Inhibition of Interleukin-4 Production in CD4+ T Cells by Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Ligands: Involvement of Physical Association between PPAR-γ and the Nuclear Factor of Activated T Cells Transcription Factor

Molecular Pharmacology

Volumn 64, Issue 5, 2003, Pages 1169-1179

  Chung, Su Wol ^a   Kang, Bok Yun ^b   Kim, Tae Sung ^a  

^a Chonnam National University   (South Korea)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ANTIGEN; CIGLITAZONE; CYTOKINE; INTERLEUKIN 4; IONOMYCIN; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHORBOL 12 ACETATE 13 MYRISTATE; PROTEIN P300; TRANSCRIPTION FACTOR NFAT;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INHIBITION; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFLAMMATION; LYMPH NODE CELL; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; REL SIMILARITY DOMAIN; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TRANSACTIVATION;

ANIMALS; BINDING SITES; CARCINOGENS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; DNA-BINDING PROTEINS; DRUG INTERACTIONS; E1A-ASSOCIATED P300 PROTEIN; EPOXY COMPOUNDS; INTERLEUKIN-4; IONOMYCIN; LIGANDS; MICE; MICE, INBRED BALB C; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN D2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TETRADECANOYLPHORBOL ACETATE; THIAZOLIDINEDIONES; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0142210174     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.5.1169     Document Type: Article

References (42)

