메뉴 건너뛰기




Volumn 19, Issue 5, 2003, Pages 1574-1582

Effects of Three-Dimensional Culturing on Osteosarcoma Cells Grown in a Fibrous Matrix: Analyses of Cell Morphology, Cell Cycle, and Apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOSARCOMA CELLS;

EID: 0141977175     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp034024w     Document Type: Article
Times cited : (21)

References (86)
  • 2
    • 0002500678 scopus 로고
    • Microcarrier technology, present status and perspectives
    • van der Velden-de Groot, C. A. M. Microcarrier technology, present status and perspectives. Cytotechnol. 1995,18, 51-56.
    • (1995) Cytotechnol. , vol.18 , pp. 51-56
    • Van Der Velden-de Groot, C.A.M.1
  • 3
    • 0027525878 scopus 로고
    • Cultivation of mammalian cells as aggregates in bioreactors: Effect of calcium concentration on spatial distribution of viability
    • Peshwa, M. V.; Kyung, Y. S.; McClure, D. B.; Hu, W. S. Cultivation of mammalian cells as aggregates in bioreactors: Effect of calcium concentration on spatial distribution of viability. Biotechnol. Bioeng. 1993, 41, 179-187.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 179-187
    • Peshwa, M.V.1    Kyung, Y.S.2    McClure, D.B.3    Hu, W.S.4
  • 4
    • 0024961817 scopus 로고
    • Production of human immune interferon by recombinant mammalian cells cultivated on microcarriers
    • Smiley, A. L.; Hu, W. S.; Wang, D. I. C. Production of human immune interferon by recombinant mammalian cells cultivated on microcarriers. Biotechnol. Bioeng. 1989, 33, 1182-1190.
    • (1989) Biotechnol. Bioeng. , vol.33 , pp. 1182-1190
    • Smiley, A.L.1    Hu, W.S.2    Wang, D.I.C.3
  • 5
    • 0034281735 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells
    • Sunstrom, N. S.; Gay, R. D.; Wong, D. C.; Kitchen, N. A.; DeBoer, L.; Gray P. P. Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells. Biotechnol Prog. 2000, 16, 698-702.
    • (2000) Biotechnol Prog. , vol.16 , pp. 698-702
    • Sunstrom, N.S.1    Gay, R.D.2    Wong, D.C.3    Kitchen, N.A.4    DeBoer, L.5    Gray, P.P.6
  • 6
    • 0029636792 scopus 로고
    • Protein-free human-human hybridoma cultures in an intercalated-spiral alternate-dead-ended hollow fiber bioreactors
    • Brotherton, J.; Chau, P. C. Protein-free human-human hybridoma cultures in an intercalated-spiral alternate-dead-ended hollow fiber bioreactors. Biotechnol. Bioeng. 1995, 47, 384-400.
    • (1995) Biotechnol. Bioeng. , vol.47 , pp. 384-400
    • Brotherton, J.1    Chau, P.C.2
  • 7
    • 0030993725 scopus 로고    scopus 로고
    • Hybridoma growth in a new generation hollow fiber bioreactor: Antibody productivity and consistency
    • Kessler, N.; Thomas, G.; Gerentes, L.; Delfosse, G.; Armard, M. Hybridoma growth in a new generation hollow fiber bioreactor: antibody productivity and consistency. Cytotechnol. 1997, 24, 109-119.
    • (1997) Cytotechnol. , vol.24 , pp. 109-119
    • Kessler, N.1    Thomas, G.2    Gerentes, L.3    Delfosse, G.4    Armard, M.5
  • 8
    • 0030294324 scopus 로고    scopus 로고
    • Cyclic operation of ceramic-matrix animal cell bioreactors for controlled secretion of an endocrine hormone: A comparison of single-pass and recycle modes of operation
    • Grampp, G. E.; Applegate, M. A.; Stephanopoulos, G. Cyclic operation of ceramic-matrix animal cell bioreactors for controlled secretion of an endocrine hormone: a comparison of single-pass and recycle modes of operation. Biotechnol. Prog. 1996, 12, 837-846.
