Insulin-like growth factor I production is essential for anabolic effects of thyroid hormone in osteoblasts

Journal of Bone and Mineral Research

Volumn 15, Issue 2, 2000, Pages 188-197

  Huang, Bill K ^a   Golden, Laurence A ^a   Tarjan, Gabor ^a   Madison, Laird D ^a   Stern, Paula H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Bone formation markers; Growth factor regulation; Insulin like growth factor I; Osteoblasts; Thyroid hormone

Indexed keywords

ALKALINE PHOSPHATASE; ANTISENSE OLIGONUCLEOTIDE; LIOTHYRONINE; MONOCLONAL ANTIBODY; OSTEOCALCIN; PROLINE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; THYROID HORMONE; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE METABOLISM; BONE MINERALIZATION; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HORMONAL REGULATION; HORMONE ACTION; MITOGENICITY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECEPTOR GENE;

EID: 0033981461     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.2.188     Document Type: Article

References (56)

1. Deftos LJ 1978 The thyroid gland in skeletal and calcium metabolism. In: Avioli LV, Krane SM (eds.) Metabolic Bone Disease, vol. II. Academic Press, Inc., New York, NY, U.S.A. pp 447-487.
2. Stern PH 1996 Thyroid hormone and bone. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, U.S.A., pp 521-531.
3. Mosekilde L, Eriksen EF, Charles P 1990 Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North AM 19:35-63.
4. Heyerdahl S, Kase BF, Stake G 1994 Skeletal maturation during thyroxin treatment in children with congenital hypothyroidism. Acta Paediatr 83:618-622.
5. Glasscock GF, Nicoll CS 1981 Hormonal control of growth in the infant rat. Endocrinology 109:176-184.
6. Schlesinger B, Fisher OD 1951 Accelerated skeletal development from thyrotoxicosis and thyroid overdosage in childhood. Lancet 2:289-290.
7. Fraser SA, Anderson JB, Smith DA, Wilson GM 1971 Osteoporosis and fractures following thyrotoxicosis. Lancet 1:981-983.
8. Franklyn JA, Sheppard MC 1992 The thyroid and osteoporosis. Trends Endocrinol Metab 3:113-116.
9. Allain TJ, Thomas MR, McGregor AM, Salisbury JR 1995 Histomorphometric study of bone changes in thyroid dysfunction in rats. Bone 16:505-509.
10. Garnero P, Vassy V, Bertholin A, Riou JP, Delmas PD 1994 Markers of bone turnover in hyperthyroidism and the effects of treatment. J Clin Endocrinol Metab 78:955-959.
11. Abu EO, Bord S, Horner A, Chatterjee Vk, Compston JE 1997 The expression of thyroid hormone receptors in human bone. Bone 21:137-142.
12. Bland R, Sammons RL, Sheppard MC, Willliams GR 1997 Thyroid hormone, vitamin D and retinoid receptor expression and signaling in primary cultures of rat osteoblastic and immortalized osteosarcoma cells. J Endocrinol 154:63-74.
13. Allain TJ, Yen PM, Flanagan AM, McGregor AM 1996 The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts. Eur J Clin Invest 26:418-425.
14. Brent GA, Moore DD, Larsen PR 1991 Thyroid hormone regulation of gene expression. Annu Rev Physiol 53:17-35.
15. Rizzoli R, Poser J, Burgi U 1986 Nuclear thyroid hormone receptors in cultured bone cells. Metabolism 35:71-74.
16. Kassem M, Mosekilde L, Eriksen EF 1993 Effects of triiodothyronine on DNA synthesis and differentiation markers of normal human osteoblast-like cells in vitro. Biochem Mol Biol Int 30:779-788.
17. Klaushofer K, Hoffmann O, Gleispach H, Leis HJ, Czerwenka E, Koller K, Peterlik M 1989 Bone-resorbing activity of thyroid hormones is related to prostaglandin production in cultured neonatal mouse clavaria. J Bone Miner Res 4:305-312.
