Effect of 6-aminonicotinamide and other protein synthesis inhibitors on formation of platinum-DNA adducts and cisplatin sensitivity

Molecular Pharmacology

Volumn 57, Issue 3, 2000, Pages 529-538

  Budihardjo, I Imawati ^a,c   Boerner, Scott A ^c   Eckdahl, Steven ^c   Svingen, Phyllis A ^c   Rios, Robert ^b,c   Ames, Matthew M ^c   Kaufmann, Scott H ^c,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^c MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINONICOTINAMIDE; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOHEXIMIDE; DACTINOMYCIN; METHIONINE; SULFUR 35;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DNA ADDUCT; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SENSITIVITY; HUMAN; HUMAN CELL; ISOTOPE LABELING; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

EID: 0034049134     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.57.3.529     Document Type: Article

References (36)

1. Berger NA, Berger SJ and Hirschler NV (1989) Pyridine Nucleotide Metabolism as a Target for Cancer Chemotherapy, pp 366-371, Springer-Verlag, New York.
2. Berger NA, Catino DM and Vietti TJ (1983) Synergistic antileukemic effect of 6-aminonicotinamide and BCNU in 11210 cells in vitro and in vivo. Cancer Res 42:4382-4386.
3. Berger SJ, Manory I, Sudar DC, Krothapalli D and Berger NA (1987) Pyridine nucleotide analog interference with metabolic processes in mitogen-stimulated human T lymphocytes. Exp Cell Res 173:379-387.
4. Brostrom MA, Prostko CR, Gmitter D and Brostrom CO (1995) Independent signaling of GRP78 gene transcription and phosphorylation of eukaryotic initiator factor 2 alpha by the stressed endoplasmic reticulum. J Biol Chem 270:4127-4132.
5. Budihardjo II, Walker DL, Svingen PA, Buckwalter CA, Desnoyers S, Eckdahl S, Shah GM, Poirier GG, Reid JM, Ames MM and Kaufmann SH (1998) 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin. Clin Cancer Res 4:117-130.
6. Chabner BA and Loo TL (1996) Cancer Chemotherapy and Biotherapy: Principles and Practice, 2nd ed., pp 485-492, Lippincott-Raven, Philadelphia.
7. Chatterjee S, Cheng M-F, Berger RB, Berger SJ and Berger NA (1995) Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide. Cancer Res 55:868-883.
8. Chatterjee S, Hirota H, Belfi CA, Berger SJ and Berger NA (1997) Hypersensitivity to DNA cross-linking agents associated with up-regulation of glucose-regulated stress protein GRP78. Cancer Res 57:5112-5116.
9. Clancy BM, Harrison SA, Buxton JM and Czech MP (1991) Protein synthesis inhibitors activate glucose transport without increasing plasma membrane glucose transporters in 3T3-L1 adipocytes. J Biol Chem 266:10122-10130.
10. de Murcia JM, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver FJ, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P and de Murcia G (1997) Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 94:7303-7307.
11. Dornish JM, Pettersen EO and Oftebro R (1989) Modifying effect of cinnamaldehyde and cinnamaldehyde derivatives on cell inactivation and cellular uptake of cisdiamminedichloroplatinum(II) in human NHIK 3025 cells. Cancer Res 49:3917-3921.
12. Gately DP and Howell SB (1993) Cellular accumulation of the anticancer agent cisplatin: A review. Br J Cancer 67:1171-1176.
13. Harrison SA, Clancy BM, Pessino A and Czech MP (1992) Activation of cell surface glucose transporters measured by photoaffinity labeling of insulin-sensitive 3T3-L1 adipocytes. J Biol Chem 267:3783-3788.
14. Herken H, Lange K and Kolbe H (1969) Brain disorders induced by pharmacological blockade of the pentose phosphate pathway. Biochem Biophys Res Commun 36: 93-100.
