Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures

Journal of Bone and Mineral Research

Volumn 12, Issue 8, 1997, Pages 1272-1279

  Sugimoto, Toshitsugu ^a   Nishiyama, Katsuhito ^a   Kuribayashi, Fumihiko ^b   Chihara, Kazuo ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; BLOOD LEVEL; FEMALE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; RISK ASSESSMENT; SPINE FRACTURE;

ADULT; AGED; AGED, 80 AND OVER; AGING; BLOOD PROTEINS; BONE DENSITY; CROSS-SECTIONAL STUDIES; DENSITOMETRY, X-RAY; FEMALE; FEMUR NECK; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; JAPAN; LUMBAR VERTEBRAE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; REGRESSION ANALYSIS; SPINAL FRACTURES; THORACIC VERTEBRAE;

EID: 0030741644     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.8.1272     Document Type: Article

References (44)

1. Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL 1982 Changes in bone mineral density of the proximal femur and spine with aging: Differences between the postmenopausal and senile osteoporosis syndrome. J Clin Invest 70:716-723.
2. Norimatsu H, Mori S, Uesaka T, Yoshikawa T, Katsuyama N 1989 Bone mineral density of the spine and proximal femur in normal and osteoporotic subjects in Japan. Bone Miner 5:213-222.
3. Kitazawa R, Fukase M, Imai Y, Sugimoto T, Kano J, Kaji H, Fujita T 1993 Assessment of lumbar bone mineral density in normal Japanese women. Osteoporos Int 3:S245.
4. Sugimoto T, Kanbara Y, Shiraishi H, Kawakatsu M, Negishi H, Fukase M, Fujita T, Chihara K, Tsutsumi M 1994 Femoral and spinal bone mineral density in Japanese osteoporotics with hip fracture. Osteoporos Int 4:144-148.
5. Civitelli R, Gonneli S, Zacchei F, Bigazzi S, Vattimo A, Avioli LV, Gennari C 1988 Bone turnover in postmenopausal osteoporosis: Effect of calcitonin treatment. J Clin Invest 82:1268-1274.
6. Uebelhart D, Schlemmer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD 1991 Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. J Clin Endocrinol Metab 72:367-373.
7. Rosen CJ, Donahue LR, Hunter SJ 1994 Insulin-like growth factors and bone: The osteoporosis connection. Exp Biol Med 206:83-102.
8. 281] insulin-like growth factor-binding protein 2 inhibits both basal and insulin-like growth factor-I-stimulated proliferation and collagen synthesis in fetal rat calvariae. J Biol Chem 266:19469-19474.
9. Andress DL, Birnbaum RS 1992 Human osteoblast-derived insulin-like growth factor (IGF) binding protcin-5 stimulates osteoblast mitogenesis and potentiates IGF action. J Biol Chem 267:22467-22472.
10. Schiltz PM, Mohan S, Baylink DJ 1993 Insulin-like growth factor binding protein-4 inhibits both basal and IGF-mediated chick pelvic cartilage growth in vitro. J Bone Miner Res 8:391-396.
11. Schwander JC, Hauri C, Zapf J, Froesch ER 1983 Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: Dependence on growth hormone status. Endocrinology 113:297-305.
12. Spencer EM, Liu CC, Si ECC, Howard GA 1991 In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats. Bone 12:21-26.
13. Johansson AG, Lindh E, Ljunghall S 1992 Insulin-like growth factor I stimulates bone turnover in osteoporosis. Lancet 339:1619.
14. Corpas E, Harman SM, Blackman MR 1993 Human growth hormone and human aging. Endocr Rev 14:20-39.
15. O'halloran DJ, Tsatsoulis A, Whitehouse RW, Holmes SJ, Adams JE, Shalet SM 1993 Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab 76:1344-1348.
16. Bing-You RG, Denis M-C, Rosen CJ 1993 Low bone mineral density in adults with previous hypothalamic-pituitary tumors: Correlations with serum growth hormone responses to GH-releasing hormone, insulin-like growth factor I, and IGF binding protein 3. Calcif Tissue Int 52:183-187.
17. Johansson AG, Forslund A, Hambraeus L, Blum WF, Ljunghall S 1994 Growth hormone-dependent insulin-like growth factor binding protein is a major determinant of bone mineral density in healthy men. J Bone Miner Res 9:915-921.
18. Baxter RC 1993 Circulating binding proteins for the insulinlike growth factors. Trends Endocrinol Metab 4:91-96.
19. Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ, Bierich JR 1990 A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: Its use for diagnosis of GH deficiency. J Clin Endocrinol Metab 70:1292-1298.
20. Laron Z, Klinger B, Blum WF, Silbergeld A, Ranke MB 1992 IGF binding protein 3 in patients with Laron type dwarfism: Effect of exogenous rIGF-I. Clin Endocriol 36:301-304.
