Intracellular Mg2+ depletion depresses the delayed rectifier K+ current in guinea pig ventricular myocytes

Japanese Journal of Physiology

Volumn 48, Issue 1, 1998, Pages 81-89

  Hirahara, Kenji ^a   Matsubayashi, Taro ^a   Matsuura, Hiroshi ^a   Ehara, Tsuguhisa ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Delayed rectifier potassium current; Guinea pig; Intracellular magnesium; Ventricular myocyte

Indexed keywords

MAGNESIUM; POTASSIUM; ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE 5'-O-(3-THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; IONOPHORE; ISOPRENALINE; OKADAIC ACID; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CELL LEVEL; GUINEA PIG; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE WALL; NONHUMAN; POTASSIUM CELL LEVEL; POTASSIUM CURRENT; ANIMAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; HEART VENTRICLE; METABOLISM; PATCH CLAMP; PHOSPHORYLATION; PHYSIOLOGY; TIME;

ADENOSINE TRIPHOSPHATE; ADRENERGIC BETA-AGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART VENTRICLES; IONOPHORES; ISOPROTERENOL; MAGNESIUM; OKADAIC ACID; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; POTASSIUM CHANNELS; TIME FACTORS;

EID: 54749109160     PISSN: 0021521X     EISSN: None     Source Type: Journal    
DOI: 10.2170/jjphysiol.48.81     Document Type: Article

References (31)

1. White RE and Hartzell HC: Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes Science 239: 778-780, 1988
2. 2+ in frog ventricular cells. Pflügers Arch 431 305-317, 1996
3. Agus ZS, Kelepouris E, Dukes I, and Morad M: Cytosolic magnesium modulates calcium channel activity in mammalian ventricular cells Am J Physiol 256: C452-C455, 1989
4. + channels are blocked and inactivated by internal divalent cations. Pflügers Arch 410: 313-320, 1987
5. Horie M, Irisawa H, and Noma A: Voltage-dependent magnesium block of adenosine-triphosphate-sensitive potassium channel in guinea-pig ventricular cells. J Physiol (Lond) 387: 251-272, 1987
6. + current by magnesium ion in guinea pig atrial cells. Am J Physiol 253: H210-H214, 1987
7. 2+. Nature 325 156-159, 1987
8. Matsuda H. Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells. J Physiol (Lond) 397: 237-258, 1988
9. Vandenberg CA: Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proc Natl Acad Sci USA 84: 2560-2564, 1987
10. + current in guinea-pig cardiac myocytes. J Physiol (Lond) 419: 297-320, 1989
11. K in single frog atrial cells. Am J Physiol 257: H1633-1669, 1989
12. Duchatelle-Gourdon I, Hartzell HC, and Lagrutta AL Modulation of the delayed rectifier potassium current in frog cardiomyocytes by β-adrenergic agonists and magnesium. J Physiol (Lond) 415: 251-274, 1989
13. 2+ on basal and β-adrenergic-stimulated delayed rectifier potassium current in frog atrial myocytes. J Physiol (Lond) 435: 333-347, 1991
14. Powell T. Terrar DA, and Twist VW: Electrical properties of individual cells isolated from adult rat ventricular myocardium. J Physiol (Lond) 302: 131-153, 1980
15. Isenberg G and Klöckner U: Calcium tolerant ventricular myocytes prepared by preincubation in a 'KB medium.' Pflügers Arch 395: 6-18, 1982
16. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pflügers Arch 391: 85-100, 1981
17. Soejima M and Noma A: Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells. Pflügers Arch 400: 424-431, 1984
18. Fabiato A and Fabiato F: Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol (Lond) 57: 463-505, 1979
19. Tsien RY and Rink TJ: Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium Biochem Biophys Acta 242: 67-69, 1980
20. Noma A, Nakayama T, Kurachi Y, and Irisawa H: Resting conductances in pacemaker and non-pacemaker heart cells of the rabbit Jpn J Physiol 34: 245-254, 1984
21. White RE and Hartzell HC Magnesium ions in cardiac function. Regulator of ion channels and second messengers. Biochem Pharmacol 38: 859-867, 1989
22. + current in guinea pig heart cells. Am J Physiol 253: H1321-H1324, 1987
23. Yazawa K and Kameyama M: Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea-pig ventricular myocytes. J Physiol (Lond) 421: 135-150, 1990
24. Hartzell HC, Hirayama Y, and Petit-Jacques J: Effects of protein phosphatase and kinase inhibitors on the cardiac L-type Ca current suggest two sites are phosphorylated by protein kinase A and another protein kinase. J Gen Physiol 106: 393-414, 1995
25. Hescheler J, Mieskes G, Rüegg JC, Takai A, and Trautwein W: Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes. Pflügers Arch 412: 248-252, 1988
26. K in guinea pig ventricular myocytes. Am J Physiol 272 H1292-H1301, 1997
27. K to intracellular trypsin: implications for channel structure and function. Cardiovasc Res 26 1131-1136, 1992
28. 2+ and Excitable Membranes, ed. Strata P and Carbone E, Springer-Verlag, Berlin and Heidelberg: pp 1-19, 1991
29. 2+ in rat ventricular myocytes studied with the fluorescent indicator furaptra. Jpn J Physiol 44: 357-378, 1994
30. + current: differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96: 195-215, 1990
31. + current is composed of two currents in guinea pig atrial cells. Am J Physiol 260: H393-H399, 1991