Solution 1H NMR of the active site of substrate-bound, cyanide-inhibited human heme oxygenase: Comparison to the crystal structure of the water-ligated form

Journal of Biological Chemistry

Volumn 276, Issue 19, 2001, Pages 15676-15687

  La Mar, Gerd N ^a   Asokan, Anbanandam ^a   Espiritu, Bryan ^a   Yeh, Deok Cheon ^a   Auclair, Karine ^b   Ortiz de Montellano, Paul R ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; CYANIDES; HYDROGEN BONDS; NUCLEAR MAGNETIC RESONANCE; SOLUTIONS; WATER;

AXIAL LIGANDS;

ENZYMES;

CYANIDE; HEME; HEME OXYGENASE; HYDROXYL GROUP; PEROXIDE; TYROSINE; WATER; HYDROGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; STEREOSPECIFICITY; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYANIDES; HEME; HEME OXYGENASE (DECYCLIZING); HUMANS; HYDROGEN; HYDROGEN BONDING; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY; TYROSINE; WATER;

EID: 0035844131     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009974200     Document Type: Article

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