Requirement for SAPK-JNK signaling in the induction of apoptosis by ribosomal stress in REH lymphoid leukemia cells

Leukemia

Volumn 17, Issue 11, 2003, Pages 2140-2148

  Johnson, C R ^a   Jiffar, T ^a   Fischer, U M ^b   Ruvolo, P P ^a   Jarvis, W D ^a,c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLOGNE   (Germany)

^c Dominion Diagnostics   (United States)

Author keywords

Apoptosis; Blasticidin S; Cycloheximide; Kasugamycin; Ribotoxic ribostatic stress response; SAPK JNK cascade

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIBIOTIC AGENT; BLASTICIDIN S; CASPASE 3; CASPASE 8; CASPASE 9; CYCLOHEXIMIDE; DNA; IMIDAZOLE DERIVATIVE; JANUS KINASE; KASUGAMYCIN; PEPTIDE; PROTEIN C JUN; PROTEIN KINASE INHIBITOR; PYRAZOLONE DERIVATIVE; RNA 18S; RNA 28S; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR; TRANSFER RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL DAMAGE; CELL DISRUPTION; CONTROLLED STUDY; CYTOLYSIS; DNA DEGRADATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; EXPOSURE; HUMAN; HUMAN CELL; LETHALITY; LEUKEMIA CELL LINE; LYMPHATIC LEUKEMIA; PRIORITY JOURNAL; RIBOSOME; RNA BINDING; RNA TRANSLATION; RNA TRANSPORT; STRESS; TRANSLATION INITIATION;

EID: 0242475244     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403132     Document Type: Article

References (32)

1. Eastman A, Rigas JR. Modulation of apoptosis signaling pathways and cell cycle regulation. Semin Oncol 1999; 26: 7-16.
2. Reed JC. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med 2001; 7: 314-319.
3. Rich T, Watson CJ, Wyllie A. Apoptosis: the germs of death. Nat Cell Biol 1999; 1: E69-E71.
4. Maguire BA, Zimmermann RA. The ribosome in focus. Cell 2001; 104: 813-816.
5. Iordanov MS, Pribnow D, Magun JL, Dinh TH, Pearson JA, Chen SL et al. Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the sarcin/ricin loop in the 28S-rRNA. Mol Cell Biol 1997; 17: 3373-3381.
6. Iordanov MS, Pribnow D, Magun JL, Dinh TH, Pearson JA, Magun BE. Ultraviolet (C) radiation triggers the ribotoxic stress response in mammalian cells. J Biol Chem 1998; 273: 15794-15803.
7. + mimics ribotoxic stress: inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, JNK-1, and p38/HOC1 by palytoxin. J Biol Chem 1998; 273: 3528-3534.
8. Iordanov MS, Magun BE. Different mechanisms of JNK-1 activation by ultraviolet (B) radiation and by oxidative stressors. J Biol Chem 1999; 274: 25801-25806.
9. Iordanov MS, Wong J, Newton DL, Rybak SM, Bright RK, Flavell RA et al. Differential requirement for the stress-activated protein kinase/c-Jun N-terminal kinase in RNA damage-induced apoptosis in primary and immortalized fibroblasts. Mol Cell Biol Res Commun 2000; 4: 122-128.
10. Shifrin VI, Anderson P. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase, and induces apoptosis. J Biol Chem 1999; 274: 13985-13992.
11. Jarvis WD, Kolesnick RN, Fornari FA, Traylor RS, Gewirtz DA, Grant S. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc Natl Acad Sci USA 1994; 91: 73-77.
12. Jarvis WD, Fornari Jr FA, Auer KL, Freemerman AJ, Szabo E, Birrer MJ et al. Coordinate regulation of stress-activated and mitogen-activated protein kinase cascades in the apoptotic actions of ceramide and sphingosine. Mol Pharmacol 1997; 52: 935-947.
13. Jarvis WD, Johnson CR, Fornari FA, Park J-S, Dent P, Grant S. Evidence that the apoptotic actions of etoposide and teniposide are independent of SAPK-JNK activity and c-Jun/AP1-mediated transregulation. J Pharmacol Exp Ther 1999; 290: 1384-1392.
14. Jarvis WD, Fornari FA, Browning JL, Gewirtz DA, Kolesnick RN, Grant S. Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J Biol Chem 1994; 269: 31685-31692.
15. Jarvis WD, Fornari FA, Traylor RS, Martin HA, Kramer LB, Erukulla RK, Bittman R, Grant S et al. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. J Biol Chem 1996; 271: 8275-8284.
16. Matousek J. Ribonucleases and their antitumor activity. Comp Biochem Physiol C 2001; 129: 175-191.
17. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W et al. SP-600125, an anthrapyrazolone inhibitor of c-Jun N-terminal kinase. Proc Natl Acad Sci USA 2001; 98: 13681-13686.
18. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF et al. SB-203580 is a specific inhibitor of a MAP kinase homologue stimulated by cellular stresses and interleukin-1. FEBS Lett 1995; 364: 229-233.
19. Stadheim TA, Kucera CL. C-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells. Leuk Res 2002; 26: 55-66.
20. Baldassare JJ, Bi Y, Bellone CJ. The role of p38 mitogen-activated protein kinase in IL-1β transcription. J Immunol 1999; 162: 5367-5373.
21. Kotlyarov A, Neininger A, Schubert C, Eckert R, Birchmeier C, Volk HD et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol 1999; 1: 94-97.
22. Miyazawa K, Mori A, Miyata H, Akahane M, Ajisawa Y, Okudaira H. Regulation of IL-1β-induced IL-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase. J Biol Chem 1998; 273: 24832-24838.
23. Ruller S, Stahl C, Kohler G, Eickhoff B, Breder J, Schlaak M et al. Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. Clin Cancer Res 1999; 5: 2714-2725.
24. Dinndorf P, Krailo M, Liu-Mares W, Frierdich S, Sondel P, Reaman G. Phase I trial of anti-B4-blocked ricin in pediatric patients with leukemia and lymphoma. J Immunother 2001; 24: 511-516.
25. Herrera L, Farah RA, Pellegrini VA, Aquino DB, Sandler ES, Buchanan GR et al. Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro. Leukemia 2000; 14: 853-858.
26. Shen GL, Li JL, Ghetie MA, Ghetie V, May RD, Till M et al. Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas. Int J Cancer 1988; 42: 792-797.
27. Chen J, Zhou JH, Ball ED. Characterization of a new monoclonal antibody 6G7 that recognizes a unique antigen on myeloid and lymphoid cells. J Hematother Stem Cell Res 2001; 10: 237-246.
28. Budihardjo II, Boerner SA, Eckdahl S, Svingen PA, Rios R, Ames MM et al. Effect of 6-aminonicotinamide and other protein synthesis inhibitors on formation of platinum-DNA adducts and cisplatin sensitivity. Mol Pharmacol 2000; 57: 529-538.
29. 2-terminal kinase by dsRNA and encephalomyocarditis virus: involvement of RNase-L, PKR, and alternative pathways. Mol Cell Biol 2000; 20: 617-627.
30. Iordanov MS, Wong J, Bell JC, Magun BE. Activation of NF-κB by double-stranded RNA in the absence of protein kinase R (PKR) and ribonuclease-L (Rnase-L) demonstrates the existence of two separate dsRNA-triggered antiviral programs. Mol Cell Biol 2001; 21: 61-72.
31. Williams BRG. Signal integration via PKR. Sci STKE 2001; 89: 1-10.
32. Goh KC, deVeer MJ, Williams BRG. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J 2000; 19: 4292-4297.