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Volumn 55, Issue 7, 1996, Pages 747-757

Amyotrophic lateral sclerosis: Recent advances in understanding disease mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMIC ACID; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0030014299     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199607000-00001     Document Type: Review
Times cited : (44)

References (60)
  • 2
    • 0007522276 scopus 로고
    • Familial amyotrophic lateral sclerosis
    • De Jong JMBV, ed. Elsevier
    • Williams DB. Familial amyotrophic lateral sclerosis. In: De Jong JMBV, ed. Handbook of clinical neurology, Vol. 15. Elsevier: 1991: 241-51
    • (1991) Handbook of Clinical Neurology , vol.15 , pp. 241-251
    • Williams, D.B.1
  • 3
    • 12044249765 scopus 로고
    • Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity
    • Siddique T, Figlewicz DA, Pericak-Vance MA, et al. Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity. N Engl J Med 1991;324:1381-84
    • (1991) N Engl J Med , vol.324 , pp. 1381-1384
    • Siddique, T.1    Figlewicz, D.A.2    Pericak-Vance, M.A.3
  • 4
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-63
    • (1993) Nature , vol.362 , pp. 59-63
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3    Figlewicz, D.A.4    Sapp, P.5
  • 5
    • 0027426169 scopus 로고
    • Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
    • Deng H-X, Hentati A, Tainer JA, et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 1993;261:1047-51
    • (1993) Science , vol.261 , pp. 1047-1051
    • Deng, H.-X.1    Hentati, A.2    Tainer, J.A.3
  • 6
    • 0020644952 scopus 로고
    • Superoxide radical: An endogenous toxicant
    • Fridovich I. Superoxide radical: An endogenous toxicant. Ann Rev Pharmacol Toxicol 1983;23:239-57
    • (1983) Ann Rev Pharmacol Toxicol , vol.23 , pp. 239-257
    • Fridovich, I.1
  • 7
    • 0024571782 scopus 로고
    • Polyethylene glycoconjugated superoxide dismutase and catalase reduce ischaemic brain injury
    • Liu TH, Beckmann JS, Freeman BA, Hogan EL, Hsu CY. Polyethylene glycoconjugated superoxide dismutase and catalase reduce ischaemic brain injury. Am J Physiol 1989;256:H589-93
    • (1989) Am J Physiol , vol.256
    • Liu, T.H.1    Beckmann, J.S.2    Freeman, B.A.3    Hogan, E.L.4    Hsu, C.Y.5
  • 8
    • 0025074716 scopus 로고
    • Liposome entrapped superoxide dismutase reduces cerebral infarction in cerebral ischaemia in rats
    • Imaizumi S, Woolworth V, Fishman RA, Chan PH. Liposome entrapped superoxide dismutase reduces cerebral infarction in cerebral ischaemia in rats. Stroke 1990;21:1312-17
    • (1990) Stroke , vol.21 , pp. 1312-1317
    • Imaizumi, S.1    Woolworth, V.2    Fishman, R.A.3    Chan, P.H.4
  • 9
  • 10
    • 0028324543 scopus 로고
    • Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers
    • Rosen DR, Sapp P, O'Regan J, et al. Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers. Am J Med Genet 1994;51:61-69
    • (1994) Am J Med Genet , vol.51 , pp. 61-69
    • Rosen, D.R.1    Sapp, P.2    O'Regan, J.3
  • 11
    • 0028823914 scopus 로고
    • Familial amyotrophic lateral sclerosis/motor neurone disease (FALS): A review of current developments
    • de Belleroche J, Orrell R, King A. Familial amyotrophic lateral sclerosis/motor neurone disease (FALS): A review of current developments. J Med Genet 1995;32:841-47
    • (1995) J Med Genet , vol.32 , pp. 841-847
    • De Belleroche, J.1    Orrell, R.2    King, A.3
  • 12
    • 0021921322 scopus 로고
    • Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase
    • Levanon D, Lieman-Hurwitz J, Dafni N, et al. Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase. EMBO J 1985;4:77-84
    • (1985) EMBO J , vol.4 , pp. 77-84
    • Levanon, D.1    Lieman-Hurwitz, J.2    Dafni, N.3
  • 13
    • 0028244477 scopus 로고
    • Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis
