CpG DNA induced IL-12 p40 gene activation is independent of STAT1 activation or production of interferon consensus sequence binding protein

Journal of biomedical science

Volumn 9, Issue 6, 2002, Pages 688-696

  Bradford, Mary ^a   Schroeder, Arin J ^a   Morse, Herbert C ^b   Vogel, Stefanie N ^c   Cowdery, John S ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DNA BINDING PROTEIN; GAMMA INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR; INTERLEUKIN 12; INTERLEUKIN 12P40; OLIGONUCLEOTIDE; PROTEIN SUBUNIT; REPRESSOR PROTEIN; STAT1 PROTEIN; STAT1 PROTEIN, MOUSE; STAT4 PROTEIN; STAT4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL LINE; CPG ISLAND; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MACROPHAGE; METABOLISM; MOUSE; MOUSE MUTANT; PROMOTER REGION;

ANIMALS; CELL LINE; CPG ISLANDS; DNA, BACTERIAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; INTERFERON REGULATORY FACTORS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); PROTEIN SUBUNITS; REPRESSOR PROTEINS; STAT1 TRANSCRIPTION FACTOR; STAT4 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0242350759     PISSN: 10217770     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02254997     Document Type: Article

References (47)

1. Arditi M, Zhou J, Torres M, Durden DL, Stins M, Kim KS. Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p44, p42, and p41 in vascular endothelial cells in a soluble CD 14-dependent manner. J Immunol 155:3994-4003;1995.
2. Aste-Amezaga M, Ma X, Sartori A, Trinchieri G. Molecular mechanisms of the induction of II.,-12 and its inhibition by IL-10. J Immunol 160:5936-5944;1998.
3. Ballas ZK, Rasmussen WL, Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 157:1840-1845; 1996.
4. Brazolot Millan CL, Weeratna R, Krieg AM, Siegrist CA, Davis HL. CpG DNA can induce strong Th 1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc Natl Acad Sci USA 95:15553-15558;1998.
5. Chace JH, Hooker NA, Mildenstein KL, Krieg AM, Cowdery JS. Bacterial DNA-induced NK cell IFN-7 production is dependent on macrophage secretion oflL- 12. Clin Immunol Immnnopathol 84:185-193;1997.
6. Cowdery JS, Boerth N J, Norian LA, Myung PS, Koretzky GA. Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and tipopolysaccharide. J Immunol 162:6770-6775; 1999.
7. Cowdery JS, Chace JH, Yi A, Krieg AM. Bacterial DNA induces NK cells to produce IFN- γ in vivo and increases the toxicity of Iipopolysaccharides. J Immunol 156:4570-4575;1996.
8. Crowley MT, Costello PS, Fitzer-Attas C J, Turner M, Meng F, Lowell C, Tybulewicz VLJ, Defranco AL. A critical role for syk in signal transduction and phagocytosis mediated by FCT receptors on macrophages. J Exp Med 186:1027-1039;1997.
9. Davis HL, Suparto II, Weeratna RR, Jumintarto, Iskandriati DD, Chamzah SS, Ma'ruf AA, Nente CC, Pawitri DD, Krieg AM, Heriyanto, Smits W, Sajuthi DD. CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans. Vaccine 18:1920-1924;2000.
10. Giese NA, Gabriele L, Doherty TM, Klinman DM, Tadesse-Heath L, Contursi C, Epstein SL, Morse III HC. Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family regulates immune responses in vivo through control of interleukin 12 expression. J Exp Med 186: 1535-1546;1997.
11. Hacker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med 192:595-600;2000.
12. Halpem MD, Kurlander R J, Pisetsky DS. Bacterial DNA induces murine interferonq, production by stimulation of interleukin 12 and tumor necrosis factor-3,. Cell Immunol 167:72-78;1996.
13. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A toll-like receptor recognizes bacterial DNA. Nature 408:740-745;2000.
14. Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ. Cutting edge: Repurification oflipopolysaccharide eliminates sigualing through both human and murine toll-like receptor 2. J Immuno1 165: 618-622;2000.
15. Hirschfeld M, Weis J J, Toshchakov V, Salkowski CA, Cody M J, Ward DC, Qureshi N, Michalek SM, Vogel SN. Signaling by toll-like receptor 2 and 4 agonists results in different gene expression in murine macrophages. Infect Immun 69:1477-1482;2001.
16. Hottschke T, Lohler J, Kanno Y, Fehr T, Giese N, Rosenbauer F, Lou J, Knobeloch KP, Gabriele L, Waring JF, Bachmann MF, Zinkernagel R, Morse III HC, Ozato K, Horak I. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 87:307-317; 1996.
17. Kanno Y, Kozak CA, Schindler C, Driggers PH, Ennist DL, Gleason SL, Darnell JE Jr, Ozato K. The genomic structure of the mnrine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which ISGF3 alpha subunit (or similar) molecule binds. Mol Cell Biol 13:3951-3963; 1993.
18. Kantakamalakul W, Politis AD, Marecki S, Sullivan T, Ozato K, Fenton M J, Vogel SN. Regulation of IFN consensus sequence binding protein expression in murine macrophages. J hnmuno1 162:7417-7425;1999.
19. Kimbrell DA, Beutler B. The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-267;2001.
