메뉴 건너뛰기




Volumn 89, Issue 8, 2003, Pages 1581-1589

The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models

Author keywords

Confocal fluorescence microscopy; Drug distribution; Drug resistance; P glycoprotein; Tumour models

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AZIDOPINE; CALCEIN; FLUORESCENT DYE; GLYCOPROTEIN P; NICARDIPINE; PACLITAXEL; RHODAMINE 123;

EID: 0242574636     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601300     Document Type: Article
Times cited : (47)

References (60)
  • 1
    • 0242590529 scopus 로고    scopus 로고
    • A brief history of cancer chemotherapy
    • Baguley B, Kerr DJ (eds) London: Academic Press
    • Baguley B (2002) A brief history of cancer chemotherapy. In Anticancer Drug Development, Baguley B, Kerr DJ (eds) pp 1-9. London: Academic Press
    • (2002) Anticancer Drug Development , pp. 1-9
    • Baguley, B.1
  • 2
    • 0023037085 scopus 로고
    • Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells
    • Batist G, Tulpule A, Sinha BK, Katki AG, Myers CE, Cowan KH (1986) Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J Biol Chem 261: 15544-15549
    • (1986) J Biol Chem , vol.261 , pp. 15544-15549
    • Batist, G.1    Tulpule, A.2    Sinha, B.K.3    Katki, A.G.4    Myers, C.E.5    Cowan, K.H.6
  • 3
    • 0004974241 scopus 로고    scopus 로고
    • In situ localization of paclitaxel binding structures: Labeling with a paclitaxel fluorescent analogue
    • Bicamumpaka C, Page M (1998) In situ localization of paclitaxel binding structures: labeling with a paclitaxel fluorescent analogue. Int J Mol Med 2: 161-165
    • (1998) Int J Mol Med , vol.2 , pp. 161-165
    • Bicamumpaka, C.1    Page, M.2
  • 4
    • 0030921564 scopus 로고    scopus 로고
    • The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface
    • Callaghan R, Berridge G, Ferry DR, Higgins CF (1997) The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface. Biochim Biophys Acta 1328: 109-124
    • (1997) Biochim Biophys Acta , vol.1328 , pp. 109-124
    • Callaghan, R.1    Berridge, G.2    Ferry, D.R.3    Higgins, C.F.4
  • 5
    • 0030682138 scopus 로고    scopus 로고
    • P-glycoprotein expression: Critical determinant in the response to osteosarcoma chemotherapy
    • Chan HS, Grogan TM, Haddad G, DeBoer G, Ling V (1997) P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. J Natl Cancer Inst 89: 1706-1715
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1706-1715
    • Chan, H.S.1    Grogan, T.M.2    Haddad, G.3    DeBoer, G.4    Ling, V.5
  • 7
    • 0029762815 scopus 로고    scopus 로고
    • DNA repair: Enzymatic mechanisms and relevance to drug response
    • Chaney SG, Sancar A (1996) DNA repair: enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 88: 1346-1360
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1346-1360
    • Chaney, S.G.1    Sancar, A.2
  • 8
    • 0035166135 scopus 로고    scopus 로고
    • Drug resistance mechanisms in acute leukemia
    • Chauncey TR (2001) Drug resistance mechanisms in acute leukemia. Curr Opin Oncol 13: 21-26
    • (2001) Curr Opin Oncol , vol.13 , pp. 21-26
    • Chauncey, T.R.1
  • 9
    • 0023874147 scopus 로고
    • A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: Application to lens ATPases
    • Chifflet S, Chiesa UTR, Tolosa S (1988) A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases. Anal Biochem 168: 1-4
    • (1988) Anal Biochem , vol.168 , pp. 1-4
    • Chifflet, S.1    Chiesa, U.T.R.2    Tolosa, S.3
  • 11
    • 0033800091 scopus 로고    scopus 로고
    • Multicellular resistance: A paradigm for clinical resistance?