18. Tarjan G, Stern PH 1995 Triiodothyronine potentiates the stimulatory effects of interleukin-1-beta on bone resorption in neonatal mouse parietal bones. Calcif Tissue Int 55:114-119.
19. Lowe WL 1991 Biological actions of the insulin-like growth factors. In: LeRoith D (ed.) Insulin-Like Growth Factor: Molecular and Cellular Aspects. CRC Press, Boca Raton, FL, U.S.A., pp 49-85.
20. Baserga R, Hongo A, Rubini M, Prisco M, Valentinis B 1997 The IGF-I receptor in cell growth, transformation and apoptosis. Biochem Biophys Acta 1332:F105-F126.
21. Canalis E 1980 Effect of insulin-like growth factor on DNA and protein synthesis in cultured rat calvaria. J Clin Invest 66:709-719.
22. Canalis E, Centrella M, Burch W, McCarthy TL 1989 Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60-65.
23. Lakatos P, Caplice MD, Khanna V, Stern PH 1993 Thyroid hormones increase insulin-like growth factor-I content in the medium of rat bone tissue. J Bone Miner Res 8:1475-1481.
24. Schmid C, Schlapfer I, Futo E, Waldvogel M, Schwander J, Zapf J, Froesch ER 1992 Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro. Acta Endocrinol (Copenh) 126:467-473.
25. Varga F, Rumpler M, Klaushofer K 1994 Thyroid hormones increase insulin-like growth factor mRNA levels in the clonal osteoblastic cell line MC3T3-E1. FEBS Lett 345(1):67-70.
26. Wolf M, Ingbar SH, Moses AC 1989 Thyroid hormone and growth hormone interact to regulate insulin-like growth factor-I messenger ribonucleic acid and circulating levels in the rat. Endocrinology 125:2905-2914.
27. Gaspard T, Wondergem R, Hamamdzic M. Klitgaard HM 1978 Serum somatomedin stimulation in thyroxin-treated hypophy-sectomized rats. Endocrinology 102:601-611.
28. Gray TK, Mohan S, Linkhart TA, Baylink DJ 1989 Estradiol stimulates in vitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106. Biochem Biophys Res Commun 158:407-412.
29. McCarthy TL, Centrella M, Canalis E 1989 Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology 124:1247-1253.
30. Sanders JL, Stern PH 1996 Expression and phorbol ester-induced down-regulation of protein kinase C isozymes in osteoblasts. J Bone Miner Res 11:1862-1872.
31. Quarles LD, Yohay DA, Lever LW, Caton R, Wenstrup RJ 1992 Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in cultures: An in vitro model of osteoblast development. J Bone Miner Res 7:683-692.
32. Samuels HH, Stanley F, Casanova J 1979 Depletion of L-3,5,3′-triiodothyronine and L-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone. Endocrinology 105:80-85.
33. Shlossman M, Brown M, Shapiro E, Dziak R 1982 Calcitonin effects on isolated bone cells. Calcif Tissue Int 34:190-196.
34. Rohlik QT, Adams D, Kull Jr. FC, Jacobs S 1987 An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissues culture. Biochem Biophy Res Commun 149:276-281.
35. Pietrzkowski Z, Wernicke D, Porcu P, Jameson BA, Baserga R 1992 Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor I. Cancer Res 52:6447-6451.
36. Lowry OH, Rosebrough NJ, Fair AL, Randall RJ 1951 Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
37. Refetoff S, Weiss RE, Usala SJ 1993 The syndromes of resistance to thyroid hormone. Endocr Rev 14:348-399.
38. Liu J, Baker J, Perkins AS, Robertson EJ, Efstratiadis A 1993 Mice carrying null mutations of genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igflr). Cell 75:59-72.
