Inhibition of dipeptidyl peptidase I in the human mast cell line HMC-1: Blocked activation of tryptase, but not of the predominant chymotryptic activity

Biochemical Pharmacology

Volumn 66, Issue 11, 2003, Pages 2251-2262

  Sheth, Parimal D ^a   Pedersen, John ^b   Walls, Andrew F ^a   McEuen, Alan R ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b Prozymex A/S   (Denmark)

Author keywords

Cathepsin G; Chymase; Dipeptidyl peptidase I; Gly Phe diazomethyl ketone; Proenzyme activation; Tryptase

Indexed keywords

CHYMASE; DIPEPTIDYL PEPTIDASE I; GLYCYLPHENYLDIAZOMETHYL KETONE; KETONE DERIVATIVE; TRYPTASE; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL LYSATE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME INACTIVATION; ENZYME SPECIFICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNODETECTION; IMMUNOPHARMACOLOGY; IMMUNOREACTIVITY; MAST CELL; PRIORITY JOURNAL; PROTEINASE INHIBITION; STATISTICAL SIGNIFICANCE;

EID: 0242408767     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.08.002     Document Type: Article

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