Camptothecin causes cell cycle perturbations within T-lymphoblastoid cells followed by dose dependent induction of apoptosis

Leukemia Research

Volumn 21, Issue 10, 1997, Pages 961-972

  Johnson, Nicholas ^a,b   Ng, Tony T C ^a   Parkin, Jacqueline M ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Camptothecin; Cell cycle; Jurkat t cell

Indexed keywords

CAMPTOTHECIN; DNA POLYMERASE; RNA POLYMERASE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DNA SYNTHESIS; DOSE RESPONSE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOBLASTOID CELL; MITOSIS; PRIORITY JOURNAL; T LYMPHOBLAST;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APHIDICOLIN; APOPTOSIS; CAMPTOTHECIN; CELL CYCLE; CELL SURVIVAL; DNA FRAGMENTATION; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; KINETICS; RNA; T-LYMPHOCYTES;

EID: 0030772293     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(97)00077-5     Document Type: Article

References (37)

1. Lynch, D. H., Ramsdell, F. and Alderson, M. R., Fas and FasL in the homeostatic regulation of immune responses. Immunology Today, 1995, 16, 569.
2. Akbar, A. N., Borthwick, N., Salmon, M., Gombert, W., Bofill, M., Shamsadeen, N., Pilling, D., Pett, S., Grundy, J. E. and Janossy, G., The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. Journal of Experimental Medicine, 1993, 178, 427.
3. Dive, C. and Hickman, J. A., Drug-target interactions: only the first step in a commitment to a programmed cell death? British Journal of Cancer, 1991, 64, 192.
4. Slichenmeyer, W. J., Rowinsky, E. K., Donehower, R. C. and Kaufmann, S. H., The current status of camptothecin analogs as anticancer agents. Journal of the National Cancer Institute, 1993, 85, 271.
5. Lui, L. F., DNA topoisomerase poisons as antitumour drugs. Annual Review of Biochemistry, 1989, 58, 351.
6. Schellens, J. H. M., Creemers, G. J., Beijnen, J. H., Rosing, H., De Boer-Dennert, M., McDonald, M., Davies, B. and Verwij, J., Bioavailability and pharmacokinetics of oral topecan: a new topoisomerase I inhibitor. British Journal of Cancer, 1996, 73, 1268.
7. Dancey, J. and Eisenhauer, E. A., Current perspectives on camptothecin in cancer treatment. British Journal of Cancer, 1996, 74, 327.
8. Hertzberg, R. P., Caranfa, M. J. and Hecht, S. M., On the mechanism of topoisomerase inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex. Biochemistry, 1989, 28, 4629.
9. Wang, J. C., DNA topoisomerases. Annual Review of Biochemistry, 1985, 54, 665.
10. Hsiang, Y.-H., Lihou, M. G. and Liu, L. F., Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Research, 1989, 49, 5077.
11. Chou, S., Kaneko, M., Nakaya, K. and Nakamura, Y., Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin. Biochemical and Biophysical Research Communications, 1990, 166, 160.
12. Aller, P., Ruis, C., Mata, F., Zorilla, A., Cabanas, C., Bellon, T. and Bernabeu, C., Camptothecin induces differentiation-related genes in U937 human promonocytic leukemia cells. Cancer Research, 1992, 52, 1245.
13. Kaufmann, S. H., Induction of endonucleolytic DNA cleavage in human myelogenous leukemia cells by etoposide, camptothecin and other cytotoxic anticancer drugs: a cautionary note. Cancer Research, 1989, 49, 5870.
14. Lennon, S. V., Martin, S. J. and Cotter, T. G., Dose-dependent induction of apoptosis in human tumor cell lines by widely divergent stimuli. Cell Proliferation, 1991, 24, 203.
15. Gorczyca, W., Gong, J., Ardelt, B., Traganos, F. and Darzynkiewicz, Z., The cell Cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumour agents. Cancer Research, 1993, 53, 3186.
16. Solary, E., Bertrand, R., Kohn, K. W. and Pommier, Y., Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors. Blood, 1993, 81, 1359.