    • (1996) Biotechnol. Prog. , vol.12 , pp. 837-846
    • Grampp, G.E.1    Applegate, M.A.2    Stephanopoulos, G.3
  • 10
    • 0027908934 scopus 로고
    • Packed bed bioreactor with porous ceramic beads for animal cell culture
    • Park, S.; Stephanopoulos, G. Packed bed bioreactor with porous ceramic beads for animal cell culture. Biotechnol. Bioeng. 1993, 41, 25-34.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 25-34
    • Park, S.1    Stephanopoulos, G.2
  • 11
    • 0025961924 scopus 로고
    • Polyester nonwoven fabric as surfaces for mammalian tissue cell attachment and growth
    • Baker, D. J.; Lages, A. C.; Swartz, R. W.; Sussan, M. V. Polyester nonwoven fabric as surfaces for mammalian tissue cell attachment and growth. INDA J. 1991, 3, 44-48.
    • (1991) INDA J. , vol.3 , pp. 44-48
    • Baker, D.J.1    Lages, A.C.2    Swartz, R.W.3    Sussan, M.V.4
  • 13
    • 0026416662 scopus 로고
    • A fiber-bed bioreactor for anchorage-dependent animal cell cultures: Part I. Bioreactor design and operation
    • Chiou, T.-W.; Murakami, S.; Wang, D. I. C. A fiber-bed bioreactor for anchorage-dependent animal cell cultures: Part I. bioreactor design and operation. Biotechnol. Bioeng. 1991, 37, 755-761.
    • (1991) Biotechnol. Bioeng. , vol.37 , pp. 755-761
    • Chiou, T.-W.1    Murakami, S.2    Wang, D.I.C.3
  • 14
    • 0030570256 scopus 로고    scopus 로고
    • Large-scale production of murine bone marrow cells in an airlift packed bed bioreactor
    • Highfill, J. G.; Haley, S. D.; Kompala, D. S. Large-scale production of murine bone marrow cells in an airlift packed bed bioreactor. Biotechnol. Bioeng. 1996, 50, 514-520.
    • (1996) Biotechnol. Bioeng. , vol.50 , pp. 514-520
    • Highfill, J.G.1    Haley, S.D.2    Kompala, D.S.3
  • 15
    • 0024961994 scopus 로고
    • Fiber bed reactor design for animal cell culture
    • Perry, S. D.; Wang, D. I. C. Fiber bed reactor design for animal cell culture. Biotechnol. Bioeng. 1989, 34, 1-9.
    • (1989) Biotechnol. Bioeng. , vol.34 , pp. 1-9
    • Perry, S.D.1    Wang, D.I.C.2
  • 16
    • 0028500555 scopus 로고
    • Three-dimensional mammalian cell growth on nonwoven polyester fabric disks
    • Petti, S. A.; Sussman, M. V. Three-dimensional mammalian cell growth on nonwoven polyester fabric disks. Biotechnol. Prog. 1994, 10, 548-550.
    • (1994) Biotechnol. Prog. , vol.10 , pp. 548-550
    • Petti, S.A.1    Sussman, M.V.2
  • 18
    • 0026207304 scopus 로고
    • Flow through mixed fibrous porous materials
    • Ethier, C. R. Flow through mixed fibrous porous materials. AIChE J. 1991, 37, 1227-1236.
    • (1991) AIChE J. , vol.37 , pp. 1227-1236
    • Ethier, C.R.1
  • 19
    • 0022736108 scopus 로고
    • The permeability of fibrous porous media
    • Jackson, G. W.; James D. F. The permeability of fibrous porous media. Can. J. Chem. Eng. 1986, 64, 364-374.
    • (1986) Can. J. Chem. Eng. , vol.64 , pp. 364-374
    • Jackson, G.W.1    James, D.F.2
  • 20
    • 0001309767 scopus 로고
    • Model for predicting pressure drop and filtration efficiency in fibrous media
    • Spielman, L.; Goren, S. L. Model for predicting pressure drop and filtration efficiency in fibrous media. Environ. Sci. Technol. 1968, 2, 279-287.
    • (1968) Environ. Sci. Technol. , vol.2 , pp. 279-287
    • Spielman, L.1    Goren, S.L.2
  • 22
    • 0032484697 scopus 로고    scopus 로고
    • Optimizing seeding and culture methods to engineer smooth muscle tissue on biodegradable polymer matrixes
    • Kim, B. S.; Putnam, A. J.; Kulik, T. J.; Mooney, D. J. Optimizing seeding and culture methods to engineer smooth muscle tissue on biodegradable polymer matrixes. Biotechnol. Bioeng. 1998, 57, 46-54.
