T-bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-γ by γδ T cells

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1566-1571

  Yin, Zhinan ^a   Chen, ChangHung ^a   Szabo, Susanne J ^a   Glimcher, Laurie H ^a   Ray, Anuradha ^a   Craft, Joe ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

EID: 0037083457     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1566     Document Type: Article

References (20)

1. IL-10 inhibits cytokine production by activated macrophages
2. Antiproliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine Th lymphocyte clones
3. A novel transcription factor, T-bet, directs Th1 lineage commitment
4. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
5. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
6. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
7. GATA-3 significantly downregulates 1FN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
8. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
9. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo
10. Primary γδ cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation
11. Dominance of IL-12 over IL-4 in γδ T cell differentiation leads to default production of IFN-γ: Failure to down-regulate IL-12 receptor β2 chain expression
12. Turnover of naive- and memory-phenotype T cells
13. Lifespan of γ/δ T cells
14. 7 integrins in mediating human B-cell lymphoma adhesion and chemotaxis on fibronectin through recognition of multiple synergizing binding sites within the central cell-binding domain
15. Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: Phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression
16. - TCR-γδ-expressing peripheral T cells
17. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
18. Lineage commitment in the immune system: The T helper lymphocyte grows up
19. + T cells
20. Distinct effects of T-bet in Th1 lineage commitment and IFN-γ production in CD4 and CD8 T cells