1. Abbas AK, Murphy KM, and Sher A (1996) Functional diversity of helper T lymphocytes. Nature (Lond) 383:787-793.
2. Alleva DG, Johnson EB, Lio FM, Boehme SA, Conlon PJ, and Crowe PD (2002) Regulation of murine macrophage proinflammatory and anti-inflammatory cytokines by ligands for peroxisome proliferators-activated receptor-γ: counter-regulatory activity by IFN-γ. J Leukoc Biol 71:677-685.
3. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, and Struhl K (1995) Current Protocols in Molecular Biology. Greene Associates, New York.
4. Avila PC, Kishiyama JL, and Adelman DC (2002) Pharmacological approaches. Clin Allergy Immunol 16:469-494.
5. Brown MA and Hural J (1997) Functions of IL-4 and control of its expression. Crit Rev Immunol 17:1-32.
6. Choi P and Reiser H (1998) IL-4: role in disease and regulation of production. Clin Exp Immunol 113:317-319.
7. Chung SW, Kang BY, Kim SH, Pak YK, Cho D, Trinchierii G, and Kim TS (2000) Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor-κB. J Biol Chem 275:32681-32687.
8. Forman BM, Chen J, and Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferators-activated receptor α and δ. Proc Natl Acad Sci USA 94:4312-4317.
9. 2 is a ligand for the adipocyte determination factor PPAR-γ. Cell 83:803-812.
10. Fukushi J, Ono M, Morikawa W, Iwamoto Y, and Kuwano M (2000) The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13. J Immunol 165:2818-2823.
11. Garcia-Rodriguez C and Rao A (1998) Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/ CREB-binding protein (CBP). J Exp Med 187:2031-2036.
12. 2 on nitridergic and prostanoid pathway. Nitric Oxide 6:214-220.
13. Gonzalez E, Punzon C, Gonzalez M, and Fresno M (2001) HIV-1 Tat inhibits IL-2 gene transcription through qualitative and quantitative alterations of the cooperative Rel/AP1 complex bound to the CD28RE/AP1 composite element of the IL-2 promoter. J Immunol 166:4560-4569.
14. Harris SG and Phipps RP (2001) The nuclear receptor PPAR-γ is expressed by mouse T lymphocytes and PPAR-γ agonists induce apoptosis. Eur J Immunol 31:1098-1105.
15. 2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. J Immunol 168:1372-1379.
16. Hikida M, Ueura N, Hukue C, and Ohmori H (1999) IL-4-dependent IgE class switching in an anti-trinitrophenyl B-cell hybridoma after engagement of antigen receptors. Immunol Lett 65:161-166.
17. Houseknecht KL, Cole BM, and Steele PJ (2002) Peroxisome proliferator-activated receptor-γ (PPAR-γ) and its ligands: a review. Domest Anim Endocrinol 22:1-23.
18. Kim TS, Chung SW, Kim SH, and Kang BY (2000) Therapeutic anti-tumor response induced with epitope-pulsed fibroblasts genetically engineered for B7. 1 expression and IFN-γ secretion. Int J Cancer 87:427-433.
19. Lee JW, Lee YC, Na SY, Jung DJ, and Lee SK (2001) Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors. Cell Mol Life Sci 58:289-292.
20. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, and Kliewer SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor-γ (PPAR-γ). J Biol Chem 270:12953-12956.
21. Lemberger T, Desvergne B, and Wahli W (1996) Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12:335-363.
22. Li-Weber M, Giasi M, and Krammer PH (1998) Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28. J Biol Chem 273:32460-32466.
23. Marx N, Kehrle B, Kohlhammer K, Grub M, Koenig W, Hombach V, Libby P, and Plutzky J (2002) PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res 90:703-710.
24. McKay LI and Cidlowski JA (1999) Molecular control of immune/ inflammatory responses: interactions between nuclear factor-κB and steroid receptor-signaling pathways. Endocr Rev 20:435-459.
25. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, Afkarian M, and Murphy TL (2000) Signaling and transcription in T helper development. Annu Rev Immunol 18:451-494.
26. Na SY, Kang BY, Chung SW, Han SJ, Ma X, Trinchieri G, Im SY, Lee JW, and Kim TS (1999) Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NF-κB. J Biol Chem 274:7674-7680.
27. Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK, and Milburn MV (1998) Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ. Nature (Lond) 395:137-143.
28. Qi C, Zhu Y, and Reddy JK (2000) Peroxisome proliferator-activated receptors, coactivators and downstream targets. Cell Biochem Biophys 32:187-204.
29. Rao A, Luo C, and Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707-747.
30. Ricote M, Li AC, Willson TM, Kerry CJ, and Glass CK (1998) The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature (Lond) 391:79-82.
31. 2 inhibits multiple steps in the NF-κB signaling pathway. Proc Natl Acad Sci USA 97:4844-4849.
32. Subbaramaiah K, Lin DT, Hart JC, and Dannenberg AJ (2001) Peroxisome proliferator-activated receptor-γ ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300. J Biol Chem 276:12440-12448.
33. Szabo SJ, Glimcher LH, and Ho IC (1997) Genes that regulate interleukin-4 expression in T cells. Curr Opin Immunol 9:776-781.
34. 3-mediated effects. J Immunol 160:209-218.
35. Tara D, Weiss DL, and Brown MA (1993) An activation-responsive element in the murine IL-4 gene is the site of an inducible DNA-protein interaction. J Immunol 151:3617-3626.
36. 3 receptor. Implications for allosteric influences on nuclear receptor structure and function by a DNA element. J Biol Chem 273:10338-10348.
37. Uyemura K, Demer L, Castle SC, Jullien D, Berliner JA, Gately MK, Warrier RR, Pham N, Fogelman AM, and Modlin RL (1996) Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Investig 97:2130-2138.
38. Wang P, Anderson PO, Chen S, Paulsson KM, Sjogren HO, and Li S (2001) Inhibition of the transcription factors AP-1 and NF-κB in CD4 T cells by peroxisome proliferator-activated receptor-γ ligands. Int Immunopharmacol 1:803-812.
39. Wierenga EA, Walchner M, Kick G, Kapsenberg ML, Weiss EH and Messer G (1999) Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element PO in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients. Int Immnunol 11:297-306.
40. Wolfe SA, Zhou P, Dotsch V, Chen L, You A, Ho SN, Crabtree GR, Wagner G, and Verdine GL (1997) Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. Nature (Lond) 385:172-176.
41. Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, and Spiegelman BM (2000) A synthetic antagonist for the peroxisome proliferators-activated receptor γ inhibits adipocyte differentiation. J Biol Chem 275:1873-1877.
42. Yang XY, Wang LH, Chen T, Hodge DR, Resau JH, DaSilva L, and Farrar WL (2000) Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists. PPAR-γ co-association with transcription factor NFAT. J Biol Chem 275:4541-4544.