Relationship between baseline insulin-like growth factor-I (IGF-I) and femoral bone density in women aged over 70 years: Potential implications for the prevention of age-related bone loss

Journal of the American Geriatrics Society

Volumn 44, Issue 11, 1996, Pages 1301-1306

  Boonen, Steven ^a,b   Lesaffre, Emmanuel ^a   Dequeker, Jan ^a   Aerssens, Jeroen ^a   Nijs, Jos ^a   Pelemans, Walter ^a   Bouillon, Roger ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIFEDIOL; CALCITRIOL; OSTEOCALCIN; PARATHYROID HORMONE; PYRIDINIUM DERIVATIVE; SOMATOMEDIN C;

AGED; AGING; ARTICLE; BODY MASS; BONE ATROPHY; BONE DENSITY; BONE MINERAL; BONE REMODELING; DYNAMOMETRY; FEMALE; FEMUR; HUMAN; HUMAN EXPERIMENT; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRENGTH; NORMAL HUMAN; OSTEOLYSIS; QUADRICEPS FEMORIS MUSCLE;

EID: 0029854293     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.1996.tb01399.x     Document Type: Article

References (55)

1. Cummings S, Kelsey J, Nevitt M, O'Dowd K. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985;7:178-208.
2. Melton L. Hip fractures: A worldwide problem today and tomorrow. Bone 1993;14:S1-8.
3. Smith C, Smith D. Relations between age, mineral density and mechanical properties of human femoral compacta. Acta Orthop Scan 1976;47:496-502.
4. Ross P, Davis J, Vogel J, Wasnich R. A critical review of bone mass and the risk of fractures in osteoporosis. Calcif Tissue Int 1990;46:149-161.
5. Black D, Cummings S, Melton L, Appendicular bone mineral and a woman's lifetime risk of hip fracture. J Bone Miner Res 1992;7:639-646.
6. Cummings S, Black D, Nevitt M, et al. Bone density at various sites for the prediction of hip fractures. Lancet 1993;341:72-75.
7. Vermeulen A. Nyctohemeral growth hormone profiles in young and aged men: Correlation with somatomedin-C levels. J Clin Endocrinol Metab 1987;64:884-888.
8. Bellantoni M, Harman S, Cho D, Blackman M. Effects of progestin-opposed transdermal estrogen administration of GH and IGF-I in post-menopausal women of different ages. J Clin Endocrinol Metab 1991;72:172-178.
9. Rudman D, Kutner MH, Roger CM, et al. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest 1981;67:1361-1369.
10. Clemmons D, Van Wyck J. Factors controlling blood concentration of somatomedin. J Clin Endocrinol Metab 1984;13:113-143.
11. Bouillon R. Growth hormone and bone. Horm Res 1991;6:49-55.
12. Hall K, Brandt J, Enberg G, Fryklund L. Immunoreactive somatomedin A in human serum. J Clin Endocrinol Metab 1979;48:271-278.
13. Corpas E, Harman S, Blackman M. Human growth hormone and human aging. Endocrinol Rev 1993;14:20-39.
14. McCarthy T, Centrella M, Canalis E. Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells. Endocrinology 1989;125:2118-2126.
15. Hock J, Centrella M, Canalis E. Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 1988;122:254-260.
16. Marcelli C, Yates A, Mundy G. In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice. J Bone Miner Res 1990;5:1087-1096.
17. Canalis E. Skeletal growth factors and aging. J Clin Endocrinol Metab 1994;78:1009-1010.
18. Farley JR, Tarbaux N, Murphy LA, et al. In vitro evidence that bone formation may be coupled to resorption by release of mitogen(s) from resorbing bone. Metabolism 1987;36:314-321.
19. Martin T. Hormones in the coupling of bone resorption and formation. Osteop Int 1993;3:S121-S125.
20. Nicolas V, Prewett A, Bettica P, et al. Age-related decreases in insulin-like growth factor-I and transforming growth factor-β in femoral cortical bone from both men and women: Implications for bone loss with aging. J Clin Endocrinol Metab 1994;78:1011-1016.
21. O'Neill TW, Cooper C, Algra D, et al. Design and development of a questionnaire for use in a multicentre study of vertebral osteoporosis in Europe: The European Vertebral Osteoporosis Study (EVOS). Rheumatology in Europe 1995;24:75-81.
22. Angus R, Sambrook P, Pocock N, Eisman J. A simple method for assessing calcium intake in Caucasian women. J Am Diet Assoc 1989;89:209-214.
23. Cockroft D, Gault M. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
24. Quesada J, Coopmans W, Ruiz R, et al. Influence of vitamin D on parathyroid function in the elderly. J Clin Endocrinol Metab 1992;75:494-501.
25. 3 in serum. Clin Chem 1976;22:364-368.
26. Bouillon R, Van Baelen H, De Moor P. The measurement of the vitamin D-binding protein in human serum. J Clin Endocrinol Metab 1977;5:225-231.