15. Hofs HP, Wagener DJ, De Valk-Bakker V, Van Rennes H, De Vos D, Doesburg WH, Ottenheijm HC and De Grip WJ (1995) Preclinical antitumor activity of ethyldeshydroxysparsomycin in combination with cisplatin. Invest New Drugs 13:23-32.
16. Hromas RA and Yung WK (1986) Anguidine potentiates cis-platinum in human brain tumor cells. J Neuro-Oncol 3:343-348.
17. Hunting D, Gowans B and Henderson JF (1985) Effects of 6-aminonicotinamide on cell growth, poly(ADP-ribose) synthesis and nucleotide metabolism. Biochem Pharmacol 34:3999-4003.
18. Kaufmann SH (1989) Additional members of the rat liver lamin polypeptide family: Structural and immunological characterization. J Biol Chem 264:13946-13955.
19. Kaufmann SH and Shaper JH (1984) A subset of non-histone nuclear proteins reversibly stabilized by the sulfhydryl cross-linking reagent tetrathionate: Polypeptides of the internal nuclear matrix. Exp Cell Res 155:477-495.
20. 6-glial cells. Naunyn-Schmiedeberg's Arch Pharmacol 294:213-215.
21. Lee AS (1992) Mammalian stress response: Induction of the glucose-regulated protein family. Curr Opin Cell Biol 4:267-273.
22. Lindquist S and Craig EA (1988) The heat-shock proteins. Annu Rev Genet 22:631-677.
23. Little E, Ramakrishnan M, Roy B, Gazit G and Lee AS (1994) The glucose-regulated proteins (GRP78 and GRP94): Functions, gene regulation, and applications. Crit Rev Eukaryot Gene Expr 4:1-18.
24. Low BC, Ross IK and Grigor MR (1994) Glucose deprivation and acute cycloheximide treatment stimulate system L amino acid transport in cultured vascular smooth muscle cells. J Biol Chem 269:32098-32103.
25. Martin DS and Schwartz GK (1997) Chemotherapeutically induced DNA damage, ATP depletion, and the apoptotic biochemical cascade. Oncol Res 9:1-5.
26. Moldave K (1985) Eukaryotic protein synthesis. Ann Rev Biochem 54:1109-1149.
27. O'Farrell PZ, Goodman HM and O'Farrell PH (1977) High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell 12:1133-1141.
28. Pain VM (1986) Initiation of protein synthesis in mammalian cells. Biochem J 235:625-637.
29. Patierno SR, Tuscano JM, Kim KS, Landolph JR and Lee AS (1987) Increased expression of the glucose-regulated gene encoding the Mr 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells. Cancer Res 47:6220-6224.
30. Sims JL, Sikorski GW, Catino DM, Berger SJ and Berger NA (1982) Poly(adenosine-diphosphoribose) polymerase inhibitors stimulate unscheduled deoxyribonucleic acid synthesis in normal human lymphocytes. Biochemistry 21:1813-1821.
31. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85.
32. Sternberg SS and Philips FS (1958) 6-Aminonicotinamide and acute degenerative changes in the central nervous system. Science (Wash DC) 127:644-645.
33. 31P NMR investigation of effect of 6-aminonicotinamide on metabolism of RIF-1 tumor cells in vitro. J Biol Chem 271:4113-4119.
34. Varnes ME (1988) Inhibition of pentose cycle of A549 cells by 6-aminonicotinamide: Consequences of aerobic and hypoxic radiation response and for radiosensitizer action. NCI (Natl Cancer Inst) Monogr 6:199-203.
35. Walker DL, Reid JM, Svingen PA, Rios R, Covey JM, Alley MC, Hollingshead MG, Budihardjo II, Eckdahl S, Boerner S, Kaufmann SH and Ames MM (1999) Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent. Biochem Pharmacol 58:1057-1066.
36. Warrington RC, Fang WD and Zhang LU (1996) L-Histidinol reverses resistance to cisplatinum and other antineoplastics in a tumorigenic epithelial cell line. Anticancer Res 16:3641-3646.