Strong DNA binding by covalently linked dimeric Lac headpiece: Evidence for the crucial role of the hinge helices

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 11, 2001, Pages 6039-6044

  Kalodimos, Charalampos G ^a   Folkers, Gert E ^a   Boelens, Rolf ^a   Kaptein, Robert ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CURVED DNA; DIMER; GENE PRODUCT; PROTEIN LAC; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COVALENT BOND; DNA BINDING; DNA PROTEIN COMPLEX; GENE CONTROL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN INDUCTION; PROTEIN STABILITY;

BACTERIAL PROTEINS; BINDING SITES; DIMERIZATION; DNA; ESCHERICHIA COLI PROTEINS; OPERATOR REGIONS (GENETICS); OXIDATION-REDUCTION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; REPRESSOR PROTEINS;

EID: 0035933104     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.101129898     Document Type: Article

References (32)

1. Spronk, C. A. E. M., Slijper, M., van Boom, J. H., Kaptein, R. & Boelens, R. (1996) Nat. Struct. Biol. 3, 916-919.
2. Schumacher, M. A., Choi, K. Y., Zalkin, H. & Brennan, K. G. (1994) Science 266, 763-770.
3. Lewis, M., Chang, G., Horton, N. C., Kercher, M. A., Pace, H. C., Schumacher, M. A., Brennan, R. G. & Lu, P. (1996) Science 271, 1247-1254.
4. Spronk, C. A. E. M., Bonvin, A., Radha, P. K., Melacini, G., Boelens, R. & Kaptein, R. (1999) Structure 7, 1483-1492.
5. Bell, C. E. & Lewis, M. (2000) Nat. Struct. Biol. 7, 209-214.
6. Spronk, C. A. E. M., Folkers, G. E., Noordman, A. M. G. W., Wechselberger, R., van der Brink, N., Boelens, R. & Kaptein, R. (1999) EMBO J. 18, 6472-6480.
7. Suckow, J., Markiewicz, P., Kleina, L. G., Miller, J. H., Kisters-Woike, B. & Müller-Hill, B. (1996) J. Mol. Biol. 261, 509-523.
8. Chakerian, A. E. & Matthews, K. S. (1991) J. Biol. Chem. 266, 22206-22214.
9. Cavanagh, J., Fairbrother, W. J., Palmer, A. G., III, & Skelton, N. J. (1996) Protein NMR Spectroscopy: Principles and Practice (Academic, London).
10. Dayie, K. T. & Wagner, G. J. (1994) J. Magn. Reson. 111, 121-126.
11. Pervushin, K., Riek, R., Wider, G. & Wuthrich, K. (1997) Proc. Natl. Acad. Sci. USA 94, 12366-12371.
12. Delaglio, F., Grzesiek, S., Vuister, G., Zhu, G., Pfeifer, J. & Bax, A. (1995) J. Biomol. NMR 6, 277-293.
13. Johnson, B. A. & Blevins, R. A. (1994) J. Biomol. NMR 4, 603-614.
14. Falcon, C. M., Swint-Kruse, L. & Matthews, K. S. (1997) J. Biol. Chem. 272, 26818-26821.
15. Robinson, C. R. & Sauer, R. T. (2000) Biochemistry 39, 12494-12502.
16. Matthews, B. W., Nicholson, H. & Becktel, W. J. (1987) Proc. Natl. Acad. Sci. USA 84, 6663-6667.
17. Matsumura, M., Becktel, W. J., Levitt, M. & Matthews, B. W. (1989) Proc. Natl. Acad. Sci. USA 86, 6562-6566.
18. Sauer, R. T., Hehir, K., Stearman, R. S., Weiss, M. A., Jeitler-Nilsson, A., Suchanek, E. G. & Pabo, C. O. (1986) Biochemistry 25, 5992-5998.
19. Tsodikov, O. V., Saecker, R. M., Melcher, S. E., Levandoski, M. M., Diane, E. F., Capp, M. W. & Record, M. T., Jr. (1999) J. Mol. Biol. 294, 639-655.
20. Moore. I., Gälveiler, L., Grosskopf, D., Schell, J. & Palme, K. (1998) Proc. Natl. Acad. Sci. USA 95, 376-381.
21. Beerli, R. R., Dreier, B. & Bardas, C. F., III (2000) Proc. Natl. Acad. Sci. USA 97, 1495-1500. (First Published January 31, 2000; 10.1073/pnas.040552697)
22. Sasmor, H. M. & Betz, J. L. (1990) Gene 89, 1-6.
23. Falcon, C. M. & Matthews, K. S. (2000) Biochemistry 39, 11074-11083.
24. Horton, N., Lewis, M. & Lu, P. (1997) J. Mol. Biol. 265, 1-7.
25. Ogata, R. T. & Gilbert, W. (1977) Proc. Natl. Acad. Sci. USA 74, 4973-4976.
26. Becker, E. D. (1996) in Encyclopedia of Nuclear Magnetic Resonance, eds. Grant, D. M. & Harris, R. K. (Wiley, Chichester, U.K.), pp. 2409-2415.
27. Zhang, X. & Gottlieb, P. A. (1995) Nucleic Acids Res. 23, 1502-1511.
28. Lehming, N., Santorius, J., Niemoller, M., Genenger, G., Wilcken-Bergmann, B. & Müller-Hill, B. (1987) EMBO J. 6, 3145-3153.
29. Lesser, D. R., Kurpiewski, M. R. & Jen-Jacobson, L. (1990) Science 250, 776-786.
30. Jen-Jacobson, L. (1997) Biopolymers 44, 153-180.
31. Foster, M. P., Wuttke, D. S., Clemes, K. R., Jahnke, W., Radhakrishnan, I., Tennant, L., Reymond, M., Chung, J. & Wright, P. E. (1998) J. Biomol. NMR 12, 51-71.
32. Koradi, R., Billeter, M. & Wüthrich, K. (1996) J. Mol. Graphics 14, 52-55.