    • Desoize B, Jardillier J (2000) Multicellular resistance: a paradigm for clinical resistance? Crit Rev Oncol Hematol 36: 193-207
    • (2000) Crit Rev Oncol Hematol , vol.36 , pp. 193-207
    • Desoize, B.1    Jardillier, J.2
  • 12
    • 0036193019 scopus 로고    scopus 로고
    • Expression of the multidrug transporter P-glycoprotein is highly correlated with clinical outcome in childhood acute lymphoblastic leukemia: Results of a long-term prospective study
    • Dhooge C, De Moerloose B, Laureys G, Ferster A, De Bacquer D, Philippe J, Leroy J, Benoit Y (2002) Expression of the multidrug transporter P-glycoprotein is highly correlated with clinical outcome in childhood acute lymphoblastic leukemia: results of a long-term prospective study. Leuk lymphoma 43: 309-314
    • (2002) Leuk Lymphoma , vol.43 , pp. 309-314
    • Dhooge, C.1    De Moerloose, B.2    Laureys, G.3    Ferster, A.4    De Bacquer, D.5    Philippe, J.6    Leroy, J.7    Benoit, Y.8
  • 13
    • 0022532384 scopus 로고
    • Chemosensitivity testing in V79 spheroids: Drug delivery and cellular microenvironment
    • Durand RE (1986) Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment. J Natl Cancer Inst 77: 247-252
    • (1986) J Natl Cancer Inst , vol.77 , pp. 247-252
    • Durand, R.E.1
  • 14
    • 0025296555 scopus 로고
    • Slow penetration of anthracyclines into spheroids and tumors: A therapeutic advantage?
    • Durand RE (1990) Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage? Cancer Chemother Pharmacol 26: 198-204
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 198-204
    • Durand, R.E.1
  • 15
    • 0019502044 scopus 로고
    • Flow cytometry studies of intracellular adriamycin in single cells in vitro
    • Durand RE, Olive PL (1981) Flow cytometry studies of intracellular adriamycin in single cells in vitro. Cancer Res 41: 3489-3494
    • (1981) Cancer Res , vol.41 , pp. 3489-3494
    • Durand, R.E.1    Olive, P.L.2
  • 16
    • 0022183581 scopus 로고
    • Cytotoxicity of cisplatin and cisdiammine-1,1 -cyclobutane dicarboxylate in MGH-U1 cells grown as monolayers, spheroids, and xenografts
    • Erlichman C, Vidgen D, Wu A (1985) Cytotoxicity of cisplatin and cisdiammine-1,1 -cyclobutane dicarboxylate in MGH-U1 cells grown as monolayers, spheroids, and xenografts. J Natl Cancer Inst 75: 499-505
    • (1985) J Natl Cancer Inst , vol.75 , pp. 499-505
    • Erlichman, C.1    Vidgen, D.2    Wu, A.3
  • 19
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 20
    • 0037663678 scopus 로고    scopus 로고
    • Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508
    • Gabriel MP, Storm J, Rothnie A, Taylor AM, Linton KJ, Kerr ID, Callaghan R (2003) Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508. Biochemistry 42: 7780-7789
    • (2003) Biochemistry , vol.42 , pp. 7780-7789
    • Gabriel, M.P.1    Storm, J.2    Rothnie, A.3    Taylor, A.M.4    Linton, K.J.5    Kerr, I.D.6    Callaghan, R.7
  • 21
    • 0030003252 scopus 로고    scopus 로고
    • MDR1 gene expression in solid tumours
    • Goldstein LJ (1996) MDR1 gene expression in solid tumours. Eur J Cancer 32A: 1039-1050
    • (1996) Eur J Cancer , vol.32 A , pp. 1039-1050
    • Goldstein, L.J.1
  • 22
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 23
  • 24
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 25
    • 0032698874 scopus 로고    scopus 로고
    • ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans
    • Holland IB, Blight MA (1999) ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans. J Mol Biol 293: 381-399
    • (1999) J Mol Biol , vol.293 , pp. 381-399
    • Holland, I.B.1    Blight, M.A.2
  • 27
    • 0029558068 scopus 로고
    • Clinical drug resistance: The role of factors other than P-glycoprotein
    • Kaye SB (1995) Clinical drug resistance: the role of factors other than P-glycoprotein. Am J Med 99(6A): 40S-44S
    • (1995) Am J Med , vol.99 , Issue.6 A
    • Kaye, S.B.1
  • 28
    • 0031728267 scopus 로고    scopus 로고
    • Multidrug resistance: Clinical relevance in solid tumours and strategies for circumvention
    • Kaye SB (1998) Multidrug resistance: clinical relevance in solid tumours and strategies for circumvention. Curr Opin Oncol 10(Suppl 1): S15-S19
    • (1998) Curr Opin Oncol , vol.10 , Issue.1 SUPPL.