17. Porfiri, E., Hoffbrand, A. V. and Wickremasinghe, R. G., Granulocytic differentiation of HL-60 human promyelocytic leukemia cells is preceded by a reduction in levels of inositol lipid-derived second messengers. Experimental Hematology, 1988, 16, 641.
18. Gorzyca, W., Melamed, M. R. and Darzynkiewicz, Z., Apoptosis of S-phase HL-60 cells induced by DNA topoisomerases: Detection of DNA strand breaks by flow cytometry using the in situ nick translation assay. Toxicology Letters, 1993, 67, 249.
19. Cotter, T. G., Glynn, J. M., Echeverri, F. and Green, D. G., The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle. Anticancer Research, 1992, 12, 773.
20. O'Conner, P. M., Ferris, D. K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D. L. and Kohn, D. W., G2 delay induced by nitrogen mustard in human cells affects cyclin B1/cdc2-kinase complexes differently. Journal of Biological Chemistry, 1993, 268, 8298.
21. Nicolleti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C., A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods, 1991, 139, 271.
22. Chapman, R. S., Whetton, A. D., Chresta, C. M. and Dive, C., Characterisation of drug resistance mediated via the suppression of apoptosis by abelson protein tyrosine kinase. Molecular Pharmacology, 1995, 48, 334.
23. Wyllie, A. H., Kerr, J. F. R. and Currie, A. R., Cell death: the significance of apoptosis. International Review of Cytology, 1980, 68, 251.
24. Arends, M. J., Morris, R. G. and Wyllie, A. H., Apoptosis: the role of the endonuclease. American Journal of Pathology, 1990, 136, 593.
25. Poot, M., Hiller, K. H., Heimpel, S. and Hoehn, H., Distinct patterns of cell cycle disturbance elicited by compounds interfering with DNA topoisomerse I and II activity. Experimental Cell Research, 1995, 218, 326.
26. Vaux, D. L. and Strasser, A., The molecular biology of apoptosis. Proceedings of the National Academy of Sciences of the USA, 1996, 93, 2239.
27. Del Bino, G. and Darzynkiewicz, Z., Camptothecin, teniposide, or 04′-(9-acridylamine)-3-methanesulfon-m-aniside, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells. Cancer Research, 1991, 51, 1165.
28. Zhu, L. and Anasetti, C., Cell cycle control of apoptosis in human leukaemia T cells. Journal of Immunology, 1995, 154, 192.
29. Borner, M. M., Myers, C. E., Sartor, P., Sei, Y., Toku, T., Trepel, J. B. and Schneider, E., Drug induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3. Cancer Research, 1995, 55, 2122.
30. Bruno, S., Giaretti, W. and Darzynkiewicz, Z., Effect of camptothecin on mitogenic stimulation of human lymphocytes: Involvement of DNA topoisomerase I in cell transition from G0 to G1 phase of the cell cycle and in DNA replication. Journal of Cellular Physiology, 1992, 151, 478.
31. Rossi, F., Labourier, E., Forne, T., Divita, G., Riou, J. F., Antoine, E., Cathata, G., Brunel, C. and Tazi, J., Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I. Nature, 1996, 381, 80.
32. Lane, A. P., A death in the life of p53. Nature, 1993, 362, 786.
33. Lowe, S. W., Schmitt, E. W., Smith, S. W., Osborne, B. A. and Jacks, T., p53 is required for radiation induced apoptosis in mouse thymocytes. Nature, 1993, 362, 847.
34. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L. and Wyllie, A. H., Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 1993, 362, 849.
35. Gualberto, A. and Baldwin, A. S. Jr., p53 and Sp1 interact and cooperate in the tumour necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat. Journal of Biological Chemistry, 1995, 270, 19680.
36. Shimuzu, T., O'Connor, P. M., Kohn, K. W. and Pommier, Y., Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukaemia cell line HL60 cells undergoing apoptosis induced by DNA damage. Cancer Research, 1995, 55, 228.
37. Meikrantz, W. and Schegel, R., Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. Journal of Biological Chemistry, 1996, 271, 10205.