    • Esteban J, Rosen DR, Bowling AC, Sapp P, McKenna-Yasek D. Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis. Human Mol Genet 1994;3:997-98
    • (1994) Human Mol Genet , vol.3 , pp. 997-998
    • Esteban, J.1    Rosen, D.R.2    Bowling, A.C.3    Sapp, P.4    McKenna-Yasek, D.5
  • 15
    • 0029047111 scopus 로고
    • Two novel mutations in the gene for copper zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis
    • Enayat ZE, Orrell RW, Claus A, Ludolph A, Powell PN, Leigh PN, de Belleroche J. Two novel mutations in the gene for copper zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis. Hum Molec Genet 1995;4:1239-40
    • (1995) Hum Molec Genet , vol.4 , pp. 1239-1240
    • Enayat, Z.E.1    Orrell, R.W.2    Claus, A.3    Ludolph, A.4    Powell, P.N.5    Leigh, P.N.6    De Belleroche, J.7
  • 17
    • 0029080304 scopus 로고
    • Familial amyotrophic lateral sclerosis with a point mutation of SOD-1: Intrafamilial heterogeneity of disease duration associated with neurofibrillary tangles
    • Orrell RW, King AW, Hilton DA, Campbell MJ, Lane RJM, de Belleroche J. Familial amyotrophic lateral sclerosis with a point mutation of SOD-1: Intrafamilial heterogeneity of disease duration associated with neurofibrillary tangles. J Neurol Neurosurg Psychiat 1995;59:266-70
    • (1995) J Neurol Neurosurg Psychiat , vol.59 , pp. 266-270
    • Orrell, R.W.1    King, A.W.2    Hilton, D.A.3    Campbell, M.J.4    Lane, R.J.M.5    De Belleroche, J.6
  • 19
    • 0028204413 scopus 로고
    • A novel mutation in Cu/Zn superoxide dismutase gene in Japanese familial amyotrophic lateral sclerosis
    • Nakano R, Sato S, Inuzuka T et al. A novel mutation in Cu/Zn superoxide dismutase gene in Japanese familial amyotrophic lateral sclerosis. Biochem Biophys Res Commun 1994;200:695-703
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 695-703
    • Nakano, R.1    Sato, S.2    Inuzuka, T.3
  • 20
    • 0028273306 scopus 로고
    • Identification of a novel SOD-1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of IIe113Thr in three others
    • Jones CT, Swingler RJ, Brock DJH. Identification of a novel SOD-1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of IIe113Thr in three others. Human Mol Genet 1994;3:649-50
    • (1994) Human Mol Genet , vol.3 , pp. 649-650
    • Jones, C.T.1    Swingler, R.J.2    Brock, D.J.H.3
  • 21
    • 0027997236 scopus 로고
    • Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis
    • Tsuda T, Munthasser S, Fraser PE, et al. Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis. Neuron 1994;13:727-36
    • (1994) Neuron , vol.13 , pp. 727-736
    • Tsuda, T.1    Munthasser, S.2    Fraser, P.E.3
  • 22
    • 0028168971 scopus 로고
    • Familial amyotrophic lateral sclerosis (ALS) in Japan associated with H46R mutation in Cu/Zn superoxide dismutase gene: A possible new subtype of familial ALS
    • Aoki M, Ogasawara M, Matsubara Y, Narisawa K, Nakamura S, Itoyama Y, Abe K. Familial amyotrophic lateral sclerosis (ALS) in Japan associated with H46R mutation in Cu/Zn superoxide dismutase gene: A possible new subtype of familial ALS. J Neurol Sci 1994; 126:77-83
    • (1994) J Neurol Sci , vol.126 , pp. 77-83
    • Aoki, M.1    Ogasawara, M.2    Matsubara, Y.3    Narisawa, K.4    Nakamura, S.5    Itoyama, Y.6    Abe, K.7
  • 23
    • 0028123297 scopus 로고
    • Identification of a new missense point mutation in exon 4 of the Cu/Zn superoxide dismutase (SOD-1) gene in a family with amyotrophic lateral sclerosis
    • Elshafey A, Lanyon WG, Connor JM. Identification of a new missense point mutation in exon 4 of the Cu/Zn superoxide dismutase (SOD-1) gene in a family with amyotrophic lateral sclerosis. Human Mol Genet 1994;3:363-64
    • (1994) Human Mol Genet , vol.3 , pp. 363-364
    • Elshafey, A.1    Lanyon, W.G.2    Connor, J.M.3
  • 25
    • 0027944708 scopus 로고
    • Identification of a novel exon 4 SOD1 mutation in a sporadic amyotrophic lateral sclerosis patient
