Chemiluminescent nitrogen detection for HPLC: An important new tool in organic analytical chemistry

Tetrahedron Letters

Volumn 38, Issue 10, 1997, Pages 1689-1692

  Fitch, William L ^a   Szardenings, A Katrin ^a   Fujinari, Eugene M ^b  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

^b Antek Instruments Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITROGEN;

ANALYTIC METHOD; ARTICLE; CHEMOLUMINESCENCE; DRUG PURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUANTITATIVE ASSAY; SYNTHESIS; TECHNIQUE;

EID: 0031562404     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00191-3     Document Type: Article

References (40)

1. 1. Reviews: a) Gordon, E.M.; Barrett, R.W.; Dower, W.J.; Fodor, S.P.A.; Gallop, M.A. J. Med. Chem. 1994, 37, 1385-1401.
2. b) Patel, D.V.; Gordon, E.M. Drug Discovery Topics, 1996, 1, 134-144.
3. c) Thompson, L.A.; Ellman, J.A. Chem. Rev. 1996, 96, 555-600.
4. 2. Review: Fitch, W.L. Analytical Methods for Quality Control of Combinatorial Libraries. In Annual Reports in Combinatorial Chemistry & Molecular Diversity, Volume 1; Moos, W.H., Pavia, M.R., Ellington, A.D., and Kay, B.K.; eds., ESCOM Science Publishers, Leiden, in press, 1997.
5. 3. a) Bunin, B.A.; Plunkett, M.J.; Ellman, J.A. Proc. Nat. Acad. Sci. 1994, 91, 4708-4712.
6. b) Tempest, P.A.; Brown, S.D.; Armstrong, R.W. Angew. Chem. Int. Ed. Engl. 1996, 35, 640-642.
7. 4. a) Editors J. Org. Chem. 1996, 61, 7A-10A.
8. b) Editors J. Med. Chem. 1996, 39, 7A-12A.
9. c) Editors J. Am. Chem. Soc. 1996, 118, 9A-13A.
10. d) Editors Tetrahedron 1996, 52, 1.
11. 5. Stavely, L. A. K. The Characterization of Chemical Purity: Organic Compounds; Butterworths: London, 1971, pp 173.
12. 6. Smart, S.S.; Mason, T.J.; Bennell, P.S.; Maeji, N.J.; Geysen, H.M. Int. J. Pept. Protein Res. 1996, 47, 47-55.
13. 7. a) Giron, D. Boll. Chim. Farma. 1994, 133, 201-220.
14. b) Dreux, M., Lafosse, M., Morin-Allory, L. LC/GC International 1996, 148-156.
15. c) Kibbey, C.E. Molecular Diversity, 1995, 1, 247-258.
16. 8. Picchioni, G. A.; Watada, A. E.; Whitaker, B. D. Lipids 1996, 31, 217-221.
17. 9. a) Bizanek, R.; Manes, J.D.; Fujinari, E.M. Pept. Res. 1996, 9, 40-44.
18. b) Fujinari, E.M., Manes, J.D., Bizanek, R.J. J. Chromatogr. A 1996, 743, 85-89.
19. 10. a) Young, R.J.; Fujinari, E.M. Am. Lab. 1994, 26, 38-45.
20. b) Shi, H.; Strode, J.T.B.; Taylor, L.T.; Fujinari, E.M. J. Chromatogr. A 1996, 734, 303-310.
21. c) Fujinari, E.M.; Manes, J.D. Dev. Food Sci. 1995, 37A, 379-396.
22. d) Fujinari, E.M., Ribble, E., Piserchio, M.V. Dev. Food Sci. 1993, 32, 75-89.
23. e) Fujinari, E.M. Dev. Food Sci. 1993, 33, 1033-1048.
24. f) Fujinari, E.M. Dev. Food Sci. 1994, 34, 367-379.
25. g) Fujinari, E.M., Manes, J.D. Dev. Food Sci. 1995, 37A, 929-949.
26. h) Fujinari, E.M., Manes, J.D., Bizanek, R.J. J. Chromatogr. A 1996, 743, 85-89.
27. i) Benn, S.M., Myung, K., Fujinari, E.M. Dev. Food Sci. 1993, 32, 65-73.
28. j) Shi, H., Taylor, L.T., Fujinari, E.M. J. High Resolut. Chromatogr. 1996, 19, 213-216.
29. k) Shi, H., Taylor, L.T., Fujinari, E.M. J. Chromatogr. A 1997, 757, 183-191.
30. 11. The ACD and the MDDR are commercial databases available from MDL Information Systems Inc., San Leandro, CA.
31. 12. a) Gordeev, M. F.; Patel, D.V.; Gordon, E.M. J. Org. Chem. 1996, 61, 924-928.
32. b) Gordon, E. M.; Gallop, M.A.; Patel, D.V. Acct. Chem. Res. 1996, 29, 144-154.
33. c) Holmes, C. P.; Chinn, J.P.; Look, G.C.; Gordon, E.M.; Gallop, M.A. J. Org. Chem. 1995, 60, 7328-7333.
34. d) Murphy, M. M.; Schullek, J.R.; Gordon, E.M.; Gallop, M.A. J. Am. Chem. Soc. 1995, 117, 7029-7030.
35. e) Ruhland, B.; Bhandari, A.; Gordon, E.M.; Gallop, M.A. J. Am. Chem. Soc. 1996, 118, 253-254.
36. f) Atuegbu, A., Maclean, D., Nguyen, C., Gordon, E.M., Jacobs, J.W. Bioorg. Med. Chem. Lett. 1996, 4, 1097-1106.
37. 13. Szardenings, A. K.; Burkoth, T.C.; Look, G.C.; Lu, H. H.; Tien D.W.; Campbell D.A. submitted to Tetrahedron 1996.
38. 3CN cannot be used in the mobile phase.
39. 9a
40. 16. Benzamide was chosen for its chromatographic properties and its availability in 99.9% purity(Aldrich). Linearity over the range of 0-.598 μg of N injected was demonstrated.