Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

Biochemistry

Volumn 35, Issue 26, 1996, Pages 8495-8503

  Huntington, James A ^a   Olson, Steven T ^b   Fan, Bingqi ^b   Gettins, Peter G W ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; HEPARIN;

ANTICOAGULATION; ARTICLE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; PRIORITY JOURNAL;

ANTITHROMBIN III; BINDING SITES; FACTOR XA; HEPARIN; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN FOLDING; SUBSTRATE SPECIFICITY;

EID: 0029897204     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9604643     Document Type: Article

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