39. Klaushofer K, Varga F, Glantschnig N, Fratzl-Zelman N, Czerwenka E, Leis HJ, Koller K, Peterlik M 1995 The regulatory role of thyroid hormones in bone cell growth and differentiation. J Nutr 125:1996S-2003S.
40. Kawaguchi H, Pilbeam CC, Raisz LG 1994 Anabolic effects of 3,3′,5-triiodothyronine and triiodothyroacetic acid in cultured neonatal mouse parietal bones. Endocrinology 135:971-976.
41. LeBron BA, Pekary AE, Mirell C, Hahn TJ, Hershman JM 1989 Thyroid hormone 5′-deiodinase activity, nuclear binding, effects on mitogenesis in UMR-106 osteoblaslic osteosarcoma cells. J Bone Miner Res 4:173-178.
42. Ernst M, Froesch E 1987 Triiodothyronine stimulates proliferation of osteoblast-like cells in serum-free culture. FEBS Letters 220:163-166.
43. Allain TJ, McGregor AM 1993 Thyroid hormone and bone. J Endocrinol 139:9-18.
44. Muller M, Dietel M, Turzynski A, Wiechen K 1998 Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells. Int J Cancer 77:567-571.
45. Centrella M, McCarthy TL, Canalis E 1990 Receptors for insulin-like growth factors-I and -II in osteoblast-enriched cultures from fetal rat bone. Endocrinology 126:39-44.
46. Canalis E 1993 Insulin like growth factors and the local regulation of bone formation. Bone 14:273-276.
47. Wergedal JE, Mohan S, Lundy M, Baylink DJ 1990 Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells. J Bone Miner Res 5:179-186.
48. Pirskanen A, Jaaskelainen T, Maenpaa PH 1993 Insulin-like growth factor-I modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. Eur J Biochem 218:883-891.
49. Langdahl BL, Kassem M, Moller MK, Eriksen EF 1998 The effects of IGF-I and IGF-II on proliferation and differentiation of human osteoblasts and interactions with growth hormone. Eur J Clin Invest 28:176-183.
50. Conover CA 1996 The role of insulin-like growth factors and binding proteins in bone cell biology. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, U.S.A., pp 607-618.
51. Suwanwalaikorn S, Ongphiphadhanakul B, Braverman LE, Baran DT 1996 Differential responses of femoral and vertebral bones to long-term excessive L-thyroxine administration in adult rats. Eur J Endocrinol 134:655-659.
52. Suwanwalaikorn S, Van Auken M, Kang MI, Alex S, Braverman LE, Baran DT 1997 Site selectivity of osteoblast gene expression response to thyroid hormone localized by in situ hybridization. Am J Physiol 272:E212-217.
53. Milne M, Kang ML, Quail JM, Baran DT 1998 Thyroid hormone excess increases insulin-like growth factor I transcript in bone marrow cell cultures: Divergent effects on vertebral and femoral cell cultures. Endocrinology 139:2527-2534.
54. Malpe R, Baylink DJ, Linkhart TA, Wergedal JE, Mohan S 1997 Insulin-like growth factor (IGF-)-I, -II, IGF binding Proteins (IGFBP)-3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent. J Bone Miner Res 12:423-430.
55. Feyen JHM, Evans DB, Binkert C, Heinrich GH, Geisse S, Kocher HP 1991 Recombinant human insulin-like growth factor-binding protein-2 inhibits both basal and insulin-like growth factor-I stimulated proliferation and collagen synthesis fetal rat calvaria. J Biol Chem 266:19469-19474.
56. Schmid C, Schlapfer I, Keller A, Waldvogel M, Froesch ER, Zapf J 1995 Effects of insulin-like growth factor (IGF) binding proteins (BP)-3 and -6 on DNA synthesis of rat osteoblasts: further evidence for a role of auto-/paracrine IGF I but not IGF II in stimulating osteoblast growth. Biochem Biophys Res Commun 212:242-248.