    • Jones CT, Shaw PJ, Chari G, Brock DJH. Identification of a novel exon 4 SOD1 mutation in a sporadic amyotrophic lateral sclerosis patient. Mol Cell Probes 1994;8:329-30
    • (1994) Mol Cell Probes , vol.8 , pp. 329-330
    • Jones, C.T.1    Shaw, P.J.2    Chari, G.3    Brock, D.J.H.4
  • 26
    • 0029945513 scopus 로고    scopus 로고
    • Difficulties in distinguishing sporadic from familial forms of amyotrophic lateral sclerosis
    • Orrell RW, Habgood J, Rudge P, Lane RJM, de Belleroche J. Difficulties in distinguishing sporadic from familial forms of amyotrophic lateral sclerosis. Ann Neurol 1996;39:810-18
    • (1996) Ann Neurol , vol.39 , pp. 810-818
    • Orrell, R.W.1    Habgood, J.2    Rudge, P.3    Lane, R.J.M.4    De Belleroche, J.5
  • 27
  • 28
    • 0027965073 scopus 로고
    • Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity
    • Borchelt DR, Lee MK, Slunt HS, et al. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci USA 1994;91:8292-96
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8292-8296
    • Borchelt, D.R.1    Lee, M.K.2    Slunt, H.S.3
  • 29
    • 0028149084 scopus 로고
    • Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those encoded for in familial amyotrophic lateral sclerosis
    • Nishida CR, Gralla EB, Valentine JS. Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those encoded for in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 1994;91:9906-10
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9906-9910
    • Nishida, C.R.1    Gralla, E.B.2    Valentine, J.S.3
  • 30
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    • Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994;264:1772-75
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1    Pu, H.2    Chiu, A.Y.3
  • 32
    • 0028040278 scopus 로고
    • Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischaemia
    • Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, Epstein CJ, Camii H. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischaemia. Stroke 1994;25:165-70
    • (1994) Stroke , vol.25 , pp. 165-170
    • Yang, G.1    Chan, P.H.2    Chen, J.3    Carlson, E.4    Chen, S.F.5    Weinstein, P.6    Epstein, C.J.7    Camii, H.8
  • 33
    • 0027765510 scopus 로고
    • Brain infarction is not reduced in SOD-1 transgenic mice after permanent focal cerebral ischaemia
    • Chan PH, Kamii H, Yang G, Gafni J, Epstein CJ, Carlson E, Reola L. Brain infarction is not reduced in SOD-1 transgenic mice after permanent focal cerebral ischaemia. NeuroReport 1993;5:293-96
    • (1993) NeuroReport , vol.5 , pp. 293-296
    • Chan, P.H.1    Kamii, H.2    Yang, G.3    Gafni, J.4    Epstein, C.J.5    Carlson, E.6    Reola, L.7
  • 34
  • 35
    • 0028022870 scopus 로고
    • Superoxide dismutase mRNA levels are increased in sporadic amyotrophic lateral sclerosis
    • Bergeron C, Muntasser S, Somerville MJ, Weyer L, Percy ME. Superoxide dismutase mRNA levels are increased in sporadic amyotrophic lateral sclerosis. Brain Res 1994;659:272-76
    • (1994) Brain Res , vol.659 , pp. 272-276
    • Bergeron, C.1    Muntasser, S.2    Somerville, M.J.3    Weyer, L.4    Percy, M.E.5
  • 37
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • Gurney ME, Cutting FB, Zhai P, Doble A, Taylor CP, Andrus PK, Hall ED. Benefit of vitamin E, riluzole and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 1996;39:147-57
    • (1996) Ann Neurol , vol.39 , pp. 147-157
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3    Doble, A.4    Taylor, C.P.5    Andrus, P.K.6    Hall, E.D.7
  • 39
    • 0028001606 scopus 로고
    • Variants of the human heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis
    • Figlewicz DA, Krizus A, Martinole M, et al. Variants of the human heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Human Mol Genet 1994;3:1757-61
    • (1994) Human Mol Genet , vol.3 , pp. 1757-1761
    • Figlewicz, D.A.1    Krizus, A.2    Martinole, M.3
  • 40
    • 0028933344 scopus 로고
    • Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: A model of familial amyotrophic lateral sclerosis (FALS)
    • Dal Canto MC, Gurney ME. Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: A model of familial amyotrophic lateral sclerosis (FALS). Brain Res 1995;676: 25-40
    • (1995) Brain Res , vol.676 , pp. 25-40
    • Dal Canto, M.C.1    Gurney, M.E.2
  • 41
    • 0028096795 scopus 로고
    • Decrease in Cu/Zn- and Mn-superoxide dismutase activities in brain and spinal cord of patients with amyotrophic lateral sclerosis
    • Uchino M, Ando Y, Tanaka Y, Nakamura T, Uyama E, Mita S, Murakami T, Ando M. Decrease in Cu/Zn- and Mn-superoxide dismutase activities in brain and spinal cord of patients with amyotrophic lateral sclerosis. J Neurol Sci 1995; 127:61-67
    • (1995) J Neurol Sci , vol.127 , pp. 61-67
    • Uchino, M.1    Ando, Y.2    Tanaka, Y.3    Nakamura, T.4    Uyama, E.5    Mita, S.6    Murakami, T.7    Ando, M.8
  • 42
    • 0027966078 scopus 로고
    • Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis
    • Shibata N, Hirano A, Kobayashi M, et al. Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis. Neurosci Lett 1994:179:149-52
    • (1994) Neurosci Lett , vol.179 , pp. 149-152
    • Shibata, N.1    Hirano, A.2    Kobayashi, M.3
  • 43
    • 0029142863 scopus 로고
    • Investigation of a null mutation in the CNTF gene in familial amyotrophic lateral sclerosis
    • Orrell RW, King AW, Lane RM, de Belleroche J. Investigation of a null mutation in the CNTF gene in familial amyotrophic lateral sclerosis. J Neurol Sci 1995;132:126-28
    • (1995) J Neurol Sci , vol.132 , pp. 126-128
    • Orrell, R.W.1    King, A.W.2    Lane, R.M.3    De Belleroche, J.4
  • 44
    • 0028827252 scopus 로고
    • Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
    • Li Y, Huang T-T, Carlson EJ, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature Genetics 1995;11:376-81
    • (1995) Nature Genetics , vol.11 , pp. 376-381
    • Li, Y.1    Huang, T.-T.2    Carlson, E.J.3
  • 45
    • 0028991091 scopus 로고
    • Apolipoprotein E ∈4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis
    • Mui S, Rebeck GW, McKenna-Yasek D, Hyman BT, Brown RH. Apolipoprotein E ∈4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis. Ann Neurol 1995;38:460-63
    • (1995) Ann Neurol , vol.38 , pp. 460-463
    • Mui, S.1    Rebeck, G.W.2    McKenna-Yasek, D.3    Hyman, B.T.4    Brown, R.H.5
  • 46
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 1992;326:1464-68
    • (1992) N Engl J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 47
    • 0029030610 scopus 로고
    • Selective loss of glial transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein JD, Van Kammen M, Levey AI, et al. Selective loss of glial transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84
    • (1995) Ann Neurol , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3
  • 48
    • 0027204133 scopus 로고
    • Abnormal glycine metabolism in motor neurone disease: Studies on plasma and cerebrospinal fluid
    • Lane RJM, Bandopadhyay R, de Belleroche J. Abnormal glycine metabolism in motor neurone disease: Studies on plasma and cerebrospinal fluid. J Roy Soc Med 1993;86:501-6
    • (1993) J Roy Soc Med , vol.86 , pp. 501-506
    • Lane, R.J.M.1    Bandopadhyay, R.2    De Belleroche, J.3
  • 49
    • 0028903269 scopus 로고
    • Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA
    • Virgo L, de Belleroche J. Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA. Brain Res 1995;676:196-204
    • (1995) Brain Res , vol.676 , pp. 196-204
    • Virgo, L.1    De Belleroche, J.2
  • 51
    • 0026438284 scopus 로고
    • Characterization of the distribution of choline acetyltransferase messenger RNA in human spinal cord and its depletion in motor neurone disease
    • Virgo L, de Belleroche J, Rossi M, Steiner TJ. Characterization of the distribution of choline acetyltransferase messenger RNA in human spinal cord and its depletion in motor neurone disease. J Neurol Sci 1992;112:126-32
