Daidzein conjugates are more bioavailable than genistein conjugates in rats

American Journal of Clinical Nutrition

Volumn 68, Issue 6 SUPPL., 1998, Pages

  King, Roger A ^a  

^a CSIRO   (Australia)

Author keywords

4 ethyl phenol; Bioavailability; Conjugates; Daidzein; Equol; Genistein; Isoflavones; Rats; Soy

Indexed keywords

4 ETHYLPHENOL; DAIDZEIN; EQUOL; GENISTEIN; ISOFLAVONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOAVAILABILITY; BLOOD LEVEL; CONFERENCE PAPER; CONJUGATE; CONTROLLED STUDY; DIETARY INTAKE; FECES ANALYSIS; MALE; NONHUMAN; RAT; SOYBEAN; URINARY EXCRETION;

ANIMALIA; BACTERIA (MICROORGANISMS); GLYCINE MAX;

EID: 0031795626     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/68.6.1496S     Document Type: Conference Paper

References (23)

1. Messina MJ, Persky V, Setchell KDR, Barnes S. Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 1994;21:113-31.
2. Hertog MGL, Feskens EJ, Hollman PCH, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993;342:1007-11.
3. Keli SO, Hertog MGL, Feskens EJM, Kromhout D. Dietary flavonoids, antioxidant vitamins, and incidence of stroke - the Zutphen study. Arch Intern Med 1996;156:637-42.
4. Maugeri D, Panebianco P, Russo MS, et al. Ipriflavone-treatment of senile osteoporosis: results of a multicenter, double-blind clinical trial of 2 years. Arch Gerontol Geriatr 1994;19:253-63.
5. 14C](+)-cyanidanol-3) and its metabolite, 3′-O-methyl-(+)-catechin. Xenobiotica 1987;17:423-34.
6. Griffiths LA, Barrow A. The fate of orally and parenterally administered flavonoids in the mammal. The significance of biliary excretion. Angiologica 1972;9:162-74.
7. Gugler R, Leschik M, Dengler HJ. Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol 1975;9:229-34.
8. Yeuh T, Chu H. The metabolic fate of daidzein. Sci Sin 1977;20:513-21.
9. Saito AM. Pharmacokinetic study of ipriflavone (TC-80) by oral administration in healthy male volunteers. Jpn Pharm Ther J 1985;13:7223-33.
10. Xu X, Harris KS, Wang HJ, Murphy PA, Hendrich S. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 1995;125:2307-15.
11. Xu X, Wang H-J, Murphy PA, Cook L, Hendrich S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 1994;124:825-32.
12. Tew B-Y, Xu X, Wang H-J, Murphy PA, Hendrich S. A diet high in wheat fiber decreases the bioavailability of soybean isoflavones in a single meal fed to women. J Nutr 1996;126:871-7.
13. Supko JG, Malspeis L. Plasma pharmacokinetics of genistein in mice. Int J Oncol 1995;7:847-54.
14. King RA, Broadbent JL, Head RJ. Absorption and excretion of the soy isoflavone genistein in rats. J Nutr 1996;126:176-82.
15. Hutchins AM, Slavin JL, Lampe JW. Urinary iosflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J Am Diet Assoc 1995;95:545-51.
16. Hollman PCH, De Vries JHM, van Leeuwen SD, Mengelers MJB, Katan MB. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 1995;62:1276-82.
17. National Health and Medical Research Council, CSIRO, and Australian Agricultural Research Council. Code of practice for the care and use of animals for experimental purposes. Canberra, Australia: Australian Government Publishing Service, 1985.
18. Manach C, Regerat F, Texier O, Agullo G, Demigne C, Remesy C. Bioavailability, metabolism and physiological impact of 4-oxoflavonoids. Nutr Res 1996;16:517-44.
19. Yasuda T, Mizunuma S, Kano Y, Saito K, Ohsawa K. Urinary and biliary metabolites of genistein in rats. Biol Pharm Bull 1996; 19:413-7.
20. Kelly GE, Nelson C, Waring MA, Joannou GE, Reeder AY. Metabolites of dietary (soya) isoflavones in human urine. Clin Chim Acta 1993;223:9-22.
21. Griffiths LA, Barrow A. Metabolism of flavonoid compounds in germ-free rats. Biochem J 1972;130:1161-2.
22. Xu X, Wang H-J, Murphy PA, Cook LR, Hendrich S. Disposition of a single dose of soy milk isoflavones in adult females. In: Bidlack WR, Omaye ST, eds. Natural protectants against natural toxicants. Lancaster, PA: Technomic Publishing Co Inc 1995:51-8.
23. Griffiths LA, Smith GE. Metabolism of apigenin and related compounds in the rat. Biochem J 1972;128:901-11.