Characterization of Small Combinatorial Chemistry Libraries by 1H NMR. Quantitation with a Convenient and Novel Internal Standard

Journal of Combinatorial Chemistry

Volumn 3, Issue 5, 2001, Pages 434-440

  Pinciroli, Vittorio ^a   Biancardi, Roberto ^a   Colombo, Nicoletta ^a   Colombo, Maristella ^a   Rizzo, Vincenzo ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRIMETHYLSILYL DERIVATIVE;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REPRODUCIBILITY; STANDARD; ULTRAVIOLET SPECTROPHOTOMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; TRIMETHYLSILYL COMPOUNDS;

EID: 0035465188     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc000101t     Document Type: Article

References (17)

1. Kyranos, J. N.; Hogan, J. C. High-Throughput Characterization of Combinatorial Libraries Generated by Parallel Synthesis. Anal. Chem. 1998, 70, 389A-395A.
2. Fang, L.; Wan, M.; Pennacchio, M.; Jianmin, P. Evaluation of Evaporative Light-Scattering Detector for Combinatorial Library Quantitation by Reversed Phase HPLC. J. Comb. Chem. 2000, 2, 254-257.
3. Fitch, W. L.; Szardenings, A. K.; Fujinari, E. M. Chemiluminescent Nitrogen Detection for HPLC: An important New Tool in Organic Analytical Chemistry. Tetrahedron Lett. 1997, 38, 1689-1692.
4. Taylor, E. W.; Qian, M. G.; Dollinger, G. D. Simultaneous On-Line Characterization of Small Organic Molecules Derived from Combinatorial Libraries for Identity, Quantity, and Purity by Reversed Phase HPLC with Chemiluminescent Nitrogen, UV, and Mass Spectrometric Detection. Anal. Chem. 1998, 70, 3339-3347.
5. Larive, C. K.; Jayawickrama, D.; Orfi, L. Quantitative Analysis of Peptides with NMR Spectroscopy. Appl. Spectrosc. 1997, 51 (10), 1531-1536.
6. Griffiths, L.; Irving, A. M. Assay by Nuclear Magnetic Resonance Spectroscopy: Quantification Limits. Analyst 1998, 123, 1061-1068.
7. 31P NMR Spectroscopy. Applications to Analytical Standards and Agricultural Chemicals. Anal. Chem. 1998, 70, 4921-4928.
8. Keifer, P. A.; Smallcombe, S. H.; Williams, E. H.; Salomon, K. E.; Mendez, G.; Belletire, J. L.; Moore, C. D. Direct-Injection NMR (DI-NMR): A Flow NMR Technique for the Analysis of Combinatorial Chemistry Libraries. J. Comb. Chem. 2000, 2, 151-171.
9. Williams, A. Recent Advances in NMR Prediction and Automated Structure Elucidation Software. Curr. Opin. Drug Discovery Dev. 2000, 3 (3), 298-305
10. Hamper, B. C.; Kolodziej, S. A.; Scates, A. M.; Smith, R. G.; Cortez, E. Solid Phase Synthesis of β-Peptoids: N-Substituted β-Aminopropionic Acid Oligomers. J. Org. Chem. 1998, 63, 708-718.
11. 1H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library. J. Comb. Chem. 1999, 1, 140-150.
12. 1H NMR. J. Comb. Chem. 2000, 2, 39-41.
13. Weinshenker, N. M.; Shen, C. M.; Wong, J. Y. Polymeric carbodiimide preparation. Org. Synth. 1988, 6, 951-954.
14. Wright, S. W.; Hageman, D. L.; McClure, L. D. Fluoride-Mediated Boronic Acid Coupling Reactions. J. Org. Chem. 1994, 59 (20), 6095-6097.
15. Bui, C. T.; Rasoul, F. A.; Ercole, F.; Pham, Y.; Maeji, N. J. Efficiencies of Reductive Amination Reactions on Different Solid Supports. Tetrahedron Lett. 1998, 39 (50), 9279-9282.
16. 2) Receptor. Bioorg. Med. Chem. Lett. 1995, 5 (23), 2879-2884.
17. Hoult, D. I.; Chen, C. N.; Eden, H.; Eden, M. Elimination of baseline artifacts in spectra and their integrals. J. Magn. Reson. 1983, 51, 110-117.