21. Corpas E, S.M. Harman SM, Blackman MR 1992 Serum IGF-binding protein-3 is related to IGF-I, but not to spontaneous GH release in healthy old men. Horm Metab Res 24:543-545.
22. Bennett AE, Wahner HW, Riggs BL, Hintz RL 1984 Insulin-like growth factor I and II: Aging and bone density in women. J Clin Endocrinol Metab 59:701-704.
23. Kelly PJ, Eisman JA, Stuart MC, Pocock NA, Sambrook PN, Gwinn TH 1990 Somatomedin-C, physical fitness, and bone density. J Clin Endocrinol Metab 70:718-723.
24. Ljunghall S, Johansson AG, Burman P, Lindh KE, Karlsson FA 1992 Low plasma levels of insulin-like growth factor I (IGF-I) in male patients with idiopathic osteoporosis. J Intern Med 232:59-64.
25. Wuster C, Blum WF, Schlemilch S, Ranke MB, Ziegler R 1993 Decreased serum levels of insulin-like growth factors and IGF binding protein 3 in osteoporosis. J Intern Med 234:249-255.
26. Daughaday WH, Mariz IK, Blethen SL 1980 Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: A comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum. J Clin Endocrinol Metab 51:781-788.
27. Albertsson K, Hall K 1987 Growth hormone treatment in short children: Relationship between growth and serum insulin-like growth factor I and II levels. J Clin Endocrinol Metab 65: 671-678.
28. Reid IR, Plank LD, Evans MC 1992 Fat mass is an important determinant of whole body bone density in premenopausal women but not in men. J Clin Endocrinol Metab 75:779-782.
29. Melton LJ, Chao EYS, Lane J 1988 Biomechanical aspects of fractures. In: Riggs BL, Melton LJ (eds.) Osteoporosis: Etiology, Diagnosis, and Management. Raven Press, New York, NY, U.S.A., pp. 111-131.
30. Blum WF, Ranke MB 1990 Insulin-like growth factor binding proteins (IGFBPs) with special reference to IGFBP-3. Acta Paediatr Scand (Suppl)367:55-62.
31. Sklar C, Sarafoglou K, Whittam E 1993 Efficacy of insulin-like growth factor binding protein 3 in predicting the growth hormone response to provocative testing in children treated with cranial irradiation. Acta Endocrinol 129:511-515.
32. Zapf J, Schmid C, Guler HP, Wahdvogel M, Hauri CH, Futo E, Hossenlopp P, Binoux M, Froesch ER 1990 Regulation of binding proteins for insulin-like growth factors (IGFs) in humans: Increased expression of IGF binding protein 2 during IGF-I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia. J Clin Invest 86:952-961.
33. Young SCJ, Underwood LE, Celniker A, Clemmons DR 1992 Effect of recombinant insulin-like growth factor-I (IGF-I) and growth hormone on serum IGF-binding proteins in calorically restricted adults. J Clin Endocrinol Metab 75:603-608.
34. Amarnani S, Merriman HL, Linkhart TA, Baylink DJ, Mohan S 1993 Autocrine regulators of MC3T3-E1 cell proliferation. J Bone Miner Res 8:157-165.
35. 3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts. Endocrinology 129:3139-3146.
36. Rosen C, Donahue LR, Hunter S, Holick M, Kavookjian H, Kirschenbaum A, Mohan S, Baylink DJ 1992 The 24/25-kDa serum insulin-like growth factor-binding protein is increased in elderly women with hip and spine fractures. J Clin Endocrinol Metab 74:24-27.
37. Ernst M, Rodan GA 1990 Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): Positive correlation with the presence of the GH-induced IGF-binding protein BP-3. Endocrinology 127:807-814.
38. Mohan S 1993 Insulin-like growth factor binding proteins in bone cell regulation. Growth Regul 1:67-70.
39. Narusawa K, Nakamura T, Suzuki K, Matsuoka Y, Lee L-J, Tanaka H, Seino Y 1995 The effects of recombinant human insulin-like growth factor (rhIGF)-1 and rhIGF-1/IGF binding protein-3 administration on rat osteopenia induced by ovariectomy with concomitant bilateral sciatic neurectomy. J Bone Miner Res 10:1853-1864.
40. Conover CA 1991 Glycosylation of insulin-like growth factor binding protein-3 (IGFBP-3) is not required for potentiation of IGF action: Evidence for processing of cell-bound IGFBP-3. Endocrinology 129:3259-3268.
41. Conover CA 1992 Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: Studies of underlying mechanism. Endocrinology 130:3191-3199.
42. Blum WF, Jenne EW, Reppin F, Kietzmann K, Ranke MB, Bierich JR 1989 Insulin-like growth factor I (IGF-I)-binding protein complex is a better mitogen than free IGF-I. Endocrinology 125:766-772.
43. Oh Y, Muller HL, Pham H, Rosenfeld RG 1993 Demonstration of receptors for insulin-like growth factor binding protein-3 on HS578T human breast cancer cells. J Biol Chem 268:26045-26048.
44. Valentinis B, Bhala A, DeAngelis T, Baserga R, Cohen P 1995 The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene. Mol Endocrinol 9:361-367.