Stem cell research: The facts, the myths and the promises

Journal of Urology

Volumn 170, Issue 6 I, 2003, Pages 2453-2458

  Lo, Kirk C ^a   Chuang, Weber W ^a   Lamb, Dolores J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Pluripotent stem cells; Spermatogenesis; Stem cell transplantation; Stem cells

Indexed keywords

CELL FATE; CELL RENEWAL; EMBRYO CELL; HUMAN; LIVER CELL; MEDICAL RESEARCH; MUSCLE CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL;

EID: 0242608431     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000087170.97532.ff     Document Type: Review

References (75)

1. Evans, M. J. and Kaufman, M. H.: Establishment in culture of pluripotential cells from mouse embryos. Nature, 292: 154, 1881
2. Martin, G. R.: Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA, 78: 7634, 1981
3. Matsui, Y., Zsebo, K. and Hogan, B. L.: Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell, 70: 841, 1992
4. Burdon, T., Smith, A. and Savatier, P.: Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol, 12: 432, 2002
5. Rohwedel, J., Guan, K., Hegert, C. and Wobus, A. M.: Embryonic stem cells as an in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies: present state and future prospects. Toxicol In Vitro, 15: 741, 2001
6. Capecchi, M. R.: The new mouse genetics: altering the genome by gene targeting. Trends Genet, 5: 70-76, 1989
7. Bjorklund, L. M., Sanchez-Pernaute, R., Chung, S., Andersson, T., Chen, I. Y., McNaught, K. S. et al: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA, 99: 2344, 2002
8. Brustle, O., Jones, K. N., Learish, R. D., Karram, K., Choudhary, K., Wiestler, O. D. et al: Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science, 285: 754, 1999
9. Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R. and McKay, R.: Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science, 292: 389, 2001
10. Wiles, M. V. and Keller, G.: Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development, 111: 259, 1991
11. Risau, W., Sariola, H., Zerwes, H. G., Sasse, J., Ekblom, P., Kemler, R. et al: Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development, 102: 471, 1988
12. Rohwedel, J., Maltsev, V., Bober, E., Arnold, H. H., Hescheler, J. and Wobus, A. M.: Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents. Dev Biol, 164: 87, 1994
13. Kramer, J., Hegert, C., Guan, K., Wobus, A. M., Muller, P. K. and Rohwedel, J.: Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4. Mech Dev, 92: 193, 2000
14. Hamazaki, T., Iiboshi, Y., Oka, M., Papst, P. J., Meacham, A. M., Zon, L. I. et al: Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett, 497: 15, 2001
15. Dani, C., Smith, A. G., Dessolin, S., Leroy, P., Staccini, L., Villageois, P. et al: Differentiation of embryonic stem cells into adipocytes in vitro. J Cell Sci, 110: 1279, 1997
16. Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergriel, J. J., Marshall, V. S. et al: Embryonic stem cell lines derived from human blastocysts. Science, 282: 1145, 1998
17. Shamblott, M. J., Axelman, J., Wang, S., Bugg, E. M., Littlefield, J. W., Donovan, P. J. et al: Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci USA, 95: 13726, 1998
18. Schuldiner, M., Yanuka, O., Itskovitz-Eldor, J., Melton, D. A. and Benvenisty, N.: Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci USA, 97: 1307, 2000
19. Assady, S., Maor, G., Amit, M., Itskovitz-Eldor, J., Skorecki, K. L. and Tzukerman, M.: Insulin production by human embryonic stem cells. Diabetes, 50: 1691, 2001
20. Kehat, I., Kenyagin-Karsenti, D., Snir, M., Segev, H., Amit, M., Gepstein, A. et al: Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest, 108: 407, 2001
21. Reubinoff, B. E., Itsykson, P., Turetsky, T., Pera, M. F., Reinhartz, E., Itzik, A. et al: Neural progenitors from human embryonic stem cells. Nat Biotechnol, 19: 1134, 2001
