NG2 proteoglycan mediates β1 integrin-independent cell adhesion and spreading on collagen VI

Journal of Cellular Biochemistry

Volumn 86, Issue 4, 2002, Pages 726-736

  Tillet, Emmanuelle ^a   Gential, Blandine ^a   Garrone, Robert ^a   Stallcup, William B ^b  

^a UNIVERSITÉ LYON 1   (France)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Cell adhesion; Cell spreading; Collagen V; Collagen VI; NG2; Proteoglycan

Indexed keywords

ACTIN; BETA1 INTEGRIN; COLLAGEN TYPE 5; COLLAGEN TYPE 6; DIMER; LAMININ 1; LIGAND; PROTEOGLYCAN; PROTEOGLYCAN NG2; UNCLASSIFIED DRUG; ANTIGEN; CHONDROITIN SULFATE PROTEOGLYCAN 4; COMPLEMENTARY DNA; FIBRONECTIN; LAMININ; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; SCLEROPROTEIN;

ACTIN POLYMERIZATION; ARTICLE; CELL ADHESION; CELL LINE; CELL SPREADING; CELL STRUCTURE; CYTOSKELETON; EXTRACELLULAR MATRIX; LAMELLIPODIUM; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; HUMAN; METABOLISM; PHYSIOLOGY; RAT; WESTERN BLOTTING;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIGENS; BLOTTING, WESTERN; CELL ADHESION; CELL LINE, TRANSFORMED; COLLAGEN TYPE VI; DNA, COMPLEMENTARY; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; LAMININ; LIGANDS; PROTEOGLYCANS; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; ANIMALS; HUMANS;

EID: 0036022140     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10268     Document Type: Article

References (64)

1. The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2
2. Functions of cell surface heparan sulfate proteoglycans
3. Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts
4. Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excytotoxic hippocampal lesion
5. Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules
6. A central segment of the NG2 proteoglycan is critical for the ability of glioma cells to bind and migrate toward type VI collagen
7. NG2 proteoglycan-binding peptides target tumor neovasculature
8. Syndecans: Multifunctional cell-surface co-receptors
9. Expression of type VI collagen in uveal melanoma: Its role in pattern formation and tumor progression
10. Molecular features of the collagen V heparin binding site
11. 1 integrin and NG2, during avian corneal stromal development
12. Syndecan-4 core protein is sufficient for the assembly of focal adhesions and actin stress fibers
13. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1, and p130cas
14. Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration
15. 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts
16. Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor
17. 1-deficient epithelial cells requires activation of members of the Rho family of GTPases and downregulation of cadherin and catenin function
18. A new adhesion assay using buoyancy to remove non-adherent cells
19. Participation of the NG2 proteoglycan in rat aortic smooth muscle cell responses to platelet-derived growth factor
20. PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse
21. Expression of type VI collagen during glioblastoma cell invasion in brain tissue cultures
22. Integrins: Versatility, modulation, and signaling in cell adhesion
23. 1 integrin
24. Response of the oligodendrocyte progenitor cell population (defined by NG2 labeling) to demyelination of the adult spinal cord
25. Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen
26. The chondroitin sulfate proteoglycan NG2 is a tumour-specific antigen on the chemically induced rat chondrosarcoma HSN
27. Expression of type XIV collagen during the differentiation of fetal bovine skin: Immunolabeling with monoclonal antibody is prominent in morphogenetic areas
28. Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury
29. Interaction of the NG2 proteoglycan with the actin cytoskeleton
30. Control of morphology, cytoskeleton, and migration by syndecan-4
31. Betaglycan can act as a dual modulator of TGF-β access to signaling receptors: Mapping of ligand binding and GAG attachment sites
32. Engagement of the NG2 proteoglycan triggers cell spreading via Rac and p130cas
33. Distribution of type VI collagen in human gliomas: Comparison with fibronectin and glioma-mesenchymal matrix glycoprotein
34. Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord
35. Expression of NG2 proteoglycan causes retention of type VI collagen on the cell surface
36. The expression of NG2 proteoglycan in the developing rat limb
37. Generation of truncated forms of the NG2 proteoglycan by cell surface proteolysis
38. Co-localization of NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells in the developing rat brain
39. Structural diversity and domain composition of a unique collagenous fragment (intima collagen) obtained from human placenta
40. Expression of type VI collagen mRNA during wound healing
41. The NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
42. NG2 proteoglycan expression by pericytes in pathological vasculature
43. Specificities of heparan sulphate proteoglycans in developmental processes
44. Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI
45. Co-localization of von Willebrand factor and type VI collagen in human vascular subendothelium
46. Surface antigens of melanomas and melanocytes defined by mouse monoclonal antibodies: Specificity analysis and comparison of antigen expression in cultured cells and tissues
47. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
48. Interactions between cells and collagen V molecules or single chains involve distinct mechanisms
49. Regulation of angiogenesis by extracellular matrix: The growth and the glue
50. Syndecan-4 signals cooperatively with integrins in a Rho-dependant manner in the assembly of focal adhesions and actin stress fibers
51. Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds
52. Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells
53. The human homologue of rat NG2, a chondroitin sulfate proteoglycan, is not expressed on the cell surface of normal hematopoietic cells but is expressed by acute myeloid leukemia blasts from poor-prognosis patients with abnormalities of chromosome band 11q23
54. Chondroitin sulfate and cytoplasmic domain-dependant membrane targeting of the NG2 proteoglycan promotes retraction fiber formation and cell polarization
55. Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen
56. The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein
57. Microfibrillar collagen type VI
58. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique α and common β subunits
59. Beta 1 integrin-dependent and -independent polymerization of fibronectin
60. Syndecans: Synergistic activators of cell adhesion
61. Syndecan proteoglycans and cell adhesion
62. Chondroitin sulfate proteoglycans in the nervous system
63. Normal and hypertrophic scars: Quantification and localization of mRNAs for type I, II, and VI collagens
64. Correlation between putative inhibitory molecules at the dorsal root entry zone and failure of dorsal root axonal regeneration