    • (1998) Biotechnol. Bioeng. , vol.57 , pp. 46-54
    • Kim, B.S.1    Putnam, A.J.2    Kulik, T.J.3    Mooney, D.J.4
  • 24
    • 0035869811 scopus 로고    scopus 로고
    • Thermal compression and characterization of 3-D nonwoven PET matrixes as tissue engineering scaffolds
    • Li, Y.; Ma, T.; Yang, S. T.; Kniss D. A. Thermal compression and characterization of 3-D nonwoven PET matrixes as tissue engineering scaffolds. Biomaterials 2001, 22, 609-618.
    • (2001) Biomaterials , vol.22 , pp. 609-618
    • Li, Y.1    Ma, T.2    Yang, S.T.3    Kniss, D.A.4
  • 25
    • 0033166937 scopus 로고    scopus 로고
    • Tissue engineering human placenta trophoblast cells in 3-D fibrous matrix: Spatial effects on cell proliferation and function
    • Ma, T.; Li, Y.; Kniss, D. A.; Yang, S. T. Tissue engineering human placenta trophoblast cells in 3-D fibrous matrix: spatial effects on cell proliferation and function. Biotechnol. Prog. 1999, 15, 715-724.
    • (1999) Biotechnol. Prog. , vol.15 , pp. 715-724
    • Ma, T.1    Li, Y.2    Kniss, D.A.3    Yang, S.T.4
  • 26
    • 0032971235 scopus 로고    scopus 로고
    • Development of an in vitro human placenta model by cultivation of human trophoblasts in a fiber-based bioreactor system
    • Ma, T.; Yang, S. T.; Kniss, D. A. Development of an in vitro human placenta model by cultivation of human trophoblasts in a fiber-based bioreactor system. Tissue Eng. 1999, 5, 91-102.
    • (1999) Tissue Eng. , vol.5 , pp. 91-102
    • Ma, T.1    Yang, S.T.2    Kniss, D.A.3
  • 27
    • 0034694885 scopus 로고    scopus 로고
    • Effects of pore size in 3-D fibrous matrix on human trophoblast tissue development
    • Ma T.; Li Y.; Yang S. T.; Kniss D. A. Effects of pore size in 3-D fibrous matrix on human trophoblast tissue development. Biotechnol. Bioeng. 2000, 70, 606-618.
    • (2000) Biotechnol. Bioeng. , vol.70 , pp. 606-618
    • Ma, T.1    Li, Y.2    Yang, S.T.3    Kniss, D.A.4
  • 28
    • 0141901131 scopus 로고    scopus 로고
    • Covalent linkage of recombinant hirudin to poly(ethyleneterephthalate) (Dacron): Creation of a novel antithrombin surface
    • Phaneuf, M. D.; Berceli, S. A.; Bide, M. J.; Quist, W. C.; LoGerfo, F. W. Covalent linkage of recombinant hirudin to poly(ethyleneterephthalate) (Dacron): creation of a novel antithrombin surface. Biomaterials 1997, 28, 7755-765.
    • (1997) Biomaterials , vol.28 , pp. 7755-7765
    • Phaneuf, M.D.1    Berceli, S.A.2    Bide, M.J.3    Quist, W.C.4    LoGerfo, F.W.5
  • 30
    • 0037125260 scopus 로고    scopus 로고
    • A fibrous-bed bioreactor for continuous production of developmental endothelial locus-1 by osteosarcoma cells
    • Chen, C.; Huang, Y. L.; Yang, S. T. A fibrous-bed bioreactor for continuous production of developmental endothelial locus-1 by osteosarcoma cells. J. Biotechnol. 2002, 97, 23-39.
    • (2002) J. Biotechnol. , vol.97 , pp. 23-39
    • Chen, C.1    Huang, Y.L.2    Yang, S.T.3
  • 33
    • 0032929251 scopus 로고    scopus 로고
    • Analysis of cell viability and differential activity of mouse hepatocytes under 3D and 2D culture in agarose gel
    • Ise, H.; Takashima, S.; Nagaoka, M.; Ferdous, A.; Akaike, T. Analysis of cell viability and differential activity of mouse hepatocytes under 3D and 2D culture in agarose gel. Biotechnol. Lett. 1999, 21, 209-213.