    • Kaye, S.B.1
  • 30
  • 31
    • 0031883574 scopus 로고    scopus 로고
    • Multicellular spheroids: A three-dimensional in vitro culture system to study tumour biology
    • Kunz-Schughart LA, Kreutz M, Knuechel R (1998) Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology. Int J Exp Pathol 79: 1-23
    • (1998) Int J Exp Pathol , vol.79 , pp. 1-23
    • Kunz-Schughart, L.A.1    Kreutz, M.2    Knuechel, R.3
  • 32
    • 0038471662 scopus 로고    scopus 로고
    • Three-dimensional culture
    • Animal Cell Culture, Masters JRW (ed) Press Oxford: Oxford University Press
    • Kunz-Schughart LA, Meuller-Klieser W (2000) Three-dimensional culture. In Animal Cell Culture, Masters JRW (ed) pp 123-148. Practical Approach Series Press Oxford: Oxford University Press
    • (2000) Practical Approach Series , pp. 123-148
    • Kunz-Schughart, L.A.1    Meuller-Klieser, W.2
  • 33
    • 0022258124 scopus 로고
    • The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs - An in vitro study using EMT6 multicellular spheroids
    • Kwok TT, Twentyman PR (1985) The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs - an in vitro study using EMT6 multicellular spheroids. Int J Cancer 35: 675-682
    • (1985) Int J Cancer , vol.35 , pp. 675-682
    • Kwok, T.T.1    Twentyman, P.R.2
  • 34
    • 0032881342 scopus 로고    scopus 로고
    • The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein
    • Martin C, Berridge G, Mistry P, Higgins C, Charlton P, Callaghan R (1999) The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol 128: 403-411
    • (1999) Br J Pharmacol , vol.128 , pp. 403-411
    • Martin, C.1    Berridge, G.2    Mistry, P.3    Higgins, C.4    Charlton, P.5    Callaghan, R.6
  • 35
    • 0031851580 scopus 로고    scopus 로고
    • Use of fluorochrome-tagged taxol to produce fluorescent microtubules in solution
    • Melan MA (1998) Use of fluorochrome-tagged taxol to produce fluorescent microtubules in solution. Biotechniques 25: 188-192
    • (1998) Biotechniques , vol.25 , pp. 188-192
    • Melan, M.A.1
  • 36
    • 0034328531 scopus 로고    scopus 로고
    • Tumor biology and experimental therapeutics
    • Mueller-Klieser W (2000) Tumor biology and experimental therapeutics. Crit Rev Oncol Hematol 36: 123-139
    • (2000) Crit Rev Oncol Hematol , vol.36 , pp. 123-139
    • Mueller-Klieser, W.1
  • 37
    • 0023746784 scopus 로고
    • Penetration of substances into tumour tissue. Model studies using saccharides, thymidine and thymidine-5′-triphosphate in cellular spheroids
    • Nederman T, Carlsson J, Kuoppa K (1988) Penetration of substances into tumour tissue. Model studies using saccharides, thymidine and thymidine-5′-triphosphate in cellular spheroids. Cancer Chemother Pharmacol 22: 21-25
    • (1988) Cancer Chemother Pharmacol , vol.22 , pp. 21-25
    • Nederman, T.1    Carlsson, J.2    Kuoppa, K.3
  • 38
    • 0030742692 scopus 로고    scopus 로고
    • Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids
    • Nicholson KM, Bibby MC, Phillips RM (1997) Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids. Eur J Cancer 33: 1291-1298
    • (1997) Eur J Cancer , vol.33 , pp. 1291-1298
    • Nicholson, K.M.1    Bibby, M.C.2    Phillips, R.M.3
  • 39
    • 0031798535 scopus 로고    scopus 로고
    • Evaluation of a novel in vitro assay for assessing drug penetration into a vascular regions of tumours
    • Phillips RM, Loadman PM, Cronin BP (1998) Evaluation of a novel in vitro assay for assessing drug penetration into a vascular regions of tumours. Br J Cancer 77: 2112-2119
