A mathematical description of regulation of the G1-S transition of the mammalian cell cycle

Biotechnology and Bioengineering

Volumn 65, Issue 6, 1999, Pages 631-637

  Hatzimanikatis, V ^a   Lee, K H ^b   Bailey, J E ^c  

^a CARGILL INC   (United States)

^b Cornell University   (United States)

^c ETH ZURICH   (Switzerland)

Author keywords

Cancer; Cell cycle; Metabolic engineering

Indexed keywords

BIFURCATION (MATHEMATICS); MATHEMATICAL MODELS; METABOLISM; MOLECULAR STRUCTURE; PROTEINS;

TUMOR BIOLOGY;

CYTOLOGY;

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; MAMMAL CELL; MATHEMATICAL MODEL; NONHUMAN;

ANIMALS; CARRIER PROTEINS; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; G1 PHASE; KINETICS; MAMMALS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RETINOBLASTOMA PROTEIN; S PHASE; THERMODYNAMICS; TIME FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0033590255     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19991220)65:6<631::AID-BIT3>3.0.CO;2-7     Document Type: Article

References (42)

1. Bailey JE, Ollis D. 1986. Biochemical Engineering Fundamentals. 2nd edition. New York: McGraw-Hill, p 100-105.
2. Dulic V, Lees E, Reed SI. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257:1958-1961.
3. Elledge SJ. 1996. Cell cycle checkpoints: Preventing an identity crisis. Science 274:1664-1672.
4. Fueyo J, Gomez-Manzano C, Yung WK, Liu TJ, Alemany R, McDonnell TJ, Shi X, Rao JS, Levin VA, Kyritsis AP. 1998. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat Med 4:685-690.
5. Fussenegger M, Bailey JE. 1998. Molecular regulation of cell-cycle progression and apoptosis in mammalian cells: Implications for biotechnology. Biotechnol Progr 14:807-833.
6. Geng Y, Eaton EN, Picon M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA. 1996. Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12:1173-1180.
7. Goldbeter A. 1991. A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. Proc Natl Acad Sci USA 88: 9107-9111.
8. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, et al. 1995. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 6: 387-400.
9. Hartwell L. 1995. Introduction to cell cycle controls. In: Hutchison C, Glover D, editors. Cell Cycle Control. Oxford: TRL Press.
10. Hartwell L, Kastan MB. 1994. Cell cycle control and cancer. Science 266:1821-1828.
11. Hatzimanikatis V, Lee KH. 1999. Dynamical analysis of gene networks requires both mRNA and protein expression information. Metabolic Engineering 1:E1-E7.
12. Hatzimanikatis V, Lee KH, Renner WA, Bailey JE. 1995. A mathematical model for the G1/S transition of the mammalian cell cycle. Biotechnol Lett 17:669-674.
13. Helin K, Harlow E. 1993. The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol. 3:43-46.
14. Hiebert SW, Chellappan SP, Horowitz JM, Nevins JR. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev 6:177-185.
15. Keyomarsi K, Pardee AB. 1993. Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci USA 90:1112-1116.
16. Knoblich JA, Sauer K, Jones L, Richardson H, Saint R, Lehner CF. 1994. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis and is required for the arrest of cell proliferation. Cell 77:107-120.
17. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM. 1992. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257:1689-1694.
18. LaThangue N. 1994. DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem Sci 19:108-114.
19. Lee KH, Sburlati A, Renner W, Bailey JE. 1995. Deregulated expression of cloned transcription factor E2F-1 in Chinese hamster ovary cells shifts protein patterns and activates growth in protein-free medium. Biotechnol Bioeng 50:273-279.
20. Lees E, Faha B, Dulic V, Reed S, Harlow E. 1992. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev 6:1874-1885.
21. MacLachlan TK, Sang N, Giordano A. 1995. Cyclins, cyclin-dependent kinases and cdk inhibitors: Implications in cell cycle control and cancer. Crit Rev Euk Gene Exp 5:127-156.
22. MacNeill SA, Fantes PA. 1995. Controlling entry into mitosis in fission yeast. In: Hutchison C, Glover O, editors. Cell Cycle Control. Oxford: TRL Press.
23. Nasmyth K. 1996. Viewpoint: putting the cell cycle in order. Science 274:1643-1645.
24. Nevins J. 1992. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
25. Norel R, Agur Z. 1991. A model for the adjustment of the mitotic clock by cyclin and MPF levels. Science 251:1076-1078.
26. Novak B, Tyson JJ. 1993a. Modeling of the cell division cycle: M-phase trigger, oscillations, and size control. J Theor Biol 165:101-134.
27. Novak B, Tyson JJ. 1993b. Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos. J Cell Sci 106:1153-1168.
28. Obeyesekere MN, Herbert JR, Zimmerman SO. 1995. A model of the G1 phase of the cell cycle incorporating cyclin E/cdk2 complex and retinoblastoma protein. Oncogene 11:1199-1205.
29. Ohtsubo M, Roberts J. 1993. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259:1908-1912.
30. Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M. 1995. Human cyclin E, a nuclear protein essential for the G1 to S phase transition. Mol Cell Biol 15:2612-2624.
31. Pagano M, Draetta G, Jansen-Dürr P. 1992. Association of cdk2 kinase with the transcription factor E2F during S phase. Science 255: 1144-1147.
32. Peeper D, van der Eb A, Zantema A, 1994. The G1/S cell-cycle checkpoint in eukaryotic cells. Biochem Biophys Acta 1198:215-230.
33. Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A. 1994. p27Kipl, a cyclin-cdk inhibitor, links transforming growth factor β and contact inhibition to cell cycle arrest. Genes Dev 8:9-22.
34. Renner W, Lee KH, Hatzimanikatis V, Bailey JE, Eppenberger H. 1995. Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium. Biotechnol Bioeng 47:476-482.
35. Resnitzky D, Gossen M, Bujard H, Reed S. 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol 14:1669-1679.
36. Sherr C. 1994. G1 phase progression: Cycling on cue. Cell 79:551-555.
37. Sherr CJ. 1996. Cancer cell cycles. Science 274:1672-1677.
38. Sherr C, Roberts JM. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9:1149-1163.
39. Singh P, Wong SH, Hong W. 1994. Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J 13:3329-3338.
40. Soos TJ, Kiyokawa H, Van JS, Rubin MS, Giordano A, DeBlasio A, Bottega S, Wong B, Mendelsohn J, Koff A. 1996. Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Diff 7:135-146.
41. Toyoshima H, Hunter T. 1994. p27, a novel inhibitor of G1 cyclin/cdk protein kinase activity, is related to p21. Cell 78:67-74.
42. Zhang H, Hannon GJ, Beach D. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8:1750-1758.