    • (1999) Biotechnol. Lett. , vol.21 , pp. 209-213
    • Ise, H.1    Takashima, S.2    Nagaoka, M.3    Ferdous, A.4    Akaike, T.5
  • 34
    • 0030697292 scopus 로고    scopus 로고
    • Three-dimensional cell cultures: From molecular mechanisms to clinical applications
    • Mueller-Klieser, W. Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am. J. Physiol. Cell Physiol. 1997, 273, C1109-C1123.
    • (1997) Am. J. Physiol. Cell Physiol. , vol.273
    • Mueller-Klieser, W.1
  • 35
    • 85088078361 scopus 로고    scopus 로고
    • Apoptosis in cell culture technology
    • Al-Rubeai, M. Apoptosis in cell culture technology. Adv. Biochem. Eng./Biotechnol. 1998, 9, 225-247.
    • (1998) Adv. Biochem. Eng./Biotechnol. , vol.9 , pp. 225-247
    • Al-Rubeai, M.1
  • 36
    • 0028765762 scopus 로고
    • Induction of apoptosis in nutrient deprived cultures of hybridoma and myeloma cells
    • Mercille, S.; Massie, B. Induction of apoptosis in nutrient deprived cultures of hybridoma and myeloma cells. Biotechnol. Bioeng. 1994, 44, 1140-1154.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 1140-1154
    • Mercille, S.1    Massie, B.2
  • 37
    • 0032486578 scopus 로고    scopus 로고
    • In hybridoma culures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of bcl-2 gene
    • Simpson, H. N.; Sigh, R. P.; Perani, C.; Al-Rubeai, M. In hybridoma culures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of bcl-2 gene. Biotechnol. Bioeng. 1998, 59, 90-98.
    • (1998) Biotechnol. Bioeng. , vol.59 , pp. 90-98
    • Simpson, H.N.1    Sigh, R.P.2    Perani, C.3    Al-Rubeai, M.4
  • 39
    • 0027535559 scopus 로고
    • Toward an understanding of the molecular mechanisms of physiological cell death
    • Vaux, D. L. Toward an understanding of the molecular mechanisms of physiological cell death. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 786-789.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 786-789
    • Vaux, D.L.1
  • 40
    • 0029256479 scopus 로고
    • Death mechanisms of animal cells in conditions of intensive agitation
    • Al-Rubeai, M.; Singh, R. P.; Goldman, M. H., Emery, A. N. Death mechanisms of animal cells in conditions of intensive agitation. Biotechnol. Bioeng. 1995, 45, 463-472.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 463-472
    • Al-Rubeai, M.1    Singh, R.P.2    Goldman, M.H.3    Emery, A.N.4
  • 41
    • 0025499794 scopus 로고
    • Cell cycle- and growth phase-dependent variations in size distribution, antibody productivity, and oxygen demand in hybridoma cultures
    • Octavio, T. R.; Mutharasan R. Cell cycle- and growth phase-dependent variations in size distribution, antibody productivity, and oxygen demand in hybridoma cultures. Biotechnol. Bioeng. 1990, 36, 839-848.
    • (1990) Biotechnol. Bioeng. , vol.36 , pp. 839-848
    • Octavio, T.R.1    Mutharasan, R.2
  • 42
    • 0028472596 scopus 로고
    • Cell cycle kinetics and monoclonal antibody productivity of hybridoma cells during perfusion culture
    • Park, S. H.; Ryu, D. Y. Cell cycle kinetics and monoclonal antibody productivity of hybridoma cells during perfusion culture. Biotechnol. Bioeng. 1994, 44, 361-367.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 361-367
    • Park, S.H.1    Ryu, D.Y.2
  • 43
    • 0005667062 scopus 로고    scopus 로고
    • Biological significance and molecular mechanisms of p53-induced apoptosis
    • Bedi, A.; Mookerjee, B. Biological significance and molecular mechanisms of p53-induced apoptosis. Apoptosis 1998, 3, 237-244.
    • (1998) Apoptosis , vol.3 , pp. 237-244
    • Bedi, A.1    Mookerjee, B.2
  • 44
    • 0032210683 scopus 로고    scopus 로고
    • Molecular regulation of cell-cycle progression and apoptosis in mammalian cells: Implications for biotechnology
    • Fussenegger, M.; Bailey, J. E. Molecular regulation of cell-cycle progression and apoptosis in mammalian cells: implications for biotechnology. Biotechnol. Prog. 1998, 14, 807-833.