    • (1998) Br J Cancer , vol.77 , pp. 2112-2119
    • Phillips, R.M.1    Loadman, P.M.2    Cronin, B.P.3
  • 41
    • 0025003374 scopus 로고
    • Immunohistochemical analysis of P-glycoprotein expression correlated with chemotherapy resistance in locally advanced breast cancer
    • Ro J, Sahin A, Ro JY, Fritsche H, Hortobagyi G, Blick M (1990) Immunohistochemical analysis of P-glycoprotein expression correlated with chemotherapy resistance in locally advanced breast cancer. Hum Pathol 21: 787-791
    • (1990) Hum Pathol , vol.21 , pp. 787-791
    • Ro, J.1    Sahin, A.2    Ro, J.Y.3    Fritsche, H.4    Hortobagyi, G.5    Blick, M.6
  • 42
    • 0032970945 scopus 로고    scopus 로고
    • Three-dimensional spheroid model in tumour biology
    • Santini MT, Rainaldi G (1999) Three-dimensional spheroid model in tumour biology. Pathobiology 67: 148-157
    • (1999) Pathobiology , vol.67 , pp. 148-157
    • Santini, M.T.1    Rainaldi, G.2
  • 44
    • 0032523818 scopus 로고    scopus 로고
    • Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein
    • Shapiro AB, Ling V (1998) Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein. Eur] Biochem 254: 189-193
    • (1998) Eur Biochem , vol.254 , pp. 189-193
    • Shapiro, A.B.1    Ling, V.2
  • 45
    • 0005578015 scopus 로고    scopus 로고
    • Biologic and pharmacologic basis of cancer chemotherapy
    • Skeel RT (ed) Baltimore, MD: Lippincott Williams and Wilkins
    • Skeel RT (1999) Biologic and pharmacologic basis of cancer chemotherapy. In Handbook of Cancer Chemotherapy, Skeel RT (ed) pp 3-20. Baltimore, MD: Lippincott Williams and Wilkins
    • (1999) Handbook of Cancer Chemotherapy , pp. 3-20
    • Skeel, R.T.1
  • 46
    • 0030003254 scopus 로고    scopus 로고
    • Reversal of multidrug resistance in acute myeloid leukaemia and other haematological malignancies
    • Sonneveld P (1996) Reversal of multidrug resistance in acute myeloid leukaemia and other haematological malignancies. Eur J Cancer 32A: 1062-1069
    • (1996) Eur J Cancer , vol.32 A , pp. 1062-1069
    • Sonneveld, P.1
  • 47
    • 0015762456 scopus 로고
    • A human cell line from a pleural effusion derived from a breast carcinoma
    • Soule HD, Vazquez J, Long A, Albert S, Brennan M (1973) A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst 51: 1409-1416
    • (1973) J Natl Cancer Inst , vol.51 , pp. 1409-1416
    • Soule, H.D.1    Vazquez, J.2    Long, A.3    Albert, S.4    Brennan, M.5
  • 48
    • 0033740397 scopus 로고    scopus 로고
    • Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56+lymphocytes after oral and intravenous administration
    • Stewart A, Steiner J, Mellows G, Laguda B, Norris D, Bevan P (2000) Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56+lymphocytes after oral and intravenous administration. Clin Cancer Res 6: 4186-4191
    • (2000) Clin Cancer Res , vol.6 , pp. 4186-4191
    • Stewart, A.1    Steiner, J.2    Mellows, G.3    Laguda, B.4    Norris, D.5    Bevan, P.6
  • 51
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson R, Gray L (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9: 539-549
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.1    Gray, L.2
  • 52
    • 0035403271 scopus 로고    scopus 로고
    • Effects of MDR1/P-glycoprotein expression on prognosis in advanced colorectal cancer after surgery
    • Tokunaga Y, Hosogi H, Hoppou T, Nakagami M, Tokuka A, Ohsumi K (2001) Effects of MDR1/P-glycoprotein expression on prognosis in advanced colorectal cancer after surgery. Oncol Rep 8: 815-819