22. Zhang, S. C., Wernig, M., Duncan, I. D., Brustle, O. and Thomson, J. A.: In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol, 19: 1129, 2001
23. Kaufman, D. S. and Thomson, J. A.: Human ES cells-haematopoiesis and transplantation strategies. J Anat, 200: 243, 2002
24. Ruiz-Canela, M.: Embryonic stem cell research: the relevance of ethics in the progress of science. Med Sci Monit, 8: SR21, 2002
25. McLaren, A.: Ethical and social considerations of stem cell research. Nature, 414: 129, 2001
26. Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S. et al: Embryonic stem cell lines derived from human blastocysts. Science, 282: 1145, 1998
27. Campbell K. H., McWhir, J., Ritchie W. A. and Wilmut, I.: Sheep cloned by nuclear transfer from a cultured cell line. Nature, 380: 64, 1996
28. Till, J. E. and McCullough, E. A.: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res, 14: 1419, 1961
29. Weissman, I. L.: Stem cells: units of development, units of regeneration, and units in evolution. Cell, 100: 157, 2000
30. Blau, H. M., Brazelton, T. R. and Weimann, J. M.: The evolving concept of a stem cell: entity or function. Cell, 105: 829, 2001
31. Poulsom, R., Alison, M. R., Forbes, S. J. and Wright, N. A.: Adult stem cell plasticity. J Pathol, 197: 441, 2002
32. Morrison, S. J., Wandycz, A. M., Hemmati, H. D., Wright, D. E. and Weissman, I. L.: Identification of a lineage of multipotent hematopoietic progenitors. Development, 124: 1929, 1997
33. Uchida, N., Tsukamoto, A., He, D., Friera, A. M., Scollay, R. and Weissman, I. L.: High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts. J Clin Invest, 101: 961, 1998
34. Morrison, S. J. and Weissman, I. L.: The long-term repopulating subset of hematopoietic stem cell is deterministic and isolatable by phenotype. Immunity, 1: 661, 1994
35. Cameron, H. A. and Gould, E.: Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience, 61: 203, 1994
36. Gage, F. H.: Mammalian neural stem cells. Science, 287: 1433, 2000
37. Gaiano, N. and Fishell, J.: Transplantation as a tool to study progenitors within the vertebrate nervous system. J Neurobiol, 36: 152, 1998
38. Gage, F. H., Coates, P. W., Palmer, T. D., Kuhn, H. G., Fisher, L. J., Suhonen, J. O. et al: Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc Natl Acad Sci USA, 92: 11879, 1995
39. Suhonen, J. O., Peterson, D. A., Ray, J. and Gage, F. H.: Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature, 383: 624, 1996
40. Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V. et al: Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci USA, 97: 14720, 2000
41. Auerbach, J. M., Eiden, M. V. and McKay, R. D.: Transplanted CNS stem cells form functional synapses in vivo. Eur J Neurosci, 12: 1696, 2000
42. Kondziolka, D., Wechsler, L., Goldstein, S., Meltzer, C., Thulborn, K. R., Gebel, J. et al: Transplantation of cultured human neuronal cells for patients with stroke Neurology, 55: 565, 2000
43. Freed, C. R., Greene, P. E., Breeze, R. E., Tsai, W. Y., DuMouchel, W., Kao, R. et al: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med, 344: 710, 2001
44. Vessay, C. J. and de la Hall, P. M.: Hepatic stem cells: a review. Pathology, 33: 130, 2001
45. Peterson, B. E., Zajac, A. F. and Michalopoulos, G. K.: Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats. Hepatology, 27: 1030, 1998
46. Farber, E.: Similarities in the sequence of early histologic changes induced in the livers of rats by ethionine, 2-acetylaminobenzene, and 3 [prime]-methyl-4-dimethylaminoazobenzene. Cancer Res, 16: 142, 1956
47. Thorgeirsson, S. S.: Hepatic stem cells in liver regeneration. FASEB J, 10: 1249, 1996
48. Roskams, T., De Vos, R., Van Eyken, P., Myazaki, H., Van Damme, B. and Desmet, V.: Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. J Hepatol, 29: 455, 1998
49. Strom, S. C., Fisher, R. A., Thompson, M. T., Sanyal, A. J., Cole, P. E., Ham, J. M. et al: Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Tranplantation, 63: 559, 1997
