Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the 'optical probe technique'

Cytometry

Volumn 31, Issue 2, 1998, Pages 137-145

  Wartenberg, Maria ^a   Hescheler, Jürgen ^a   Acker, Helmut ^b   Diedershagen, Heike ^a   Sauer, Heinrich ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Confocal laser scanning microscopy; Doxorubicin; Multicellular cancer spheroids; Multidrug resistance; Multidrug resistance associated protein; Optical probe technique; P glycoprotein

Indexed keywords

CYCLOSPORIN A; DOXORUBICIN; GENISTEIN; GLYCOPROTEIN P; INDOMETACIN; MULTIDRUG RESISTANCE PROTEIN; ORTHOVANADIC ACID; QUINIDINE;

ALGORITHM; ARTICLE; CONFOCAL LASER MICROSCOPY; DRUG DISTRIBUTION; FLUORESCENCE; HUMAN; HUMAN CELL; LIGHT SCATTERING; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROSTATE CANCER; SPHEROID CELL; TECHNIQUE;

ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; HUMANS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; OPTICS; P-GLYCOPROTEIN; PROSTATIC NEOPLASMS; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 0031914029     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0320(19980201)31:2<137::AID-CYTO9>3.0.CO;2-J     Document Type: Article

References (28)

1. Cheng PC, Summers RG: Image contrast in confocal light microscopy. In: Handbook of Biological Confocal Light Microscopy, Pawley JB. (ed). Plenum Press, New York, 1990, pp 179-195.
2. Draper MP, Martell RL, Levy SB: Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, hut not P-glycoprotein. Br J Cancer 75:810-815.
3. Durand RE: Use of Hoechst 33342 for cell selection from multicell systems. J Histochem Cytochem 30:117-122, 1982.
4. Durand RE: Multicell spheroids as a model for cell kinetic studies. Cell Tissue Kinet 23:141-159, 1990.
5. Erlanson M, Daniel-Szolgay E, Carlsson J: Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids. Cancer Chemother Pharmacol 29:343-353, 1992.
6. Erlichman C, Vidgen D: Cytotoxicity of doxorubicin in MGH-U1 cells grown as monolayer cultures, spheroids and xenografts in immune-deprived mice. Cancer Res 44:5469-5475, 1984.
7. Freyer JP: Role of necrosis in regulating the growth saturation of muiticellular spheroids. Cancer Res 48:2432-2439, 1988.
8. Gottesman MM, Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427, 1993.
9. Haji-Karim M, Carlsson J: Proliferation and viability in cellular spheroids of human origin. Cancer Res 38:1457-1464, 1978.
10. Hofmann RM: The three dimensional question: can clinically relevant tumor drug resistance be measured in vitro? Cancer Metastas Rev 13:169-173, 1994.
11. Inoue S, Ohnuma T, Takaoka K, Suzuki Y, Kaneko M, Safirstein R, Holland JF: Effects of doxorubicin and cisplatin on muiticellular tumor spheroids from human lung cancer. Cancer Drug Del 4:213-224, 1987.
12. Kobayashi H, Man S, Graham CH, Kapitain SJ, Teicher BA, Kerbel RS: Aquired multicellular-mediated resistance to alkylating agents in cancer. Proc Natl Acad Sci USA 90:3294-3298, 1993.
13. Kwok TT, Twentyman PR: The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs - an in vitro study using EMT6 muiticellular spheroids. Int J Cancer 35:675-682, 1985.
14. Meschini S, Molinari A, Calcabrini A, Citro G, Arancia G: Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study. J Microscopy 176:204-210, 1994.
15. Nederman T, Carlsson J: Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids. Cancer Chemother Pharmacol 13:131-135, 1984.
16. Nederman T, Carlsson J, Kuoppa K: Penetration of substances into tumour tissue. Model studies using saccharides, thymidine and thymidine-5'-triphosphate in cellular spheroids. Cancer Chemother Pharmacol 22:21-25, 1988.
17. Oldmixon EH, Carlsson K: Methods for large data volumes from confocal scanning laser microscopy of lung. J Microscopy 170:221-228, 1993.
18. Olive P, Durand RE: Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metastas Rev 13:121-138, 1994.
19. Rigaut JP, Vassy J: High-resolution three-dimensional images from confocal scanning laser microscopy. Analyt Quant Cytol Histol 13:223-232, 1991.
20. Rigaut JP, Vassy J, Herlin P, Duigou F, Masson E, Briane D, Foucrier J, Carvajal-Gonzalez S, Downs AM, Mandard A-M: Three-dimensional DNA image cytometry by confocal scanning laser microscopy in thick tissue blocks. Cytometry 12:511-524, 1991.
21. Sakata K, Kwok TT, Gordon GR, Waleh NS, Sutherland RM: Resistance to verapamil sensitization of multidriig-resistant cells grown as multicellular spheroids. Int J Cancer 59:282-286, 1994.
22. Strasters KC, Smeulders AWM, Bujis M, Houtsmuller AB, van der Voort HTM, Nanninga NN: A 3-D model for chromatin organisation of G1 and G2 populations from quantitative confocal image analysis. Cytometry 27:201-212, 1997.
23. Sutherland RM, Eddy HA, Bareham B, Reich K, Vanantwerp D: Resistance to adriamycin in multi-cellular spheroids. Int J Radiat Oncol Biol Phys 5:1225-1230, 1979.
24. Sutherland RM: Cell and environment interactions in tumor microregions: The multicell spheroid model. Science 240:177-184, 1988.
25. Takeda Y, Nishio K, Niitani H, Saijo N: Reversal of multidrug resistance by tyrosine-kinase inhibitors in a non-P-glycoprotein-mediated multidrug-resistant cell line. Int J Cancer 57:229-239, 1994.
26. Wartenberg M, Acker H: Quantitative recording of vitality patterns in living multicellular spheroids by confocal microscopy. Micron 26:395-404, 1995.
27. Wartenberg M, Acker H: Induction of cell death by doxorubicin in multicellular spheroids studied by confocal laser scanning microscopy. Anticancer Res 16:573-580, 1996.
28. Zachcrl J, Hamilton G, Thalhammer T, Riegler M, Cosentini EP, Ellinger A, Bischof G, Schweitzer M, Teleky B, Koperna T, Wenzl E: Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH. Cancer Chemother Pharmacol 34:125-132.