    • (1998) Biotechnol. Prog. , vol.14 , pp. 807-833
    • Fussenegger, M.1    Bailey, J.E.2
  • 45
    • 0033590255 scopus 로고    scopus 로고
    • A mathematical description of regulation of the G1-S transition of the mammalian cell cycle
    • Hatzimanikatis, V.; Lee, K. H.; Bailey, J. E. A mathematical description of regulation of the G1-S transition of the mammalian cell cycle. Biotechnol. Bioeng. 1999, 65, 631-637.
    • (1999) Biotechnol. Bioeng. , vol.65 , pp. 631-637
    • Hatzimanikatis, V.1    Lee, K.H.2    Bailey, J.E.3
  • 46
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F. R.; Wyllie, A. H.; Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 47
    • 0032785413 scopus 로고    scopus 로고
    • Cytokines as suppressors of apoptosis
    • Lotem, J.; Sachs, L. Cytokines as suppressors of apoptosis. Apoptosis 1999, 4 (3), 187-196.
    • (1999) Apoptosis , vol.4 , Issue.3 , pp. 187-196
    • Lotem, J.1    Sachs, L.2
  • 48
    • 0028362879 scopus 로고
    • Cell death gene: Drosophilla enters the field
    • Raff, M. Cell death gene: Drosophilla enters the field. Science 1994, 264, 668-683.
    • (1994) Science , vol.264 , pp. 668-683
    • Raff, M.1
  • 50
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis: An overview of cell death
    • Majno, G.; Joris, J. Apoptosis, oncosis, and necrosis: an overview of cell death. Am. J. Path. 1995, 146, 3-16.
    • (1995) Am. J. Path. , vol.146 , pp. 3-16
    • Majno, G.1    Joris, J.2
  • 51
    • 0037707222 scopus 로고    scopus 로고
    • Effects of three-dimensional scaffolds on cell organization and tissue development
    • Li, Y.; Yang, S-T. Effects of three-dimensional scaffolds on cell organization and tissue development. Biotechnol. Bioprocess Eng. 2001, 6, 311-325.
    • (2001) Biotechnol. Bioprocess Eng. , vol.6 , pp. 311-325
    • Li, Y.1    Yang, S.-T.2
  • 53
    • 0001877780 scopus 로고    scopus 로고
    • Measurements of cell death by flow cytometry
    • Cotter T. G., Martin, S. J., Eds.; Portland Press: London
    • Darzynkiewicz, Z.; Li, X. Measurements of cell death by flow cytometry. In: Techniques in Apoptosis: A User's Guide. Cotter T. G., Martin, S. J., Eds.; Portland Press: London, 1996; pp 71-106.
    • (1996) Techniques in Apoptosis: A User's Guide , pp. 71-106
    • Darzynkiewicz, Z.1    Li, X.2
  • 54
    • 0029619116 scopus 로고
    • Labeling DNA strand breaks with BrdUTP: Detection of apoptosis and cell proliferation
    • Li, X.; Darzynkiewicz, Z. Labeling DNA strand breaks with BrdUTP: detection of apoptosis and cell proliferation. Cell Prolif. 1995, 28, 571-579.
    • (1995) Cell Prolif. , vol.28 , pp. 571-579
    • Li, X.1    Darzynkiewicz, Z.2
  • 55
    • 0027985477 scopus 로고
    • A study of apoptosis in normal and physiological nervous tissue after in-situ end-labeling of DNA strand breaks
    • Migheli, A.; Cavalla, P.; Marino, S.; Schiffer, D. A study of apoptosis in normal and physiological nervous tissue after in-situ end-labeling of DNA strand breaks. J. Neuropath. Exp. Neurol. 1994, 53, 606-616.
    • (1994) J. Neuropath. Exp. Neurol. , vol.53 , pp. 606-616
    • Migheli, A.1    Cavalla, P.2    Marino, S.3    Schiffer, D.4
  • 56
    • 0014589578 scopus 로고
    • Mechanical method for the efficient release of contact inhibition
    • Kolodny, G. M.; Gross, P. R. Mechanical method for the efficient release of contact inhibition. Exp. Cell Res. 1969, 57, 423-432.
    • (1969) Exp. Cell Res. , vol.57 , pp. 423-432
    • Kolodny, G.M.1    Gross, P.R.2
  • 59
    • 0025819161 scopus 로고
    • Ultraviolet B irradiation of human leukemia HL-60 cells in vitro induces apoptosis
    • Martin, S. J.; Cotter, T. G. Ultraviolet B irradiation of human leukemia HL-60 cells in vitro induces apoptosis. Int. J. Radiat. Biol. 1991, 59, 1001-1016.