50. Reyes, J., Rubinstein, W. S. and Mieles, L.: The use of cultured hepatocyte infusion via portal vein for the treatment of ornithine transcarbamoylase deficiency by transplantation of enzymatically competent ABO/Rh-matched cells. Hepatology, 24: 308a, 1996
51. Fox, I. J., Chowdhury, J. R., Kaufman, S. S., Goertzen, T. C., Chowdhury, N. R., Warkentin, P. I. et al: Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med, 338: 1422, 1998
52. Goldring, K., Parttridge, T. and Watt, D.: Muscle stem cells. J Pathol, 197: 457, 2002
53. Mauro, A.: Satellite cells of skeletal muscle fibers. J Biophys, 9: 493, 1961
54. Feldman, J. L. and Stockdale, F. E.: Temporal appearance of satellite cells during myogenesis. Dev Biol, 153: 217, 1992
55. Lipton, B. H. and Schultz, E.: Developmental fate of skeletal muscle satellite cells. Science, 205: 1292, 1979
56. Wakitani, S., Saito, T. and Caplan, A. I.: Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve, 18: 1417, 1995
57. Galli, R., Borello, U., Grittie, A., Minasi, M. G., Bjornson, C., Coletta, M. et al: Skeletal muscle potential of human and mouse neuronal stem cell. Nat Neurosci, 3: 986, 2000
58. Pye, S. and Watt, D. J.: Dermal fibroblasts participate in the formation of new muscle fibres when implanted into regenerating normal mouse muscle. J Anat, 198: 163, 2001
59. Rando, T. A. and Blau, H. M.: Methods for my oblast transplantation. Methods Cell Biol, 52: 261, 1997
60. Brinster, R. L. and Zimmermann, J. W.: Spermatogenesis following male germ-cell transplantation. Pro Natl Acad Sci USA, 91: 11298, 1994
61. Clouthier, D. E., Avarbock, M. R., Maika, S. D., Hammer, R. E. and Brinster, R. L.: Rat spermatogenesis in mouse testis. Nature, 381: 418, 1996
62. Cozzolino, D. J. and Lamb, D. J.: Germ cell transplantation: a potential treatment of severe testicular failure. Curr Urol Rep, 1: 262, 2000
63. Ferrari, G., Cusella-De Angelis, G., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G. et al: Muscle regeneration by bone marrow-derived myogenic progenitors. Science, 279: 1528, 1998
64. Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N. et al: Bone marrow was a potential source of hepatic oval cells. Science, 284: 1168, 1999
65. Bjornson, C. R., Rietze, R. L., Reynolds, B. A., Magli, M. C. and Vescovi, A. L.: Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science, 283: 534, 1999
66. Sanchez-Ramos, J. R.: Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res, 60: 880, 2002
67. Poulsom, R., Forbes, S. J., Hodivala-Dilke, K., Ryan, E., Wyles, S., Navaratnarasah, S. et al: Bone marrow contributes to renal parenchymal turnover and regeneration. J Pathol, 195: 229, 2001
68. Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B. et al: Bone marrow cells regenerate infarcted myocardium. Nature, 410: 701, 2001
69. Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R. et al: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 418: 41, 2002
70. Jiang, Y., Vaessen, B., Lenvik, T., Blackstad, M., Reyes, M. and Verfaillie, C. M.: Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol, 30: 896, 2002
71. Anderson, D. J., Gage, F. H. and Weissman, I. L.: Can stem cells cross lineage boundaries? Nat Med, 7: 393, 2001
72. Morshead C. M., Benveniste, P., Iscove N. N. and van der Kooy, D.: Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med, 8: 268, 2002
73. Castro, R. F., Jackson, K. A., Goodell, M. A., Robertson, C. S., Liu, H. and Shine, H. D.: Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science, 297: 1299, 2002
74. Ying, Q. L., Nichols, J., Evans, E. P. and Smith, A. G.: Changing potency by spontaneous fusion. Nature, 416: 545, 2002
75. Terada, N., Hamazaki, T., Oka, M., Hoki, M., Mastalerz, D. M., Nakano, Y. et al: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature, 416: 542, 2002