a genetic deficiency in bilirubin uridine diphosphate-glucuronosyltransferase. J. Pharmacol. Exp. Ther., 263, 334-342.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 334-342
    • Hu, Z.1    Wells, P.G.2
  • 39
    • 0027363349 scopus 로고
    • Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism
    • Penning, T.M. (1993) Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism. Chem.-Biol. Interactions, 89, 1-34.
    • (1993) Chem.-Biol. Interactions , vol.89 , pp. 1-34
    • Penning, T.M.1
  • 40
    • 0028824573 scopus 로고
    • Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (±) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes
    • Flowers-Geary,L., Harvey,R.G. and Penning,T.M. (1995) Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (±) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes. Carcinogenesis, 16, 2707-2715.
    • (1995) Carcinogenesis , vol.16 , pp. 2707-2715
    • Flowers-Geary, L.1    Harvey, R.G.2    Penning, T.M.3
  • 41
    • 0022763396 scopus 로고
    • Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard
    • Wattenberg,L.W. and Bueding,E. (1986) Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard. Carcinogenesis, 7, 1379-1381.
    • (1986) Carcinogenesis , vol.7 , pp. 1379-1381
    • Wattenberg, L.W.1    Bueding, E.2
  • 42
    • 0028212905 scopus 로고
    • Coordinate induction of glutathione S-transferase α, μ and π expression in murine liver after a single administration of oltipraz
    • Clapper,M.L., Everley,L.C., Strobel,L.A., Townsend,A.J. and Engstrom,P.F. (1994) Coordinate induction of glutathione S-transferase α, μ and π expression in murine liver after a single administration of oltipraz. Molec. Pharmacol., 45, 469-474.
    • (1994) Molec. Pharmacol. , vol.45 , pp. 469-474
    • Clapper, M.L.1    Everley, L.C.2    Strobel, L.A.3    Townsend, A.J.4    Engstrom, P.F.5
  • 43
    • 0027497708 scopus 로고
    • Preferential increase of glutathione S-transferase class a transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene and dithiolethiones
    • Morel,F., Fardel,O., Meyer,D.J., Langouet,S., Gilmore,K.S., Meunier,B., Tu,C.-P., Kensler,T.W., Ketterer,B. and Guillouzo,A. (1993) Preferential increase of glutathione S-transferase class a transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene and dithiolethiones. Cancer Res., 53, 231-234.
    • (1993) Cancer Res. , vol.53 , pp. 231-234
    • Morel, F.1    Fardel, O.2    Meyer, D.J.3    Langouet, S.4    Gilmore, K.S.5    Meunier, B.6    Tu, C.-P.7    Kensler, T.W.8    Ketterer, B.9    Guillouzo, A.10
  • 44
    • 0018743766 scopus 로고
    • Deoxyribonucleic acid binding of 3-hydroxy- and 9-hydroxybenzo[a]pyrene following further metabolism by mouse liver microsomal cytochrome P1-450
    • Owens,I.S., Legraverend,C. and Pelkonen,O. (1979) Deoxyribonucleic acid binding of 3-hydroxy- and 9-hydroxybenzo[a]pyrene following further metabolism by mouse liver microsomal cytochrome P1-450. Biochem. Pharmacol., 28, 1623-1629.
    • (1979) Biochem. Pharmacol. , vol.28 , pp. 1623-1629
    • Owens, I.S.1    Legraverend, C.2    Pelkonen, O.3
  • 45
    • 0025602894 scopus 로고
    • Induction of drug-metabolizing enzymes by xenobiotics
    • Bock,K.W., Lipp,H.-P. and Bock-Hennig,B.S. (1990) Induction of drug-metabolizing enzymes by xenobiotics. Xenobiotica, 20, 1101-1111.
    • (1990) Xenobiotica , vol.20 , pp. 1101-1111
    • Bock, K.W.1    Lipp, H.-P.2    Bock-Hennig, B.S.3
  • 46
    • 0026335219 scopus 로고
    • Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat)
    • Iyanagi,T. (1991)Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). J. Biol. Chem., 266, 24048-24052.
    • (1991) J. Biol. Chem. , vol.266 , pp. 24048-24052
    • Iyanagi, T.1
  • 47
    • 0027978702 scopus 로고
    • Glucuronidation of carcinogenic arylamines and their N-hydroxy derivatives by rat and human phenol UDP-glucuronosyltransferase of the UGT1 gene complex
    • Orzechowski,A., Schrenk,D., Bock-Hennig,B.S. and Bock,K.W. (1994) Glucuronidation of carcinogenic arylamines and their N-hydroxy derivatives by rat and human phenol UDP-glucuronosyltransferase of the UGT1 gene complex. Carcinogenesis, 15, 1549-1553.
    • (1994) Carcinogenesis , vol.15 , pp. 1549-1553
    • Orzechowski, A.1    Schrenk, D.2    Bock-Hennig, B.S.3    Bock, K.W.4
  • 48
    • 0020793569 scopus 로고
    • A technique for radiolabeling DNA restriction fragments to high specific activity
    • Feinberg,A. and Vogelstein,B. (1983) A technique for radiolabeling DNA restriction fragments to high specific activity. Anal. Biochem., 132, 6-13.
    • (1983) Anal. Biochem. , vol.132 , pp. 6-13
    • Feinberg, A.1    Vogelstein, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.