The Expression of Smads in Human Endometrium and Regulation and Induction in Endometrial Epithelial and Stromal Cells by Transforming Growth Factor-β

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 10, 2003, Pages 4967-4976

  Luo, Xiaoping ^a   Xu, Jingxia ^a   Chegini, Nasser ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; SMAD PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; BLEEDING DISORDER; CANCER; CONTROLLED STUDY; CYTOPLASM; ENDOMETRIOSIS; ENDOMETRIUM; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; NIDATION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADULT; CELL LINE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIUM; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; HUMANS; PREMENOPAUSE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; STROMAL CELLS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0242351762     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030276     Document Type: Article

References (51)

1. Kauma SW 2000 Cytokines in implantation. J Reprod Fertil Suppl 55:31-42
2. Chegini N, Williams RS 2000 Implication of growth factor and cytokine networks in endometrium. In Hill J, ed. Cytokines in human reproduction. New York: Wiley and Sons; 92-132
3. Selam B, Arici A 2000 Implantation defect in endometriosis: endometrium or peritoneal fluid. J Reprod Fertil Suppl 55:121-128
4. Burton JL, Wells M 1998 Recent advances in the histopathology and molecular pathology of carcinoma of the endometrium. Histopathology 33:297-303
5. Bulun SE, Gurates B, Fang Z, Tamura M, Sebastian S, Zhou J, Amin S, Yang S 2002 Mechanisms of excessive estrogen formation in endometriosis. J Reprod Immunol 55:21-33
6. Lawrence DA 1996 Transforming growth factor-beta: a general review. Eur Cytokine Netw 7:363-374
7. Branton MH, Kopp JB 1999 TGF-β and fibrosis. Microbes Infect 1:1349-1365
8. 125I]TGF- β1-binding sites. Endocrinology 135: 439-449
9. Chegini N, Tang XM, Dou Q 1999 The expression, activity and regulation of granulocyte macrophage-colony stimulating factor in human endometrial epithelial and stromal cells. Mol Hum Reprod 5:459-466
10. Arici A, MacDonald PC, Casey ML 1996 Modulation of the levels of transforming growth factor β messenger ribonucleic acids in human endometrial stromal cells. Biol Reprod 54:463-469
11. Dumont N, O'Connor-McCourt MD, Philip A 1995 Transforming growth factor-β receptors on human endometrial cells: identification of the type I, II, and III receptors and glycosyl-phosphatidylinositol anchored TGF-β binding proteins. Mol Cell Endocrinol 111:57-66
12. Casslen B, Sandberg T, Gustavsson B, Willen R, Nilbert M 1998 Transforming growth factor β1 in the human endometrium. Cyclic variation, increased expression by estradiol and progesterone, and regulation of plasminogen activators and plasminogen activator inhibitor-1. Biol Reprod 58:1343-1350
13. Sandberg T, Casslen B, Gustavsson B, Benraad TJ 1998 Human endothelial cell migration is stimulated by urokinase plasminogen activator:plasminogen activator inhibitor 1 complex released from endometrial stromal cells stimulated with transforming growth factor β1; possible mechanism for paracrine stimulation of endometrial angiogenesis. Biol Reprod 59:759-767
14. Lea RG, Underwood J, Flanders KC, Hirte H, Banwatt D, Finotto S, Ohno I, Daya S, Harley C, Michel M 1995 A subset of patients with recurrent spontaneous abortion is deficient in transforming growth factor β-2-producing "suppressor cells" in uterine tissue near the placental attachment site. Am J Reprod Immunol 34:52-64
15. Bruner KL, Eisenberg E, Gorstein F, Osteen KG 1999 Progesterone and transforming growth factor-β coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis. Steroids 64:648-653
16. Blobe GC, Schiemann WP, Lodish HF 2000 Role of transforming growth factor β in human disease. N Engl J Med 342:1350-1358
17. Chegini N, Gold LI, Williams RS 1994 Localization of transforming growth factor β isoforms TGF-β1, TGF-β2, and TGF-β3 in surgically induced endometriosis in the rat. Obstet Gynecol 83:455-461
18. Chegini N, Rong H, Bennett B, Stone IK 1999 Peritoneal fluid cytokine and eicosanoid levels and their relation to the incidence of peritoneal adhesion. J Soc Gynecol Invest 6:153-157
19. Ripley D, Tang XM, Ma C, Chegini N 2001 The expression and action of granulocyte macrophage-colony stimulating factor and its interaction with TGF-β in endometrial carcinoma. Gynecol Oncol 81:301-309
20. Gold LI, Saxena B, Mittal KR 1994 Increased expression of transforming growth factor beta isoforms and basic fibroblast growth factor in complex hyperplasia and adenocarcinoma of the endometrium: evidence for paracrine and autocrine action. Cancer Res 54:2347-2358
21. Zimmerman CM, Padgett RW 2000 Transforming growth factor beta signaling mediators and modulators. Gene 249:17-30
22. Massague J, Wotton D 2000 Transcriptional control by the TGF-β/Smad signaling system. EMBO J 19:1745-1754
23. Moustakas A, Souchelnytskyi S, Heldin CH 2001 Smad regulation in TGF-β signal transduction. J Cell Sci 114:4359-4369
24. Kato S, Ueda S, Tamaki K, Fuji M, Miyazono K, ten Dijke P, Morimatsu M, Okuda S 2001 Ectopic expression of Smad7 inhibits transforming growth factor-beta responses in vascular smooth muscle cells. Life Sci 69:2641-2652