    • (1991) Int. J. Radiat. Biol. , vol.59 , pp. 1001-1016
    • Martin, S.J.1    Cotter, T.G.2
  • 60
    • 0030772293 scopus 로고    scopus 로고
    • Camptothecin causes cell cycle perturbations within T-lymphoblastoid cells followed by dose dependent induction of apoptosis
    • Johnson, N.; Ng, T. T.; Parkin, J. M. Camptothecin causes cell cycle perturbations within T-lymphoblastoid cells followed by dose dependent induction of apoptosis. Leuk. Res. 1997, 21, 961-972.
    • (1997) Leuk. Res. , vol.21 , pp. 961-972
    • Johnson, N.1    Ng, T.T.2    Parkin, J.M.3
  • 61
    • 0025786007 scopus 로고
    • Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry
    • Telford, W. G.; King, L. E.; Fraker, P. J. Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry. Cell Prolif. 1991, 24, 447-459.
    • (1991) Cell Prolif. , vol.24 , pp. 447-459
    • Telford, W.G.1    King, L.E.2    Fraker, P.J.3
  • 62
    • 0029036412 scopus 로고
    • Alternation in mitochodrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
    • Petit, P. X.; Lecoeur, H.; Zorn, E.; Dauguet, C.; Mignotte, B.; Gougeon, M. Alternation in mitochodrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J. Cell Biol. 1995, 130, 157.
    • (1995) J. Cell Biol. , vol.130 , pp. 157
    • Petit, P.X.1    Lecoeur, H.2    Zorn, E.3    Dauguet, C.4    Mignotte, B.5    Gougeon, M.6
  • 64
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff, M. C. Social controls on cell survival and cell death. Nature 1992, 356, 397-399.
    • (1992) Nature , vol.356 , pp. 397-399
    • Raff, M.C.1
  • 66
    • 0032007559 scopus 로고    scopus 로고
    • Overcoming apoptosis: New methods for improving protein-expression systems
    • Mastrangelo, A. J.; Betenbaugh, M. J. Overcoming apoptosis: new methods for improving protein-expression systems. Trends Biotechnol. 1998, 16, 88-95.
    • (1998) Trends Biotechnol. , vol.16 , pp. 88-95
    • Mastrangelo, A.J.1    Betenbaugh, M.J.2
  • 67
    • 0028979478 scopus 로고
    • Starvation-induced programmed death of hybridoma cell: Prevention by amino acid mixtures
    • Franek, F. Starvation-induced programmed death of hybridoma cell: prevention by amino acid mixtures. Biotechnol. Bioeng. 1995, 45, 86-90.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 86-90
    • Franek, F.1
  • 68
    • 0030249013 scopus 로고    scopus 로고
    • Protection of B lymphocyte hybridoma against starvation-induced apoptosis: Survival-signal role of some amino acids
    • Franek, F.; Sramkova, K. Protection of B lymphocyte hybridoma against starvation-induced apoptosis: survival-signal role of some amino acids. Immunol. Lett. 1996, 52, 139-144.
    • (1996) Immunol. Lett. , vol.52 , pp. 139-144
    • Franek, F.1    Sramkova, K.2
  • 69
    • 0028986332 scopus 로고
    • Cell death (apoptosis) in cell culture systems
    • Cotter, T. G.; Al-Rubeai, M. Cell death (apoptosis) in cell culture systems. Trends Biotechnol. 1995, 13, 150-155.
    • (1995) Trends Biotechnol. , vol.13 , pp. 150-155
    • Cotter, T.G.1    Al-Rubeai, M.2
  • 70
    • 0026588374 scopus 로고
    • N-(2-mercaptoethyl)-1,3-propanediamine (WR1065) protects thymocytes from programmed cell death
    • Ramakrishnan, N.; Catravas, G. N-(2-mercaptoethyl)-1,3-propanediamine (WR1065) protects thymocytes from programmed cell death. J. Immunol. 1992, 148, 1817-1821.
