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Volumn 70, Issue 1, 2004, Pages 607-609

A Complete Library of Amino Acid Alterations at N304 in Streptomyces clavuligerus Deacetoxycephalosporin C Synthase Elucidates the Basis for Enhanced Penicillin Analogue Conversion

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; ENZYMES; MICROORGANISMS; MUTAGENESIS;

EID: 0345868794     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.70.1.607-609.2004     Document Type: Article
Times cited : (22)

References (12)
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    • Chin, H. S., and T. S. Sim. 2002. C-terminus modification of Streptomyces clavuligerus deacetoxycephalosporin C synthase improves catalysis with all expanded substrate specificity. Biochem. Biophys. Res. Commun. 295:55-61.
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    • Chin, H.S.1    Sim, T.S.2
  • 2
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    • Mutation of N304 to leucine in Streptomyes clavuligerus deacetoxycephalosporin C synthase creates an enzyme with increased penicillin analogue conversion
    • Chin, H. S., J. Sim, and T. S. Sim. 2001. Mutation of N304 to leucine in Streptomyes clavuligerus deacetoxycephalosporin C synthase creates an enzyme with increased penicillin analogue conversion. Biochem. Biophys. Res. Commun. 287:507-513.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 507-513
    • Chin, H.S.1    Sim, J.2    Sim, T.S.3
  • 3
    • 0037469271 scopus 로고    scopus 로고
    • Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity
    • Chin, H. S., J. Sim, K. I. Seah, and T. S. Sim. 2003. Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity. FEMS Microbiol. Lett. 218:251-257.
    • (2003) FEMS Microbiol. Lett. , vol.218 , pp. 251-257
    • Chin, H.S.1    Sim, J.2    Seah, K.I.3    Sim, T.S.4
  • 4
    • 0027631543 scopus 로고
    • The enzyme involved in biosynthesis of penicillin and cephalosporin: Their structure and function
    • Cooper, R. D. G. 1993. The enzyme involved in biosynthesis of penicillin and cephalosporin: their structure and function. Bioorg. Med. Chem. 1:1-17.
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  • 8
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    • The iron (11) and 2-oxoacid-dependent dioxygenases and their role in metabolism
    • Prescott, A. G., and M. D. Lloyd. 2000. The iron (11) and 2-oxoacid-dependent dioxygenases and their role in metabolism. Nat. Prod. Rep. 17:367-383.
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    • Prescott, A.G.1    Lloyd, M.D.2
  • 9
    • 0035499604 scopus 로고    scopus 로고
    • The hunchback and its neighbors: Proline as an environmental modulator
    • Reiersen, H., and A. R. Rees. 2001. The hunchback and its neighbors: proline as an environmental modulator. Trends Biochem. Sci. 26:679-684.
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    • Reiersen, H.1    Rees, A.R.2
  • 10
    • 0035812391 scopus 로고    scopus 로고
    • In vitro conversion of penicillin G and ampicillin by recombinant Streptomyces clavuligerus NRRL 3585 deacetoxycephalosporin C synthase
    • Sim, J., and T. S. Sim. 2001. In vitro conversion of penicillin G and ampicillin by recombinant Streptomyces clavuligerus NRRL 3585 deacetoxycephalosporin C synthase. Enzyme Microbial Technol. 29:240-245.
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  • 11
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    • Environmentally safe production of 7-aminodeacetoxycephalosporamic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum
    • Velasco, J., J. L. Adrio, M. A. Moreno, B. Diez, G. Soler, and J. L. Barredo. 2000. Environmentally safe production of 7-aminodeacetoxycephalosporamic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum. Nat. Biotechnol. 18:857-861.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.