MHC Class II-Peptide Complexes in Dendritic Cell Lipid Microdomains Initiate the CD4 Th1 Phenotype

Journal of Immunology

Volumn 171, Issue 11, 2003, Pages 5812-5819

  Buatois, Vanessa ^a   Baillet, Marjorie ^a   Bécart, Stéphane ^b   Mooney, Nuala ^b   Leserman, Lee ^a,c   Machy, Patrick ^a,c  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b INSERM   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CHOLESTEROL; FC RECEPTOR; IMMUNOGLOBULIN G; INTERLEUKIN 12; LIPID; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHYL BETA CYCLODEXTRIN; PEPTIDE; SILVER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL POLARITY; CHELATION; COMPLEX FORMATION; CONTROLLED STUDY; DENDRITIC CELL; ENDOCYTOSIS; LYMPHOCYTE DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; OPSONIZATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

EID: 0344153912     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.11.5812     Document Type: Article

References (43)

1. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
2. Murphy, K. M., and S. L. Reiner. 2002. Decision making in the immune system: the lineage decisions of helper T cells. Nat. Rev. Immunol. 2:933.
3. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297.
4. Moser, M., and K. M. Murphy. 2000. Dendritic cell regulation of TH1-TH2 development. Nat. Immunol. 1:199.
5. Medzhitov, R., and C. A. Janeway, Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295.
6. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropthocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: down-regulation by cytokines and bacterial products. J. Exp. Med. 182:389.
7. Serre, K., P. Machy, J.-C. Grivel, G. Jolly, N. Brun, J. Barbet, and L. Leserman. 1998. Efficient presentation of multivalent antigens targeted to various cell surface molecules of dendritic cells and surface immunoglobulin of antigen-specific B cells. J. Immunol. 161:6059.
8. Regnault, A., D. Lankar, V. Lacabanne, A. Rodriguez, C. Théry, M. Rescigno, T. Saito, S. Verbeek, C. Bonnerot, P. Ricciardi-Castagnoli, and S. Amigorena. 1999. Fcγ receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J. Exp. Med. 189:371.
9. Turley, S. J., K. Inaba, W. S. Garrett, M. Ebersold, J. Unternaehrer, R. M. Steinman, and I. Mellman. 2000. Transport of peptide-MHC class II complexes in developing dendritic cells. Science 288:522.
10. Thery, C., and S. Amigorena. 2001. The cell biology of antigen presentation in dendritic cells. Curr. Opin. Immunol. 13:45.
11. Chow, A., D. Toomre, W. Garrett, and I. Mellman. 2002. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 418:988.
12. + T cells. J. Exp. Med. 179:1539.
13. Nelson, C., S. Petzold, and E. Unanue. 1994. Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell. Nature 371:250.
14. Barnden, M. J., J. Allison, W. R. Heath, and F. R. Carbone. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements, Immunol. Cell Biol. 76:34.
15. Inaba, K., M. Inaba, N. Romani. H. Aya, M. Deguchi, S. Lkehara, S. Muramatsu, and R. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony stimulating factor. J. Exp. Med. 176:1693.
16. Cherukuri, A., M. Dykstra. and S. K. Pierce. 2001. Floating the raft hypothesis: lipid rafts play a role in immune cell activation. Immunity 14:657.
17. Anderson, H. A., E. M. Hiltbold, and P. A. Roche. 2000. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat. Immunol. 1:156.
18. + T cells engaging class II molecules in cholesterol-rich domains. J. Immunol. 168:1172.
19. Machy, P., K. Serre, and L. Leserman. 2000. Class I-restricted presentation of exogenous antigen acquired by Fcγ receptor-mediated endocytosis is regulated in dendritic cells. Eur. J. Immunol. 30:848.
20. Viner, N. J., C. A. Nelson, B. Deck, and E. R. Unanue. 1996. Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing. J. Immunol. 156:2365.
21. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 9:143.
22. Oi, V. T., P. P. Jones, J. W. Goding, and L. A. Herzenberg. 1978. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens. Curr. Top. Microbiol. J. Immunol. 81:115.
23. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
24. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
25. Setterblad, N., S. Becart, D. Charron, and N. Mooney. 2001. Signalling via MHC class II molecules modifies the composition of GEMs in APC. Scand. J. Immunol. 54:87.
26. Harmon, P., D. Cabral-Lilly, R. A. Reed, F. P. Maurio, J. C. Franklin. and A. Janoff. 1997. The release and detection of endotoxin from liposomes. Anal. Biochem. 250:139.
27. Huby, R. D., R. J. Dearman, and I. Kimber. 1999. Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. J. Biol. Chem. 274:22591.
28. Trinchieri. G. 1995. Interieukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
29. Langenkamp, A., M. Messi, A. Lanzavecchia, and F. Sallusto. 2000. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat. Immunol. 1:311.
30. Cochran, J. R., T. O. Cameron, J. D. Stone, J. B. Lubetsky, and L. J. Stem. 2001. Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation. J. Biol. Chem. 276:28068.
31. Wulfing, C., C. Sumen, M. D. Sjaastad. L. C. Wu, M. L. Dustin, and M. M. Davis. 2002. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat. Immunol. 3:42.
32. Huang, J., P. F. Lo, T. Zal. N. R. Gascoigne, B. A. Smith, S. D. Levin, and H. M. Grey. 2002. CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse. Proc. Natl. Acad. Sci. USA 20:20.
33. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-I2R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817.
34. Grogan, J. L., and R. M. Locksley. 2002. T helper cell differentiation: on again, off again. Curr. Opin. Immunol. 14:366.
35. Kaisho, T., O. Takeuchi, T. Kawai, K. Hoshino, and S. Akira, 2001. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166:5688.
36. Vidalain, P.-A., O. Azocar, C. Servet-Delprat, C. Rabourdin-Combe, D. Gerlier, and S. Manié 2000. CD40 signaling in human dendritic cells is initiated within membrane rafts. EMBO J. 19:3304.
37. Cella, M., D. Scheidegger, K. Palmer-Lehmann. P. Lane, A. Lanzavecchia, and G. Albert. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
38. Chikuma, S., J. B. Imboden, and J. A. Bluestone. 2003. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 197:129.
39. Balamuth, F., D. Leitenberg, J. Untemaehrer, I. Mellman, and K. Bottomly. 2001. Distinct pattems of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 15:729.
40. Kropshofer, H., S. Spindeldreher, T. A. Rohn, N. Platania, C. Grygar, N. Daniel, A. Wolpl, H. Langen, V. Horejsi, and A. B. Vogt. 2002. Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Nat. Immun. 3:61.
41. Kupfer, A., S. L. Swain, C. A. J. Janeway, and S. J. Singer. 1986. The specific direct interaction of helper T cells and antigen-presenting B cells. Proc. Natl. Acad. Sci. USA 83:6080.
42. Grakoui, A., S. K. Bromley, C. Sumen, M. M. Davis, A. S. Shaw, P. M. Allen, and M. L. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science 285:221.
43. Al-Alwan, M. M., G. Rowden, T. D. G. Lee, and K. A. West. 2001. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J. Immunol. 166:1452.