25. Chegini N, Rossi MJ, Masterson BJ 1992 Platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and EGF and PDGF β-receptors in human endometrial tissue: localization and in vitro action. Endocrinology 130:2373-2385
26. Tang XM, Zhao Y, Rossi MJ, Abu-Rustum RS, Ksander GA, Chegini N 1994 Expression of transforming growth factor-β (TGF β) isoforms and TGF β type II receptor messenger ribonucleic acid and protein, and the effect of TGF βs on endometrial stromal cell growth and protein degradation in vitro. Endocrinology 135:450-459
27. Desai NN, Kennard EA, Kniss DA, Friedman CI 1994 Novel human endometrial cell line promotes blastocyst development. Fertil Steril 61:760-766
28. Xu J, Luo X, Chegini N 2003 Differential expression, regulation, and induction of Smads, transforming growth factor-β signal transduction pathway in leiomyoma, and myometrial smooth muscle cells and alteration by gonadotropin-releasing hormone analog. J Clin Endocrinol Metab 88:1350-1361
29. Itoh S, Landstrom M, Hermansson A, Itoh F, Heldin CH, Heldin NE, ten Dijke P 1998 Transforming growth factor β1 induces nuclear export of inhibitory Smad7. J Biol Chem 273:29195-29201
30. Liu C, Gaca MD, Swenson ES, Vellucci VF, Reiss M, Wells RG 2003 Smads 2 and 3 are differentially activated by transforming growth factor-β (TGF-β) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-β-independent. J Biol Chem 278:11721-11728
31. Mori Y, Chen SJ, Varga J 2000 Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta. Exp Cell Res 258:374-383
32. Stopa M, Anhuf D, Terstegen L, Gatsios P, Gressner AM, Dooley S 2000 Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-β)-induced activation of Smad7. The TGF-β response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J Biol Chem 275:29308-29317
33. Dong C, Zhu S, Wang T, Yoon W, Li Z, Alvarez RJ, ten Dijke P, White B, Wigley FM, Goldschmidt-Clermont PJ 2002 Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc Natl Acad Sci USA 99:3908-3913
34. Chegini N, Ripley D, Ripps BA 2001 Expression of Smads, transforming growth factor β signal transduction protein, in normal endometrium and endometrial cancer. J Soc Gynecol Investig 8(Suppl):196A
35. Wu L, Wu Y, Gathings B, Wan M, Li X, Grizzle W, Liu Z, Lu C, Mao Z, Cao X 2003 Smad4 as a transcription corepressor for estrogen receptor α. J Biol Chem 278:15192-15200
36. Matsuda T, Yamamoto T, Muraguchi A, Saatcioglu F 2001 Cross-talk between transforming growth factor-β and estrogen receptor signaling through Smad3. J Biol Chem 276:42908-42914
37. Pouliot F, Labrie C 1999 Expression profile of agonistic Smads in human breast cancer cells: absence of regulation by estrogens. Int J Cancer 81:98-103
38. Hayes SA, Zarnegar M, Sharma M, Yang F, Peehl DM, ten Dijke P, Sun Z 2001 Smad3 represses androgen receptor-mediated transcription. Cancer Res 61:2112-2118
39. Landstrom M, Heldin NE, Bu S, Hermansson A, Itoh S, ten Dijke P, Heldin CH 2000 Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells. Curr Biol 10:535-538
40. Chegini N, Tang XM, Ma C, Williams RS 2002 The effects of gonadotropin releasing hormone analogues "add-back" antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cells growth and transforming growth factor β expression. Mol Hum Reprod 12:1071-1078
41. Inagaki Y, Mamura M, Kanamaru Y, Greenwel P, Nemoto T, Takehara K, Ten Dijke P, Nakao A 2001 Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 187:117-123
42. Parekh TV, Gama P, Wen X, Demopoulos R, Munger JS, Carcangiu ML, Reiss M, Gold LI 2002 Transforming growth factor β signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition. Cancer Res 62:2778-2790
43. Mulder KM 2000 Role of Ras and MAPKs in TGF-β signaling. Cytokine Growth Factor Rev 11:23-35
44. Yakymovych I, Ten Dijke P, Heldin CH, Souchelnytskyi S 2001 Regulation of Smad signaling by protein kinase C. FASEB J 15:553-555
45. Scherer A, Graff JM 2000 Calmodulin differentially modulates Smad1 and Smad2 signaling. J Biol Chem 275:41430-41438
46. Tamura M, Sebastian S, Yang S, Gurates B, Fang Z, Bulun SE 2002 2002 Interleukin-1β elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. J Clin Endocrinol Metab 87:3263-3273
47. Simmen RC, Zhang XL, Michel FJ, Min SH, Zhao G, Simmen FA 2002 Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Kruppel-like factor BTEB1. DNA Cell Biol 21:115-128
48. Luo X, Xu J, Chegini N 2003 Transforming growth factor beta and gonadotropin releasing hormone analogue recruit and activate MAPK in endometrial epithelial and stromal cells. J Soc Gynecol Invest 10:106A
49. de Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, Lechleider RJ 1998 Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev 12:1587-1592
50. Hall JM, Couse JF, Korach KS 2001 The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276:36869-36872
51. Richer JK, Lange CA, Manning NG, Owen G, Powell R, Horwitz KB 1998 Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Progesterone receptors regulate signal transducers and activators of transcription expression and activity. J Biol Chem 273:31317-31326