Telomeres and telomerase activity. Their role in senescence and in neoplastic development

Medicina

Volumn 61, Issue 3, 2001, Pages 335-342

  Cottliar, A S H ^a   Slavutsky, I R ^a  

^a INST DE INVEST HEMATOLOGICAS   (Argentina)

Author keywords

Ageing; Human neoplasias; Telomerase; Telomere; Telomeric length

Indexed keywords

DNA; PROTEIN; RIBONUCLEOPROTEIN; RNA; TELOMERASE; TUMOR MARKER; TUMOR PROTEIN;

AGING; ARTICLE; CANCER CHEMOTHERAPY; CARCINOGENESIS; CHROMOSOME; CONTROLLED STUDY; DEGRADATION; DNA SEQUENCE; DRUG TARGETING; ENZYME ACTIVITY; ERROR; EUKARYOTE; GENE AMPLIFICATION; GENE FUSION; HEMATOLOGIC DISEASE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALIGNANT TRANSFORMATION; METAPHASE; MITOSIS; PREVALENCE; PROBABILITY; SENESCENCE; SOLID TUMOR; SYNTHESIS; TANDEM REPEAT; TELOMERE; BLOOD DISEASE; CELL AGING; CELL TRANSFORMATION; ENZYMOLOGY; METABOLISM; NEOPLASM; PHYSIOLOGY; REVIEW;

CELL AGING; CELL TRANSFORMATION, NEOPLASTIC; HEMATOLOGIC NEOPLASMS; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; TELOMERASE; TELOMERE;

EID: 0035232341     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. Telomeres: Beginning to understand the end
2. Structure and function of telomeres
3. Regulation of telomerase activity in immortal cells lines
4. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
5. Chromosome healing, telomere capture and mechanisms of radiation-induced chromosome breakage
6. Telomeric fusions in cultured human fibroblast as a source of genomic instability
7. Telomeric associations
8. High frequency of telomeric associations and chromatid exchanges and breaks in human ovarian carcinoma
9. Specific association of human telomerase activity with immortal cells and cancer
10. Telomerase activity in vivo in human malignant hematopoietic cells
11. Telomeres and telomerase in human leukemias
12. Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression
13. Telomere reduction in human colorectal carcinoma and with aging
14. Telomeric association: Another characteristic of cancer chromosomes?
15. Incremento de asociaciones teloméricas en mieloma múltiple y linfomas no-Hodgkin
16. Human telomeres: Fusion and interstitial sites
17. Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells
18. Accelerated telomere shortening and telomerase activation in Fanconi's anaemia
19. Human somatic chromosome chains and rings
20. Telomeric fusion and chromosome instability in multiple tissues of a patient with mosaic Ullrich-Turner syndrome
21. Clinical implications of basic research: Telomeres, cancer, and immortality
22. Telomeric associations in the progression of chromosome aberrations in pediatric solid tumors
23. High frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma viral oncogenes
24. Telomeric association in women with breast and uterine cervix cancer
25. Telomeric association of chromosomes in B-cell lymphoid leukemia
26. Telomeric fusion in pre-T-cell acute lymphoblastic leukemia
27. Oligoclonal B-cell leukemia characterized by spontaneous cell division and telomere association
28. Telomeric associations in a patient with B-cell prolymphocytic leukaemia
29. Telomeres shorten during ageing of human fibroblasts
30. A human telomeric protein
31. Control of telomere length by the human telomeric protein TRF1
32. TIN2, a new regulator of telomere length in human cells
33. TRF2 protects human telomeres from end-to-end fusions
34. Telomere length in fibroblasts and blood cells from healthy centenarians
35. Clonal telomeric fusions and chromosome instability in a subcutaneous sacrococcygeal myxopapillary ependimoma
36. Can ends justify the means? Telomeres and mechanisms of replicative senescence and immortalization in mammalian cells
37. CIP1/WAF1 gene in normal diploid human fibroblasts
38. Extension of life span by introduction of telomerase into normal cells
39. The limited in vitro lifetime of human diploid cell strains
40. Staining of human telomeres with primed in situ labeling (PRINS)
41. Telomere length dinamics in human lymphocyte populations measured by flow cytometry
42. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
43. Cytogenetic analysis on giant cell tumor of bone
44. Telomeric association and loss of telomeric DNA repeats in renal tumors
45. Telomeric structure in cells with chromosome ends associations
46. Telomere reduction in hematologic cells
47. Telomerase activity in normal leukocytes and in hematologic malignancies
48. Cardiac myxoma characterized by clonal telomeric association
49. High Frequencies of Telomeric Associations, Chromosome Aberrations and Sister Chromatid Exchanges in Ulcerative Colitis
50. Evidence of chromosome instability in Chronic Pancreatitis
51. Lengths of telomeres are reduced in the mucosa of long-standing ulcerative colitis
52. Clinical implications of telomerase activity levels in acute leukemia
53. Telomerase activity in human acute myelogenous leukemia: Inhibition of telomerase activity by differentiation-inducing agents
54. Telomere shortening associated with disease evolution in myelodisplastic syndromes
55. Telomeric length variation in human testicular germ cell tumours: Very long and homogeneous telomeres in spermatocytic seminoma
56. Telomerase activity and germ cell cancers and mature teratomas
57. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis
58. Telomerase activity in human renal carcinoma
59. Telomere reduction in giant cell tumor of bone and with aging
60. Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy
61. Telomerase activity, Telomere length and DNA pliody in prostatic intrepithelial neoplasia (PIN)
62. Detection of telomerase activity in skin, melanocytic nevi and melanoma by telomerase PCR ELISA
63. Telomeric association in two renal tumors
64. Telomerase activity in microdissected human gliomas
65. Change in telomerase activity during human colorectal carcinogenesis
66. A role for telomeric and centromeric instability in the progression of chromosome aberrations in meningioma patients
67. Nonrandom pattern of telomeric associations in atypical lipomatous tumors with ring and giant marker chromosomes
68. Telomerase activity of human squamous epithelial premalignancy in oral cavity and cervix: A comparative model for in vivo chemical and viral multistep carcinogenesis
69. Telomerase activity and germ cell cancers and mature teratomas
70. Telomeric associations evolving to ring chromosomes in a recurrent pleomorphic xanthoastrocytoma
71. Telomere length shortening is associated with disease evolution in chronic myelogenous leukemia
72. Telomeric DNA in normal and leukemic blood cells
73. Telomerase activity in reactive and neoplastic lymphoid tissues: Infrequent deletion of activity in Hogkin's disease
74. Correlation between telomerase activity and DNA ploidy in gastric cancer
75. Telomerase activity and microsatellite instability in colorectal cancer and adenoma