Identification of a Potent and Selective 5-HT6 Antagonist: One-Step Synthesis of (E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(Benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile

Journal of Medicinal Chemistry

Volumn 46, Issue 23, 2003, Pages 4834-4837

  Wu, Yong Jin ^a   He, Huan ^a   Hu, Shuanghua ^a   Huang, Yazhong ^a   Scola, Paul M ^a   Grant Young, Katharine ^a   Bertekap, Robert L ^a   Wu, Dedong ^a   Gao, Qi ^a   Li, Yi ^a   Klakouski, Cheryl ^a   Westphal, Ryan S ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (BENZENESULFONYL) 3,3 BIS(METHYLSULFANYL)ACRYLONITRILE; 3 (BENZENESULFONYL) 2 (METHYLSULFANYL)PYRIDO[1,2 A]PYRIMIDIN 4 YLIDENAMINE; ACRYLONITRILE; PYRIMIDINE DERIVATIVE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0242267916     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034142q     Document Type: Article

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