27. Bouillon R, De Moor P, Baggiolini E, Uskokovic M. A radioimmunoassay for 1,25-dihydroxycholecalciferol. Clin Chem 1980;6:562-567.
28. 3. J Clin Invest 1981;67:589-596.
29. Bouillon R, Coopmans W, Degroote D, et al. Immunoradiometric assay of parathyrin with polyclonal and monoclonal region-specific antibodies. Clin Chem 1990;36:271-276.
30. Verhoeven G, Koninckx P, De Moor P. Androgen and progesrogen production in cultured interstitial cells derived from immature rat tests. J Steroid Biochem 1982;17:319-330.
31. Bouillon R, Vanderschueren D, Van Herck E, et al. Homologous radioimmunoassay of human osteocalcin. Clin Chem 1992;38:2055-2060.
32. Vanderschueren D, Jans E, Van Herck E, et al. Time-related increase of biochemical markers of bone turnover in androgen-deficient male rats. J Bone Miner Res 1994;26:123-131.
33. Cook R, Weisberg S. An Introduction to Regression Graphics. New York: John Wiley & Sons, 1994.
34. Ooms M, Lips P, Roos J, et al. Vitamin D status and sex hormone binding globulin: Determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res 1995;10:1177-1184.
35. Bohr H, Schaadt O. Bone mineral content of the femoral neck and shaft: Relation between cortical and trabecular bone. Calcif Tissue Int 1985;37:340-344.
36. Pocock N, Eisman J, Gwinn T, et al. Muscle strength, physical fitness, and weight, but not age predict femoral neck bone mass. J Bone Miner Res 1988;3:441-448.
37. Madsen O, Schaadt O, Bliddal H, et al. Relationship between quadriceps strength and bone mineral density of the proximal tibia and distal forearm in women. J Bone Miner Res 1993;8:1439-1444.
38. Kritz-Silverstein, Barrett-Connor E. Grip strength and bone mineral density in older women. J Bone Miner Res 1994;9:45-51.
39. Bing-You R, Denis M, Rosen C. Low bone mineral density in adults with previous hypothalamic-pituitary tumours: Correlations with serum growth hormone responses to GHRH, IGF-I and IGFBP-3. Calcif Tissue Int 1993;52:183-187.
40. Ljunghall S, Johansson A, Burman P, et al. Low plasma levels of insulin-like growth factor-I (IGF-I) in male patients with idiopathic osteoporosis. J Intern Med 1992;232:59-64.
41. Johansson A, Forslund A, Hambraeus L, et al. Growth hormone-dependent insulin-like growth factor binding protein is a major determinant of bone mineral density in healthy men. J Bone Miner Res 1994;9:915-921.
42. Rudman D, Drinka P, Wilson C et al. Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol 1994;40:653-661.
43. Bennett A, Wahner H, Riggs B, Hintz R. Insulin-like growth factors I and II: Aging and bone density in women. J Clin Endocrinol Metab 1984;59:701-704.
44. Rosen CJ, Morrison A, Zhou H, et al. Elderly women in northern New England exhibit seasonal changes in bone mineral density and calciotropic hormones. Bone Miner 1994;25:83-92.
45. Hannan MT, Felson DT, Andersen JJ. Bone mineral density in elderly men and women: Results form the Framingham osteoporosis study. J Bone Miner Res 1992;7:547-553.
46. Steiger P, Cummings SR, Black DM, et al. Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 1992;7;615-632.
47. Greenspan S, Myers E, Maitland L, et al. Trochanteric bone mineral density is associated with type of hip fracture in the elderly. J Bone Miner Res 1994;9:1889-1894.
48. Nevitt M, Johnell O, Black D, et al. Bone mineral density predicts nonspine fractures in very elderly women. Osteop Int 1994;4:325-331.
49. Ebeling P, Jones J, O'Fallon W, et al. Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women. J Clin Endocrinol Metab 1993;77:1384-1387.
50. Ghiron L, Thompson J, Holloway L, et al. Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women. J Bone Miner Res 1995;10:1844-1852.
51. Riggs B, Melton L. Evidence for two distinct syndromes of involutional osteoporosis. Am J Med 1983;75:899-901.
52. Khaw K, Sneyd M, Compston J. Bone density, parathyroid hormone and 25-hydroxyvitamin D concentrations in middle aged women. Br Med J 1992;305:273-277.
53. Sherman S, Tobin J, Hollis B, et al. Biochemical parameters associated with low bone density in healthy men and women. J Bone Miner Res 1992;7:1123-1130.
54. Lips P, Obrant KJ. The pathogenesis and treatment of hip fractures. Osteop Int 1991;1:218-231.
55. Greig C, Young A, Skelton D, et al. Exercise studies with elderly volunteers. Age Ageing 1994;23:185-189.