    • (1992) J Neurol Sci , vol.112 , pp. 126-132
    • Virgo, L.1    De Belleroche, J.2    Rossi, M.3    Steiner, T.J.4
  • 52
    • 0028068994 scopus 로고
    • Focal ischaemia causes an extensive induction of immediate early genes that are sensitive to MK-801
    • Collaço-Moraes Y, Aspey BS, de Belleroche J, Harrison MJ. Focal ischaemia causes an extensive induction of immediate early genes that are sensitive to MK-801. Stroke 1994;25:1855-61
    • (1994) Stroke , vol.25 , pp. 1855-1861
    • Collaço-Moraes, Y.1    Aspey, B.S.2    De Belleroche, J.3    Harrison, M.J.4
  • 53
    • 0029004457 scopus 로고
    • Differential temporal patterns of expression of immediate early genes in the cerebral cortex induced by intracerebral excitotoxic injection: Sensitivity to MK-801 and dexamethasone
    • Collaço-Moraes Y, de Belleroche J. Differential temporal patterns of expression of immediate early genes in the cerebral cortex induced by intracerebral excitotoxic injection: Sensitivity to MK-801 and dexamethasone. Neuropharmacol 1995;34:521-31
    • (1995) Neuropharmacol , vol.34 , pp. 521-531
    • Collaço-Moraes, Y.1    De Belleroche, J.2
  • 54
    • 0026751714 scopus 로고
    • The transcription factors c-JUN, JUN-D and CREB but not FOS and KROX-24 are differentially regulated in axotomised neurons following transection of rat sciatic nerve
    • Herdegen T, Fiallos-Estrada CE, Schmid W, Bravo R, Zimmermann M. The transcription factors c-JUN, JUN-D and CREB but not FOS and KROX-24 are differentially regulated in axotomised neurons following transection of rat sciatic nerve. Mol Brain Res 1992;14: 156-65
    • (1992) Mol Brain Res , vol.14 , pp. 156-165
    • Herdegen, T.1    Fiallos-Estrada, C.E.2    Schmid, W.3    Bravo, R.4    Zimmermann, M.5
  • 55
    • 0027416834 scopus 로고
    • c-jun expression in substantia nigra neurons following striatal 6-hydroxydopamine lesions in the rat
    • Jenkins R, O'Shea R, Thomas KL, Hunt SP. c-jun expression in substantia nigra neurons following striatal 6-hydroxydopamine lesions in the rat. Neuroscience 1993;53:447-55
    • (1993) Neuroscience , vol.53 , pp. 447-455
    • Jenkins, R.1    O'Shea, R.2    Thomas, K.L.3    Hunt, S.P.4
  • 56
    • 0028210761 scopus 로고
    • Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease; association with pathology
    • Anderson AJ, Cummings BJ, Cotman CW. Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease; association with pathology. Exp Neurol 1994;125:286-95
    • (1994) Exp Neurol , vol.125 , pp. 286-295
    • Anderson, A.J.1    Cummings, B.J.2    Cotman, C.W.3
  • 57
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis
    • Bensimon G, Lasomblez L, Meininger V and the ALS/Riluzole Group. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med 1994;330:585-91
    • (1994) N Engl J Med , vol.330 , pp. 585-591
    • Bensimon, G.1    Lasomblez, L.2    Meininger, V.3
  • 58
    • 0027221998 scopus 로고
    • NMDA-dependent superoxide production and neurotoxicity
    • Lafon-Cazal M, Pietri S, Culcasi M, Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature 1993;364:535-37
    • (1993) Nature , vol.364 , pp. 535-537
    • Lafon-Cazal, M.1    Pietri, S.2    Culcasi, M.3    Bockaert, J.4
  • 60
    • 0028999575 scopus 로고
    • Pharmacokinetics and tolerability of ventricularly administered superoxide dismutase in monkeys and preliminary clinical observations in familial ALS
    • Smith RA, Balis FM, Ott KH, Elsberry DD, Sherman MR, Saifer MG. Pharmacokinetics and tolerability of ventricularly administered superoxide dismutase in monkeys and preliminary clinical observations in familial ALS. J Neurol Sci 1995;129:Suppl 13-18
    • (1995) J Neurol Sci , vol.129 , Issue.SUPPL. , pp. 13-18
    • Smith, R.A.1    Balis, F.M.2    Ott, K.H.3    Elsberry, D.D.4    Sherman, M.R.5    Saifer, M.G.6


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