NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration

Molecular Biology of the Cell

Volumn 7, Issue 12, 1996, Pages 1977-1993

  Lin, Xiao Hong ^a   Grako, Kathryn A ^a   Burg, Michael A ^a   Stallcup, William B ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; COLLAGEN TYPE 6; FIBRONECTIN; LAMININ; PROTEOGLYCAN; TENASCIN;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL POLARITY; CELL STRUCTURE; CYTOSKELETON; EXTRACELLULAR MATRIX; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029825783     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.7.12.1977     Document Type: Article

References (35)

1. Adams, J. (1995). Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospodin-1. J. Cell Sci. 108, 1977-1990.
2. Burg, M.A., Tillet, E., Timpl, R., and Stallcup, W.B. (1996). Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules. J. Biol. Chem. 271, 26110-26116).
3. Chen, W. (1981). Surface changes during retraction-induced spreading of fibroblasts. J. Cell Sci. 49, 1-13.
4. Clark, E., and Brugge, J. (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.
5. Cramer, L., and Mitchison, T. (1993). Moving and stationary actin filaments are involved in spreading of postmitotic PtK2 cells. J. Cell Biol. 122, 833-843.
6. Davis, J., and Bennett, V. (1994). Ankyrin-binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. J. Biol. Chem. 269, 27163-27166.
7. Dedhar, S., Argraves, S., Suzuki, T., Ruoslahti, E., and Pierschbacher, M. (1987). Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp containing peptide overproduce the fibronectin receptor. J. Cell Biol. 205, 1175-1188.
8. Elenius, K., and Jalkanen, M. (1994). Function of the syndecans - a family of cell surface proteoglycans. J. Cell Sci. 107, 2975-2982.
9. Fidler, I. (1986). Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Metastasis 5, 29-49.
10. Grako, K., and Stallcup, W.B. (1995). Participation of the NG2 proteoglycan in rat aortic smooth muscle cell responses to platelet-derived growth factor. Exp. Cell Res. 22, 231-240.
11. Harper, J., and Reisfeld, R. (1983). Inhibition of anchorage-dependent growth of human melanoma cells by a monoclonal antibody to a chondroitin sulfate proteoglycan. J. Natl. Cancer Inst. 72, 259-263.
12. Harper, J., and Reisfeld, R. (1987). Cell associated proteoglycans in human malignant melanoma. In: Biology of Proteoglycans, ed. T. Wight and R. Mecham, New York: Academic Press, 345-366.
13. Heath, J., and Holifield, B. (1991). Cell locomotion: New research tests old ideas on membrane and cytoskeletal flow. Cell Motil. Cytoskeleton 18, 245-257.
14. Hlavin, M., and Lemmon, V. (1991). Molecular and functional testing of human L1 CAM: an interspecies comparison. Genomics 11, 416-423.
15. 1 integrin in mediating melanoma cell adhesion to fibronec-tin. J. Cell Biol. 118, 431-444.
16. 1 integrin. Cancer Res. 55, 2177-2185.
17. Kalomiris, E., and Bourguignon, L. (1988). Mouse T lymphoma cells contain a transmembrane glycoprotein (GP85) that binds ankyrin. J. Cell Biol. 106, 319-327.
18. Lauffenburger, D., and Horwitz, A. (1996). Cell migration: a physically integrated molecular process. Cell 84, 359-369.
19. Lebakken, C., and Rapraeger, A. (1996). Syndecan-1 mediates cell spreading in transfected human lymphoblastoid (Raji) cells. J. Cell Biol. 332, 1209-1221.
20. Lin, X.-H., Dahlin, K., and Stallcup, W.B. (1996). Interaction of the NG2 proteoglycan with the actin cytoskeleton. J. Cell. Biochem. (in press).
21. Mitchison, T. (1992). Actin based motility on retraction fibers in mitotic PtK2 cells. Cell Motil. Cytoskeleton 22, 135-151.
22. Moos, M., Tacke, R., Scherer, H., Teplow, D., Fruh., K., and Schachner. M. (1988). Neural cell adhesion molecule L1 is a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Nature 334, 701-703.
23. Nishiyama, A., Dahlin, K.J., Prince, J.T., Johnstone, S.R., and Stallcup, W.B. (1991). The primary structure of NG2, a novel membrane-spanning proteoglycan. J. Cell Biol. 114, 359-371.
24. Nishiyama, A., and Stallcup, W.B. (1993). Expression of NG2 proteoglycan causes retention of type VI collagen on the cell surface. Mol. Biol. Cell. 4, 1097-1108.
25. Nishiyama, A., Lin, X.-H., Giese, N., Heldin, C.-H., and Stallcup, W.B. (1996a). Co-localization of NG2 proteoglycan and PDGF a receptor on O2A progenitor cells in the developing rat brain. J. Neurosci. Res. 43, 299-314.
26. Nishiyama, A., X.-H. Lin, Giese, N., Heldin, C.-H., and Stallcup, W.B. (1996b). Interaction between NG2 proteoglycan and PDGF α receptor on 02A progenitor cells is required for optimal response to PDGF. J. Neurosci. Res. 43, 315-330.
27. Odermatt, E., Risteili, J., vanDelding, V., and Timpl, R. (1983). Structural diversity and domain composition of a unique collagenous fragment (intima collagen) obtained from human placenta. Biochem. J. 231, 295-302.
28. Ponten, J., and Westermark, B. (1978). Properties of human malignant glioma cells in vitro. Med. Biol. 56, 184-193.
29. Scheetz, M. (1994). Cell migration by graded attachment to substrates and contraction. Semin. Cell Biol. 5, 149-155.
30. Schmidt, C., Horwitz, A., Lauffenburger, D., and Scheetz, M. (1993). Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated. J. Cell Biol. 323, 977-991.
31. Schrappe, M., Klier, F.G., Spiro, R.C., Waltz, T.A., Reisfeld, R.A., and Gladstone, C.L. (1991). Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells. Cancer Res. 51, 4986-4993.
32. Schubert, D., Heinemann, S., Carlisle, W., Tarikas, H., Kimes, B., Patrick, J., Steinbach, J., Culp, W., and Brandt, B. (1974). Clonal cell lines from the rat central nervous system. Nature 249, 224-227.
33. Stallcup, W.B., Dahlin, K., and Healy, P. (1990). Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen. J. Cell Biol. 331, 3177-3188.
34. Woods, A., and Couchman, J. (1996). Signalling from the matrix to the cytoskeleton: role of cell surface proteoglycans in matrix assembly. Kidney Int. 49, 564-567.
35. Yamashiro-Matsumura, S., and Matsumura, F. (1986). Intracellular localization of the 55 kDa actin-binding protein in cultured cells: spatial relationships with actin, α-actinin, tropomyosin, and fimbrin. J. Cell Biol. 103, 631-640.