Disruption of an Active Site Hydrogen Bond Converts Human Heme Oxygenase-1 into a Peroxidase

Journal of Biological Chemistry

Volumn 276, Issue 14, 2001, Pages 10612-10619

  Lightning, Luke Koenigs ^a   Huang, Hong Wei ^b   Moënne Loccoz, Pierre ^b   Loehr, Thomas M ^b   Schuller, David J ^c   Poulos, Thomas L ^c   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; CRYSTAL STRUCTURE; HYDROGEN BONDS; RAMAN SPECTROSCOPY; ULTRAVIOLET RADIATION;

MUTATIONS;

ENZYMES;

ALANINE; ASPARAGINE; ASPARTIC ACID; BILIVERDIN; HEME; HEME OXYGENASE 1; HISTIDINE; LEUCINE; PEROXIDASE; PHENYLALANINE; PORPHYRIN DERIVATIVE; HEME OXYGENASE; HYDROGEN;

ARTICLE; CRYSTAL STRUCTURE; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; RAMAN SPECTROMETRY; ULTRAVIOLET RADIATION; CHEMISTRY; GENE DELETION; GENETICS; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

HEME OXYGENASE (DECYCLIZING); HUMANS; HYDROGEN; PEROXIDASE; PROTEIN CONFORMATION; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035815676     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010349200     Document Type: Article

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