Fibroblast growth factor-2 induces astroglial and microglial reactivity in vivo

Journal of Anatomy

Volumn 200, Issue 1, 2002, Pages 57-67

  Goddard, Diane R ^a   Berry, Martin ^a   Kirvell, Sara L ^a   Butt, Arthur M ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Astrocyte; FGF 2; Macrophage; Microglia; Oligodendrocyte

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GLIAL FIBRILLARY ACIDIC PROTEIN; MONOCLONAL ANTIBODY; SODIUM CHLORIDE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL DENSITY; CELL TYPE; CELL VOLUME; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; CYTOPATHOLOGY; DEMYELINATION; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; IN VIVO STUDY; MACROPHAGE; MALE; MICROGLIA; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FIBROBLAST GROWTH FACTOR 2; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; MACROPHAGES; MALE; MICROGLIA; OLIGODENDROGLIA; RATS; RATS, WISTAR; TIME FACTORS;

ANIMALIA;

EID: 0036216728     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0021-8782.2001.00002.x     Document Type: Article

References (62)

1. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo
2. Basic FGF in astroglial, microglial, and neuronal cultures: Characterization of binding sites and modulation of release by lyphokines and trophic factors
3. Differential expression of two members of FGF receptor gene family, FGFR-1 and FGFR-2 mRNA, in the adult rat central nervous system
4. bFGF and FGFR-3 immunoreactivity in the rat brain following systemic kainic acid administration at convulsant doses: Localization of bFGF and FGFR-3 in reactive astrocytes, and FGFR-3 in reactive microglia
5. Regulation of FGF receptors in the oligodendrocyte lineage
6. FGF-2 converts mature oligodendrocytes to a novel phenotype
7. Post-injury myelin-breakdown products inhibit axonal growth; an hypothesis to explain the failure of axonal regeneration in the mammalian central nervous system
8. Deposition of scar tissue in the central nervous system
9. Axon-glial relationships in the anterior medullary velum of the adult rat
10. Cellular responses to penetrating CNS injury
11. Glial cells in transected optic nerves of immature rats. II. An immunohistochemical study
12. Platelet-derived growth factor delays oligodendrocyte differentiation and axonal myelination in vivo in the anterior medullary velum of the rat
13. Cells expressing the NG2 antigen contact nodes of Ranvier in adult CNS white matter
14. Oligodendrocytes and the control of myelination in vivo: New insights from the rat anterior medullary velum
15. Fibroblast growth factor-9 modulates the expression of myelin related proteins and multiple fibroblast growth factor receptors in developing oligodendrocytes
16. Basic fibroblast growth factor modulates in vitro differentiation of human fetal microglia
17. Basic fibroblast growth factor (bFGF) injection activates the glial reaction in the injured adult rat brain
18. Molecular profile of reactive astrocytes Implications for their role in neurologic disease
19. Comparing astrocytic cell lines that are inhibitory or permissive for axon growth: The major axon-inhibitory proteoglycan is NG2
20. Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of local brain wounds
21. Cortical basic fibroblast factor expression after head injury: Preliminary results
22. Localization of basic fibroblast growth factor and its mRNA after CNS injury
23. Basic fibroblast growth factor down-regulates myelin basic protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro
24. Glial cell mitogens bFGF and PDGF differentially regulate development of 04 oligodendrocyte progenitors
25. In vivo actions of fibroblast growth factor-2 and insulin-like growth factor I on oligodendrocyte development and myelination in the central nervous system
26. Fibroblast growth factor-2 inhibits myelin production by oligodendrocytes in vivo
27. Basic FGF in adult rat brain: Cellular distribution, and response to entorhinal lesion and fimbria-fornix transection
28. 1251-fibroblast growth factor-2 after intracerebral injection
29. A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain
30. In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor
31. Canine oligodendrocytes undergo morphological changes in response to basic fibroblast growth factor (bFGF) in vitro
32. Astrogliosis in culture. IV. Effects of basic fibroblast growth factor
33. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord
34. Developmental time course of acidic and basic fibroblast growth factors' expression in distinct cellular populations of the rat central nervous system
35. Insulin-like growth factor receptors and binding proteins
36. Development and differentiation of glial precursor cells in the rat cerebellum
37. Increased expression of the NG2 chondroitinsulfate proteoglycan after brain injury
38. The oligodendrocyte precursor cell in health and disease
39. Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: Temporally distinct expression of midkine and pleitrophin
40. A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized conical brain injury
41. Growth factors in CNS repair and regeneration
42. Mice expressing a bovine factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage
43. Immunohistochemical localization in the rat brain of an epitope corresponding to the fibroblast growth factor receptor-1
44. The responses of the rat cerebral hemisphere of the rat to injury. II. The neonatal rat
45. FGF modulates the PDGF-driven pathway of oligodendrocyte development
46. Distinct effects of bFGF and PDGF on oligodendrocyte progenitor cells
47. Intralesion injection of fibroblast growth factor alters glial reactivity to neural trauma
48. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination
49. Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptors-2 and - 3 mRNAs
50. Co-localization of NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells in the developing rat brain
51. Interaction between NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells is required for optimal response to PDGF
52. Normal and reactive NG2+ glial cells are distinct from resting and activated microglia
53. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis
54. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function
55. In situ expression of fibroblast growth factor receptors by oligodendrocyte progenitors and oligodendrocytes in adult mouse central nervous system
56. In vivo proliferation of oligodendrocyte progenitors expressing PFGFαR during early remyelination
57. Alterations in fibroblast growth factor receptor expression following brain injury
58. Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia
59. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan
60. Early effects of FGF-2 on glial cells in the MPTP-lesioned striatum
61. Nuclear and cytoplasmic localization of basic fibroblast growth factor in astrocytes and CM hippocampal neurons
62. Differential expression patterns of mRNAs for members of the fibroblast growth factor receptor family, FGFR-1-FGFR-4, in rat brain