    • (2001) Oncol Rep , vol.8 , pp. 815-819
    • Tokunaga, Y.1    Hosogi, H.2    Hoppou, T.3    Nakagami, M.4    Tokuka, A.5    Ohsumi, K.6
  • 53
    • 0032978250 scopus 로고    scopus 로고
    • Penetration of anticancer drugs through solid tissue: A factor that limits the effectiveness of chemotherapy for solid tumors
    • Tunggal JK, Cowan DS, Shaikh H, Tannock IF (1999) Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors. Clin Cancer Res 5: 1583-1586
    • (1999) Clin Cancer Res , vol.5 , pp. 1583-1586
    • Tunggal, J.K.1    Cowan, D.S.2    Shaikh, H.3    Tannock, I.F.4
  • 54
    • 0034007524 scopus 로고    scopus 로고
    • The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers
    • Tunggal JK, Melo T, Ballinger JR, Tannock IF (2000) The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers. Int J Cancer 86: 101-107
    • (2000) Int J Cancer , vol.86 , pp. 101-107
    • Tunggal, J.K.1    Melo, T.2    Ballinger, J.R.3    Tannock, I.F.4
  • 55
    • 0034012773 scopus 로고    scopus 로고
    • The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemia
    • van den Heuvel-Eibrink MM, Sonneveld P, Pieters R (2000) The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemia. Int J Clin Pharmacol Ther 38: 94-110
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 94-110
    • Van Den Heuvel-Eibrink, M.M.1    Sonneveld, P.2    Pieters, R.3
  • 56
    • 0242422591 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy
    • Submitted
    • Walker J, Martin C, Callaghan R (2003) Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy. Eur] Cancer, Submitted
    • (2003) Eur Cancer
    • Walker, J.1    Martin, C.2    Callaghan, R.3
  • 57
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
    • Wang CY, Cusack Jr JC, Liu R, Baldwin Jr AS (1999) Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med 5: 412-417
    • (1999) Nat Med , vol.5 , pp. 412-417
    • Wang, C.Y.1    Cusack Jr., J.C.2    Liu, R.3    Baldwin Jr., A.S.4
  • 58
    • 0029982407 scopus 로고    scopus 로고
    • Induction of cell death by doxorubicin in multicellular spheroids as studied by confocal laser scanning microscopy
    • Wartenberg M, Acker H (1996) Induction of cell death by doxorubicin in multicellular spheroids as studied by confocal laser scanning microscopy. Anticancer Res 16: 573-580
    • (1996) Anticancer Res , vol.16 , pp. 573-580
    • Wartenberg, M.1    Acker, H.2
  • 59
    • 0031914029 scopus 로고    scopus 로고
    • Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the 'optical probe technique'
    • Wartenberg M, Hescheler J, Acker H, Diedershagen H, Sauer H (1998) Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the 'optical probe technique'. Cytometry 31: 137-145
    • (1998) Cytometry , vol.31 , pp. 137-145
    • Wartenberg, M.1    Hescheler, J.2    Acker, H.3    Diedershagen, H.4    Sauer, H.5
  • 60
    • 0031452589 scopus 로고    scopus 로고
    • The prognostic significance of the expression and function of multidrug resistance transporter proteins in acute myeloid leukemia: Studies of the Southwest Oncology Group Leukemia Research Program
    • Willman CL (1997) The prognostic significance of the expression and function of multidrug resistance transporter proteins in acute myeloid leukemia: studies of the Southwest Oncology Group Leukemia Research Program. Semin Hematol 34: 25-33
    • (1997) Semin Hematol , vol.34 , pp. 25-33
    • Willman, C.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.