20. Klinman DM, Yi A, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon-γ. Proc Natl Acad Sci USA 93:2879-2883; 1996.
21. Krieg AM, Love-Homan L, Yi A, Harty JT. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J Immunol 161:2428-2434; 1998.
22. Krieg AM, Yi A, Matson S, Walschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Ktinman DM. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-549; 1995.
23. Lamont AG, Adorini L. IL-12: A key cytokine in immune regulation. Immunol Today 15: 214-217;1996.
24. Liu HM, Nwebrough SE, Bhatia SK, Krieg AM, Weiner GJ. Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony stimulating factor. Blood 92:3730-3736; 1998.
25. Ma X, Gri G, Trinchieri G. A novel ets-2-related nuclear factor is involved in transcriptional activation of the human interleukin-12 p40 gene promoter in response to interferon-γ and LPS stimulation of monocytic cells. Ann NY Acad Sci 795:357-360;1996.
26. Ma X, Neurath M, Gri G, Trinchieri G: Identification and characterization of a novel ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J Biol Chem 272:10389-10395; 1997.
27. Ma X, Chow JM, Gri G, Carra G, Gerosa F, Wolf SF, Dziato R, Trinchieri G. The interleukin 12 p40 gene promoter is primed by interferon-γ in monocytic cells. J Exp Med 183:147-157;1996.
28. Messina JP, Gilkeson GS, Pisetsky DS. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol 147:1759-1764;1991.
29. Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM. Regulation ofinterleukin 12 p40 expression through an NF-kB half-site. Mot CelI Biol 15:5258-5267; 1995.
30. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. The human toll signaling pathway: Divergence of nuclear factor kB and JNK/ SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 187:2097-2101;1998.
31. Plevy SE, Gemberling JHM, Hsu S, Domer A J, Smale ST: Multiple control elements mediate activation of the murine and human interlenkin 12 p40 promoters: Evidence of functional synergy between C/EBP and rel proteins. MoI Cell Biol 17:4572-4588; 1997.
32. Politis AD, Ozato K, Coligan JE, Vogel SN: Regulation of IFN-7-indueed nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages. J Immuno1 152: 2270-2278;1994.
33. Poltorak A, He X, Smimova I, Liu M, VanHuffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in TIN gene. Science 282:2085-2088; 1998.
34. Qureshi ST, Lariviere L, Leveque G, Clermont S, Moore K J, Gros P, Malo D. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 189:615-625;1999.
35. Re F, Strominger JL. TolMike receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 276:37692-37699;2001.
36. Roman M, Martin-Orozco E, Goodman JS, Nguyen M, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E. Immunostimulatory DNA sequences function as T helper-l-promoting adjuvants. Nat Med 3: 849-854; 1997.
37. Scharton-Keresten T, Contursi C, Masumi A, Sher A, Ozato K. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186:1523-1534;1997.
38. Sweet MJ, Campbell CC, Sester DP, Xu D, McDonald RC, Stacey KJ, Hume DA, Liew FY. Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of Toillike receptor 9, but enhances responses to lipopolysaccharide in murine macrophages. J Immunol 168:392-399;2002.
39. Thompson CB, Wang CY, Ho JC, Bohjanen RP, Petyrniak B, Junes SC, Miesfeldt H, Zhang L, Nabel GJ, Karpinski B, Leiden JN. cis-Acting sequences required for inducible interlenkin-2 enhancer function find a novel Ets-related protein Elf-1. Mol Cell Biol 12:1043-1053; 1992.
40. Trinchiefi G. Interleukin-I 2:A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251-276;1995.
41. Ulevitch RJ, Tobias PS. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 13:437-457; 1995.
42. Wang I, Contursi C, Masumi A, Ma X, Trinchieri G, Ozato K. An IFN-γ-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J Immunot 165:271-279;2000.
43. Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM. Immunostimutatory oligodeoxynucleotides containing the CpG motif are effective immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 94: 10833-10837;1997.
44. Wu C, Maeda H, Contursi C, Ozato K, Seder RA. Differential requirement of IFN consensus sequence binding protein for the production of Ig-12 and induction of Thl-type cells in response to IFN-3,. J Immunol 162:807-812; 1999.
45. Yi A, Klinman DM, Martin TL, Matson S, Krieg AM. Rapid immune activation by CpG motifs in bacterial DNA. J Immunol 157: 5394-5402;1996.
46. Yi A, Krieg AM. CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of IkBu and IkBa and sustained activation of nuclear factor-kB/c-Rel. J Immnnol 160:1240-1245;1998.
47. Yi AK, Tuetken R, Redford T, Kirsch J, Krieg AM. CpG motifs in bacterial DNA activate leukocytes through the ph-dependent generation of reactive oxygen species. J Immunol 160: 4755-4761;1998.