Securin and B-cyclin/CDK are the only essential targets of the APC

Nature Cell Biology

Volumn 5, Issue 12, 2003, Pages 1090-1094

  Thornton, Brian R ^a   Toczyski, David P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN B; ISOPROTEIN; PROTEIN SIC 1; PROTEIN SUBUNIT; SECURININE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; COMPLEX FORMATION; CONTROLLED STUDY; FEEDBACK SYSTEM; FUNGAL STRAIN; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE;

CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN B; CYCLIN-DEPENDENT KINASES; FEEDBACK, BIOCHEMICAL; NUCLEAR PROTEINS; PROTEIN SUBUNITS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0344668551     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1066     Document Type: Article

References (30)

1. Peters, J. M. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell 9, 931-943 (2002).
2. Yoon, H. J. et al. Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes. Curr. Biol. 12, 2048-2054 (2002).
3. Sikorski, R. S. et al. TPR proteins as essential components of the yeast cell cycle. Cold Spring Harb. Symp. Quant. Biol. 56, 663-673 (1991).
4. Zachariae, W. et al. Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279, 1216-1219 (1998).
5. Yu, H. et al. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science 279, 1219-1222 (1998).
6. Schwab, M., Lutum, A. S. & Seufert, W. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90, 683-693 (1997).
7. Visintin, R., Prinz, S. & Amon, A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460-463 (1997).
8. Shirayama, M., Toth, A., Galova, M. & Nasmyth, K. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 402, 203-207 (1999).
9. Yeong, F. M., Lim, H. H., Padmashree, C. G. & Surana, U. Exit from mitosis in budding yeast; biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20. Mol. Cell 5, 501-511 (2000).
10. Burton, J. L. & Solomon, M. J. D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes Dev. 15, 2381-2395 (2001).
11. Wasch, R. & Cross, F. R. APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418, 556-562 (2002).
12. Schwob, E., Bohm, T., Mendenhall, M. D. & Nasmyth, K. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244 (1994).
13. Leverson, J. D. et al. The APC11 RING-H2 finger mediates E2-dependent ubiquitination. Mol. Biol. Cell 11, 2315-2325 (2000).
14. Tang, Z. et al. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol. Biol. Cell 12, 3839-3851 (2001).
15. Gmachl, M., Gieffers, C., Podtelejnikov, A. V., Mann, M. & Peters, J. M. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. Proc. Natl Acad. Sci. USA 97, 8973-8978 (2000).
16. McMillan, J. N., Theesfeld, C. L., Harrison, J. C., Bardes, E. S. & Lew, D. J. Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol. Biol. Cell 13, 3560-3575 (2002).
17. Harvey, S. L. & Kellogg, D. R. Conservation of mechanisms controlling entry into mitosis. Budding yeast wee1 delays entry into mitosis and is required for cell size control. Curr. Biol. 13, 264-275 (2003).
18. Biggins, S. et al. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev. 13, 532-544 (1999).
19. Dahmann, C., Diffley, J. F. & Nasmyth, K. A. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol. 5, 1257-1269 (1995).
20. Nguyen, V. Q., Co, C. & Li, J. J. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411, 1068-1073 (2001).
21. Blilou, I. et al. The Arabidopsis HOBBIT gene encodes a CDC27 homolog that links the plant cell cycle to progression of cell differentiation. Genes Dev. 16, 2566-2575 (2002).
22. Zachariae, W., Schwab, M., Nasmyth, K. & Seufert, W. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 282, 1721-1724 (1998).
23. Jaspersen, S. L., Charles, J. F. & Morgan, D. O. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227-236 (1999).
24. Carroll, C. W. & Morgan, D. O. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nature Cell Biol. 4, 880-887 (2002).
25. Seufert, W. & Jentsch, S. Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. EMBO J. 9, 543-550 (1990).
26. Lew, D. J. Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae. Curr. Opin. Genet. Dev. 10, 47-53 (2000).
27. Amon, A., Tyers, M., Futcher, B. & Nasmyth, K. Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell 74, 993-1007 (1993).
28. Schneider, B. L., Yang, Q. H. & Futcher, A. B. Linkage of replication to start by the Cdk inhibitor Sic1. Science 272, 560-562 (1996).
29. Tyers, M. The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start. Proc. Natl Acad. Sci. USA 93, 7772-7776 (1996).
30. Geymonat, M., Jensen, S. & Johnston, L. H. Mitotic exit: the Cdc14 double cross. Curr. Biol. 12, R482-R484 (2002).