    • (1992) J. Immunol. , vol.148 , pp. 1817-1821
    • Ramakrishnan, N.1    Catravas, G.2
  • 71
    • 0343196706 scopus 로고    scopus 로고
    • A novel cytostatic process enhances the productivity of Chinese hamster ovary cells
    • Fussenegger, M.; Mazur, X.; Bailey, J. E. A novel cytostatic process enhances the productivity of Chinese hamster ovary cells. Biotechnol. Bioeng. 1997, 55, 927-939.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 927-939
    • Fussenegger, M.1    Mazur, X.2    Bailey, J.E.3
  • 72
    • 0343757505 scopus 로고    scopus 로고
    • Establishment of an apoptosis-resistant and growth controllable cell line by tansfecting with inducible anti-sense c-jun gene
    • Kim, Y. H.; Iida, T.; Fujita, T.; Terada, S.; Kitayama, A.; Ueda, H.; Prochownik, E. V.; Suzuki, E. Establishment of an apoptosis-resistant and growth controllable cell line by tansfecting with inducible anti-sense c-jun gene. Biotechnol. Bioeng. 1998, 58, 65-72.
    • (1998) Biotechnol. Bioeng. , vol.58 , pp. 65-72
    • Kim, Y.H.1    Iida, T.2    Fujita, T.3    Terada, S.4    Kitayama, A.5    Ueda, H.6    Prochownik, E.V.7    Suzuki, E.8
  • 73
    • 0030571210 scopus 로고    scopus 로고
    • Enhancement of survivability of mammalian cells by overexpression of the apoptosis-suppressor gene bcl-2
    • Singh, P. R.; Emery, A. N.; Al-Rubeai, M. Enhancement of survivability of mammalian cells by overexpression of the apoptosis-suppressor gene bcl-2. Biotechnol. Bioeng. 1996, 52, 66-175.
    • (1996) Biotechnol. Bioeng. , vol.52 , pp. 66-175
    • Singh, P.R.1    Emery, A.N.2    Al-Rubeai, M.3
  • 74
    • 0141901132 scopus 로고
    • Overexpression of bcl-2, apoptosis suppressing gene: Prolonged viable culture period of hybridoma and enhanced antibody production
    • Itoh, Y.; Ueda, H.; Suzuki, E. Overexpression of bcl-2, apoptosis suppressing gene: prolonged viable culture period of hybridoma and enhanced antibody production. Biotechnol. Bioeng. 1995, 42, 1029-1036.
    • (1995) Biotechnol. Bioeng. , vol.42 , pp. 1029-1036
    • Itoh, Y.1    Ueda, H.2    Suzuki, E.3
  • 75
    • 0031554004 scopus 로고    scopus 로고
    • Prevention of hybridoma cell death by bcl-2 during suboptimal culture conditions
    • Simpson, H. N.; Milner, A. E.; Al-Rubeai, M. Prevention of hybridoma cell death by bcl-2 during suboptimal culture conditions. Biotechnol. Bioeng. 1997, 54, 1-16.
    • (1997) Biotechnol. Bioeng. , vol.54 , pp. 1-16
    • Simpson, H.N.1    Milner, A.E.2    Al-Rubeai, M.3
  • 76
    • 0025701405 scopus 로고
    • Imobilization can improve the stability of hybridoma antibody productivity in serum-free media
    • Lee, G. M.; Palsson, B. Imobilization can improve the stability of hybridoma antibody productivity in serum-free media. Biotechnol. Bioeng. 1990, 36, 1049-1055.
    • (1990) Biotechnol. Bioeng. , vol.36 , pp. 1049-1055
    • Lee, G.M.1    Palsson, B.2
  • 77
    • 0031945008 scopus 로고    scopus 로고
    • Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells
    • Fussenegger, M.; Schlatter, S.; Dätwyler, D.; Mazur, X.; Bailey, J. E. Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells. Nat. Biotechnol. 1998, 16, 468-472.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 468-472
    • Fussenegger, M.1    Schlatter, S.2    Dätwyler, D.3    Mazur, X.4    Bailey, J.E.5
  • 78
    • 0032170308 scopus 로고    scopus 로고
    • Higher productivity of growth-arrested Chinese hamster ovary (CHO) cells expressing cyclin-dependent kinase inhibitor p27
    • Mazur, X.; Fussenegger, M.; Renner, W. A.; Bailey, J. E. Higher productivity of growth-arrested Chinese hamster ovary (CHO) cells expressing cyclin-dependent kinase inhibitor p27. Biotechnol. Prog. 1998, 14, 705-713.
    • (1998) Biotechnol. Prog. , vol.14 , pp. 705-713
    • Mazur, X.1    Fussenegger, M.2    Renner, W.A.3    Bailey, J.E.4
  • 79
    • 0033167341 scopus 로고    scopus 로고
    • The production of monoclonal antibody in growth-arrested hybridoma cultivated in suspension and immobilized modes
    • Seifert, D. B.; Phillips, J. A. The production of monoclonal antibody in growth-arrested hybridoma cultivated in suspension and immobilized modes. Biotechnol. Prog. 1999, 15, 655-666.
    • (1999) Biotechnol. Prog. , vol.15 , pp. 655-666
    • Seifert, D.B.1    Phillips, J.A.2
  • 80
    • 0025428793 scopus 로고
    • Enhanced antibody production at slowed growth rates: Experimental demonstration and a simple structured model
    • Suzuli, E.; Ollis, D. F. Enhanced antibody production at slowed growth rates: experimental demonstration and a simple structured model. Biotechnol. Prog. 1990, 6, 231-236.
    • (1990) Biotechnol. Prog. , vol.6 , pp. 231-236
    • Suzuli, E.1    Ollis, D.F.2
  • 81
    • 0030440611 scopus 로고    scopus 로고
    • Foreign protein expression from S phase specific promoters in continuous cultures of recombinant CHO cells
    • Banik, G. G.; Todd, P. W.; Kompala, D. S. Foreign protein expression from S phase specific promoters in continuous cultures of recombinant CHO cells. Cytotechnol. 1996, 22, 179-184.
    • (1996) Cytotechnol. , vol.22 , pp. 179-184
    • Banik, G.G.1    Todd, P.W.2    Kompala, D.S.3
  • 82
    • 0027910068 scopus 로고
    • Foreign gene expression of β-galactosidase during cell cycle phases in recombinant CHO cells
    • Gu, M. B.; Todd, P. W.; Kompala, D. S. Foreign gene expression of β-galactosidase during cell cycle phases in recombinant CHO cells. Biotechnol. Bioeng. 1993, 42, 1113-1123.
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 1113-1123
    • Gu, M.B.1    Todd, P.W.2    Kompala, D.S.3
  • 83
    • 0032421111 scopus 로고    scopus 로고
    • Engineering Chinese hamster ovary (CHO) cells to achieve an inverse growth-associated production of a foreign protein, β-galactosidase
    • Lee, F. W. F.; Elias, C. B.; Todd, P. W.; Kompala, D. S. Engineering Chinese hamster ovary (CHO) cells to achieve an inverse growth-associated production of a foreign protein, β-galactosidase. Cytotechnol. 1999, 28, 73-80.
    • (1999) Cytotechnol. , vol.28 , pp. 73-80
    • Lee, F.W.F.1    Elias, C.B.2    Todd, P.W.3    Kompala, D.S.4
  • 84
    • 84988106827 scopus 로고
    • A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH
    • Miller, W. M.; Blanch, H. W.; Wilke, C. R. A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH. Biotechnol. Bioeng. 1988, 32, 947-965.
    • (1988) Biotechnol. Bioeng. , vol.32 , pp. 947-965
    • Miller, W.M.1    Blanch, H.W.2    Wilke, C.R.3
  • 85
    • 0028486197 scopus 로고
    • Hyperosmotic hybridoma cell cultures: Increased monoclonal antibody production with addition of glycine betaine
    • Øyaas, K.; Ellingsen, T. E.; Dyrset, N.; Levine, D. W. Hyperosmotic hybridoma cell cultures: increased monoclonal antibody production with addition of glycine betaine. Biotechnol. Bioeng. 1994, 44, 991-998.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 991-998
    • Øyaas, K.1    Ellingsen, T.E.2    Dyrset, N.3    Levine, D.W.4
  • 86
    • 0027024341 scopus 로고
    • Specific monoclonal antibody productivity and the cell cycle-comparisons of batch, continuous and perfusion cultures
    • Al-Rubeai, M.; Emery, A. N.; Chalder, S.; Jan, D. C. Specific monoclonal antibody productivity and the cell cycle-comparisons of batch, continuous and perfusion cultures. Cytotechnol. 1992, 9, 85-97.
    • (1992) Cytotechnol. , vol.9 , pp. 85-97
    • Al-Rubeai, M.1    Emery, A.N.2    Chalder, S.3    Jan, D.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.